AutismKB 2.0

Annotation Detail for MAP4


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Basic Information Top
Gene Symbol:MAP4 ( DKFZp779A1753,MGC8617 )
Gene Full Name: microtubule-associated protein 4
Band: 3p21.31
Quick LinksEntrez ID:4134; OMIM: 157132; Uniprot ID:MAP4_HUMAN; ENSEMBL ID: ENSG00000047849; HGNC ID: 6862
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2075Heart failure
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001554 Benzene Benzene results in decreased expression of MAP4 mRNAdecreases expression 15929907
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MAP4 mRNAdecreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MAP4 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of MAP4 mRNAincreases expression 20106945
D019833 Genistein Genistein results in decreased expression of MAP4 mRNAdecreases expression 16705744
D007657 Ketone Bodies Ketone Bodies results in increased expression of MAP4 mRNAincreases expression 16807920
D009151 Mustard Gas Mustard Gas results in decreased expression of MAP4 mRNAdecreases expression 15674843
D010758 Phosphorus Phosphorus results in increased expression of MAP4 mRNAincreases expression 17715259
C059514 resveratrol resveratrol results in decreased expression of MAP4 mRNAdecreases expression 12569576
D012643 Selenium Selenium results in increased expression of MAP4 mRNAincreases expression 19244175
C025643 vinclozolin vinclozolin affects the expression of MAP4 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of MAP4 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 3.9616538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5120464547 20127859
MESH:D000230 Adenocarcinoma Genistein 4.5111473722
MESH:D000236 Adenoma Benzo(a)pyrene 7.016695378
MESH:D000236 Adenoma resveratrol 7.0115688382
MESH:D000544 Alzheimer Disease resveratrol 2.5916162502 16183991
MESH:D000741 Anemia, Aplastic Benzene 4.4517661222 11369114 14761424
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001169 Arthritis, Experimental resveratrol 3.5617115116
MESH:D001249 Asthma Mustard Gas 2.7410378619
MESH:D050197 Atherosclerosis resveratrol 3.3317967414 16873680
MESH:D001768 Blister Mustard Gas 5.3119167455
MESH:D001855 Bone Marrow Diseases Benzene 5.4016183116
MESH:D002545 Brain Ischemia resveratrol 4.4417600658
MESH:D001943 Breast Neoplasms Benzene 2.0311921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0320146248 17474063
MESH:D001943 Breast Neoplasms Genistein 2.0316873071 17200150 16541309
MESH:D001943 Breast Neoplasms resveratrol 2.0317651959 16393696 17534123
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1517687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.3516924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 3.3516227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.7516675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8220419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.8216227395
MESH:D002318 Cardiovascular Diseases Genistein 7.7616332659
MESH:D002318 Cardiovascular Diseases resveratrol 7.7615458977
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6012371664
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D003092 Colitis resveratrol 10.1216474422
MESH:D003092 Colitis Selenium 10.1217936198
MESH:D003110 Colonic Neoplasms Genistein 3.9917182828
MESH:D003110 Colonic Neoplasms resveratrol 3.9916338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D003327 Coronary Disease resveratrol 3.8216507316
MESH:D019465 Craniofacial Abnormalities Benzene 2.9515643154
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.9519769572
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003872 Dermatitis Benzene 4.9015902427
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8616873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5116647724
MESH:D003928 Diabetic Nephropathies resveratrol 4.0616286809
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2015131321
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema Mustard Gas 7.579260866 11428631 11402378 11428647
MESH:D004487 Edema resveratrol 7.578985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.1517872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.7416402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4311473722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.9917923197
MESH:D004890 Erythema Mustard Gas 5.319357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005234 Fatty Liver Cyclosporine 2.9619224547
MESH:D005355 Fibrosis Cyclosporine 3.2812639820 12168785
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Genistein 3.3316598420
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8720471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8716080930
MESH:D006333 Heart Failure Selenium 3.1417162251
MESH:D006402 Hematologic Diseases Benzene 4.7716183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D006561 Herpes Simplex resveratrol 4.3316876885
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006937 Hypercholesterolemia resveratrol 4.1117188708
MESH:D006949 Hyperlipidemias resveratrol 4.1416873680
MESH:D006973 Hypertension Benzene 5.5117940673
MESH:D006973 Hypertension Cyclosporine 5.5110903974
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4117488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.7817600658
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007249 Inflammation Mustard Gas 5.5911428631 17524151 11402378 8975870 9357497 11428620 16001271 9260866 11428647
MESH:D007249 Inflammation resveratrol 5.5916366677
MESH:D007251 Influenza, Human resveratrol 19.6916624496
MESH:D007251 Influenza, Human Selenium 19.6916624496
MESH:D007251 Influenza, Human Vitamin E 19.6916624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.228314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.2212488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D007938 Leukemia Benzene 6.8118335105 17119257 14694614 15935818
MESH:D007938 Leukemia Genistein 6.8117468513 18980019
MESH:D007951 Leukemia, Myeloid Benzene 4.4317506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7119478238
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6416087638
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.6717823541
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.6716169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8220195826 21137059
MESH:D008113 Liver Neoplasms resveratrol 4.8219812893 19073162 20405173 19321006
MESH:D008114 Liver Neoplasms, Experimental Benzene 3.3512562636
MESH:D008171 Lung Diseases Mustard Gas 7.7918161513 18702808
MESH:D008171 Lung Diseases Vitamin E 7.7916863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.9814698565
MESH:D008175 Lung Neoplasms Benzene 5.0012562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0020869020 18569708 20135361 18816296 6695378 20464547 18520028 17053015 20064080
MESH:D008175 Lung Neoplasms Mustard Gas 5.003148597 8781369
MESH:D008175 Lung Neoplasms Vitamin E 5.0011062179
MESH:D008223 Lymphoma Benzene 3.8117584886 17119257
MESH:D016393 Lymphoma, B-Cell resveratrol 4.4217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.9614749477
MESH:D015674 Mammary Neoplasms, Animal Benzene 10.7712562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 10.7715688416
MESH:D008325 Mammary Neoplasms, Experimental Benzene 14.9211921183
MESH:D008325 Mammary Neoplasms, Experimental Genistein 14.9214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 14.928985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Selenium 14.9215318939
MESH:D008545 Melanoma resveratrol 2.3817992120
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D008659 Metabolic Diseases resveratrol 4.4917112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009101 Multiple Myeloma Benzene 7.8917119195
MESH:D009101 Multiple Myeloma resveratrol 7.8917164350 17049120 14749477 16490592 16267019 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.0217962980
MESH:D009203 Myocardial Infarction Genistein 6.1417141266
MESH:D009203 Myocardial Infarction resveratrol 6.1417015251 16317513 16525036 17188708 16456233 17125593
MESH:D017202 Myocardial Ischemia resveratrol 4.0917015251 17125593
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7417141266
MESH:D009205 Myocarditis resveratrol 4.9117322642
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2211141357
MESH:D009374 Neoplasms, Experimental resveratrol 4.148985016
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Genistein 4.1616427766
MESH:D009436 Neural Tube Defects Benzene 3.7415643154
MESH:D019636 Neurodegenerative Diseases resveratrol 3.9017652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.5217929310
MESH:D009503 Neutropenia Mustard Gas 4.0916761898 7688884
MESH:D009784 Occupational Diseases Benzene 4.2817479406 15612468 17178637 17119257 15576619 15727169 15913788 15935809 16737584
MESH:D010024 Osteoporosis Genistein 3.3219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.5516169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 10.5517513867
MESH:D010051 Ovarian Neoplasms Benzene 5.2812562636
MESH:D010051 Ovarian Neoplasms Genistein 5.2819005980
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D011041 Poisoning Mustard Gas 3.9115727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.3716679765
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.3719015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Genistein 2.0815256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms resveratrol 2.0816731767 17636462 17718901 17675339 15767336 17804756
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0815084515
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D011537 Pruritus Mustard Gas 4.2518058305
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9617894541 17620002 17266442 10334151 17720292
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.7616325855
MESH:D015427 Reperfusion Injury resveratrol 3.3216314181 17058453 17520802 16317513 15827377
MESH:D012871 Skin Diseases Mustard Gas 5.1116961503 12880345 15451306
MESH:D012871 Skin Diseases Vitamin E 5.1118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8119755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 9.8115837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.818532709
MESH:D013274 Stomach Neoplasms Benzene 2.6012562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.602093021 20155912
MESH:D020521 Stroke Vitamin E 3.6116517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5816321402
MESH:D013953 Thymus Neoplasms Benzene 5.1110850423
MESH:D014062 Tongue Neoplasms resveratrol 4.3116227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2117053015
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2017473185
MESH:D014594 Uterine Neoplasms Benzene 10.3112562636
MESH:D014594 Uterine Neoplasms resveratrol 10.3117044934
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.4417488730
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30608
    • Releated gene ID Related gene Name
    PA358TUBB
    No data
    Releated drug ID Related drug Name
    PA452621antineoplastic agents
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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