AutismKB 2.0

Annotation Detail for MANBA


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Basic Information Top
Gene Symbol:MANBA ( MANB1 )
Gene Full Name: mannosidase, beta A, lysosomal
Band: 4q24
Quick LinksEntrez ID:4126; OMIM: 609489; Uniprot ID:MANBA_HUMAN; ENSEMBL ID: ENSG00000109323; HGNC ID: 6831
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
hsa00511Other glycan degradation
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Lysosomal storage diseases
H00140beta-Mannosidosis
Genetic disorders
No data
No data
No data
Desease Name
Mannosidosis, beta
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MANBA mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MANBA mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of MANBA mRNAdecreases expression 16788091
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MANBA mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of MANBA mRNAincreases expression 20106945
C006253 pirinixic acid pirinixic acid results in decreased expression of MANBA mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of MANBA mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D044905 beta-Mannosidosis marker/mechanism
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016097048 16227642 18705752 15700767 3786805 15673190 16011737 15721981 16192424 16050911 16124888 10355542
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7916705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7918788625
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.276135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002779 Cholestasis Cyclosporine 8.5319486331
MESH:D002779 Cholestasis pirinixic acid 8.5319176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.6916227642 17522070 11566570 21278145 7179309 15968718 19085960 4309450 19336974 10915739 6884620 9327722 7120509 2869522 15027814 10092053 6623471 3786805 16177239 7440962 3732212 15998439
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.0217595544 12795759 16239168 12631006 61145 15959796 16045604 19224547
MESH:D005234 Fatty Liver Cyclosporine 15.0219224547
MESH:D005234 Fatty Liver pirinixic acid 15.0219236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 10.0918705752
MESH:D005355 Fibrosis Cyclosporine 10.0912639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.4118467677 19176532 16221962 19772884
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.9712371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9621278145 11903743 17334410 16943688 17157831 11408273 17174718 16239168 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4018339082 12666154 15362042 15370692 18429990 18277467 16027843 17557913 15123356 17761835 15052691 15673190 18263696 15925388 18472332 16015684 17565644 17823541 15893842 18054572 15650968 18376398 14724832 12898905 17481882 18006644 18156304 15730626 12586293 17721639 14748882 18395914 17900296 18251166 11481614 18205269 18420326 17922224 18395095 17805973 16136751 12546737 17766677 17708605 17869086 12389079 17525996 18210741 15959796 14620537 16011737 16248980 12741479 15818738 18187930 18279442 12609069 12445418 18166357 18412020 16033810 10355542 18481824 16638106 18418968 14512876 16192424 12649538 12632512 17698563 17631135 14716496 20821823 12632514 14716833 15931870 15876570 17714472 16097048 18472094 17640975 15338365 12445421 12667390 17976157 17944888 18317297 16116963 12958196 18705752 15057751 13678700 15996030
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4015474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1416246199 17285989 16964402 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9916899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.987678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9819294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.9816377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.532876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.5312014681 15583823
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.9418551238 7678174
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
KEGG:04142 Lysosome
KEGG:00511 Other glycan degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30577
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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