AutismKB 2.0

Annotation Detail for MAP1B


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Basic Information Top
Gene Symbol:MAP1B ( DKFZp686E1099,DKFZp686F1345,FLJ38954,FUTSCH,MAP5 )
Gene Full Name: microtubule-associated protein 1B
Band: 5q13.2
Quick LinksEntrez ID:4131; OMIM: 157129; Uniprot ID:MAP1B_HUMAN; ENSEMBL ID: ENSG00000131711; HGNC ID: 6836
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200074Netrin-mediated signaling
200114Lissencephaly gene (LIS1) in neuronal migration and development
200051Reelin signaling pathway
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Related Diseases/Disorders Top
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Desease Name
ADHD
PSYCH
attention-deficit hyperactivity disorder
Desease Name
Attention deficit hyperactivity disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of MAP1B mRNAincreases expression 20406850
D006710 Homocysteine Homocysteine results in decreased expression of MAP1B mRNAdecreases expression 17326132
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAP1B mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of MAP1B proteindecreases expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of MAP1B mRNAincreases expression 20458559
C095105 bexarotene bexarotene results in increased expression of MAP1B mRNAincreases expression 16648578
D004958 Estradiol Estradiol results in increased expression of MAP1B mRNAincreases expression 20106945
D005492 Folic Acid Folic Acid affects the expression of MAP1B mRNAaffects expression 17320366
C008493 methylselenic acid methylselenic acid affects the expression of MAP1B mRNAaffects expression 14617803
C008493 methylselenic acid methylselenic acid results in increased expression of MAP1B mRNAincreases expression 18548127
D015735 Mifepristone Mifepristone results in increased expression of MAP1B mRNAincreases expression 17584828
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of MAP1B mRNAincreases expression 16809437
D010672 Phenytoin Phenytoin results in increased expression of MAP1B mRNAincreases expression 14741686
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of MAP1B mRNAaffects expression 20106945
C025643 vinclozolin vinclozolin affects the expression of MAP1B mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 9.073425630 6195326 8986270 9118846 9677735 10563481
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.0715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D058186 Acute Kidney Injury Folic Acid 4.4116316344 17003819 16595132
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4611798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 4.4611473722
MESH:D000236 Adenoma Folic Acid 3.8416963246
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000544 Alzheimer Disease Folic Acid 3.0617116317
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D050197 Atherosclerosis Phenytoin 3.9715136057
MESH:D001321 Autistic Disorder Folic Acid 2.7621388746
MESH:D001321 Autistic Disorder Homocysteine 2.7616297937 20468076
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.2316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms bexarotene 2.0216344269 16818667
MESH:D001943 Breast Neoplasms Estradiol 2.0217289903 17018787 12948864 16675129 14630087 18497071 19861407 17261762
MESH:D001943 Breast Neoplasms Folic Acid 2.0216777985
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6516705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6516217749 11135700 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6516924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2516247446
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Folic Acid 4.0016755160
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.856135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8518566989
MESH:D002493 Central Nervous System Diseases Phenytoin 5.404080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.9811748493
MESH:D002971 Cleft Lip Folic Acid 8.2221254359
MESH:D002971 Cleft Lip Phenytoin 8.222227380
MESH:D002972 Cleft Palate Folic Acid 10.238946559 21254359
MESH:D002972 Cleft Palate Phenytoin 10.236856622 1687470 6862529 10789828 2227380 3877104
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 10.238697196 16354765 15340226 15668235 12621046
MESH:D003103 Coloboma Phenytoin 5.239212184
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8220501625
MESH:D015179 Colorectal Neoplasms Folic Acid 2.8217245555 17116713 17087956 16963246 16985020
MESH:D000013 Congenital Abnormalities Phenytoin 9.6310627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.6314669216 17141729
MESH:D003324 Coronary Artery Disease Homocysteine 3.7816379339
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9510525206
MESH:D019465 Craniofacial Abnormalities Phenytoin 3.958986270 9212184 19952982
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9510048152 15322242 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.6316886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
OMIM:607208 DRAVET SYNDROME Phenytoin 5.4911748493
MESH:D003875 Drug Eruptions Phenytoin 5.6015024534
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.7721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 4.7717654737
MESH:D016889 Endometrial Neoplasms Estradiol 7.9218566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Folic Acid 7.9217301261
MESH:D004715 Endometriosis Mifepristone 9.4116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.419294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 5.2920235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.371399206 6251365
MESH:D004828 Epilepsies, Partial Phenytoin 5.0511558140 17116037
MESH:D004827 Epilepsy Phenytoin 3.97821787 11434505 20417680
MESH:D017029 Epilepsy, Complex Partial Phenytoin 5.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 5.183659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3312903497
MESH:D017889 Exfoliation Syndrome Folic Acid 13.7916504073
MESH:D017889 Exfoliation Syndrome Homocysteine 13.7916504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver arsenic trioxide 3.3715073043
MESH:D005313 Fetal Death Phenytoin 11.0910627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 11.0911858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005756 Gastritis Folic Acid 5.2217171786
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D005885 Gingival Hyperplasia Phenytoin 5.789029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.3716390469 14659971
MESH:D005901 Glaucoma Folic Acid 12.1516504073
MESH:D005901 Glaucoma Homocysteine 12.1516504073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Folic Acid 11.6317286298 16524890
MESH:D006330 Heart Defects, Congenital Homocysteine 11.6319638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.6311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D006679 HIV Seropositivity Folic Acid 5.6117209195
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 16354765 16959395 15340226 18606429
MESH:D020138 Hyperhomocysteinemia Folic Acid 16.1716433478 16395265 16397167 16865747 16755160
MESH:D020138 Hyperhomocysteinemia Homocysteine 16.1718234410 17369066 17292331
MESH:D020138 Hyperhomocysteinemia Phenytoin 16.1710459572
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007248 Infertility, Male vinclozolin 3.0916467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.0216627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Estradiol 2.6315618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5916705839
MESH:D007680 Kidney Neoplasms Estradiol 7.5915610895
MESH:D007938 Leukemia arsenic trioxide 2.8715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1520471514 16467208 19850784 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2612712474 12679006 9834237 15336539 11468182 17869043 19075265 17217047 16112521 11161223 16891316 16966277 17107899 17649720 15213294 12018890 17712046 15748426 16330433 16823087 19035177 19225113 19642359 16331271 15622746
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2812878042
MESH:D008107 Liver Diseases Folic Acid 4.9016877991
MESH:D008107 Liver Diseases Phenytoin 4.9014986274
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.567678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.5614682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.092876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.0920377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5319825857 11798837
MESH:D008175 Lung Neoplasms bexarotene 3.5317849452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5319555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3617718048
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.2511161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.4319196722 15591091 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4317203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.8116832597
MESH:D008591 Meningomyelocele Homocysteine 5.6416602021
MESH:D008607 Mental Retardation Phenytoin 3.699212184
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1619417148 19549372 15949261 11468182 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1816882451 16105982
MESH:D009203 Myocardial Infarction Homocysteine 3.7417412321
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.6417484760
MESH:D009224 Myotonia Congenita Phenytoin 5.531896199
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.987678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.9219196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations Estradiol 9.7811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D009436 Neural Tube Defects arsenic trioxide 12.7210525206
MESH:D009436 Neural Tube Defects Folic Acid 12.7217438019
MESH:D009436 Neural Tube Defects Phenytoin 12.729118846
MESH:D009503 Neutropenia Folic Acid 4.5916322990
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5116049721
MESH:D010018 Osteomalacia Phenytoin 5.5317016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.1212452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 8.1219401270
MESH:D010051 Ovarian Neoplasms Mifepristone 8.1216525653
MESH:D010146 Pain Phenytoin 4.0415215642
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5515580305
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010300 Parkinson Disease Homocysteine 3.6016275827
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017689 Polydactyly Phenytoin 5.119212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8811118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.8818042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6319131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.6316740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.6316205645
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D019310 Pseudolymphoma Phenytoin 5.681419762 12752131 8603615
MESH:D051437 Renal Insufficiency Folic Acid 4.8815728788
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D012559 Schizophrenia Folic Acid 4.3016641680
MESH:D012559 Schizophrenia Homocysteine 4.3016641680
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4918551238
MESH:D012640 Seizures Phenytoin 6.499844417 11044598 16876388 3137016 19919933 10029267 3691417 15946322
MESH:D012871 Skin Diseases Folic Acid 3.2718709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013118 Spinal Cord Diseases Folic Acid 5.6116361298
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 5.2620235791
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.8117007042
MESH:D013274 Stomach Neoplasms Folic Acid 2.8117171786
MESH:D020521 Stroke Folic Acid 4.3916517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1519014326
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.1812973940 20435036 11780464 12845720
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
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Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30581
    • No data
    No data
    Releated drug ID Related drug Name
    PA152241909PP2
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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