AutismKB 2.0

Annotation Detail for MAX


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Basic Information Top
Gene Symbol:MAX ( MGC10775,MGC11225,MGC18164,MGC34679,MGC36767,bHLHd4,bHLHd5,bHLHd6,bHLHd7,bHLHd8,orf1 )
Gene Full Name: MYC associated factor X
Band: 14q23.3
Quick LinksEntrez ID:4149; OMIM: 154950; Uniprot ID:MAX_HUMAN; ENSEMBL ID: ENSG00000125952; HGNC ID: 6913
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200070Signaling events mediated by HDAC Class I
200002Regulation of nuclear SMAD2/3 signaling
200093C-MYC pathway
200072Regulation of Telomerase
200045Validated targets of C-MYC transcriptional activation
Pathway IDPathway Name
P00046Oxidative stress response
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2066Lung cancer
Desease Name
Anthropometric traits
Desease Name
Anthropometric traits
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MAX mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MAX mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAX mRNAdecreases expression 19150397
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of MAX mRNAaffects cotreatment|decreases expression 18636392
D016572 Cyclosporine Cyclosporine results in increased expression of MAX mRNAincreases expression 20106945
C017180 decamethrin decamethrin results in increased expression of MAX mRNAincreases expression 19017407
D004958 Estradiol Estradiol results in increased expression of MAX mRNAincreases expression 15223131
D004958 Estradiol Estradiol results in increased expression of MAX mRNAincreases expression 20068009
C013592 mangiferin mangiferin results in decreased expression of MAX mRNAdecreases expression 15135318
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of MAX mRNAincreases expression 12634122
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of MAX mRNAaffects cotreatment|decreases expression 18636392
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAX mRNAaffects binding|increases activity|increases expression 19710929
D012643 Selenium Selenium results in increased expression of MAX mRNAincreases expression 19244175
D014212 Tretinoin Tretinoin results in increased expression of MAX mRNAincreases expression 16054129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Chlorine 9.4420601635
MESH:D055371 Acute Lung Injury pirinixic acid 9.4418653653
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6016434500
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000544 Alzheimer Disease Ozone 2.4515513908
MESH:D000707 Anaphylaxis mangiferin 5.5714669257 16536907
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1216412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.7315570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7316292516
MESH:D001249 Asthma Ozone 5.0317854713 16373670
MESH:D001249 Asthma Tretinoin 5.0316456186
MESH:D050197 Atherosclerosis mangiferin 4.1418450471
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.2516197459 16206674
MESH:D001862 Bone Resorption mangiferin 5.009881647
MESH:D001943 Breast Neoplasms Estradiol 2.1417289903 18497071 12948864 14630087 17018787 16675129 19861407 17261762
MESH:D001943 Breast Neoplasms Tretinoin 2.1416873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7419059883 18315731 17626835 15516495 14754758 18417511 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002100 Cachexia Ozone 4.8616183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.653084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.651917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3116051514 16096774
MESH:D002386 Cataract Acetaminophen 7.3810977129
MESH:D002386 Cataract Tretinoin 7.3817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.5320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.5312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.5318566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 16.532727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D002779 Cholestasis Cyclosporine 7.9619486331
MESH:D002779 Cholestasis pirinixic acid 7.9619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tretinoin 2.709407595
MESH:D003092 Colitis Selenium 9.8517936198
MESH:D003092 Colitis Tretinoin 9.8517035595
MESH:D019465 Craniofacial Abnormalities decamethrin 3.1619861644
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.1617551590 9211117 10589399 8800419 16925845 9142499 9125849 14991402 9664655 9224671
MESH:D003457 Cryptosporidiosis mangiferin 5.9916547730
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003921 Diabetes Mellitus, Experimental mangiferin 4.6619028559 12093613
MESH:D003924 Diabetes Mellitus, Type 2 mangiferin 3.5011315760 9881663
MESH:D003928 Diabetic Nephropathies Estradiol 9.5619279558
MESH:D003928 Diabetic Nephropathies mangiferin 9.5619960420 19706694
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3312392966 18071297 11529661 16227642 14550746 19416960 10774834 16177239 19923254 11834606 2444490 11287661 10663392 14986274 12153990 14725611 15619225 17562736 19420014 12705907 11739529 16081117 12540782 17906064 11743745 19739265 18713872 10915739 19164858 15968718 16393943 19085960 12594235 16781746 11461765 19370779 16485898 17522070 16109766 12958197 11421492
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004417 Dyspnea Chlorine 4.7620016425
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D004489 Edema, Cardiac Tretinoin 4.6018230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.5911473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.5916569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D005124 Eye Abnormalities Tretinoin 3.649664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 13.7119224547
MESH:D005234 Fatty Liver mangiferin 13.7115975614
MESH:D005234 Fatty Liver pirinixic acid 13.7119236843 20131406
MESH:D005355 Fibrosis Cyclosporine 9.0412639820 12168785
MESH:D005355 Fibrosis Tretinoin 9.0417994277
MESH:D005739 Gas Poisoning Chlorine 5.1420016425
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9314991402 9664655
MESH:D006331 Heart Diseases mangiferin 4.4412093613
MESH:D006333 Heart Failure pirinixic acid 7.1120558911
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1016221962 18467677 19772884 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D006561 Herpes Simplex mangiferin 5.1210715843
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006930 Hyperalgesia Acetaminophen 7.8416870215
MESH:D006930 Hyperalgesia Tretinoin 7.8416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006946 Hyperinsulinism mangiferin 5.069881663 11315760
MESH:D006949 Hyperlipidemias mangiferin 4.9415975614
MESH:D006967 Hypersensitivity mangiferin 4.7716536907
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007154 Immune System Diseases mangiferin 5.9916076520
MESH:D007249 Inflammation mangiferin 3.7015222974
MESH:D007251 Influenza, Human Selenium 4.3316624496
MESH:D007299 Insect Bites and Stings decamethrin 5.9315189238
MESH:D007333 Insulin Resistance Estradiol 12.7616627594 16393666
MESH:D007333 Insulin Resistance mangiferin 12.7611315760
MESH:D007333 Insulin Resistance pirinixic acid 12.7616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007511 Ischemia mangiferin 5.3716806951
MESH:D007569 Jaw Abnormalities Tretinoin 3.9815992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 14.8512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.8518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 14.8515618244
MESH:D007674 Kidney Diseases mangiferin 14.8512093613
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.7716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.7712371664
MESH:D007680 Kidney Neoplasms Estradiol 12.7715610895
MESH:D007859 Learning Disorders mangiferin 5.0619182383
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive mangiferin 4.6715498116
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0919850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2016935935 16823087 17506722 17361223 19075265 17294898 17368321 19035177 16788101 16891316 12679006 17107899 16140955 17217047 19225113 19642359 19029980 17339181 17301526 17649720 15748426 9834237 16766008 17712046 16331271
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5016248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6519460945 12587719 12969438 11587558 19784758 16611625 19014921 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8420007298 15890375 16377806
MESH:D008171 Lung Diseases Ozone 3.4319066396 8266340
MESH:D055370 Lung Injury Ozone 3.9520417186
MESH:D008175 Lung Neoplasms mangiferin 3.0718816296 18520028 18569708
MESH:D008175 Lung Neoplasms Ozone 3.077614698 8597069
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1911807958 17203775 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.1915318939
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008569 Memory Disorders mangiferin 5.0219182383
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D008679 Metaplasia Ozone 5.2410496685
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 6.0117671175
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D009203 Myocardial Infarction mangiferin 6.1517052832 19172585 16538859 16584858 16697266
MESH:D009203 Myocardial Infarction pirinixic acid 6.1519151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.4616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.4616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009369 Neoplasms Tretinoin 5.0316594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009410 Nerve Degeneration mangiferin 4.6717433543
MESH:D009421 Nervous System Malformations Estradiol 9.9916427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 9.999125849
MESH:D009436 Neural Tube Defects Tretinoin 3.109142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5012819281 16049721
MESH:D010051 Ovarian Neoplasms Estradiol 4.8819401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8816936753
MESH:D010146 Pain Acetaminophen 6.8116870215
MESH:D010146 Pain Tretinoin 6.8116870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4915976015
MESH:D010300 Parkinson Disease mangiferin 3.7317433543
MESH:D010518 Periodontitis mangiferin 5.7419026997
MESH:D010538 Peritonitis Ozone 4.2316369182
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D011014 Pneumonia Ozone 4.5118929643 18007984 18381685
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D011833 Radiation Injuries, Experimental mangiferin 6.5415830843
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012120 Respiration Disorders Chlorine 5.3518579056
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5818551238
MESH:D012772 Shock, Septic mangiferin 5.3515177305
MESH:D012878 Skin Neoplasms Tretinoin 2.6416467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer mangiferin 4.3517918041
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0916026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014235 Trichinellosis mangiferin 6.1914669257
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:00790 Folate biosynthesis
KEGG:04010 MAPK signaling pathway
KEGG:01100 Metabolic pathways
KEGG:05200 Pathways in cancer
KEGG:05222 Small cell lung cancer
KEGG:04122 Sulfur relay system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30656
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    PA450379mercaptopurine
    PA450428methotrexate
    PA165111697artesunate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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