AutismKB 2.0

Annotation Detail for MATN2


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Basic Information Top
Gene Symbol:MATN2 ( - )
Gene Full Name: matrilin 2
Band: 8q22.1-q22.2
Quick LinksEntrez ID:4147; OMIM: 602108; Uniprot ID:MATN2_HUMAN; ENSEMBL ID: ENSG00000132561; HGNC ID: 6908
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MATN2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MATN2 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MATN2 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MATN2 mRNAdecreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of MATN2 mRNAaffects expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MATN2 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of MATN2 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of MATN2 mRNAincreases expression 18042831
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of MATN2 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of MATN2 mRNAdecreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of MATN2 mRNAdecreases expression 14664709
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MATN2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MATN2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MATN2 mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MATN2 mRNAdecreases expression 17557909
D005047 Etoposide MATN2 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of MATN2 mRNAincreases expression 17513098
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of MATN2 proteinincreases expression 17513098
C051890 irinotecan irinotecan analog results in increased expression of MATN2 mRNAincreases expression 18927307
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of MATN2 mRNAdecreases expression 20713471
D016685 Mitomycin MATN2 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C041786 palm oil palm oil results in increased expression of MATN2 mRNAincreases expression 18042831
D013629 Tamoxifen Tamoxifen affects the expression of MATN2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of MATN2 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MATN2 mRNAdecreases expression 20106945
19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MATN2 mRNAincreases expression 11007951
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MATN2 mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MATN2 mRNAincreases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of MATN2 mRNAincreases expression 16249480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8111752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.9411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9414692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 11.2010737359
MESH:D000236 Adenoma Benzo(a)pyrene 11.206695378
MESH:D000236 Adenoma Methylcholanthrene 11.206695378 10545420
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.986705139
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3416835633
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.7815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4311922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.8016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.1314601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.7120146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 4.7120435547
MESH:D001943 Breast Neoplasms Estradiol 4.7119861407 17289903 16675129 12948864 17018787 18497071 17261762 14630087
MESH:D001943 Breast Neoplasms Etoposide 4.7116322251
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.7117474063
MESH:D001943 Breast Neoplasms Tamoxifen 4.7118997820 17440819 17049068 18629630 19066611 15565566 19289846 20544844 21138602 20135344 19103187 18351453 19487384 16873071 18984771 19221464 19410462 19189212 20005174 19155303 16818667 16202921 16273361 19115204 20390343 19084267 18821012 18815881 19244106 19189210 18425577 15668708 20065188 19142967 19288272 19011961 17242785 17893378 17261762 18855134 11161223 20859285 19059307 21152245 19200415
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.7120435547
MESH:D001943 Breast Neoplasms Tretinoin 4.7116873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002277 Carcinoma Methylcholanthrene 8.2110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.2116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 11.316705139 3581430 10737359 3084413 17761372
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.313084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.3121507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.3116924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.3116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.311917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5220419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3416120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 7.1410977129
MESH:D002386 Cataract Tretinoin 7.1417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.7920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.7912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.7918566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 15.7916192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Cyclosporine 7.6619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6617681005 17333356 16105132 11677210 16919318 15861022 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7015668235 8697196 12621046 16354765 15340226
MESH:D002972 Cleft Palate Tretinoin 5.709407595
MESH:D003092 Colitis Tretinoin 3.6617035595
MESH:D003110 Colonic Neoplasms irinotecan 2.5917287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3617159606 17454858 18259882 18509181 16391804 15273666 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.439224671 17551590 9125849 10589399 9142499 16925845 14991402 8800419 9211117 9664655
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.7119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.7119279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5119420014 16109766 15619225 11421492 10774834 15968718 10663392 11461765 19370779 14986274 2444490 12705907 17562736 11287661 12594235 10915739 16485898 16081117 12392966 19085960 16393943 16227642 19164858 17906064 12540782 16781746 17522070 16177239 14550746 19416960 11743745 11834606 11529661 18071297 11739529 18713872 12958197 14725611 19923254 19739265 12153990
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4218367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.8518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8119031437
MESH:D016889 Endometrial Neoplasms Estradiol 12.2619148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.2620544844 16202921 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 12.2616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.7216938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 18.4319224547
MESH:D005234 Fatty Liver Dietary Fats 18.4317967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.4315345470
MESH:D005234 Fatty Liver Tamoxifen 18.4319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9014633661 10962813
MESH:D005355 Fibrosis Cyclosporine 20.8312639820 12168785
MESH:D005355 Fibrosis Dietary Fats 20.8318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.8320067830
MESH:D005355 Fibrosis Tretinoin 20.8317994277
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D005909 Glioblastoma Tretinoin 2.9817312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.9620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.9611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.969664655 14991402
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.296705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.366705139
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D006561 Herpes Simplex Etoposide 4.5310809021
MESH:D006689 Hodgkin Disease Etoposide 3.8316135485 18180244 17606976 16200630 15147373
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0215340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.5016870215
MESH:D006930 Hyperalgesia Tretinoin 7.5016870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5521332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.5721332399
MESH:D006973 Hypertension Cyclosporine 4.8910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Dietary Fats 8.1420412841
MESH:D007249 Inflammation Tamoxifen 8.1419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1412200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.2718457598 11836018
MESH:D007333 Insulin Resistance Estradiol 7.2716393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Acetaminophen 9.8312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.838314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.8315618244
MESH:D007680 Kidney Neoplasms Cyclosporine 12.1612371664
MESH:D007680 Kidney Neoplasms Estradiol 12.1615610895
MESH:D007680 Kidney Neoplasms Tamoxifen 12.1618625569
MESH:D007938 Leukemia Tretinoin 2.7517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6616932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0719850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1216788101 17712046 19642359 16766008 17361223 16331271 17301526 17368321 16891316 17506722 17107899 12679006 17294898 16140955 9834237 19029980 17339181 19225113 19035177 15748426 19075265 17217047 17649720 16823087 16935935
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008064 Lipidoses Tamoxifen 3.1217567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8518296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.9018397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6212587719 16611625 16610002 11587558 19460945 12969438 19014921 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2016871587 17185352
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 17.7911376686 16273603 10737359 14678523 10672840 18001218
MESH:D008113 Liver Neoplasms Aflatoxin B1 17.7915890375 2125692 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.7921137059 20195826
MESH:D008113 Liver Neoplasms Mitomycin 17.7915113037
MESH:D008113 Liver Neoplasms Tamoxifen 17.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.7916984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 13.961399818 6150874 534488
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.968603461
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 13.96598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.9612151625
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 8.5011376686
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.5014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.506695378 17053015 18569708 18520028 20135361 20064080 18816296 20869020 20464547
MESH:D008175 Lung Neoplasms Methylcholanthrene 8.5021163286 20512841 11893704 7750092 10545420 1399818 15390079 6695378 17909032 16271038 9230183 20970405 16337739
MESH:D008175 Lung Neoplasms Tamoxifen 8.5018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.5011884234 19555203
MESH:D008223 Lymphoma Etoposide 3.8912854902 12556972
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.8717203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.8719196722 11731420 19196723 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.5519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.5519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Tamoxifen 3.2619393235 12393984
MESH:D008545 Melanoma Tretinoin 3.2616752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D052016 Mucositis irinotecan 4.9717159606
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2416810080
MESH:D009362 Neoplasm Metastasis irinotecan 5.8918259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9211141357
MESH:D009369 Neoplasms Tretinoin 4.9216946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 16.1016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.1014600291
MESH:D009421 Nervous System Malformations Tretinoin 16.109125849
MESH:D009436 Neural Tube Defects Tretinoin 3.029142499
MESH:D009447 Neuroblastoma irinotecan 3.468761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.698761367
MESH:D009765 Obesity Dietary Fats 2.2819632207 21332399 20518802 17217161 11836018 18674790 20132043 16723640 18457598
MESH:D010051 Ovarian Neoplasms Estradiol 4.7619401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.7616936753
MESH:D010146 Pain Acetaminophen 6.4616870215
MESH:D010146 Pain Tretinoin 6.4616870215
MESH:D010190 Pancreatic Neoplasms Etoposide 8.7619003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 8.7615113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.7615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611118676 11222880 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0917292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.0917172428
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0915067354
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616283617 16116481
MESH:D012512 Sarcoma, Ewing's Etoposide 4.6614601052
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.3819755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.388532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.3816192470
MESH:D012878 Skin Neoplasms Tretinoin 13.3816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4716709447
MESH:D013088 Spermatocele Tamoxifen 11.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3920155912 2093021
MESH:D013274 Stomach Neoplasms irinotecan 3.3915723263
MESH:D013274 Stomach Neoplasms Tretinoin 3.3917261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9916026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7516051514
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 8.311399818 15289314 15867355
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3117053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.3116712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D015430 Weight Gain Dietary Fats 3.7016723640
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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