AutismKB 2.0

Annotation Detail for MAOB


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Basic Information Top
Gene Symbol:MAOB ( MGC26382 )
Gene Full Name: monoamine oxidase B
Band: Xp11.3
Quick LinksEntrez ID:4129; OMIM: 309860; Uniprot ID:AOFB_HUMAN; ENSEMBL ID: ENSG00000069535; HGNC ID: 6834
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6342noradrenaline and adrenaline degradation
PWY-6402superpathway of melatonin degradation
PWY-6313serotonin degradation
PWY-6399melatonin degradation II
PWY6666-2dopamine degradation
PWY-6318phenylalanine degradation IV (mammalian, via side chain)
PWY-0putrescine degradation III
Pathway IDPathway Name
hsa00360Phenylalanine metabolism
hsa00380Tryptophan metabolism
hsa00982Drug metabolism - cytochrome P450
hsa00330Arginine and proline metabolism
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00340Histidine metabolism
hsa00260Glycine, serine and threonine metabolism
Pathway IDPathway Name
Biological oxidations
Pathway IDPathway Name
200187Alpha-synuclein signaling
Pathway IDPathway Name
P00001Adrenaline and noradrenaline biosynthesis
P043725-Hydroxytryptamine degredation
Pathway IDPathway Name
500207Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1745Huntington disease
2126Encephalopathies
1874Stress disorder, post-traumatic
2144Fibromyalgia
2198Psychotic disorder
2221Behavior disease
Desease Name
Parkinson's disease
body mass obesity
NEUROLOGICAL
METABOLIC
platelet monoamine oxidase B activity
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C053052 1,4-dinitrobenzene 1,4-dinitrobenzene results in decreased activity of MAOB proteindecreases activity 6814441
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of MAOB proteindecreases activity 16904659
C014024 2,4,5,2',4',5'-hexachlorobiphenyl [methylmercury hydroxide co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased activity of MAOB proteinaffects cotreatment|decreases activity 16904659
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MAOB mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MAOB mRNAaffects expression 21346803
C492672 3-methoxymethyl-7-(4,4,4-trifluorobutoxy)-3,3a,4,5-tetrahydro-1,3-oxazolo(3,4-a)quinolin-1-one 3-methoxymethyl-7-(4,4,4-trifluorobutoxy)-3,3a,4,5-tetrahydro-1,3-oxazolo(3,4-a)quinolin-1-one results in decreased activity of MAOB proteindecreases activity 15178694
C035815 4-dimethylaminobenzylamine MAOB protein results in increased oxidation of 4-dimethylaminobenzylamineincreases oxidation 6814441
C008629 4-nitrobenzoic acid 4-nitrobenzoic acid results in decreased activity of MAOB proteindecreases activity 6814441
D000082 Acetaminophen Acetaminophen affects the expression of MAOB mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of MAOB mRNAdecreases expression 17522070
C067527 aluminum maltolate aluminum maltolate results in increased activity of MAOB proteinincreases activity 16087240
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAOB mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of MAOB mRNAincreases expression 12205029
D003913 Dextroamphetamine SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of MAOB mRNA]decreases reaction|increases expression 12205029
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MAOB mRNAincreases expression 20713471
C095105 bexarotene bexarotene results in decreased expression of MAOB mRNAdecreases expression 16648578
D002220 Carbamazepine Carbamazepine results in increased expression of MAOB mRNAincreases expression 17112801
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of MAOB mRNAdecreases expression 17522070
D002725 Chloroform Chloroform results in decreased expression of MAOB mRNAdecreases expression 17522070
D003024 Clozapine Clozapine results in increased expression of MAOB mRNAincreases expression 17266109
D016572 Cyclosporine Cyclosporine results in decreased expression of MAOB mRNAdecreases expression 20106945
D003976 Diazinon Diazinon results in decreased expression of MAOB mRNAdecreases expression 18835401
18812211
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNAaffects cotreatment|decreases expression 18544905
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MAOB mRNAaffects cotreatment|increases expression 18544905
D004052 Diethylnitrosamine [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNAaffects cotreatment|decreases expression 18253720
D015102 3,4-Dihydroxyphenylacetic Acid [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of 3,4-Dihydroxyphenylacetic Aciddecreases abundance|decreases activity 16012872
D004298 Dopamine [Selegiline results in decreased activity of MAOB protein] which results in increased abundance of Dopaminedecreases activity|increases abundance 16012872
D004918 Erythromycin Estolate Erythromycin Estolate results in decreased expression of MAOB mRNAdecreases expression 17522070
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of MAOB mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MAOB mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAOB mRNAaffects cotreatment|increases expression 17942748
D011345 Fenofibrate [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNAaffects cotreatment|decreases expression 18253720
D005419 Flavonoids Flavonoids results in decreased expression of MAOB mRNAdecreases expression 18035473
D006719 Homovanillic Acid [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Aciddecreases abundance|decreases activity 16012872
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNAaffects cotreatment|decreases expression 18544905
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MAOB mRNAaffects cotreatment|increases expression 18544905
C059303 lazabemide lazabemide results in decreased activity of MAOB proteindecreases activity 15178694
D008701 Methapyrilene Methapyrilene results in decreased expression of MAOB mRNAdecreases expression 16393664
C020771 methylmercury hydroxide [methylmercury hydroxide co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased activity of MAOB proteinaffects cotreatment|decreases activity 16904659
C020771 methylmercury hydroxide methylmercury hydroxide results in decreased activity of MAOB proteindecreases activity 16904659
D015655 1-Methyl-4-phenylpyridinium [MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridiniumincreases chemical synthesis|increases metabolic processing 19948168
D015655 1-Methyl-4-phenylpyridinium zonisamide inhibits the reaction [[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium]decreases reaction|increases chemical synthesis|increases metabolic processing 19948168
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineincreases metabolic processing 19948168
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridiniumincreases chemical synthesis|increases metabolic processing 19948168
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine zonisamide inhibits the reaction [[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium]decreases reaction|increases chemical synthesis|increases metabolic processing 19948168
D009002 Monomethylhydrazine Monomethylhydrazine results in increased activity of MAOB proteinincreases activity 8583353
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in decreased expression of MAOB mRNAdecreases expression 17522070
D009583 Nitrofurazone Nitrofurazone results in decreased activity of MAOB proteindecreases activity 6814441
D005996 Nitroglycerin Nitroglycerin results in increased expression of MAOB mRNAincreases expression 12102619
C076029 olanzapine olanzapine results in increased expression of MAOB mRNAincreases expression 15964593
D010293 Pargyline Pargyline results in decreased activity of MAOB proteindecreases activity 18783367
D010622 Phencyclidine Phencyclidine results in increased expression of MAOB mRNAincreases expression 17266109
C029261 phenethylamine phenethylamine results in increased activity of MAOB proteinincreases activity 17561096
C025299 polyphenols polyphenols results in decreased expression of MAOB mRNAdecreases expression 16293270
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of MAOB mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of MAOB mRNAincreases expression 17404688
D018967 Risperidone Risperidone results in increased expression of MAOB mRNAincreases expression 15964593
D012642 Selegiline Selegiline binds to MAOB proteinaffects binding 19948168
D012642 Selegiline zonisamide inhibits the reaction [Selegiline binds to MAOB protein]affects binding|decreases reaction 19948168
D012642 Selegiline Selegiline results in decreased activity of MAOB proteindecreases activity 15178694
16012872
D012642 Selegiline [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of 3,4-Dihydroxyphenylacetic Aciddecreases abundance|decreases activity 16012872
D012642 Selegiline [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Aciddecreases abundance|decreases activity 16012872
D012642 Selegiline [Selegiline results in decreased activity of MAOB protein] which results in increased abundance of Dopaminedecreases activity|increases abundance 16012872
D020280 Sertraline MAOB protein results in decreased amination of and results in increased metabolism of Sertralinedecreases amination|increases metabolic processing 15547048
C021751 tanshinone tanshinone results in increased expression of MAOB mRNAincreases expression 15849732
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MAOB mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAOB mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MAOB mRNAincreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MAOB mRNAdecreases expression 18796159
D013752 Tetracycline Tetracycline results in decreased expression of MAOB mRNAdecreases expression 17522070
C022189 zonisamide zonisamide inhibits the reaction [[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium]decreases reaction|increases chemical synthesis|increases metabolic processing 19948168
C022189 zonisamide zonisamide inhibits the reaction [Selegiline binds to MAOB protein]affects binding|decreases reaction 19948168
C022189 zonisamide zonisamide results in decreased activity of MAOB proteindecreases activity 19948168
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 6.938986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.9315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.0218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3917505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.0120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.0111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.0114692618
MESH:D000236 Adenoma Benzo(a)pyrene 5.536695378
MESH:D000236 Adenoma Diethylnitrosamine 5.536695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.2719052882 17162532 17620307 16434500 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.2716835633
MESH:D000380 Agranulocytosis Clozapine 4.5316160616 12649775 14617031
MESH:D000382 Agricultural Workers' Diseases Diazinon 3.8116487989
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4811748828
MESH:D000799 Angioedema Acetaminophen 3.3010982225
MESH:D001008 Anxiety Disorders Sertraline 4.6718822694
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3215885639
MESH:D020817 Asperger Syndrome Risperidone 5.0416401163
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.4218349709
MESH:D001321 Autistic Disorder marker/mechanism 19221690
MESH:D001321 Autistic Disorder Acetaminophen 2.6318445737
MESH:D001321 Autistic Disorder olanzapine 2.6317069543 18685284
MESH:D001321 Autistic Disorder Risperidone 2.6318080171 17069546 17019624 16379507 15543515 16239862 18775368 19013209 15930063 19368416 18349709 15492353 16730335 17929164 19154706 18026891 15994720 19232924 16948927 16601648 18278980
MESH:D001321 Autistic Disorder Sertraline 2.6318775368
MESH:D001714 Bipolar Disorder Carbamazepine 10.7017594078 20046352
MESH:D001714 Bipolar Disorder Risperidone 10.7019154706 18278980
MESH:D001714 Bipolar Disorder zonisamide 10.7016855456 15383137
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.5712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4015746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7917868700
MESH:D001930 Brain Injuries Progesterone 3.7315380490 15665606 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.3120146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 3.3116818667 16344269
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.3117474063
MESH:D001943 Breast Neoplasms Estradiol 3.3118497071 12948864 17018787 17289903 19861407 14630087 17261762 16675129
MESH:D001943 Breast Neoplasms Progesterone 3.3116175315 17614352 15562024
MESH:D001943 Breast Neoplasms tanshinone 3.3119885617 15849732
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.3120435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2616011737 15673190 16124888 15721981 10355542 16227642 16097048 3786805 18705752 15700767 16192424 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3716835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.9016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.9016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.903084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.9018788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.9018971187 10672840 18494052 18210153 16779866 16328049 20432363 16288022 20101231 17173139 17162532 20514400 18785209 16502159 19418558 18393292 19107877 19052882 18665156 19171122 16569478 3084413 20084675 19539802 16830150 17138121 3581430 17055752 19394651 17978847 18691550 17761372 18056438 20935162 18978308 18788625 16540662 20727157 20512989 18506893 21159647 16878318 19383236 17428255 16698587 19701751 16807293 16935385 20524982 20214788 19519916 19919837 20007298 19335982 11831363 19208518 19822196 16681979 10737359
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.9016924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0216247446
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.8820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0516120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.2510977129
MESH:D002389 Catatonia olanzapine 5.7018071103 16772815
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.876135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.8712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.8717174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.8718566989
MESH:D014355 Chagas Disease Nitrofurazone 6.6311354658
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.8119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.8116835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.6512912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 11.1912927374 15913567 16629650 19486331 7624871 18164287 18590720 15500046
MESH:D002779 Cholestasis Cyclosporine 11.1919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.1917110522 17681005 15861022 16919318 17333356 16105132 11677210
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.3110220858 19407337
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8615668235 15340226 12621046 8697196 16354765
MESH:D003072 Cognition Disorders Clozapine 4.4417123785
MESH:D003110 Colonic Neoplasms polyphenols 2.5716293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6117141729 14669216
MESH:D019465 Craniofacial Abnormalities Carbamazepine 2.669014606
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.1518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.1518551238
MESH:D016757 Death, Sudden, Cardiac Risperidone 5.0520210726
MESH:D003704 Dementia Risperidone 4.8111575062
MESH:D003866 Depressive Disorder Sertraline 7.5915014590 18822694 20305041
MESH:D003866 Depressive Disorder zonisamide 7.5916855456
MESH:D003865 Depressive Disorder, Major Sertraline 4.9116968574
MESH:D002658 Developmental Disabilities olanzapine 4.3217069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.2016402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.2020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.2017107852
MESH:D003928 Diabetic Nephropathies Estradiol 2.9619279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9717187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 12.6215331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 12.6216379507
MESH:D053207 Diurnal Enuresis Risperidone 6.1317822346
MESH:D004314 Down Syndrome Risperidone 4.6718349709
OMIM:607208 DRAVET SYNDROME Carbamazepine 10.9111748493
OMIM:607208 DRAVET SYNDROME zonisamide 10.9111748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.0620216337 16538176 16538175 15057820
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 32.5017522070 20133375 18289764 7624871
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 32.5021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 32.5018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 32.5012540782 16109766 11743745 14725611 19420014 19416960 19370779 16781746 12392966 11421492 16393943 19739265 17562736 15968718 11739529 17522070 10774834 16227642 12594235 11834606 11529661 12958197 19164858 11461765 14550746 10663392 15619225 12705907 16485898 18071297 2444490 10915739 19923254 19085960 18713872 17906064 12153990 11287661 14986274 16081117 16177239
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 32.5017465707
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 32.5015998439 17522070 10092053 2869522 7179309 16227642 15027814 9327722 3786805 16177239 11566570 7440962 19336974 6623471 7120509 15968718 3732212 10915739 6884620 21278145 4309450 19085960
MESH:D056486 Drug-Induced Liver Injury Chloroform 32.5017522070 7120509 7440962 3104120 3732212 6884620 2862719 6623471
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 32.5019107877
MESH:D056486 Drug-Induced Liver Injury Erythromycin Estolate 32.5017522070 14998559
MESH:D056486 Drug-Induced Liver Injury polyphenols 32.5019370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 32.5020420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 32.5017522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5519426721
MESH:D004362 Drug Toxicity Carbamazepine 7.0520216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.0511462148
MESH:D050171 Dyslipidemias Clozapine 7.9016402076
MESH:D050171 Dyslipidemias Fenofibrate 7.9016707586
MESH:D004417 Dyspnea Diazinon 4.2616487989
MESH:D004487 Edema Tetrachlorodibenzodioxin 1.9211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 12.5417654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.5412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.5417692515
MESH:D016889 Endometrial Neoplasms Estradiol 6.5618566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 6.5616569247
MESH:D004715 Endometriosis Progesterone 7.3816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.3810568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.7420485159 19915237 18855540 16538176 16415921
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 10.0717275665
MESH:D004831 Epilepsies, Myoclonic zonisamide 10.073659116 3691417
MESH:D004828 Epilepsies, Partial Carbamazepine 9.1817116037 16628512 15008574
MESH:D004828 Epilepsies, Partial zonisamide 9.1811558140 3691417 15140322
MESH:D004827 Epilepsy Carbamazepine 6.6818234410 17465707 7988514 20417680 17178248 821787 19620853 9014606 19439326 19700373
MESH:D004827 Epilepsy zonisamide 6.6820196486
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 4.837750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 9.7115276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic zonisamide 9.713659116 3691417
MESH:D004916 Erythromelalgia Carbamazepine 5.1819549232
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5716302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.8616530937
MESH:D020329 Essential Tremor zonisamide 5.6518297619 17149715
MESH:D005076 Exanthema Carbamazepine 10.9420485159
MESH:D005076 Exanthema zonisamide 10.9415140322
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6011564622
MESH:D005221 Fatigue zonisamide 5.5417149715
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.5816045604 15959796 12631006 12795759 19224547 17595544 16239168 61145
MESH:D005234 Fatty Liver Cyclosporine 19.5819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.5821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.5815345470
MESH:D005234 Fatty Liver Tetracycline 19.5819224547 16917069
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 11.6918705752
MESH:D005355 Fibrosis Cyclosporine 11.6912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.6920067830
MESH:D005756 Gastritis Acetaminophen 3.1316983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.688708960
MESH:D005910 Glioma tanshinone 3.7916955220
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D006261 Headache Nitroglycerin 9.7611554966 11284996
MESH:D006261 Headache zonisamide 9.7617149715
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.4320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.4310048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8511000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 12.9818590720
MESH:D006505 Hepatitis Carbon Tetrachloride 12.9819110552 19900420
MESH:D006505 Hepatitis Diazinon 12.9816487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.3816120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.4815709030
MESH:D019584 Hot Flashes Estradiol 3.2117088409
MESH:D006816 Huntington Disease Sertraline 5.5018403212
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5015340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.2816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9916899240
MESH:D006943 Hyperglycemia Risperidone 4.7018278980
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.2710459572
MESH:D006948 Hyperkinesis Clozapine 4.3716046005
MESH:D006963 Hyperphagia olanzapine 5.6917933447
MESH:D006965 Hyperplasia Carbamazepine 4.6918773962
MESH:D006973 Hypertension Cyclosporine 4.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.1718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5615338365
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 4.7719662366
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2816945680 16569931
MESH:D007022 Hypotension Dopamine 4.536740701
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9712013081
MESH:D007248 Infertility, Male Diazinon 5.7212948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.7217937319
MESH:D007249 Inflammation Diethylnitrosamine 12.6418785209
MESH:D007249 Inflammation Flavonoids 12.6417296493
MESH:D007249 Inflammation polyphenols 12.6416366677
MESH:D007249 Inflammation Progesterone 12.6415869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.6412200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.6016627594 16393666
MESH:D002546 Ischemic Attack, Transient zonisamide 6.359372210
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8915604871
MESH:D007674 Kidney Diseases Acetaminophen 8.0612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 8.068314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 8.0615618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.1416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.1416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 14.1412371664
MESH:D007680 Kidney Neoplasms Estradiol 14.1415610895
MESH:D008064 Lipidoses Clozapine 7.3817567588
MESH:D008064 Lipidoses Sertraline 7.3817567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.5516239168 16221502 11408273 17157831 16943688 11903743 17334410 21278145 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.5520032147 19638242 18665156 18407596 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.3015370692 15893842 18376398 17565644 15730626 16097048 18472094 12609069 18251166 17900296 18277467 12958196 18472332 12741479 17714472 13678700 20821823 18205269 12389079 17761835 17698563 16011737 14748882 15959796 15673190 17640975 12649538 10355542 17481882 14724832 18412020 16027843 17869086 12445421 16015684 17721639 16136751 18317297 17557913 18279442 18006644 15876570 12632514 12632512 12898905 18166357 15925388 17976157 18054572 16033810 11481614 15362042 12445418 17631135 14716496 18263696 16638106 15123356 14620537 15996030 18395914 17766677 17922224 18481824 12666154 18420326 12546737 17708605 15818738 16116963 14512876 12667390 17823541 18187930 15931870 18429990 15338365 18418968 18210741 16192424 17805973 18395095 16248980 18156304 14716833 12586293 18705752 15057751 15052691 17525996 15650968 17944888 18339082
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.3014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 4.3015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.3012878042
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 10.6917184895
MESH:D008107 Liver Diseases Acetaminophen 10.6916611625 19460945 16610002 19784758 12587719 12969438 11587558 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 10.6917285989 15720792 15830285 16964402 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 10.6917034775
MESH:D008107 Liver Diseases polyphenols 10.6916698588
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.8517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.8516899240 14706259
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 21.8018644402 16835634
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.807678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.8021137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.8019294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.8010737359 18754104 19427195 20137499 19642983 12771043 21047994 20452335 20405173 18644402 20101389 19294768 16942905 19690152 19073162 19256749 19850985 12112319 18648771 19812893 19255062 19426721 20434301 21278145 19254457 19833225 20492335 9163691 20583210 19499222 2862719 19638242 19090486 20501860 18977376 19996281 15175105 21071580 19551842 20118626 2422723 18978307 15885732 21167192
MESH:D008113 Liver Neoplasms Fenofibrate 21.8018978307
MESH:D008113 Liver Neoplasms Methapyrilene 21.8015890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.8016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.812876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.8112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.8121159647 18775883 2563599 19009564 16842330 16267830 9362446 19539802 18282651 18079962 18093689 18544905 18308698 17854601 18164116 18253720 17174075 17942915 19004024 19519916 3124819 19126423
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 18.8118775883 18253720
MESH:D008114 Liver Neoplasms, Experimental kojic acid 18.8118544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.8112151625
MESH:D008133 Long QT Syndrome olanzapine 4.3120210726
MESH:D017563 Lung Diseases, Interstitial zonisamide 5.3817228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.1817053015 18816296 18520028 18569708 20135361 20064080 6695378 20869020 20464547
MESH:D008175 Lung Neoplasms bexarotene 4.1817849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.1820970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.1811884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.3916628512
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6211161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 7.9919196723 19196722 15591091
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 7.9917203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 7.9917203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 3.9319453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0419513568
MESH:D001523 Mental Disorders Clozapine 14.5116856516
MESH:D001523 Mental Disorders olanzapine 14.5116856516
MESH:D001523 Mental Disorders Risperidone 14.5116856516 16596465
MESH:D001523 Mental Disorders Sertraline 14.5116856516
MESH:D008607 Mental Retardation Carbamazepine 5.989014606
MESH:D008607 Mental Retardation Risperidone 5.9818349709
MESH:D008659 Metabolic Diseases olanzapine 4.9119142110
MESH:D024821 Metabolic Syndrome X Clozapine 8.7119142101
MESH:D024821 Metabolic Syndrome X Risperidone 8.7119142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2416801185
MESH:D008708 Methemoglobinemia Nitroglycerin 4.243537620
MESH:D020326 Migraine without Aura Nitroglycerin 4.6114659530
MESH:D019964 Mood Disorders Risperidone 5.3117019624
MESH:D009041 Motion Sickness Dextroamphetamine 4.971613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7716381670
MESH:D009101 Multiple Myeloma zonisamide 4.4011868602
MESH:D009203 Myocardial Infarction Nitroglycerin 3.5414729435
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.8616810080
MESH:D020191 Myoclonic Epilepsies, Progressive zonisamide 5.659477142
MESH:D009224 Myotonia Congenita Carbamazepine 4.9320399394
MESH:D009325 Nausea zonisamide 5.4616855456
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.5618551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.567678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.339029167 3581430
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 7.018820588
MESH:D009369 Neoplasms Benzo(a)pyrene 7.0111141357
MESH:D009369 Neoplasms Nitrofurazone 7.0115488632
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.2419196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2017289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.249884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8318481113 19348381
MESH:D009410 Nerve Degeneration 1-Methyl-4-phenylpyridinium 4.6217433543
MESH:D009421 Nervous System Malformations Carbamazepine 13.5316990009
MESH:D009421 Nervous System Malformations Estradiol 13.5311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.5314600291
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 16.6212349958
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenylpyridinium 16.6216353238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 16.6218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 16.6220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5720387270
MESH:D020258 Neurotoxicity Syndromes 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 4.8616725203
MESH:D053206 Nocturnal Enuresis Risperidone 5.7817822346
MESH:D009765 Obesity Clozapine 4.8519142110 18515891
MESH:D009765 Obesity olanzapine 4.8518515891
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.3312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.3316049721
MESH:D010018 Osteomalacia Carbamazepine 4.9317016548
MESH:D010051 Ovarian Neoplasms Estradiol 6.9819401270
MESH:D010051 Ovarian Neoplasms Nitrofurazone 6.9811026599
MESH:D010051 Ovarian Neoplasms Progesterone 6.9817393432 16525653
MESH:D010146 Pain Acetaminophen 9.0716870215
MESH:D010146 Pain Carbamazepine 9.0715215642
MESH:D010146 Pain zonisamide 9.0717666864 15140322 16217643
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.2116540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1911578682
MESH:D010267 Parapsoriasis Carbamazepine 5.1716538176
MESH:D010292 Paresthesia zonisamide 6.3517149715
MESH:D010300 Parkinson Disease 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 14.0216140633 11181820 15451049
MESH:D010300 Parkinson Disease 1-Methyl-4-phenylpyridinium 14.0217433543
MESH:D010300 Parkinson Disease 3-methoxymethyl-7-(4,4,4-trifluorobutoxy)-3,3a,4,5-tetrahydro-1,3-oxazolo(3,4-a)quinolin-1-one 14.0215178694
MESH:D010300 Parkinson Disease Selegiline 14.0218328768
MESH:D010300 Parkinson Disease zonisamide 14.0219594199 13677302 17200492 11755227 20196486
MESH:D020734 Parkinsonian Disorders 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 9.1012349958
MESH:D020734 Parkinsonian Disorders Homovanillic Acid 9.108817341
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.3917679678 17145499
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 11.9620133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 11.9612520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.8811026799
MESH:D011041 Poisoning Diazinon 3.8617603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0518163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.4312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.432563599
MESH:D011248 Pregnancy Complications Carbamazepine 4.639014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 8.079014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.0711118676 11896295 11222880 11399792
MESH:D017096 Prion Diseases Tetracycline 4.8710903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4020887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3617292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.3616740699
MESH:D011537 Pruritus Ethinyl Estradiol 2.7815861022 16919318
MESH:D019310 Pseudolymphoma Carbamazepine 5.059591791 12752131
MESH:D011565 Psoriasis Cyclosporine 2.0216882103
MESH:D011595 Psychomotor Agitation olanzapine 5.0618685284
MESH:D011618 Psychotic Disorders Clozapine 3.7915331141
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6418045962
MESH:D012559 Schizophrenia marker/mechanism 20479760
MESH:D012559 Schizophrenia Clozapine 5.3611763009 17123785 20580759 18806925 18855531 19369910 20107430 11151749 20452607 20168265 20521326 16141801 17726453 20521320 17667964
MESH:D012559 Schizophrenia olanzapine 5.3620107430 20521326 17726453
MESH:D012559 Schizophrenia Risperidone 5.3620107430 18278980 19154706
MESH:C537537 Segawa syndrome, autosomal recessive Homovanillic Acid 6.608817341
MESH:D012640 Seizures 2,4-dinitrotoluene 11.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.1118551238
MESH:D012640 Seizures Carbamazepine 11.1119414003 9844417 15946322 16876388 16938433 9046859 16180713
MESH:D012640 Seizures zonisamide 11.1111879338 11044598 9806000 10029267 11755227 15946322 11442880 16180713 16876388 16938433 18455367 9844417 12941455 9046859 11518630
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 4.5510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.5516192470
MESH:D012893 Sleep Disorders Carbamazepine 9.6319414003
MESH:D012893 Sleep Disorders Risperidone 9.6318278980
MESH:D013088 Spermatocele Ethinyl Estradiol 3.3916709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.7415862959 16503802
MESH:D013226 Status Epilepticus zonisamide 5.6612833885
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 10.0719694795 15057820 16538176 18855540 19915237 20485159 16415921
MESH:D013262 Stevens-Johnson Syndrome zonisamide 10.0712239465
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.1720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.1718456281
MESH:D017180 Tachycardia, Ventricular olanzapine 9.5220210726
MESH:D017180 Tachycardia, Ventricular Risperidone 9.5220210726
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.7017997062
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.2920133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.587505956
MESH:D013978 Tibial Fractures Estradiol 4.1419048282
MESH:D005879 Tourette Syndrome Risperidone 5.4219154706
MESH:D020194 Unverricht-Lundborg Syndrome zonisamide 5.6511814737
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 6.8616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 6.8616049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 6.8617053015
MESH:D014570 Urologic Diseases Diazinon 4.7316487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.2010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.2010091137
MESH:D014581 Urticaria Acetaminophen 2.4910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.7914692618
MESH:D014605 Uveitis Cyclosporine 3.441336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0615869587 14671159
MESH:D014839 Vomiting zonisamide 5.3817157078
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7015886252
MESH:D015430 Weight Gain Clozapine 14.0020564506 20107430 20521320 17502770 16141801 16402076
MESH:D015430 Weight Gain olanzapine 14.0020107430 19434072 17933447
MESH:D015430 Weight Gain Risperidone 14.0020564506 16379507
MESH:D015431 Weight Loss Clozapine 4.5417933447
MESH:D014947 Wounds and Injuries Nitrofurazone 4.9718222664 18440737
MESH:D014985 Xerophthalmia Cyclosporine 3.8917120751
Pathway ID Pathway Name
KEGG:00330 Arginine and proline metabolism
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:00340 Histidine metabolism
KEGG:01100 Metabolic pathways
KEGG:00360 Phenylalanine metabolism
KEGG:00380 Tryptophan metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA237
    • No data
    Releated disease ID Related disease Name
    PA447207Depressive Disorder
    PA445254Parkinson Disease
    PA447199Bipolar Disorder
    PA443959Dyskinesia, Drug-Induced
    PA443970Dystonia
    PA446736Hypokinesia
    PA444993Muscle Rigidity
    PA447216Schizophrenia
    PA445917Tremor
    Releated drug ID Related drug Name
    PA449396dopamine
    PA450649norepinephrine
    PA449092colchicine
    PA449396dopamine
    PA451578tacrolimus
    PA450522mirtazapine
    PA450801paroxetine
    PA449015citalopram
    PA452233antipsychotics
    PA451257risperidone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00191 antagonist Fen-phen Adrenergic Agents;Central Nervous System Stimulants;Sympathomimetics;Central Nervous System Agents;Appetite Depressants;Anorexigenic Agents;Stimulants
    DB00752 antagonist Tranylcypromine Antidepressants;Anti-anxiety Agents;Antidepressive Agents;Monoamine Oxidase Inhibitors
    DB00780 antagonist Phenelzine Antidepressants;Antidepressive Agents;Monoamine Oxidase Inhibitors
    DB00909 antagonist Zonisamide Antioxidants;Anticonvulsants
    DB01037 antagonist Selegiline Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Neuroprotective Agents;Monoamine Oxidase Inhibitors;Dopaminergics
    DB01247 antagonist Isocarboxazid Antidepressants;Antidepressive Agents;Monoamine Oxidase Inhibitors
    DB01363 antagonist Tartephedreel
    DB01367 antagonist Rasagiline Neuroprotective Agents;Monoamine Oxidase Inhibitors
    DB01442 antagonist MMDA Psychotropic Drugs
    DB01472 antagonist 4-Methoxyamphetamine Hallucinogens
    DB01577 antagonist Methamphetamine Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB01626 antagonist Pargyline Antihypertensive Agents;Monoamine Oxidase Inhibitors
    DB02095 - Isatin
    DB02211 - N-Methyl-N-Propargyl-1(R)-Aminoindan
    DB02509 - Farnesol
    DB02643 - N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate
    DB02939 - [(1e)-4-Phenylbut-1-Enyl]Benzene
    DB03147 - Flavin-Adenine Dinucleotide
    DB03894 - N-Propargyl-1(S)-Aminoindan
    DB04147 - Lauryl Dimethylamine-N-Oxide Surface-Active Agents;Detergents
    DB04307 - 5-Hydroxy-N-Propargyl-1(R)-Aminoindan
    DB04677 - N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE
    DB07512 - 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE
    DB07513 - 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE
    DB08082 - N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE
    DB08176 - (1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE
    DB08480 - 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN
    DB08516 - (S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]
    Drugbank ID Action Drug Name Description
    DB00184 - Nicotine Anti-craving Agents;Central Nervous System Agents;Autonomic drugs;Nicotinic Agonists;Ganglionic Stimulants
    DB00191 - Fen-phen Adrenergic Agents;Central Nervous System Stimulants;Sympathomimetics;Central Nervous System Agents;Appetite Depressants;Anorexigenic Agents;Stimulants
    DB00494 - Entacapone Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Enzyme Inhibitors
    DB00614 - Furazolidone Anti-Infective Agents, Local;Anti-Infective Agents, Urinary;Antitrichomonal Agents;Monoamine Oxidase Inhibitors
    DB00737 - Antivert Tab Antiemetics;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamines
    DB00780 substrate Phenelzine Antidepressants;Antidepressive Agents;Monoamine Oxidase Inhibitors
    DB00915 - Amantadine Antiviral Agents;Dopamine Agents;Antiparkinson Agents;Analgesics, Non-Narcotic
    DB00988 - Dopamine Dopamine Agents;Sympathomimetics;Cardiotonic Agents;Sympathomimetic
    DB01104 substrate Sertraline Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Antidepressive Agents;Serotonin Uptake Inhibitors
    DB01156 - Bupropion Dopamine Uptake Inhibitors;Antidepressive Agents;Antidepressive Agents, Second-Generation
    DB01171 - Moclobemide Antidepressive Agents;Monoamine Oxidase Inhibitors
    DB01235 - Sinemet CR Dopamine Agents;Antiparkinson Agents;Antidyskinetics
    DB01445 - Bufotenine Serotonin Antagonists;Hallucinogens
    DB02095 - Isatin
    DB02211 - N-Methyl-N-Propargyl-1(R)-Aminoindan
    DB02509 - Farnesol
    DB02939 - [(1e)-4-Phenylbut-1-Enyl]Benzene
    DB03147 - Flavin-Adenine Dinucleotide
    DB03894 - N-Propargyl-1(S)-Aminoindan
    DB04147 - Lauryl Dimethylamine-N-Oxide Surface-Active Agents;Detergents
    DB04307 - 5-Hydroxy-N-Propargyl-1(R)-Aminoindan
    DB04818 - Iproniazid Antidepressive Agents;Monoamine Oxidase Inhibitors
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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