AutismKB 2.0

Annotation Detail for MARK1


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Basic Information Top
Gene Symbol:MARK1 ( KIAA1477,MARK,MGC126512,MGC126513 )
Gene Full Name: MAP/microtubule affinity-regulating kinase 1
Band: 1q41
Quick LinksEntrez ID:4139; OMIM: 606511; Uniprot ID:MARK1_HUMAN; ENSEMBL ID: ENSG00000116141; HGNC ID: 6896
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1916Pervasive development disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MARK1 mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in increased expression of MARK1 mRNAincreases expression 16648578
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MARK1 mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in increased expression of MARK1 mRNAincreases expression 16648578
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MARK1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of MARK1 mRNAincreases expression 20106945
C014347 decitabine decitabine results in increased expression of MARK1 mRNAincreases expression 16367923
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MARK1 mRNAaffects cotreatment|increases expression 17942748
C025299 polyphenols polyphenols results in decreased expression of MARK1 mRNAdecreases expression 16293270
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MARK1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder marker/mechanism 18492799
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms alitretinoin 2.0516344269
MESH:D001943 Breast Neoplasms bexarotene 2.0516818667 16344269
MESH:D001943 Breast Neoplasms decitabine 2.0518320071 19208741
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916124888 15721981 3786805 16227642 16011737 15673190 16050911 16097048 10355542 16192424 18705752 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9118788625
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2816247446
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6319215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.2019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2017681005 11677210 16105132 17110522 16919318 15861022 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 15340226 15668235 8697196 12621046
MESH:D003110 Colonic Neoplasms decitabine 4.1217616700
MESH:D003110 Colonic Neoplasms polyphenols 4.1216293270
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3619164858 18713872 12594235 12540782 16393943 10774834 17906064 19923254 16081117 12153990 11461765 2444490 10915739 15619225 17562736 10663392 18071297 11529661 14986274 19420014 16485898 11739529 16109766 14550746 12958197 11743745 14725611 12392966 11287661 16227642 19085960 19370779 11834606 16781746 12705907 19416960 17522070 11421492 16177239 19739265 15968718
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.366884620 10915739 9327722 16177239 16227642 7440962 3732212 2869522 15998439 19085960 19336974 17522070 7120509 21278145 11566570 15968718 15027814 4309450 6623471 7179309 3786805 10092053
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.3619370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.3819294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.0815959796 16239168 12631006 61145 12795759 17595544 16045604 19224547
MESH:D005234 Fatty Liver Cyclosporine 14.0819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.0815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 16.0218705752
MESH:D005355 Fibrosis Cyclosporine 16.0212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0220067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6019215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male decitabine 7.0917581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0917937319
MESH:D007249 Inflammation polyphenols 5.4216366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4212200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.8716144296
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.1018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D007938 Leukemia decitabine 3.1518980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.1719117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4019387464 19010910 18206229 17679729 18704418 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7318055864
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8911408273 17334410 16943688 17174718 11903743 17157831 16221502 21278145 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3314716496 17708605 18472332 15931870 18277467 12546737 14748882 12445418 15996030 15362042 18263696 17761835 17823541 18187930 16015684 17714472 12667390 18395914 16097048 16248980 18395095 18376398 15057751 14620537 15052691 18210741 17525996 17922224 10355542 17766677 17565644 18251166 12958196 15338365 14724832 16638106 20821823 16136751 18420326 17869086 17721639 18054572 18705752 18006644 15959796 17481882 17631135 15925388 16116963 12649538 16192424 12898905 16027843 12632514 17900296 15123356 18166357 18412020 12666154 17698563 17944888 17557913 15893842 15818738 15876570 17805973 18279442 18472094 17640975 15673190 18205269 12389079 11481614 15370692 18156304 14512876 17976157 15730626 12632512 18339082 16011737 14716833 12586293 18429990 13678700 12609069 12445421 18418968 16033810 15650968 12741479 18481824 18317297
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Acetaminophen 6.8019784758 16610002 19014921 12587719 19460945 11587558 12969438 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.8015830285 16246199 15720792 16964402 17285989
MESH:D008107 Liver Diseases polyphenols 6.8016698588
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1012151625
MESH:D008175 Lung Neoplasms alitretinoin 3.6916413115
MESH:D008175 Lung Neoplasms bexarotene 3.6917849452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6919555203 11884234
MESH:D008223 Lymphoma decitabine 3.5419470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.3611161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.5119196723 19196722 15591091
MESH:D008545 Melanoma decitabine 2.2616505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009101 Multiple Myeloma decitabine 3.4618172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4719010910 16882708 19157545 18608210
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009369 Neoplasms alitretinoin 5.7616946489
MESH:D009369 Neoplasms decitabine 5.7617925555 19116145 19470736
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 5.0519196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D010051 Ovarian Neoplasms decitabine 2.6919331143 19259094
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8219294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017499 Porokeratosis alitretinoin 6.2716144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11399792 11118676 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.9417616702
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5919155313
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.5217997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4617967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7817616700 19087683
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014604 Uveal Neoplasms decitabine 5.1817785578
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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