AutismKB 2.0

Annotation Detail for MAN2A2


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Basic Information Top
Gene Symbol:MAN2A2 ( MANA2X )
Gene Full Name: mannosidase, alpha, class 2A, member 2
Band: 15q25
Quick LinksEntrez ID:4122; OMIM: 600988; Uniprot ID:MA2A2_HUMAN; ENSEMBL ID: ENSG00000196547; HGNC ID: 6825
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00510N-Glycan biosynthesis
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
ADHD
PSYCH
attention-deficit hyperactivity disorder
Desease Name
Attention deficit hyperactivity disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MAN2A2 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MAN2A2 mRNAdecreases expression 15336504
D020849 Raloxifene Raloxifene affects the expression of MAN2A2 mRNAaffects expression 14699072
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000419 Albuminuria Raloxifene 5.1817451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.6115800139
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001930 Brain Injuries Raloxifene 5.1316580743
MESH:D001943 Breast Neoplasms Raloxifene 2.6216912660 17952589 15758505 17049068 17261762 15775269 17893378 17242785 15572757 17595753 16837676 17440819
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.5217572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.7415775269
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D003072 Cognition Disorders Raloxifene 5.2715800139
MESH:D003865 Depressive Disorder, Major Raloxifene 4.5817474826
MESH:D003928 Diabetic Nephropathies Raloxifene 4.3515920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6819739265 10774834 14986274 12594235 16177239 10663392 19085960 11739529 16485898 11529661 12958197 12153990 19370779 2444490 14725611 19420014 11421492 11743745 17562736 12392966 15968718 14550746 17522070 16393943 19416960 18713872 16081117 15619225 11461765 12540782 16109766 19923254 11834606 19164858 16227642 17906064 16781746 11287661 12705907 18071297 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004487 Edema Raloxifene 3.8115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.5815845917
MESH:D005234 Fatty Liver Raloxifene 4.1017473493
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006331 Heart Diseases Raloxifene 3.8311110106
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D006973 Hypertension Raloxifene 2.9915787275 17577099
MESH:D007674 Kidney Diseases Acetaminophen 2.4212587719 15629191
MESH:D007889 Leiomyoma Raloxifene 5.0316973256
MESH:D008107 Liver Diseases Acetaminophen 1.7119014921 12587719 12969438 16610002 19460945 19784758 11587558 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6817185352 16871587
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.4215863610
MESH:D009101 Multiple Myeloma Raloxifene 3.7416497877
MESH:D009232 Myxoma Raloxifene 6.4216343187
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D010024 Osteoporosis Raloxifene 3.6419059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.7615579764 17823083 17893378 15758505
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5416536755 16220300 15731164
MESH:D011693 Purpura Raloxifene 6.4215770314
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.868532709
MESH:D020521 Stroke Raloxifene 4.1916837676
MESH:D013978 Tibial Fractures Raloxifene 6.0819048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.9517572228
MESH:D014581 Urticaria Acetaminophen 3.5010982225
MESH:D054556 Venous Thromboembolism Raloxifene 6.0816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.4216343187
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
KEGG:00510 N-Glycan biosynthesis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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