AutismKB 2.0

Annotation Detail for MAPT


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Basic Information Top
Gene Symbol:MAPT ( DDPAC,FLJ31424,FTDP-17,MAPTL,MGC138549,MSTD,MTBT1,MTBT2,PPND,TAU )
Gene Full Name: microtubule-associated protein tau
Band: 17q21.31
Quick LinksEntrez ID:4137; OMIM: 157140; Uniprot ID:TAU_HUMAN; ENSEMBL ID: ENSG00000186868; HGNC ID: 6893
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa05010Alzheimer's disease
Pathway IDPathway Name
Apoptosis
Pathway IDPathway Name
200143Signaling mediated by p38-gamma and p38-delta
200061LKB1 signaling events
200011LPA receptor mediated events
200051Reelin signaling pathway
No data
Pathway IDPathway Name
500271Caspase-mediated cleavage of cytoskeletal proteins
Related Diseases/Disorders Top
Desease IDDesease Name
H00077Progressive supranuclear palsy
H00078Pick's disease
Nervous system diseases
Neurodegenerative diseases
H00058Amyotrophic lateral sclerosis
Desease IDDesease Name
1791Neuropathy
1878Ischemia
1907Depression
1953Nervous system disease
1977Rheumatism
1982Myopathy
1983Down syndrome
1997Dental plaque
2035Brain disease
2062Neurodegenerative disorder
2134Amyotrophic lateral sclerosis
2159Hydrocephalus
2221Behavior disease
2223Central nervous system disease
2244Prion disease
Desease Name
Parkinson's disease
progressive supranuclear palsy
Neurodegenerative Diseases
Alzheimer's disease
dementia, frontotemporal
Supranuclear Palsy, Progressive
PSYCH
frontotemporal dementia and Pick-like 3R and 4R tauopathy
NEUROLOGICAL
primary progressive aphasia
cognitive ability
inherited dementia FTDP-17
Familial atypical progressive supranuclear palsy
Desease Name
Parkinson's disease
Desease Name
Supranuclear palsy, progressive
Tauopathy and respiratory failure
Parkinson disease, susceptibility to
Dementia, frontotemporal, with or without parkinsonism
Pick disease
Supranuclear palsy, progressive atypical
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in increased expression of MAPT protein modified formincreases expression 20157255
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in increased phosphorylation of MAPT proteinincreases phosphorylation 20157255
C076996 27-hydroxycholesterol LEP protein inhibits the reaction [27-hydroxycholesterol results in increased expression of MAPT protein modified form]decreases reaction|increases expression 20157255
C076996 27-hydroxycholesterol LEP protein inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of MAPT protein]decreases reaction|increases phosphorylation 20157255
D000082 Acetaminophen Acetaminophen affects the expression of MAPT mRNAaffects expression 17562736
D000171 Acrolein Acrolein results in increased phosphorylation of MAPT proteinincreases phosphorylation 12605413
D000171 Acrolein Lithium inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein]decreases reaction|increases phosphorylation 12605413
D000171 Acrolein SB 203580 inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein]decreases reaction|increases phosphorylation 12605413
D000171 Acrolein Acrolein promotes the reaction [MAPT protein binds to MAPT protein]affects binding|increases reaction 17082178
D000171 Acrolein Acrolein results in increased phosphorylation of MAPT proteinincreases phosphorylation 12605413
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MAPT proteinaffects expression 20106945
D015766 Albendazole Albendazole results in decreased expression of MAPT mRNAdecreases expression 16930453
D015766 Albendazole Albendazole results in decreased expression of MAPT proteindecreases expression 16930453
C001570 alexidine alexidine results in decreased expression of MAPT proteindecreases expression 16930453
D043582 5-alpha-Dihydroprogesterone 5-alpha-Dihydroprogesterone results in decreased expression of MAPT proteindecreases expression 17443805
D043582 5-alpha-Dihydroprogesterone 5-alpha-Dihydroprogesterone results in increased phosphorylation of MAPT proteinincreases phosphorylation 17443805
D000535 Aluminum Aluminum results in increased phosphorylation of MAPT proteinincreases phosphorylation 17662457
C041524 aluminum sulfate aluminum sulfate results in increased phosphorylation of MAPT proteinincreases phosphorylation 11388372
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAPT mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of MAPT protein modified formdecreases expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in increased phosphorylation of MAPT proteinincreases phosphorylation 12605413
D016718 Arachidonic Acid Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein]decreases reaction|increases phosphorylation 12605413
D001151 Arsenic Arsenic metabolite affects the expression of MAPT mRNAaffects expression 17553662
D016589 Astemizole Astemizole binds to MAPT protein alternative formaffects binding 20110603
D001374 Azacitidine Azacitidine results in decreased expression of MAPT proteindecreases expression 16930453
D001375 Azaguanine Azaguanine results in decreased expression of MAPT proteindecreases expression 16930453
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MAPT mRNAaffects cotreatment|increases expression 18164116
C004532 benzoquinone benzoquinone promotes the reaction [MAPT protein binds to MAPT protein]affects binding|increases reaction 16180106
D002166 Camptothecin Camptothecin results in decreased expression of MAPT mRNAdecreases expression 16930453
D002166 Camptothecin Camptothecin results in decreased expression of MAPT proteindecreases expression 16930453
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MAPT mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of MAPT mRNAdecreases expression 16644059
C062047 chelidonine chelidonine results in decreased expression of MAPT proteindecreases expression 16930453
C011585 ciclopirox ciclopirox results in decreased expression of MAPT proteindecreases expression 16930453
D003078 Colchicine Colchicine results in decreased expression of MAPT proteindecreases expression 16930453
D003520 Cyclophosphamide MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D016572 Cyclosporine Cyclosporine results in decreased expression of MAPT mRNAdecreases expression 20106945
C017160 cypermethrin [Okadaic Acid co-treated with cypermethrin] results in increased phosphorylation of MAPT proteinaffects cotreatment|increases phosphorylation 7723735
D003630 Daunorubicin Daunorubicin results in decreased expression of MAPT mRNAdecreases expression 16930453
D003630 Daunorubicin Daunorubicin results in decreased expression of MAPT proteindecreases expression 16930453
C029108 diaziquone diaziquone results in decreased expression of MAPT proteindecreases expression 16930453
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MAPT mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of and results in increased phosphorylation of MAPT proteinincreases expression|increases phosphorylation 20387270
19542621
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of MAPT mRNAdecreases expression 17005392
D004298 Dopamine Dopamine metabolite promotes the reaction [MAPT protein binds to MAPT protein]affects binding|increases reaction 16180106
D004298 Dopamine Dopamine promotes the reaction [MAPT protein binds to MAPT protein]affects binding|increases reaction 16180106
D004317 Doxorubicin Doxorubicin results in decreased expression of MAPT proteindecreases expression 16930453
D004317 Doxorubicin MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004640 Emetine Emetine results in decreased expression of MAPT proteindecreases expression 16930453
D004642 Emodin Emodin results in decreased expression of MAPT mRNAdecreases expression 16045814
D004958 Estradiol Estradiol results in increased expression of MAPT proteinincreases expression 20579400
D004958 Estradiol Tamoxifen inhibits the reaction [Estradiol results in increased expression of MAPT protein]decreases reaction|increases expression 20579400
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MAPT mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MAPT mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAPT mRNAaffects cotreatment|increases expression 17942748
D005273 Fenbendazole Fenbendazole results in decreased expression of MAPT proteindecreases expression 16930453
D005472 Fluorouracil MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C070081 fulvestrant fulvestrant results in decreased expression of MAPT proteindecreases expression 20579400
D006037 Glyoxal Glyoxal promotes the reaction [MAPT protein binds to MAPT protein]affects binding|increases reaction 17082178
D006096 Gramicidin Gramicidin results in decreased expression of MAPT proteindecreases expression 16930453
D017313 Fenretinide Fenretinide results in increased expression of MAPT mRNAincreases expression 16570282
C058028 immunomycin [Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT proteinaffects cotreatment|increases phosphorylation 7723735
C058028 immunomycin [Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT proteinaffects cotreatment|increases phosphorylation 7723735
C058028 immunomycin [Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT proteinaffects cotreatment|increases phosphorylation 7723735
D015759 Ionomycin Ionomycin results in decreased phosphorylation of MAPT proteindecreases phosphorylation 9200503
D015759 Ionomycin Okadaic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of MAPT protein]decreases phosphorylation|decreases reaction 9200503
D015759 Ionomycin Ionomycin results in decreased phosphorylation of MAPT proteindecreases phosphorylation 9200503
D015759 Ionomycin Okadaic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of MAPT protein]decreases phosphorylation|decreases reaction 9200503
C058687 lansoprazole lansoprazole binds to MAPT protein alternative formaffects binding 20110603
D007832 Lasalocid Lasalocid results in decreased expression of MAPT proteindecreases expression 16930453
D008094 Lithium Lithium inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein]decreases reaction|increases phosphorylation 12605413
D008315 Malondialdehyde Malondialdehyde promotes the reaction [MAPT protein binds to MAPT protein]affects binding|increases reaction 17082178
D008463 Mebendazole Mebendazole results in decreased expression of MAPT proteindecreases expression 16930453
D008751 Methylene Blue Methylene Blue results in decreased expression of MAPT proteindecreases expression 16930453
D008751 Methylene Blue Methylene Blue results in increased expression of MAPT mRNAincreases expression 16930453
C008493 methylselenic acid methylselenic acid results in decreased expression of MAPT mRNAdecreases expression 12517777
D009020 Morphine Morphine results in increased expression of MAPT mRNAincreases expression 15183518
D009173 Mycophenolic Acid Mycophenolic Acid results in decreased expression of MAPT proteindecreases expression 16930453
C029938 nickel sulfate nickel sulfate results in decreased expression of MAPT mRNAdecreases expression 16100012
D015739 Nocodazole Nocodazole results in decreased expression of MAPT proteindecreases expression 16930453
D009640 Norethindrone Norethindrone results in decreased expression of MAPT proteindecreases expression 16930453
D019319 Okadaic Acid [Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT proteinaffects cotreatment|increases phosphorylation 7723735
D019319 Okadaic Acid Okadaic Acid results in increased phosphorylation of MAPT proteinincreases phosphorylation 7723735
D019319 Okadaic Acid [Okadaic Acid co-treated with cypermethrin] results in increased phosphorylation of MAPT proteinaffects cotreatment|increases phosphorylation 7723735
D019319 Okadaic Acid [Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT proteinaffects cotreatment|increases phosphorylation 7723735
D019319 Okadaic Acid Okadaic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of MAPT protein]decreases phosphorylation|decreases reaction 9200503
D019319 Okadaic Acid [Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT proteinaffects cotreatment|increases phosphorylation 7723735
D019319 Okadaic Acid Okadaic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of MAPT protein]decreases phosphorylation|decreases reaction 9200503
D019319 Okadaic Acid Okadaic Acid inhibits the reaction [Potassium Chloride results in decreased phosphorylation of MAPT protein]decreases phosphorylation|decreases reaction 9200503
D019319 Okadaic Acid Okadaic Acid results in increased phosphorylation of MAPT proteinincreases phosphorylation 7723735
D010126 Ozone Ozone results in decreased expression of MAPT mRNAdecreases expression 12763052
D017239 Paclitaxel MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D017239 Paclitaxel Paclitaxel results in decreased expression of MAPT mRNAdecreases expression 16930453
D017239 Paclitaxel Paclitaxel results in decreased expression of MAPT proteindecreases expression 16930453
D011034 Podophyllotoxin Podophyllotoxin results in decreased expression of MAPT proteindecreases expression 16930453
D011189 Potassium Chloride Okadaic Acid inhibits the reaction [Potassium Chloride results in decreased phosphorylation of MAPT protein]decreases phosphorylation|decreases reaction 9200503
D011189 Potassium Chloride Potassium Chloride results in decreased phosphorylation of MAPT proteindecreases phosphorylation 9200503
D011280 Pregnanolone Pregnanolone results in decreased expression of MAPT proteindecreases expression 17443805
D011280 Pregnanolone Pregnanolone results in increased phosphorylation of MAPT proteinincreases phosphorylation 17443805
D011374 Progesterone Progesterone results in decreased expression of MAPT proteindecreases expression 17443805
D011374 Progesterone Progesterone results in increased phosphorylation of MAPT proteinincreases phosphorylation 17443805
C008704 pyrithione GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein]affects cotreatment|increases phosphorylation|increases reaction 17098228
C008704 pyrithione [Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT proteinaffects cotreatment|increases phosphorylation 17098228
D011765 Pyruvaldehyde Pyruvaldehyde promotes the reaction [MAPT protein binds to MAPT protein]affects binding|increases reaction 17082178
C059514 resveratrol resveratrol results in decreased expression of MAPT mRNAdecreases expression 12569576
C064758 Ro 31-8220 Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein]decreases reaction|increases phosphorylation 12605413
D012402 Rotenone Rotenone results in decreased expression of MAPT proteindecreases expression 16930453
C093642 SB 203580 SB 203580 inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein]decreases reaction|increases phosphorylation 12605413
D017632 Asbestos, Serpentine Asbestos, Serpentine results in decreased expression of MAPT mRNAdecreases expression 16251409
D013629 Tamoxifen Tamoxifen inhibits the reaction [Estradiol results in increased expression of MAPT protein]decreases reaction|increases expression 20579400
D013629 Tamoxifen Tamoxifen results in increased expression of MAPT proteinincreases expression 20579400
D013629 Tamoxifen Tamoxifen affects the expression of MAPT mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate affects the expression of MAPT mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MAPT mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAPT mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MAPT mRNAincreases expression 16922920
17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased phosphorylation of MAPT proteinincreases phosphorylation 18996433
D014212 Tretinoin MAPT protein affects the susceptibility to Tretinoinaffects response to substance 16417947
D014212 Tretinoin MAPT protein promotes the reaction [Tretinoin affects the localization of MAPT protein]affects localization|increases reaction 16417947
D014212 Tretinoin Tretinoin promotes the reaction [MAPT protein affects the localization of [MAPT protein binds to RARG protein]]affects binding|affects localization|increases reaction 16417947
D014212 Tretinoin MAPT protein promotes the reaction [Tretinoin results in increased activity of CASP3 protein]increases activity|increases reaction 16417947
D014212 Tretinoin Tretinoin results in increased expression of MAPT proteinincreases expression 17130476
D014635 Valproic Acid Valproic Acid results in increased expression of MAPT mRNAincreases expression 19101580
D015032 Zinc GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein]affects cotreatment|increases phosphorylation|increases reaction 17098228
D015032 Zinc [Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT proteinaffects cotreatment|increases phosphorylation 17098228
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.8114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 5.9314514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 5.938875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.2719490988
MESH:D000138 Acidosis Ammonium Chloride 2.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.2017505938
MESH:D000169 Acrodermatitis Zinc 4.6717202136 17190629 16889938
MESH:D058186 Acute Kidney Injury resveratrol 3.2116538975
MESH:D055371 Acute Lung Injury Acrolein 7.5021297076 20525806
MESH:D055371 Acute Lung Injury nickel sulfate 7.5012718980 11954676 16100012 19131640
MESH:D000230 Adenocarcinoma Doxorubicin 10.8217418594
MESH:D000230 Adenocarcinoma Estradiol 10.8211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.8214692618
MESH:D000230 Adenocarcinoma Fenretinide 10.8210697514
MESH:D000230 Adenocarcinoma Fluorouracil 10.8217638652
MESH:D000236 Adenoma beta-Naphthoflavone 8.5619389873
MESH:D000236 Adenoma Diethylnitrosamine 8.566695378 10737359
MESH:D000236 Adenoma resveratrol 8.5615688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 7.6517620307 16434500 19061943 18056438 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 7.6516835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.4717306315
MESH:D000382 Agricultural Workers' Diseases cypermethrin 4.2216487989
MESH:D000419 Albuminuria Doxorubicin 3.8521441931
MESH:D000505 Alopecia Tretinoin 3.0215955085
MESH:D000544 Alzheimer Disease marker/mechanism 20157255
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 15.7414523054 20157255
MESH:D000544 Alzheimer Disease Acrolein 15.7414715435 17570602 15207723
MESH:D000544 Alzheimer Disease Aluminum 15.7410721010 17662457
MESH:D000544 Alzheimer Disease Lithium 15.7419621015
MESH:D000544 Alzheimer Disease Ozone 15.7415513908
MESH:D000544 Alzheimer Disease resveratrol 15.7416162502 16183991
MESH:D000544 Alzheimer Disease Zinc 15.7416580781 16325427 16410023 17119284
MESH:D000550 Amblyopia Valproic Acid 4.4917688650
MESH:D000686 Amyloidosis Diethylstilbestrol 3.7915469931
MESH:D000740 Anemia Fluorouracil 11.3615504547 17963324 16511603
MESH:D000740 Anemia Malondialdehyde 11.3617278206
MESH:D000740 Anemia Tetrachlorodibenzodioxin 11.3611748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.2116916123
MESH:D000799 Angioedema Acetaminophen 9.5710982225
MESH:D000799 Angioedema Astemizole 9.572883202
MESH:D001008 Anxiety Disorders Valproic Acid 2.9817497229
MESH:D020261 Arsenic Poisoning Arsenic 2.6118414634 12569548 16835338 16251483
MESH:D001161 Arteriosclerosis Acrolein 13.1315014928
MESH:D001161 Arteriosclerosis Cyclophosphamide 13.1315014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 13.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 9.4115885639
MESH:D001169 Arthritis, Experimental resveratrol 9.4117115116
MESH:D001169 Arthritis, Experimental Tretinoin 9.4116412693
MESH:D001172 Arthritis, Rheumatoid Ozone 3.8715570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 3.8716292516
MESH:D001195 Asbestosis Asbestos, Serpentine 4.9710751356
MESH:D001249 Asthma Ozone 6.2717854713 16373670
MESH:D001249 Asthma Tretinoin 6.2716456186
MESH:D001249 Asthma Zinc 6.2717085522
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 11.8511166758 9059518
MESH:D050197 Atherosclerosis Acrolein 11.8516037261 17363696 16126721
MESH:D050197 Atherosclerosis Arsenic 11.8519371607 12928151
MESH:D050197 Atherosclerosis resveratrol 11.8517967414 16873680
MESH:D001284 Atrophy fulvestrant 4.1611514358
MESH:D001321 Autistic Disorder Acetaminophen 2.0718445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.0718582451
MESH:D001321 Autistic Disorder Valproic Acid 2.0719460635 18316065 18775368 18985861 17688650 18558336 18396377 20603192 18940202 17507914 16609825 15238991 17157402 18177632 19232924
MESH:D001471 Barrett Esophagus Tretinoin 3.7116935849
MESH:D001528 Behcet Syndrome Colchicine 5.4015870978
MESH:D001714 Bipolar Disorder Lithium 6.1920046352 20338123 19153942 17594078
MESH:D001714 Bipolar Disorder Valproic Acid 6.1917594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 6.7612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 6.7616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.0515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.3315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.338888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 3.9614601052
MESH:D001859 Bone Neoplasms Paclitaxel 3.8915867366
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.6017868700
MESH:D001930 Brain Injuries Pregnanolone 14.6015665606 15380490
MESH:D001930 Brain Injuries Progesterone 14.6015380490 15665606 15845082
MESH:D001930 Brain Injuries Zinc 14.6017109824
MESH:D002545 Brain Ischemia Morphine 8.2219211983
MESH:D002545 Brain Ischemia resveratrol 8.2217600658
MESH:D001932 Brain Neoplasms Doxorubicin 7.0017150277
MESH:D001932 Brain Neoplasms Fenretinide 7.0016187019
MESH:D001943 Breast Neoplasms Cyclophosphamide 10.6817020986 17388661 12006526 18234424 18323546 11325840 15093573 15136595 16978400
MESH:D001943 Breast Neoplasms Diethylnitrosamine 10.6817474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 10.6815324884 17129689
MESH:D001943 Breast Neoplasms Doxorubicin 10.6818382427 18695136 18628466 19526202 15668708 15939500 17369602 16264153 15993339 16096432 16826403 16935488 16595493 15136595 15692762 17426702 18234424 15567936 16322301 16115903 11325840 15634643 17983394 15994142
MESH:D001943 Breast Neoplasms Estradiol 10.6812948864 19861407 17289903 17261762 14630087 18497071 16675129 17018787
MESH:D001943 Breast Neoplasms Fenretinide 10.6816601279
MESH:D001943 Breast Neoplasms Fluorouracil 10.6816110121 19217205 16595493 15136595 16557594 18608205 18357371
MESH:D001943 Breast Neoplasms fulvestrant 10.6818984771
MESH:D001943 Breast Neoplasms Paclitaxel 10.6818223236 16115903 18323546 11325840 16244791 15136595 16273361 18234424
MESH:D001943 Breast Neoplasms Progesterone 10.6815562024 16175315 17614352
MESH:D001943 Breast Neoplasms resveratrol 10.6816393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 10.6818984771 19155303 19200415 19142967 16273361 19115204 17440819 19221464 20859285 20135344 21152245 18855134 18997820 16202921 19288272 18815881 19059307 19189210 19066611 11161223 21138602 20390343 18425577 20544844 20065188 19084267 20005174 17893378 19410462 19189212 19289846 18629630 19103187 15565566 18821012 15668708 19487384 19011961 18351453 16818667 17049068 16873071 17261762 19244106 17242785
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.6820435547
MESH:D001943 Breast Neoplasms Tretinoin 10.6816873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.0917626835 18315731 16777450 15516495 19059883 18417511 14754758
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.8616813970
MESH:D002100 Cachexia Ozone 4.0116183385
MESH:D002177 Candidiasis ciclopirox 6.3616640825
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.7416111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.0716227642 3786805 15700767 16124888 15673190 16097048 15721981 16192424 16050911 16011737 18705752 10355542
MESH:D002276 Carcinoid Tumor Doxorubicin 9.8916051944
MESH:D002276 Carcinoid Tumor Fluorouracil 9.8916051944
MESH:D002277 Carcinoma Fluorouracil 6.2217121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.2216835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.1317687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.7919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.4216168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 33.783084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 33.7821507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Arsenic 33.7817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 33.7818788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 33.7819701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 33.7817173139 10737359 17978847 16681979 18788625 16807293 20214788 19107877 19052882 19383236 16878318 18785209 16288022 17162532 20514400 20101231 16569478 20007298 17761372 20935162 18506893 17428255 20727157 18056438 16935385 18691550 3581430 18978308 19539802 16830150 16328049 18494052 17138121 11831363 19919837 19394651 16502159 20432363 3084413 20084675 19171122 18971187 19701751 19208518 18210153 16698587 18393292 19418558 19335982 20524982 17055752 19519916 10672840 16540662 21159647 20512989 19822196 18665156 16779866
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 33.7816924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 33.7816234567 18059187 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 33.7816924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 33.7817159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 33.7816332177 16799960 17045692 17088986 18930000 17971768
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 33.7816313753
MESH:D006528 Carcinoma, Hepatocellular resveratrol 33.7819321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 33.7816924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 33.781917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 9.0816152834
MESH:D018827 Carcinoma, Lewis Lung resveratrol 9.0816675471
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 8.5516201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 8.5516201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 8.5518695887
MESH:D002294 Carcinoma, Squamous Cell Arsenic 17.6217687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 17.626189445
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 17.6216274795
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 17.6216757204 16280240 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell resveratrol 17.6216227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 17.6216051514 16096774
MESH:D002294 Carcinoma, Squamous Cell Zinc 17.6216543248
MESH:D002295 Carcinoma, Transitional Cell Arsenic 7.3718640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.3717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 1.9218850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.0216651473 17382496 16269455 16952015 18627295 16278810 17308081 16612575 17351982 17974986 17329180 17007740 17928571 17924179 15476868 15811867 16109756 15792986 15505089 16242529 16731534 17519947 16364871 16455267 17131338
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.6416243910 17334414
MESH:D002318 Cardiovascular Diseases Arsenic 9.2015738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases resveratrol 9.2015458977
MESH:D002318 Cardiovascular Diseases Zinc 9.2016936243
MESH:D002340 Carotid Artery Diseases Arsenic 3.6818022660 16973168
MESH:D002386 Cataract Acetaminophen 5.6410977129
MESH:D002386 Cataract Tretinoin 5.6417460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 8.0712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 8.0717174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 8.0718566989
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 10.5616154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 10.5616129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.3920734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.2519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.2516835633
MESH:D002779 Cholestasis Cyclosporine 5.9019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 5.9016105132 15861022 17681005 17333356 16919318 17110522 11677210
MESH:D002822 Choriocarcinoma Tretinoin 4.4216461808
MESH:D016770 Ciliophora Infections Albendazole 5.3412113305
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.538697196 15668235 15340226 12621046 16354765
MESH:D002972 Cleft Palate Tretinoin 4.539407595
MESH:D003092 Colitis resveratrol 7.2816474422
MESH:D003092 Colitis Tretinoin 7.2817035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.2817725105 16510598 17172411 15001691 17016597 17018589 17287894 18772588 16340194 17169374
MESH:D003110 Colonic Neoplasms resveratrol 3.2816338953
MESH:D015179 Colorectal Neoplasms Acrolein 8.7317597105
MESH:D015179 Colorectal Neoplasms Azacitidine 8.7319934284
MESH:D015179 Colorectal Neoplasms Doxorubicin 8.7318259882 18802399
MESH:D015179 Colorectal Neoplasms Fenretinide 8.7317273769
MESH:D015179 Colorectal Neoplasms Fluorouracil 8.7315148649 17094418 16303861 18448328 16331619 16391804 15289873 20501625 17454858 18288408 18509181 18949393 17695437 17255274 18383874 17594712 17401013 17016601 16524972 14970324 18802399 16282729
MESH:D015179 Colorectal Neoplasms Paclitaxel 8.7318802399
MESH:D015179 Colorectal Neoplasms resveratrol 8.7316550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.4417141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.2516507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.4215322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.429211117 17551590 8800419 9142499 9224671 10589399 14991402 16925845 9664655 9125849
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.428888407 16575769 17688650
MESH:D019465 Craniofacial Abnormalities Zinc 4.4219302082
MESH:D003456 Cryptorchidism Diethylstilbestrol 3.8612952375 16002989
MESH:D003556 Cystitis Acrolein 9.6312161096
MESH:D003556 Cystitis Cyclophosphamide 9.6318433785 18295254 10498854 16651033 15276878 17979934 12913760 10700343 18372110 12161096 15643279 18483878 16614059 18710439 12388444 16989017 18093676 17010015 16413132 11948286
MESH:D007644 Darier Disease Fluorouracil 10.8016733453
MESH:D007644 Darier Disease Lithium 10.8020338123
MESH:D003704 Dementia marker/mechanism
MESH:D003711 Demyelinating Diseases Tamoxifen 3.6519031437
MESH:D003715 Dengue 27-hydroxycholesterol 4.9619427377
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.0216823706 11298694 16780908
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.0319244398
MESH:D003920 Diabetes Mellitus Zinc 3.5816479319
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 6.6715331540 10990075 11751995
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 6.6716873680
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 2.9418772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.4120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.4117107852
MESH:D003928 Diabetic Nephropathies Estradiol 11.4219279558
MESH:D003928 Diabetic Nephropathies resveratrol 11.4216286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 11.4219279558
MESH:D003929 Diabetic Neuropathies Pregnanolone 10.0917187935
MESH:D003929 Diabetic Neuropathies Progesterone 10.0917187935
MESH:D003967 Diarrhea Morphine 3.852540324
MESH:D004244 Dizziness Astemizole 5.723105558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.4911529661 18713872 17522070 11743745 17906064 16081117 16781746 15619225 14725611 17562736 19739265 19085960 12705907 19164858 10663392 19370779 12958197 16177239 10915739 12392966 15968718 19923254 11287661 16393943 19416960 11739529 18071297 2444490 11461765 12594235 11421492 12153990 16109766 10774834 11834606 19420014 16227642 14550746 14986274 12540782 16485898
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.4910915739 6623471 17522070 3786805 19085960 19336974 15968718 15027814 16177239 3732212 4309450 15998439 2869522 7120509 9327722 11566570 21278145 10092053 16227642 6884620 7440962 7179309
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.4919107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.4917416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.4920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.491733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.3619426721
MESH:D004362 Drug Toxicity Doxorubicin 6.2318602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.2311462148
MESH:D004381 Duodenal Ulcer lansoprazole 4.9217151854
MESH:D004417 Dyspnea cypermethrin 4.6616487989
MESH:D004421 Dystonia Valproic Acid 3.371851702
MESH:D004487 Edema Arachidonic Acid 7.9215177302 7990266 16716910 9599246 11698051 9831321
MESH:D004487 Edema resveratrol 7.928985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.9212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.4918230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 9.4918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 21.4817410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 21.4812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 21.4817692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 21.4817872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 21.4819031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 3.9716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 17.9116804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 17.9117359293
MESH:D016889 Endometrial Neoplasms Estradiol 17.9119148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 17.9117893378 19155303 16202921 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 17.9116569247
MESH:D004715 Endometriosis Progesterone 6.8116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 6.819294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.4218037988
MESH:D004751 Enteritis lansoprazole 5.4716328016
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.1417923197
MESH:D004802 Eosinophilia Astemizole 7.171355641
MESH:D004802 Eosinophilia Cyclophosphamide 7.1711006010
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.4517275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.183922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.5120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 2.976426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.597750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.343659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.3816302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 5.9517638652 15173087 16481741 16785472 16337965
MESH:D004938 Esophageal Neoplasms Paclitaxel 5.9516481741
MESH:D004938 Esophageal Neoplasms Zinc 5.9516543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 6.9511564622
MESH:D005124 Eye Abnormalities Tretinoin 6.959664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.3016045604 15959796 16239168 12631006 19224547 12795759 61145 17595544
MESH:D005234 Fatty Liver Cyclosporine 22.3019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.3021071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.3015345470
MESH:D005234 Fatty Liver Tamoxifen 22.3019224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 22.3014986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.5815751030 16513791 16534752 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.5816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.7511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.448888407 18558336
MESH:D005334 Fever Arachidonic Acid 4.0211852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.8014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.0319069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.0319069698
MESH:D005355 Fibrosis Carbon Tetrachloride 20.3118705752
MESH:D005355 Fibrosis Cyclosporine 20.3112639820 12168785
MESH:D005355 Fibrosis Emodin 20.3119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.3120067830
MESH:D005355 Fibrosis Tretinoin 20.3117994277
MESH:D005393 Fish Diseases Albendazole 5.3012113305
MESH:D005499 Folliculitis Astemizole 5.181671328
MESH:D005534 Foot Diseases Arsenic 4.826392382
MESH:D057180 Frontotemporal Dementia marker/mechanism
MESH:D005756 Gastritis Acetaminophen 8.7116983495
MESH:D005756 Gastritis Zinc 8.7117241300
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.2216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.498708960
MESH:D005909 Glioblastoma Doxorubicin 12.8517150277
MESH:D005909 Glioblastoma Fenretinide 12.8516187019
MESH:D005909 Glioblastoma Okadaic Acid 12.8517312396
MESH:D005909 Glioblastoma Tretinoin 12.8517312396
MESH:D005910 Glioma Fluorouracil 2.5316145905
MESH:D018316 Gliosarcoma Cyclophosphamide 4.7911389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.8510696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.3215172196 11014644 16376943
MESH:D006130 Growth Disorders Zinc 3.4517217573
MESH:D006258 Head and Neck Neoplasms Doxorubicin 9.9215692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 9.9215162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 9.9216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.4216084493
MESH:D006330 Heart Defects, Congenital Lithium 8.7419638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 8.7411294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 8.749664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 2.9516495754 16244371 18006777 16330681 16879835 17888722 17875725 16707910 16244372 12587719 14766674 18674790 16144979
MESH:D006333 Heart Failure Doxorubicin 5.8117481944
MESH:D006333 Heart Failure Zinc 5.8117162251
MESH:D006335 Heart Injuries Zinc 5.0317074742
MESH:D016481 Helicobacter Infections Malondialdehyde 8.9517278206
MESH:D016481 Helicobacter Infections Zinc 8.9517241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.2515692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.6915720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.5811918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.6811000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 4.7914986274
MESH:D006505 Hepatitis Carbon Tetrachloride 7.5419900420 19110552
MESH:D006505 Hepatitis cypermethrin 7.5416487989
MESH:D006527 Hepatolenticular Degeneration Zinc 3.9817276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.2012621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.2915709030
MESH:D006561 Herpes Simplex resveratrol 3.4616876885
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.0017440010
MESH:D006689 Hodgkin Disease Cyclophosphamide 5.6816135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 5.6817606976 15147373 18501091
MESH:D019584 Hot Flashes Estradiol 3.0217088409
MESH:D006849 Hydrocephalus Valproic Acid 4.1417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.3015340226 16354765 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 5.6716870215
MESH:D006930 Hyperalgesia Tretinoin 5.6716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.8016899240
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 7.6217873880
MESH:D006937 Hypercholesterolemia resveratrol 7.6217188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.8616778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 3.8117050553
MESH:D006949 Hyperlipidemias resveratrol 3.3616873680
MESH:D006965 Hyperplasia Diethylstilbestrol 3.7312960047 14722030
MESH:D006973 Hypertension Arsenic 6.5716076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 6.5710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 6.5718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.3815338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.6617488730
MESH:D006987 Hypesthesia Arsenic 4.8216093927
MESH:D007021 Hypospadias Diethylstilbestrol 8.8916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 8.8916569931 16945680
MESH:D007022 Hypotension Dopamine 4.356740701
MESH:D007154 Immune System Diseases Cyclophosphamide 4.5916076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.1315869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 9.1317600658
MESH:D007246 Infertility Diethylstilbestrol 3.6615036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.7912013081
MESH:D007248 Infertility, Male Cyclophosphamide 8.377193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 8.3717937319
MESH:D007248 Infertility, Male fulvestrant 8.3711514358
MESH:D007249 Inflammation Aluminum 17.5816052892
MESH:D007249 Inflammation Arachidonic Acid 17.5817371808 15177302 9831321
MESH:D007249 Inflammation Diethylnitrosamine 17.5818785209
MESH:D007249 Inflammation Progesterone 17.5815869954
MESH:D007249 Inflammation resveratrol 17.5816366677
MESH:D007249 Inflammation Tamoxifen 17.5819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.5812200463 12878042
MESH:D007251 Influenza, Human resveratrol 3.8116624496
MESH:D007299 Insect Bites and Stings cypermethrin 5.2415189238
MESH:D007333 Insulin Resistance Estradiol 2.4616627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.0617994277
MESH:D007511 Ischemia Zinc 3.9216584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.7516580747
MESH:D007569 Jaw Abnormalities Tretinoin 7.7515992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.7015604871
MESH:D007642 Keratosis Arsenic 4.2612749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 17.8115629191 12587719
MESH:D007674 Kidney Diseases Acrolein 17.8112488133
MESH:D007674 Kidney Diseases Cyclosporine 17.8110903974 18776723 8314463
MESH:D007674 Kidney Diseases Doxorubicin 17.8116775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 17.8115618244
MESH:D007674 Kidney Diseases Zinc 17.8116960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 13.2416707910
MESH:D007676 Kidney Failure, Chronic Malondialdehyde 13.2416518626
MESH:D007676 Kidney Failure, Chronic Zinc 13.2416518626
MESH:D007680 Kidney Neoplasms Cyclosporine 16.9712371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.9715003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 16.9715610895
MESH:D007680 Kidney Neoplasms Fluorouracil 16.9716985049
MESH:D007680 Kidney Neoplasms Tamoxifen 16.9718625569
MESH:D007859 Learning Disorders Colchicine 7.9211749816
MESH:D007859 Learning Disorders Diethylstilbestrol 7.9217184923
MESH:D007938 Leukemia Azacitidine 8.2219148494
MESH:D007938 Leukemia Cyclophosphamide 8.2210602166
MESH:D007938 Leukemia Tretinoin 8.2217143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.4216085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.1317008537 17658394 17802794 18587576 17296974 18172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 4.3717077332
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.5310373061
MESH:D007951 Leukemia, Myeloid Azacitidine 7.6119077051
MESH:D007951 Leukemia, Myeloid Tretinoin 7.6116482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 5.0817596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.0817596541 19850784 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.0816294345 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.5119299654
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 9.8417339181
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 9.8416087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 9.8417712046 17217047 17649720 16140955 19642359 19035177 9834237 12679006 19075265 17368321 16891316 17506722 16788101 19225113 16823087 16331271 17294898 16766008 17339181 16935935 17361223 17301526 17107899 15748426 19029980
MESH:D007970 Leukopenia Cyclophosphamide 4.2410052129 11830472
MESH:D007972 Leukoplakia, Oral Fenretinide 5.3016707609
MESH:D017513 Lichen Nitidus Astemizole 5.722563723
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.769224671
MESH:D008064 Lipidoses Tamoxifen 2.6115342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.1417353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.1016239168 21278145 16943688 11903743 11408273 17174718 17157831 16221502 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.1020032147 18407596 18665156 18522880 19638242
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.7512667390 18412020 10355542 12546737 15893842 15370692 17525996 14748882 17631135 16136751 17708605 17481882 18339082 15925388 15123356 20821823 17900296 17823541 15650968 17714472 12632512 17698563 13678700 12898905 18205269 17805973 16097048 18277467 17721639 18395914 18279442 16638106 12741479 18006644 15959796 14716496 12958196 11481614 17565644 12666154 15362042 17944888 15052691 12649538 18187930 17922224 16192424 17869086 18156304 15931870 15996030 18054572 18429990 18376398 12586293 16015684 17766677 16248980 16027843 14724832 16116963 15818738 16011737 14512876 12445421 18210741 17976157 14620537 17640975 18472332 18317297 18472094 18263696 18705752 15876570 12632514 18418968 17761835 16033810 15057751 12609069 17557913 18395095 12445418 18420326 12389079 18481824 15673190 14716833 18251166 18166357 15338365 15730626
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.7516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Emodin 8.7515288473
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.7514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.7518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.7512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.7516248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 9.7619784758 12587719 19460945 16610002 19014921 11587558 12969438 16611625
MESH:D008107 Liver Diseases Arsenic 9.7611134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.7617285989 16964402 15830285 16246199 15720792
MESH:D008107 Liver Diseases cypermethrin 9.7615991261
MESH:D008107 Liver Diseases Diethylnitrosamine 9.7617034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.4515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.2817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.2814706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 26.759163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Arsenic 26.7516368122
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 26.7519389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 26.7519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 26.7518648771 19850985 19499222 21071580 12112319 19255062 19294768 18978307 12771043 20118626 18977376 16942905 18644402 20501860 19426721 19642983 19690152 9163691 19833225 15885732 21278145 20101389 20137499 2862719 19812893 15175105 20452335 20583210 19638242 19427195 18754104 19090486 19073162 19996281 21047994 21167192 20492335 10737359 20405173 2422723 19256749 19254457 19551842 20434301
MESH:D008113 Liver Neoplasms Diethylstilbestrol 26.7515890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 26.7518383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms resveratrol 26.7519073162 19812893 20405173 19321006
MESH:D008113 Liver Neoplasms Tamoxifen 26.7516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 26.7516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.968603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 16.9618164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.9612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.9619519916 16267830 9362446 19539802 21159647 18544905 17174075 18079962 19004024 18093689 18308698 18775883 17942915 19009564 18253720 3124819 16842330 18164116 18282651 2563599 17854601 19126423
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 16.9617085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.9612151625
MESH:D008133 Long QT Syndrome Astemizole 4.0218472280 11989578
MESH:D008171 Lung Diseases Acrolein 13.4711504702
MESH:D008171 Lung Diseases Aluminum 13.4716052892
MESH:D008171 Lung Diseases Asbestos, Serpentine 13.4717200189
MESH:D008171 Lung Diseases Ozone 13.478266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.5217228818
MESH:D055370 Lung Injury Ozone 3.1520417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 14.7614755239
MESH:D008175 Lung Neoplasms Arsenic 14.7617306315 19168569 17976673
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 14.7611198217
MESH:D008175 Lung Neoplasms Azacitidine 14.7621224363
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.7620970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 14.7617418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 14.7615246190
MESH:D008175 Lung Neoplasms Ozone 14.768597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 14.7618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.7619555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.0615086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.4215166399
MESH:D008223 Lymphoma Cyclophosphamide 9.5112854902
MESH:D008223 Lymphoma Diethylstilbestrol 9.5115700306
MESH:D008223 Lymphoma Doxorubicin 9.5116098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 8.2316675587
MESH:D016393 Lymphoma, B-Cell resveratrol 8.2317088997
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 15.7511911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 15.7517654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 15.7514749477
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 15.7514749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 3.8615621674
MESH:D008288 Malaria Astemizole 4.2116816845
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.7716002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 7.6015688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 7.6019428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 20.7715458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 20.7711807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 20.7710697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 20.7711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 20.7711606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 20.7719196723 14580682 19196722 11731420 16827153
MESH:D008325 Mammary Neoplasms, Experimental Zinc 20.7712773700
MESH:D020149 Manganese Poisoning Estradiol 10.1919453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.1919453300
MESH:D008527 Medulloblastoma Tretinoin 2.4417453147
MESH:D008545 Melanoma Doxorubicin 9.9816827129
MESH:D008545 Melanoma Fenretinide 9.9816270382
MESH:D008545 Melanoma Paclitaxel 9.9812025231 16342250 12040289
MESH:D008545 Melanoma resveratrol 9.9817992120
MESH:D008545 Melanoma Tamoxifen 9.9812393984 19393235
MESH:D008545 Melanoma Tretinoin 9.9816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.4615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 14.3919513568
MESH:D008546 Melanoma, Experimental Acrolein 14.3910803710
MESH:D008546 Melanoma, Experimental Cyclophosphamide 14.3916388313
MESH:D008591 Meningomyelocele Tretinoin 3.7116940565
MESH:D008654 Mesothelioma Doxorubicin 2.7117638057
MESH:D008659 Metabolic Diseases resveratrol 3.7217112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.0516801185
MESH:D008679 Metaplasia Ozone 4.3610496685
MESH:D008881 Migraine Disorders Valproic Acid 2.6518765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.8415792986
MESH:D009006 Monosomy Azacitidine 5.3419299654
MESH:D009062 Mouth Neoplasms Fenretinide 7.0216274795
MESH:D009062 Mouth Neoplasms Fluorouracil 7.0216757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.0617415656
MESH:D009101 Multiple Myeloma Azacitidine 9.1718443271 19549372
MESH:D009101 Multiple Myeloma Paclitaxel 9.1714749477
MESH:D009101 Multiple Myeloma resveratrol 9.1717164350 17049120 16267019 16490592 14749477 17935668
MESH:D020528 Multiple Sclerosis, Chronic Progressive Aluminum 5.6317086897
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Aluminum 5.6317086897
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.1417962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.378888407
MESH:D009190 Myelodysplastic Syndromes Azacitidine 9.7117596541 19805378 17611569 18720364
MESH:D009190 Myelodysplastic Syndromes Tretinoin 9.7117596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 9.7117596541
MESH:D009203 Myocardial Infarction Doxorubicin 7.6019429709 15857846
MESH:D009203 Myocardial Infarction Lithium 7.6016288908
MESH:D009203 Myocardial Infarction resveratrol 7.6016525036 16317513 17188708 17125593 16456233 17015251
MESH:D017202 Myocardial Ischemia Arsenic 11.8715371236
MESH:D017202 Myocardial Ischemia resveratrol 11.8717015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 11.8712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.7016810080
MESH:D009205 Myocarditis resveratrol 4.0317322642
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 10.663581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 10.6618259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 10.6615867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 10.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2219410462
MESH:D009369 Neoplasms Acrolein 14.3817329238
MESH:D009369 Neoplasms Cyclophosphamide 14.3818854779
MESH:D009369 Neoplasms Diethylstilbestrol 14.3815313581
MESH:D009369 Neoplasms Fenretinide 14.3815958647 17353921
MESH:D009369 Neoplasms Fluorouracil 14.3818239605 18600527 16928823
MESH:D009369 Neoplasms Tretinoin 14.3816594593 16946489
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 7.3211704859
MESH:D009374 Neoplasms, Experimental resveratrol 7.328985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.2619189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.0117289903
MESH:D009393 Nephritis Acrolein 5.5512653641
MESH:D009401 Nephrosis Doxorubicin 4.0616636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.7017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.2219348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.2215640375 16889571
MESH:D009410 Nerve Degeneration Rotenone 3.3118619942 15790535 17356569
MESH:D009421 Nervous System Malformations Diethylstilbestrol 17.8011399458
MESH:D009421 Nervous System Malformations Estradiol 17.8011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.8014600291
MESH:D009421 Nervous System Malformations Tretinoin 17.809125849
MESH:D009436 Neural Tube Defects Arsenic 9.2216620997
MESH:D009436 Neural Tube Defects Tretinoin 9.229142499
MESH:D009436 Neural Tube Defects Valproic Acid 9.2216359493 8888407
MESH:D009447 Neuroblastoma Cyclophosphamide 5.778761367 15176712 16115947
MESH:D009447 Neuroblastoma Doxorubicin 5.7715555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 15.1718514411
MESH:D019636 Neurodegenerative Diseases Acrolein 15.1711342003
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 15.1720387270
MESH:D019636 Neurodegenerative Diseases resveratrol 15.1717652729
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.1612837982 8761367
MESH:D020078 Neurogenic Inflammation Arsenic 8.4617056641
MESH:D020078 Neurogenic Inflammation resveratrol 8.4617929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.3820387270
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 4.9516303764
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 2.9116436463
MESH:D009503 Neutropenia Cyclophosphamide 3.668291058
MESH:D009759 Nystagmus, Pathologic Astemizole 5.726135121
MESH:D009845 Oligospermia Cyclophosphamide 3.9916517039
MESH:D010014 Osteolysis Paclitaxel 4.2515867366
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.5817513867
MESH:D012516 Osteosarcoma Doxorubicin 3.5215930896
MESH:D010051 Ovarian Neoplasms Arsenic 14.9517306315
MESH:D010051 Ovarian Neoplasms Estradiol 14.9519401270
MESH:D010051 Ovarian Neoplasms Fenretinide 14.9516133793
MESH:D010051 Ovarian Neoplasms Paclitaxel 14.9511161223
MESH:D010051 Ovarian Neoplasms Progesterone 14.9516525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 14.9516936753
MESH:D010146 Pain Acetaminophen 11.2716870215
MESH:D010146 Pain Cyclophosphamide 11.2718093676 12161096
MESH:D010146 Pain Morphine 11.2716273134 6776300 20225289 18699797 15275824 15215642
MESH:D010146 Pain Tretinoin 11.2716870215
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 12.8011332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 12.8016540662
MESH:D010190 Pancreatic Neoplasms Fenretinide 12.8015580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 12.8019003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.8015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.0111578682
OMIM:260540 PARKINSON-DEMENTIA SYNDROME marker/mechanism
MESH:D010300 Parkinson Disease marker/mechanism 20711177 19915575
MESH:D010300 Parkinson Disease Acrolein 4.7517690948
MESH:D010300 Parkinson Disease Rotenone 4.7519114014 19232380 11535288 18191903 11445065 18619942 16412576 16140633 15451049
MESH:D020734 Parkinsonian Disorders marker/mechanism
MESH:D020734 Parkinsonian Disorders Rotenone 3.4418197244 15927086 15795934 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5112520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.4916093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.2616905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 3.4316369182
MESH:D010787 Photosensitivity Disorders Acrolein 5.0011550810
MESH:D003557 Phyllodes Tumor Doxorubicin 4.4217983394
MESH:D020774 Pick Disease of the Brain marker/mechanism
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.4314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 3.9616977796 15687265
MESH:D010995 Pleural Diseases Asbestos, Serpentine 4.9810923243
MESH:D010997 Pleural Neoplasms Doxorubicin 4.4217638057
MESH:D011014 Pneumonia Ozone 3.6718007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.8718163543
MESH:D011230 Precancerous Conditions Cyclosporine 6.8712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 6.872563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 6.7321297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Daunorubicin 6.7321297632
MESH:D011225 Pre-Eclampsia Zinc 3.5917114810
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 17.3517184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 17.3516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.3511118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.3520603192
MESH:D011317 Priapism Methylene Blue 6.499542685
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.2220887781
MESH:D011471 Prostatic Neoplasms Arsenic 5.0116140617
MESH:D011471 Prostatic Neoplasms Azacitidine 5.0118324645
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 5.0117136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 5.0115846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 5.0115749863 16729912 16868541 16888761 15897917 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 5.0116740699
MESH:D011471 Prostatic Neoplasms Fenretinide 5.0117024972
MESH:D011471 Prostatic Neoplasms Fluorouracil 5.0119082440 18626508
MESH:D011471 Prostatic Neoplasms methylselenic acid 5.0116205645
MESH:D011471 Prostatic Neoplasms Paclitaxel 5.0116356831 17172428 17136230 16729912
MESH:D011471 Prostatic Neoplasms resveratrol 5.0115767336 17636462 17718901 17804756 17675339 16731767
MESH:D011471 Prostatic Neoplasms Tamoxifen 5.0115067354
MESH:D011471 Prostatic Neoplasms Zinc 5.0112429649 16606632 16517595 16700911
MESH:D011507 Proteinuria Arsenic 7.0521343184
MESH:D011507 Proteinuria Tretinoin 7.0516636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.6015861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 3.8012752131 11422049
MESH:D011565 Psoriasis Cyclosporine 1.9216882103
MESH:D011625 Pterygium Tretinoin 4.0616723453
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 5.6515466366
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 5.1918569384 15511213
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.1916636934
MESH:D012004 Rectal Neoplasms Fluorouracil 3.3915538739 16160472 18722050 18286688
MESH:D051437 Renal Insufficiency Acrolein 8.2512732208
MESH:D051437 Renal Insufficiency Doxorubicin 8.2517922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.8416325855
MESH:D015427 Reperfusion Injury Morphine 5.8319211983
MESH:D015427 Reperfusion Injury resveratrol 5.8316314181 17520802 17058453 16317513 15827377
MESH:D012131 Respiratory Insufficiency marker/mechanism
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.1418990726
MESH:D012162 Retinal Degeneration Fenretinide 7.5016303925
MESH:D012162 Retinal Degeneration Zinc 7.5016584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 8.6216283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 8.6219155313
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 4.6910822083
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.5418045962
MESH:D012509 Sarcoma Doxorubicin 3.3516767912 17710206 15625365 15675481 17203757 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.5514601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.0617846226
MESH:D012559 Schizophrenia Valproic Acid 1.9515737665 19110320
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.1516636934
MESH:D012640 Seizures Lithium 4.7619660546
MESH:D012640 Seizures Valproic Acid 4.7611738929 14763951 15475178 3137016 17978042 1511512 11044598 16876388
MESH:D012871 Skin Diseases Arsenic 2.5116759981 15952646 17548696 16353154 6392382 17938729 17050553 17453740 18709164 19834688 16702368
MESH:D012878 Skin Neoplasms Arsenic 21.0115504454 17050553 17029826 16251483 19538983 17976673
MESH:D012878 Skin Neoplasms Doxorubicin 21.0115692506
MESH:D012878 Skin Neoplasms Fenretinide 21.0116467112
MESH:D012878 Skin Neoplasms Okadaic Acid 21.0112628509
MESH:D012878 Skin Neoplasms resveratrol 21.018985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 21.0116192470
MESH:D012878 Skin Neoplasms Tretinoin 21.0116467112
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 5.3011254748
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.8616767912 17203757 15625365
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 5.6419812052
MESH:D013088 Spermatocele Diethylstilbestrol 15.8716709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 15.8716709447
MESH:D013088 Spermatocele Tamoxifen 15.8716709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.7916517039
MESH:D013119 Spinal Cord Injuries Progesterone 8.4615862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 8.4619457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.2019490988
MESH:D013226 Status Epilepticus Lithium 10.2119951488 19570321 19430551
MESH:D013226 Status Epilepticus Valproic Acid 10.2112833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.8518456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.8517172411 16424979 19084572 18396642 17498489 17522103 18567086 15786421 16951190 19015929
MESH:D013274 Stomach Neoplasms Paclitaxel 3.8518506536 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 3.8517261132
MESH:D013276 Stomach Ulcer lansoprazole 4.4317918041 18726076 11906479 18087811 17895592
MESH:D020521 Stroke Acrolein 3.9716269634
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.8416321402
MESH:D013494 Supranuclear Palsy, Progressive marker/mechanism
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.3312837982
MESH:D024801 Tauopathies marker/mechanism
MESH:D024801 Tauopathies Albendazole 28.2616930453
MESH:D024801 Tauopathies Camptothecin 28.2616930453
MESH:D024801 Tauopathies Daunorubicin 28.2616930453
MESH:D024801 Tauopathies Methylene Blue 28.2616930453
MESH:D024801 Tauopathies Paclitaxel 28.2616930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.9411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.5315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.1612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 8.707505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 8.7017909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 8.7017045167 16026305
MESH:D013978 Tibial Fractures Estradiol 3.9419048282
MESH:D014062 Tongue Neoplasms Fluorouracil 18.4116280240
MESH:D014062 Tongue Neoplasms resveratrol 18.4116227395
MESH:D014062 Tongue Neoplasms Tretinoin 18.4116051514
MESH:D014062 Tongue Neoplasms Zinc 18.4116543248
MESH:D016171 Torsades de Pointes Astemizole 4.499583453 8256756
MESH:D014178 Translocation, Genetic Valproic Acid 4.4917262798
MESH:D014376 Tuberculosis Tretinoin 2.7316040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.793119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 15.3011144890 15987713 19429237 17306315 19322015 18640142 17976673
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 15.3014692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 15.3016712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 15.3017653716
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 15.3016720286
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.3016712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.938888407
MESH:D014570 Urologic Diseases cypermethrin 5.1316487989
MESH:D014581 Urticaria Acetaminophen 6.8110982225
MESH:D014581 Urticaria Astemizole 6.812859714 2147912 2883202 1976298 3097109 2565098 2568013 3080510 2568189 1683191 2885854 3134034
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 22.9116175088
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 22.9116154183
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 22.9116803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 22.9117473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 22.9116129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.4314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 12.0916690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 12.0914692618
MESH:D014594 Uterine Neoplasms resveratrol 12.0917044934
MESH:D014604 Uveal Neoplasms Tretinoin 3.8716752155
MESH:D014605 Uveitis Cyclosporine 3.241336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.7316513791 16002989
MESH:D014652 Vascular Diseases Arsenic 4.0117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.8512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.8815869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 7.9917678736 17638931 17334414 16364871
MESH:D018487 Ventricular Dysfunction, Left resveratrol 7.9917488730
MESH:D014717 Vertigo Astemizole 5.723105558
MESH:D014820 Vitiligo Tretinoin 3.3616761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5115886252
MESH:D009396 Wilms Tumor Tretinoin 3.3416287080
MESH:D014985 Xerophthalmia Cyclosporine 3.7017120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
REACT:578 Apoptosis
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA238
    • Releated gene ID Related gene Name
    PA358TUBB
    Releated disease ID Related disease Name
    PA446850Blindness, Cortical
    PA443970Dystonia
    PA445021Myoclonus
    PA446858Neurodegenerative Diseases
    PA165110266Posterior Cortical Atrophy
    PA445254Parkinson Disease
    PA445118Niemann-Pick Diseases
    PA151958645Argyrophilic Grain Disease (AGD)
    PA447077Pick Disease of the Brain
    PA445776Supranuclear Palsy, Progressive
    PA151958647Corticobasal degeneration
    PA151958646FTDP-17
    PA443319Alzheimer Disease
    PA443450Asthma
    Releated drug ID Related drug Name
    PA152241909PP2
    PA448803carboplatin
    PA449383docetaxel
    PA450761paclitaxel
    PA450243lithium
    PA452621antineoplastic agents
    PA448068salbutamol
    PA134687887selective beta-2-adrenoreceptor agonists
    PA164713253Selective beta-2-adrenoreceptor agonists
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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