AutismKB 2.0

Annotation Detail for PIM3


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Basic Information Top
Gene Symbol:PIM3 ( pim-3 )
Gene Full Name: pim-3 oncogene
Band: 22q13.33
Quick LinksEntrez ID:415116; OMIM: 610580; Uniprot ID:PIM3_HUMAN; ENSEMBL ID: ENSG00000198355; HGNC ID: 19310
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PIM3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PIM3 mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of PIM3 mRNAincreases expression 18687144
D003345 Corticosterone Corticosterone results in increased expression of PIM3 mRNAincreases expression 15755911
D004041 Dietary Fats Dietary Fats results in decreased expression of PIM3 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol affects the expression of PIM3 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PIM3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIM3 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PIM3 mRNAdecreases expression 17557909
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PIM3 mRNAincreases expression 17351261
D019833 Genistein Genistein results in increased expression of PIM3 mRNAincreases expression 12075121
D010126 Ozone Ozone results in decreased expression of PIM3 mRNAdecreases expression 12763052
C041786 palm oil palm oil results in decreased expression of PIM3 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in decreased expression of PIM3 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of PIM3 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PIM3 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PIM3 mRNAincreases expression 18445702
17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PIM3 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIM3 mRNAaffects cotreatment|increases expression 17942748
D015032 Zinc Zinc results in increased expression of PIM3 mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of PIM3 mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.466195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4611752688 15322242 14514962
MESH:D000138 Acidosis Zinc Sulfate 4.967265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D000169 Acrodermatitis Zinc 5.4517190629 17202136 16889938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Estradiol 7.1111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1114692618
MESH:D000230 Adenocarcinoma Genistein 7.1111473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.6017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.6016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.6016835633
MESH:D000544 Alzheimer Disease Ozone 4.4715513908
MESH:D000544 Alzheimer Disease Zinc 4.4716410023 16325427 17119284 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.9416916123
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D000860 Anoxia Zinc Sulfate 5.077265320
MESH:D001161 Arteriosclerosis Dietary Fats 10.0515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5615570426
MESH:D001249 Asthma Ozone 5.2016373670 17854713
MESH:D001249 Asthma Zinc 5.2017085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001930 Brain Injuries Zinc 4.7317109824
MESH:D001943 Breast Neoplasms Dietary Fats 1.9520435547
MESH:D001943 Breast Neoplasms Estradiol 1.9514630087 12948864 16675129 17289903 17261762 18497071 19861407 17018787
MESH:D001943 Breast Neoplasms Genistein 1.9517200150 16541309 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7015516495 17626835 18417511 19059883 18315731 16777450 14754758
MESH:D002100 Cachexia Ozone 4.7916183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.923084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.9216924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.9216924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.9217173139 20007298 6705139 1701930 20935162
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.9116543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Genistein 7.6416332659
MESH:D002318 Cardiovascular Diseases Zinc 7.6416936243
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.736135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.294080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8111677210 17110522 16105132 15861022 16919318 17333356 17681005
MESH:D002779 Cholestasis pirinixic acid 7.8119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1115340226 8697196 15668235 16354765 12621046
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Zinc 2.6819302082
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003920 Diabetes Mellitus Zinc 4.2316479319
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.1621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.1610663392 19739265 12392966 19416960 11739529 17906064 19420014 11287661 12153990 11421492 15968718 16227642 11743745 14986274 16393943 12705907 12594235 14725611 19164858 11461765 19370779 12540782 16177239 12958197 16485898 11529661 16081117 16109766 15619225 18071297 17562736 14550746 18713872 11834606 2444490 16781746 19085960 17522070 10774834 10915739 19923254
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004421 Dystonia Phenobarbital 4.041851702
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.6416402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.5711473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.5711473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.153659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.933922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.576401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.297750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.073659116
MESH:D004938 Esophageal Neoplasms Zinc 2.8616543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Dietary Fats 13.2319551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.2315345470
MESH:D005234 Fatty Liver pirinixic acid 13.2320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Dietary Fats 8.7618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7620067830
MESH:D005756 Gastritis Acetaminophen 11.3816983495
MESH:D005756 Gastritis Zinc 11.3817241300
MESH:D005909 Glioblastoma Genistein 3.2816598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006130 Growth Disorders Zinc 3.9817217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 7.2020558911
MESH:D006333 Heart Failure Zinc 7.2017162251
MESH:D006335 Heart Injuries Zinc 5.8317074742
MESH:D016481 Helicobacter Infections Zinc 4.5617241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006527 Hepatolenticular Degeneration Zinc 11.4617276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 11.4617063115
MESH:D006529 Hepatomegaly Phenobarbital 14.6416109766
MESH:D006529 Hepatomegaly pirinixic acid 14.6418467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.6412621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1118606429 16959395 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007022 Hypotension Zinc Sulfate 4.507265320
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Dietary Fats 4.9620412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9612878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 12.4011836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.4016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.4016306350
MESH:D007511 Ischemia Zinc 4.6716584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Acetaminophen 10.2015629191 12587719
MESH:D007674 Kidney Diseases Estradiol 10.2015618244
MESH:D007674 Kidney Diseases Zinc 10.2016960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.4516518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.4416705839
MESH:D007680 Kidney Neoplasms Estradiol 7.4415610895
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.2815237267
MESH:D007938 Leukemia Genistein 3.0418980019 17468513
MESH:D008103 Liver Cirrhosis Dietary Fats 6.7118296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7121047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.9617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9612878042
MESH:D008107 Liver Diseases Acetaminophen 3.9519014921 11587558 12969438 16611625 19784758 12587719 19460945 16610002
MESH:D008107 Liver Diseases Phenobarbital 3.9519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.767678174
MESH:D008113 Liver Neoplasms Phenobarbital 10.7619482888 19073162 21047994 15975961 8742319 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 10.7615890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.896135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.891399818 17172636 18308698 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.8912151625
MESH:D008171 Lung Diseases Ozone 3.3919066396 8266340
MESH:D055370 Lung Injury Asbestos, Crocidolite 9.3917365036
MESH:D055370 Lung Injury Ozone 9.3920417186
MESH:D008175 Lung Neoplasms Ozone 2.397614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3919555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 14.5012807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.5011408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 14.5012929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Zinc 14.5012773700
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1916166281 18303189 16966607
MESH:D008679 Metaplasia Ozone 5.1710496685
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction Genistein 5.7117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.7119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.3016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.3017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.3016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5317484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.917678174 18551238
MESH:D009369 Neoplasms pirinixic acid 1.9617405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009421 Nervous System Malformations Estradiol 16.5916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 16.5916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity Dietary Fats 4.4518457598 18674790 11836018 19632207 20132043 21332399 20518802 17217161 16723640
MESH:D009765 Obesity pirinixic acid 4.4520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4616049721
MESH:D010018 Osteomalacia Phenobarbital 4.4117016548
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D010051 Ovarian Neoplasms Estradiol 4.9319401270
MESH:D010051 Ovarian Neoplasms Genistein 4.9319005980
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5016965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010538 Peritonitis Ozone 4.1716369182
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9310923243
MESH:D011014 Pneumonia Ozone 4.4418007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.652563599
MESH:D011225 Pre-Eclampsia Zinc 4.1917114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.6616740699
MESH:D011471 Prostatic Neoplasms Genistein 2.6615256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Zinc 2.6612429649 16700911 16606632 16517595
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.5612752131
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0415814490 17365031 17975199 17322281
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012162 Retinal Degeneration Zinc 4.1516584753
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9918551238
MESH:D012640 Seizures Phenobarbital 5.993137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.071399818
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D014062 Tongue Neoplasms Zinc 4.4216543248
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3016049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3710091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5715869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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