AutismKB 2.0

Annotation Detail for STS


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Basic Information Top
Gene Symbol:STS ( ARSC,ARSC1,ASC,ES,SSDD,XLI )
Gene Full Name: steroid sulfatase (microsomal), isozyme S
Band: Xp22.31
Quick LinksEntrez ID:412; OMIM: 300747; Uniprot ID:STS_HUMAN; ENSEMBL ID: ENSG00000101846; HGNC ID: 11425
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00140Steroid hormone biosynthesis
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of lipid/glycolipid metabolism
H00134X-linked ichthyosis
Genetic disorders
Desease IDDesease Name
1831Prostate cancer
1860Brain tumor
1881Uterine disease
1893Esotropia
1901Endometriosis
1944Breast cancer
1954Stroke
2067Primary tumor
2102Polycystic ovary syndrome
2124Autistic disorder
2190Attention deficit hyperactivity disorder
2237Neoplasm metastasis
2191Meningioma
No data
No data
Desease Name
Ichthyosis, X-linked
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C477931 1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate 1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of STS mRNAaffects expression 21346803
C500344 2-methoxyestradiol-3,17-bis-O,O-sulfamate 2-methoxyestradiol-3,17-bis-O,O-sulfamate analog results in decreased activity of STS proteindecreases activity 15862969
C500344 2-methoxyestradiol-3,17-bis-O,O-sulfamate 2-methoxyestradiol-3,17-bis-O,O-sulfamate results in decreased activity of STS proteindecreases activity 14623540
15862969
12711022
C526438 2-methoxyestradiol-3,17-O,O-bis(sulfamate) 2-methoxyestradiol-3,17-O,O-bis(sulfamate) results in decreased activity of STS proteindecreases activity 18450955
C041525 3,3',4,5'-tetrahydroxystilbene 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C038864 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS proteinincreases activity 16178010
C038864 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid AGN 194310 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]decreases reaction|increases activity 16178010
C038864 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid wortmannin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]decreases reaction|increases activity 16178010
C021228 4-nitrocatechol sulfate 4-nitrocatechol sulfate results in decreased activity of STS proteindecreases activity 6874424
C023379 4-nitrophenyl sulfate 4-nitrophenyl sulfate results in decreased activity of STS proteindecreases activity 6874424
C489251 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C412043 667 coumate 667 coumate results in decreased activity of STS proteindecreases activity 12711022
14623540
C054852 7-hydroxystaurosporine 7-hydroxystaurosporine inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D000082 Acetaminophen Acetaminophen affects the expression of STS mRNAaffects expression 17562736
C412373 AG 1879 AG 1879 inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C090766 AGN 190299 AGN 190299 results in increased activity of STS proteinincreases activity 16178010
C121616 AGN 194310 AGN 194310 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]decreases reaction|increases activity 16178010
C121616 AGN 194310 AGN 194310 inhibits the reaction [AGN 195183 results in increased activity of STS protein]decreases reaction|increases activity 16178010
C121616 AGN 194310 AGN 194310 inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C492393 AGN 195183 AGN 194310 inhibits the reaction [AGN 195183 results in increased activity of STS protein]decreases reaction|increases activity 16178010
C492393 AGN 195183 AGN 195183 results in increased activity of STS proteinincreases activity 16178010
C492393 AGN 195183 wortmannin inhibits the reaction [AGN 195183 results in increased activity of STS protein]decreases reaction|increases activity 16178010
C103303 alitretinoin alitretinoin results in increased activity of STS proteinincreases activity 16178010
C068073 Am 580 Am 580 results in increased activity of STS proteinincreases activity 16178010
D000643 Ammonium Chloride Ammonium Chloride affects the expression of STS mRNAaffects expression 16483693
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of STS mRNAincreases expression 15912405
C059975 bistratene A [Tretinoin co-treated with bistratene A] results in increased activity of STS proteinaffects cotreatment|increases activity 16178010
D020001 1-Butanol 1-Butanol inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D002330 Carmustine Carmustine results in increased expression of STS mRNAincreases expression 15980968
C105934 celecoxib celecoxib inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D002746 Chlorpromazine Chlorpromazine inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D003474 Curcumin Curcumin results in decreased expression of STS mRNAdecreases expression 17198877
D016572 Cyclosporine Cyclosporine results in decreased expression of STS mRNAdecreases expression 20106945
C107676 deguelin deguelin inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D003687 Dehydroepiandrosterone STS protein results in increased chemical synthesis of Dehydroepiandrosteroneincreases chemical synthesis 16054388
D019314 Dehydroepiandrosterone Sulfate STS protein affects the metabolism of Dehydroepiandrosterone Sulfateaffects metabolic processing 16054388
C121718 dicyclanil dicyclanil results in decreased expression of STS mRNAdecreases expression 15664270
D019794 2,3-Diphosphoglycerate 2,3-Diphosphoglycerate inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D004855 Equilenin STS protein results in increased metabolism of Equileninincreases metabolic processing 6874424
D004970 Estrone STS protein results in increased chemical synthesis of Estroneincreases chemical synthesis 16054388
C088768 estrone-3-O-sulfamate estrone-3-O-sulfamate results in decreased activity of STS proteindecreases activity 12711022
C017296 estrone sulfate STS protein affects the metabolism of estrone sulfateaffects metabolic processing 16054388
C081021 Go 6976 Go 6976 inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C475919 hydroxytamoxifen hydroxytamoxifen results in decreased expression of STS mRNAdecreases expression 16849584
C064769 N-acetylsphingosine N-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C002669 parthenolide parthenolide inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C093973 PD 98059 PD 98059 inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D010710 Phosphates Phosphates results in decreased activity of STS proteindecreases activity 6874424
D010712 Phosphatidic Acids Phosphatidic Acids promotes the reaction [Tretinoin results in increased activity of STS protein]increases activity|increases reaction 16178010
C006253 pirinixic acid pirinixic acid results in decreased expression of STS mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of STS mRNA]decreases expression|increases reaction 20059764
D011433 Propranolol Propranolol inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C085746 rottlerin rottlerin inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D020123 Sirolimus Sirolimus inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C118258 SN50 peptide SN50 peptide inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C010634 sodium borate sodium borate results in decreased activity of STS proteindecreases activity 6874424
C515227 STX 213 STX 213 results in decreased activity of STS proteindecreases activity 18450955
C520511 STX64 compound STX64 compound results in decreased activity of STS proteindecreases activity 18450955
C086827 tazarotene tazarotene metabolite results in increased activity of STS proteinincreases activity 16178010
C086827 tazarotene tazarotene results in increased activity of STS proteinincreases activity 16178010
C086827 tazarotene wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014108 Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin 1-Butanol inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin 1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin 2,3-Diphosphoglycerate inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin 7-hydroxystaurosporine inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin AG 1879 inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin AGN 194310 inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin bisindolylmaleimide I inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin celecoxib inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin Chlorpromazine inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin deguelin inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin Go 6976 inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin N-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin parthenolide inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin PD 98059 inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin Phosphatidic Acids promotes the reaction [Tretinoin results in increased activity of STS protein]increases activity|increases reaction 16178010
D014212 Tretinoin PRKCA protein affects the reaction [Tretinoin results in increased activity of STS protein]affects reaction|increases activity 16178010
D014212 Tretinoin PRKCD protein affects the reaction [Tretinoin results in increased activity of STS protein]affects reaction|increases activity 16178010
D014212 Tretinoin Propranolol inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin RARA protein promotes the reaction [Tretinoin results in increased activity of STS protein]increases activity|increases reaction 16178010
D014212 Tretinoin rottlerin inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin Sirolimus inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin SN50 peptide inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin [Tretinoin co-treated with bistratene A] results in increased activity of STS proteinaffects cotreatment|increases activity 16178010
D014212 Tretinoin Tretinoin results in increased activity of STS proteinincreases activity 16178010
D014212 Tretinoin U 0126 inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
D014212 Tretinoin wortmannin inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C113580 U 0126 U 0126 inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
C009687 wortmannin wortmannin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]decreases reaction|increases activity 16178010
C009687 wortmannin wortmannin inhibits the reaction [AGN 195183 results in increased activity of STS protein]decreases reaction|increases activity 16178010
C009687 wortmannin wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]decreases reaction|increases activity 16178010
C009687 wortmannin wortmannin inhibits the reaction [Tretinoin results in increased activity of STS protein]decreases reaction|increases activity 16178010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 2.9518287403
MESH:D000168 Acrocephalosyndactylia U 0126 4.8817694057
MESH:D055371 Acute Lung Injury pirinixic acid 2.5618653653
MESH:D018248 Adenoma, Liver Cell dicyclanil 8.5117162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.5116434500
MESH:D011125 Adenomatous Polyposis Coli celecoxib 4.5516215675 19003578
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.1717302879
MESH:D019973 Alcohol-Related Disorders Curcumin 4.4617887948
MESH:D000505 Alopecia Tretinoin 3.1215955085
MESH:D000544 Alzheimer Disease Curcumin 2.4615590663
MESH:D000799 Angioedema Acetaminophen 3.2210982225
MESH:D001169 Arthritis, Experimental Tosylphenylalanyl Chloromethyl Ketone 6.6518706406
MESH:D001169 Arthritis, Experimental Tretinoin 6.6516412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.1116807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1116292516
MESH:D001249 Asthma Tretinoin 2.1316456186
MESH:D001259 Ataxia 1-Butanol 5.027820390
MESH:D050197 Atherosclerosis Curcumin 2.9418704882
MESH:D001289 Attention Deficit Disorder with Hyperactivity marker/mechanism 18413370
MESH:D001321 Autistic Disorder Acetaminophen 2.6118445737
MESH:D001321 Autistic Disorder Dehydroepiandrosterone Sulfate 2.6115820420
MESH:D001321 Autistic Disorder Propranolol 2.6118766980
MESH:D001321 Autistic Disorder Sirolimus 2.6121115397
MESH:D001327 Autoimmune Diseases Curcumin 3.9019761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8216935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.1619483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.1616206674 16197459
MESH:D001919 Bradycardia Propranolol 4.966740701
MESH:D002545 Brain Ischemia Curcumin 3.7316770732
MESH:D001932 Brain Neoplasms Carmustine 7.4116187019
MESH:D001932 Brain Neoplasms Curcumin 7.4117596214
MESH:D001943 Breast Neoplasms 2-methoxyestradiol-3,17-bis-O,O-sulfamate 4.0517957467 12711013 12711022 17426705 15862969 14970876
MESH:D001943 Breast Neoplasms 2-methoxyestradiol-3,17-O,O-bis(sulfamate) 4.0518223236 18985042 18506995 18026194
MESH:D001943 Breast Neoplasms alitretinoin 4.0516344269
MESH:D001943 Breast Neoplasms Curcumin 4.0518462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms deguelin 4.0517035597 18593368
MESH:D001943 Breast Neoplasms estrone sulfate 4.0517261762
MESH:D001943 Breast Neoplasms parthenolide 4.0516873071
MESH:D001943 Breast Neoplasms Tretinoin 4.0516443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9816813970
MESH:D002277 Carcinoma Curcumin 3.3518593918
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5416168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.6416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.643084413
MESH:D006528 Carcinoma, Hepatocellular deguelin 9.6418575727
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 9.6417162532
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 9.6419335982
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.641917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7418414057
MESH:D002292 Carcinoma, Renal Cell celecoxib 3.8716369983
MESH:D002294 Carcinoma, Squamous Cell Curcumin 6.4618462866
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 6.4619435901
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.4616051514 16096774
MESH:D002386 Cataract Acetaminophen 10.2210977129
MESH:D002386 Cataract Am 580 10.2217460283
MESH:D002386 Cataract Tretinoin 10.2217460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 5.136135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.1312371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9816129372
MESH:D002779 Cholestasis Cyclosporine 6.2119486331
MESH:D002779 Cholestasis pirinixic acid 6.2119176532
MESH:D002822 Choriocarcinoma Tretinoin 4.5416461808
MESH:D002972 Cleft Palate Tretinoin 2.389407595
MESH:D003092 Colitis Am 580 12.7817035595
MESH:D003092 Colitis Curcumin 12.7816782535 18200517 16804969
MESH:D003092 Colitis Tretinoin 12.7817035595
MESH:D003103 Coloboma Curcumin 4.0018809619
MESH:D003110 Colonic Neoplasms celecoxib 3.8716004971
MESH:D003110 Colonic Neoplasms Curcumin 3.8719359593 16340194
MESH:D015179 Colorectal Neoplasms celecoxib 3.1611197048 18349538
MESH:D016510 Corneal Neovascularization Curcumin 4.3018497527
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.7916925845 9224671 17551590 9142499 9125849 9211117 14991402 9664655 8800419 10589399
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.4218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1118249437
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.4816616286
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.5318403477
MESH:D003928 Diabetic Nephropathies Curcumin 3.4918204486
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 5.1121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.1111743745 19923254 18071297 11834606 19416960 16227642 10915739 12958197 10774834 2444490 19164858 17522070 19739265 16081117 12153990 17562736 11461765 16485898 14550746 14725611 11529661 16393943 11739529 19085960 19420014 16109766 15619225 16781746 10663392 15968718 12705907 16177239 11287661 14986274 18713872 11421492 17906064 19370779 12540782 12594235 12392966
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 5.1111461765
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.4819426721
MESH:D004381 Duodenal Ulcer Curcumin 3.4817351913
MESH:D004487 Edema bisindolylmaleimide I 5.528273558
MESH:D004487 Edema pirinixic acid 5.5212083418
MESH:D004489 Edema, Cardiac Tretinoin 3.8518230668
MESH:D016889 Endometrial Neoplasms 2-methoxyestradiol-3,17-O,O-bis(sulfamate) 14.7418450955
MESH:D016889 Endometrial Neoplasms STX 213 14.7418450955
MESH:D016889 Endometrial Neoplasms STX64 compound 14.7418450955
MESH:D016889 Endometrial Neoplasms Tretinoin 14.7416569247
MESH:D004715 Endometriosis celecoxib 4.4315652904
MESH:D005124 Eye Abnormalities Tretinoin 3.119664655 16938888
MESH:D005234 Fatty Liver Curcumin 9.9819297423
MESH:D005234 Fatty Liver Cyclosporine 9.9819224547
MESH:D005234 Fatty Liver pirinixic acid 9.9820131406 19236843
MESH:D005355 Fibrosis Curcumin 11.4418705752
MESH:D005355 Fibrosis Cyclosporine 11.4412639820 12168785
MESH:D005355 Fibrosis Tretinoin 11.4417994277
MESH:D005756 Gastritis Acetaminophen 3.0616983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1018462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.618708960
MESH:D005909 Glioblastoma Carmustine 9.6016187019
MESH:D005909 Glioblastoma Curcumin 9.6017596214
MESH:D005909 Glioblastoma Tretinoin 9.6017312396
MESH:D006258 Head and Neck Neoplasms Curcumin 10.6418829502 18462866
MESH:D006258 Head and Neck Neoplasms Sirolimus 10.6419435901
MESH:D006258 Head and Neck Neoplasms Tretinoin 10.6416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.559664655 14991402
MESH:D006333 Heart Failure pirinixic acid 6.1820558911
MESH:D006333 Heart Failure Propranolol 6.1820082655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8115720958
MESH:D006529 Hepatomegaly pirinixic acid 7.1119176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Propranolol 7.1116371745
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.4417701891
MESH:D006561 Herpes Simplex Chlorpromazine 4.691682908
MESH:D006930 Hyperalgesia Acetaminophen 6.0116870215
MESH:D006930 Hyperalgesia Tretinoin 6.0116870215
MESH:D017588 Hyperandrogenism Dehydroepiandrosterone Sulfate 5.9217392600
MESH:D006937 Hypercholesterolemia Curcumin 3.5118704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9716778211
MESH:D006943 Hyperglycemia pirinixic acid 2.6520558911
MESH:D006973 Hypertension Cyclosporine 1.8410903974
MESH:D006984 Hypertrophy Sirolimus 4.6819211884
MESH:D007022 Hypotension Propranolol 4.626740701
MESH:D016114 Ichthyosis, X-Linked marker/mechanism
MESH:D007249 Inflammation bisindolylmaleimide I 4.708273558
MESH:D007249 Inflammation Curcumin 4.7016956363 17151092 18403477
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9318200517 18596194
MESH:D007333 Insulin Resistance pirinixic acid 2.2216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.1817994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.6910783313
MESH:D007569 Jaw Abnormalities Tretinoin 3.3515992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8215604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.0316144296
MESH:D007674 Kidney Diseases Acetaminophen 4.5415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 4.548314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 9.7216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 9.7212371664
MESH:D007680 Kidney Neoplasms Estrone 9.7215610895
MESH:D007889 Leiomyoma Curcumin 4.0118555241
MESH:D007938 Leukemia 1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate 16.1712970779
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16.1712970779
MESH:D007938 Leukemia Curcumin 16.1718462866
MESH:D007938 Leukemia SN50 peptide 16.1712970779
MESH:D007938 Leukemia Tretinoin 16.1717143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.6616106398
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 10.0716972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 10.0716972261
MESH:D007951 Leukemia, Myeloid Tretinoin 3.1516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9619850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.7317217047 17301526 17712046 19225113 19035177 16823087 17107899 16331271 17339181 12679006 19642359 15748426 16891316 16935935 17368321 17506722 9834237 17649720 17294898 16766008 19075265 16788101 16140955 19029980 17361223
MESH:D015458 Leukemia, T-Cell Curcumin 4.1816106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.869224671
MESH:D008064 Lipidoses Chlorpromazine 4.3015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 4.2118705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.2115474484
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 4.2117050028
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.2118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 5.5816611625 16610002 12969438 19784758 19014921 19460945 12587719 11587558
MESH:D008107 Liver Diseases Chlorpromazine 5.5814986274
MESH:D008107 Liver Diseases Curcumin 5.5816956363
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.557678174
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 8.5518709148
MESH:D008113 Liver Neoplasms dicyclanil 8.5520118626
MESH:D008113 Liver Neoplasms pirinixic acid 8.5520007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.052876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 5.058603461
MESH:D008175 Lung Neoplasms alitretinoin 3.3416413115
MESH:D008175 Lung Neoplasms Curcumin 3.3419359593 18462866 16243823
MESH:D008175 Lung Neoplasms deguelin 3.3419336726 16288123
MESH:D008223 Lymphoma Curcumin 3.1418462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.1016173963
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 5.6212104042 19196722
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 5.6216457693
MESH:D008527 Medulloblastoma Tretinoin 2.5117453147
MESH:D008545 Melanoma 2-methoxyestradiol-3,17-bis-O,O-sulfamate 8.2814970876
MESH:D008545 Melanoma Carmustine 8.2812393984
MESH:D008545 Melanoma Curcumin 8.2818462866 17885582
MESH:D008545 Melanoma Sirolimus 8.2819282848
MESH:D008545 Melanoma Tretinoin 8.2816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 2.9719513568
MESH:D008569 Memory Disorders Curcumin 3.5817263510
MESH:D008591 Meningomyelocele Tretinoin 3.8316940565
MESH:D001523 Mental Disorders Chlorpromazine 7.0416856516
MESH:D001523 Mental Disorders Phosphates 7.0412686366
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.1716801185
MESH:D009062 Mouth Neoplasms Sirolimus 4.2319435901
MESH:D009101 Multiple Myeloma celecoxib 6.4316123214
MESH:D009101 Multiple Myeloma Curcumin 6.4319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.3117962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9116239165
MESH:D009175 Mycoplasma Infections Chlorpromazine 5.3810773494
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.7017596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.8619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.4716411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.2618551238 7678174
MESH:D009361 Neoplasm Invasiveness Curcumin 3.7918495463
MESH:D009369 Neoplasms 2-methoxyestradiol-3,17-O,O-bis(sulfamate) 12.2118630502 19156141 18841154
MESH:D009369 Neoplasms alitretinoin 12.2116946489
MESH:D009369 Neoplasms deguelin 12.2117764071
MESH:D009369 Neoplasms pirinixic acid 12.2117405874
MESH:D009369 Neoplasms Tretinoin 12.2116946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 9.3119196722
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.3112497104
MESH:D009389 Neovascularization, Pathologic 2-methoxyestradiol-3,17-bis-O,O-sulfamate 9.4417426705
MESH:D009389 Neovascularization, Pathologic parthenolide 9.4416921510
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.7719348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 3.209125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.0118462866
MESH:D009436 Neural Tube Defects Tretinoin 2.649142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.3718514411
MESH:D009765 Obesity Curcumin 3.9619297423
MESH:D009765 Obesity pirinixic acid 3.9620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 2.9016049721
MESH:D010024 Osteoporosis Curcumin 3.0718719352
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 4.4716397352
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9.4516211241
MESH:D010051 Ovarian Neoplasms Curcumin 9.4519020741 18462866
MESH:D010051 Ovarian Neoplasms Tretinoin 9.4516936753
MESH:D010051 Ovarian Neoplasms U 0126 9.4516211241
MESH:D010146 Pain Acetaminophen 4.9616870215
MESH:D010146 Pain Tretinoin 4.9616870215
MESH:D010190 Pancreatic Neoplasms Curcumin 4.5717440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.5715976015
MESH:D010300 Parkinson Disease Sirolimus 3.4919682553
MESH:D017499 Porokeratosis alitretinoin 5.3816144296
MESH:D011230 Precancerous Conditions Cyclosporine 2.7112371664
MESH:D011471 Prostatic Neoplasms 2-methoxyestradiol-3,17-O,O-bis(sulfamate) 2.5318985042 18026194
MESH:D011471 Prostatic Neoplasms celecoxib 2.5317908994 15570007
MESH:D011471 Prostatic Neoplasms Curcumin 2.5318769126 11398177 10851300 18226269 18156803 12497104 15129424
MESH:D011471 Prostatic Neoplasms parthenolide 2.5316921510
MESH:D011507 Proteinuria Tretinoin 3.0516636307
MESH:D011565 Psoriasis Cyclosporine 5.6416882103
MESH:D011565 Psoriasis tazarotene 5.6415989518 16605289
MESH:D011625 Pterygium Tretinoin 4.1816723453
MESH:D011656 Pulmonary Emphysema Curcumin 3.9919168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.0619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.4718379247 10666014
MESH:D012175 Retinoblastoma SN50 peptide 5.8812466137
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.5416283617 16116481
MESH:D012509 Sarcoma Curcumin 3.5918462866
MESH:D012640 Seizures 2,6-dinitrotoluene 2.1318551238
MESH:D018805 Sepsis Curcumin 3.5718389075
MESH:D012878 Skin Neoplasms deguelin 5.2716041863
MESH:D012878 Skin Neoplasms Tretinoin 5.2716467112
MESH:D013274 Stomach Neoplasms celecoxib 2.7515609394
MESH:D013274 Stomach Neoplasms Tretinoin 2.7517261132
MESH:D013276 Stomach Ulcer Curcumin 2.9819188055 16631530
MESH:D013964 Thyroid Neoplasms Tretinoin 2.5616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.2516051514
MESH:D014376 Tuberculosis Tretinoin 2.8216040207
MESH:D014402 Tuberous Sclerosis Sirolimus 4.9921115397 18495876
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.3116049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 4.3118593936
MESH:D014565 Urogenital Neoplasms Curcumin 4.6518462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.7110091137
MESH:D014581 Urticaria Acetaminophen 2.4210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.1516129372
MESH:D014594 Uterine Neoplasms celecoxib 4.5118645019
MESH:D014604 Uveal Neoplasms Tretinoin 3.9916752155
MESH:D014605 Uveitis Cyclosporine 10.011336536
MESH:D014605 Uveitis Sirolimus 10.011336536
MESH:D014820 Vitiligo Tretinoin 3.4816761959
MESH:D009396 Wilms Tumor Tretinoin 3.4516287080
MESH:D014985 Xerophthalmia Cyclosporine 3.8217120751
Pathway ID Pathway Name
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36225
    • No data
    Releated disease ID Related disease Name
    PA444929Mental Retardation
    Releated drug ID Related drug Name
    PA165290929norelgestromin/ethinyl estradiol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02735 - 2-Amino-3-Oxo-4-Sulfo-Butyric Acid
    DB03122 - B-Octylglucoside Detergents
    Drugbank ID Action Drug Name Description
    DB06713 inhibitor Ortho Evra Contraceptives;Contraceptive Agents, Female
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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