AutismKB 2.0

Annotation Detail for MAZ


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Basic Information Top
Gene Symbol:MAZ ( PUR1,Pur-1,SAF-1,SAF-2,SAF-3,ZF87,ZNF801,Zif87 )
Gene Full Name: MYC-associated zinc finger protein (purine-binding transcription factor)
Band: 16p11.2
Quick LinksEntrez ID:4150; OMIM: 600999; Uniprot ID:MAZ_HUMAN; ENSEMBL ID: ENSG00000103495; HGNC ID: 6914
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1876Gouts
1917Cerebellar disease
1944Breast cancer
1963Amyloidosis
2025Polyarthritis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MAZ mRNAaffects expression 17562736
D019833 Genistein Genistein results in decreased expression of MAZ mRNAdecreases expression 16705744
C008493 methylselenic acid methylselenic acid results in decreased expression of MAZ mRNAdecreases expression 12517777
D012643 Selenium Selenium results in increased expression of MAZ mRNAincreases expression 19244175
D014212 Tretinoin Tretinoin results in increased expression of MAZ mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Genistein 2.5411473722
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816206674 16197459
MESH:D001943 Breast Neoplasms Genistein 2.2516873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tretinoin 2.2516873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.833084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.8316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.831917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716051514 16096774
MESH:D002318 Cardiovascular Diseases Genistein 3.5416332659
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002386 Cataract Tretinoin 7.8517460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Selenium 11.1617936198
MESH:D003092 Colitis Tretinoin 11.1617035595
MESH:D003110 Colonic Neoplasms Genistein 2.3317182828
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 8800419 16925845 9211117 17551590 9224671 9664655 9142499 14991402 9125849
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5516647724
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0718071297 16227642 17906064 17522070 19923254 11421492 19420014 12392966 14550746 16109766 10774834 12705907 11743745 19739265 15619225 16177239 11739529 16393943 11529661 15968718 19370779 19085960 12594235 19416960 18713872 14986274 12540782 11461765 17562736 14725611 12153990 16781746 19164858 16081117 2444490 11834606 10663392 12958197 16485898 11287661 10915739
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D004714 Endometrial Hyperplasia Genistein 5.1316402032
MESH:D016889 Endometrial Neoplasms Genistein 8.2811473722
MESH:D016889 Endometrial Neoplasms Tretinoin 8.2816569247
MESH:D005124 Eye Abnormalities Tretinoin 3.849664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005909 Glioblastoma Genistein 7.9416598420
MESH:D005909 Glioblastoma Tretinoin 7.9417312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0514991402 9664655
MESH:D006333 Heart Failure Selenium 3.2717162251
MESH:D006930 Hyperalgesia Acetaminophen 8.6016870215
MESH:D006930 Hyperalgesia Tretinoin 8.6016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D007251 Influenza, Human Selenium 4.8116624496
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2715992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007938 Leukemia Genistein 6.9218980019 17468513
MESH:D007938 Leukemia Tretinoin 6.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.379834237 12679006 17712046 17217047 19035177 17301526 17339181 17506722 17649720 16766008 19642359 15748426 19075265 16331271 17107899 19225113 17361223 19029980 16891316 17368321 16823087 16935935 17294898 16140955 16788101
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.6917823541
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.6918397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6919460945 12587719 19014921 16610002 12969438 19784758 11587558 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.8814578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.8815318939
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009203 Myocardial Infarction Genistein 2.9817141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.9317141266
MESH:D009369 Neoplasms Tretinoin 2.5516946489 16594593
MESH:D009421 Nervous System Malformations Genistein 11.3216427766
MESH:D009421 Nervous System Malformations Tretinoin 11.329125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D010024 Osteoporosis Genistein 3.4519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.4916169203
MESH:D010051 Ovarian Neoplasms Genistein 5.2419005980
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2416936753
MESH:D010146 Pain Acetaminophen 7.6116870215
MESH:D010146 Pain Tretinoin 7.6116870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011471 Prostatic Neoplasms Genistein 3.5115256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.5116205645
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30657
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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