AutismKB 2.0

Annotation Detail for MBP


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Basic Information Top
Gene Symbol:MBP ( MGC99675 )
Gene Full Name: myelin basic protein
Band: 18q23
Quick LinksEntrez ID:4155; OMIM: 159430; Uniprot ID:MBP_HUMAN; ENSEMBL ID: ENSG00000197971; HGNC ID: 6925
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1828Encephalitis
1860Brain tumor
1877Multiple sclerosis
Desease Name
tuberculosis
RENAL
multiple sclerosis
systemic lupus erythematosus
IMMUNE
nephropathy, IgA
INFECTION
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of MBP mRNAincreases expression 19933214
C055506 4-(diethylamino)benzaldehyde 4-(diethylamino)benzaldehyde affects the expression of MBP mRNAaffects expression 16839543
D024502 alpha-Tocopherol alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased expression of MBP protein]decreases reaction|increases expression 14645110
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MBP mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of MBP proteindecreases expression 18722528
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MBP mRNAaffects cotreatment|decreases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MBP mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MBP mRNAdecreases expression 20018196
19150397
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of MBP mRNAincreases expression 19925653
D003024 Clozapine Clozapine results in increased expression of MBP mRNAincreases expression 17266109
D004041 Dietary Fats Dietary Fats results in increased expression of MBP mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MBP mRNAaffects cotreatment|decreases expression 18164116
D005047 Etoposide MBP protein affects the susceptibility to Etoposideaffects response to substance 16217747
D019833 Genistein Genistein results in increased expression of MBP mRNAincreases expression 17341692
D006220 Haloperidol Haloperidol results in decreased expression of MBP mRNAdecreases expression 17177202
D007213 Indomethacin Indomethacin inhibits the reaction [CTSB protein results in increased degradation of MBP protein]decreases reaction|increases degradation 11071371
D007213 Indomethacin Indomethacin inhibits the reaction [CAPN2 protein results in increased degradation of MBP protein]decreases reaction|increases degradation 11071371
D007455 Iodine Iodine results in decreased expression of MBP mRNAdecreases expression 16229266
D007455 Iodine Selenium inhibits the reaction [Iodine results in decreased expression of MBP mRNA]decreases expression|decreases reaction 16229266
C051890 irinotecan irinotecan analog results in decreased expression of MBP mRNAdecreases expression 18927307
D007657 Ketone Bodies Ketone Bodies results in increased expression of MBP mRNAincreases expression 15469884
D008345 Manganese Manganese results in increased expression of MBP mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of MBP mRNAincreases expression 17175027
D008713 Methimazole Methimazole results in decreased expression of MBP mRNAdecreases expression 17403546
D008770 Methylnitrosourea Methylnitrosourea results in decreased expression of MBP mRNAdecreases expression 17341692
D016685 Mitomycin MBP protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D009538 Nicotine Nicotine results in increased phosphorylation of MBP proteinincreases phosphorylation 15983034
C041786 palm oil palm oil results in increased expression of MBP mRNAincreases expression 18042831
C494474 perchlorate perchlorate results in increased expression of MBP mRNAincreases expression 17403546
D010622 Phencyclidine Phencyclidine results in increased expression of MBP mRNAincreases expression 17266109
C035988 procymidone procymidone results in decreased expression of MBP mRNAdecreases expression 15686871
D011441 Propylthiouracil Propylthiouracil results in increased expression of MBP mRNAincreases expression 17403546
C089730 rosiglitazone [rosiglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of MBP mRNAaffects binding|decreases expression|increases activity 18543250
C089730 rosiglitazone T 0070907 inhibits the reaction [[rosiglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of MBP mRNA]affects binding|decreases expression|decreases reaction|increases activity 18543250
D012643 Selenium Selenium inhibits the reaction [Iodine results in decreased expression of MBP mRNA]decreases expression|decreases reaction 16229266
C458508 T 0070907 T 0070907 inhibits the reaction [[rosiglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of MBP mRNA]affects binding|decreases expression|decreases reaction|increases activity 18543250
D013629 Tamoxifen alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased expression of MBP protein]decreases reaction|increases expression 14645110
D013629 Tamoxifen Tamoxifen results in increased expression of MBP proteinincreases expression 14645110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MBP mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MBP mRNAincreases expression 19933214
D019772 Topotecan MBP protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin results in decreased expression of MBP proteindecreases expression 7579340
C025643 vinclozolin vinclozolin affects the expression of MBP mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of MBP mRNAdecreases expression 15686871
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.3520464547 20127859
MESH:D000230 Adenocarcinoma Genistein 9.3511473722
MESH:D000230 Adenocarcinoma Indomethacin 9.3516537180
MESH:D000230 Adenocarcinoma Methylnitrosourea 9.3515688392 15113128
MESH:D000236 Adenoma Benzo(a)pyrene 14.166695378
MESH:D000236 Adenoma beta-Naphthoflavone 14.1619389873
MESH:D000236 Adenoma Diethylnitrosamine 14.166695378 10737359
MESH:D000236 Adenoma Indomethacin 14.1611497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.7918056438 16434500 19061943 17162532 19052882 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7916835633
MESH:D000380 Agranulocytosis Clozapine 4.6816160616 12649775 14617031
MESH:D000505 Alopecia Tretinoin 3.3215955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9817225004
MESH:D000544 Alzheimer Disease Indomethacin 6.3117627676 15579461
MESH:D000544 Alzheimer Disease Nicotine 6.3116627626
MESH:D000544 Alzheimer Disease rosiglitazone 6.3119621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6211748828
MESH:D000756 Anemia, Sideroblastic Manganese 9.9016910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 9.9016910769
MESH:D001008 Anxiety Disorders vinclozolin 3.3419015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.4910231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.4719183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.4710388637
MESH:D001161 Arteriosclerosis Dietary Fats 3.5215238619
MESH:D018771 Arthralgia Indomethacin 4.782160914
MESH:D001169 Arthritis, Experimental Tretinoin 2.8416412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.4311248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4316292516
MESH:D001249 Asthma Tretinoin 2.2216456186
MESH:D001321 Autistic Disorder Haloperidol 2.7819368416 18080171
MESH:D001471 Barrett Esophagus Tretinoin 4.0416935849
MESH:D001477 Bartter Syndrome Indomethacin 4.6110684365
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 13.4519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.4512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.4516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.7714601052
MESH:D001929 Brain Edema Indomethacin 4.6411481608
MESH:D002545 Brain Ischemia Indomethacin 4.0412524144
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.5320146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 6.5320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.5317474063
MESH:D001943 Breast Neoplasms Etoposide 6.5316322251
MESH:D001943 Breast Neoplasms Genistein 6.5317200150 16541309 16873071
MESH:D001943 Breast Neoplasms Indomethacin 6.5317401462
MESH:D001943 Breast Neoplasms Methylnitrosourea 6.5311306469 16253758 14633655
MESH:D001943 Breast Neoplasms Tamoxifen 6.5317242785 19155303 21152245 18815881 19288272 19189210 19289846 18351453 18855134 15565566 18997820 15668708 19142967 19084267 18821012 11161223 18984771 20544844 19066611 19011961 19200415 17893378 20005174 20135344 20390343 20859285 19410462 19189212 16818667 19115204 20065188 18629630 19487384 19221464 16873071 17049068 19059307 17261762 16202921 21138602 19244106 18425577 17440819 16273361 19103187
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.5320435547
MESH:D001943 Breast Neoplasms Tretinoin 6.5316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2116813970
MESH:D002056 Burns Indomethacin 4.3310459503
MESH:D002100 Cachexia Indomethacin 4.6215141370 16537180 15625704 11239499
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1319066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7716168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.1219107877 17761372 19822196 16288022 19383236 17138121 3581430 3084413 18665156 19919837 19335982 19052882 18978308 10672840 10737359 18393292 16540662 16569478 19418558 19208518 16935385 17428255 20512989 17173139 20214788 16328049 18971187 16502159 16698587 20727157 16830150 19171122 11831363 19394651 16779866 19519916 20432363 18785209 18494052 20084675 18056438 19539802 20007298 20514400 16681979 18506893 18691550 17055752 17162532 16878318 21159647 19701751 20101231 17978847 20524982 18210153 20935162 18788625 16807293
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.1216924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.1216391822
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.1216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.121917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.3511053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.9718791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.1917341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.8520419170
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 6.8512636206 15482327
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.8516051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1516120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.0416332659
MESH:D002375 Catalepsy Haloperidol 4.5315215559 1977408
MESH:D002386 Cataract Methylnitrosourea 6.9812484553
MESH:D002386 Cataract Tretinoin 6.9817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.7920889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.7917174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 9.792727394 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.2616835633
MESH:D002764 Cholecystitis Indomethacin 4.7811181007
MESH:D002822 Choriocarcinoma Tretinoin 4.7716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2015668235 8697196 15340226 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.209407595
MESH:D003072 Cognition Disorders Clozapine 4.5917123785
MESH:D003092 Colitis Selenium 8.2617936198
MESH:D003092 Colitis Tretinoin 8.2617035595
MESH:D003110 Colonic Neoplasms Genistein 5.4817182828
MESH:D003110 Colonic Neoplasms Indomethacin 5.4815786552 11260862 15637740 15936596 15625704 15963497
MESH:D003110 Colonic Neoplasms irinotecan 5.4817287894 17725105
MESH:D015179 Colorectal Neoplasms Indomethacin 2.7611197048 12606626 17054584 18059344
MESH:D015179 Colorectal Neoplasms irinotecan 2.7616303861 15273666 18509181 18259882 17454858 17159606 16391804
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7414669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.3317302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3220055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.3217551590 9142499 16925845 9664655 9224671 9125849 9211117 8800419 10589399 14991402
MESH:D003456 Cryptorchidism vinclozolin 3.9814966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.4920210726
MESH:D003704 Dementia Haloperidol 4.2411575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9919031437
MESH:D003920 Diabetes Mellitus rosiglitazone 3.9817446233
MESH:D003924 Diabetes Mellitus, Type 2 alpha-Tocopherol 15.8516506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 15.8516402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 15.8520387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 15.8516647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 15.8512642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 15.8517107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.1619279558
MESH:D003967 Diarrhea Indomethacin 3.447907874 7237001
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1715331141
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.4819107877
MESH:D056486 Drug-Induced Liver Injury Selenium 5.4815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.4820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.7718446180 16133044 18043480 17190690 16326151 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 3.7811535926 10671773 17329845 11991626 17045617 16699067 17151854 17351913 11595431 11595415 17202747
MESH:D050171 Dyslipidemias Clozapine 7.9516402076
MESH:D050171 Dyslipidemias Dietary Fats 7.9518367378
MESH:D020821 Dystonic Disorders Nicotine 5.5417881519
MESH:D004487 Edema Indomethacin 9.667907874 8985016 7990266 19703484 8273558 16100529 10653021
MESH:D004487 Edema rosiglitazone 9.6612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.6612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.6518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental T 0070907 8.8116091293
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8119031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.2116402032
MESH:D016889 Endometrial Neoplasms Genistein 11.0211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.0217893378 20544844 16202921 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 11.0216569247
MESH:D004715 Endometriosis Indomethacin 7.9815652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.989294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.1218509659
MESH:D004751 Enteritis Indomethacin 4.3610567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.6117980183
MESH:D004802 Eosinophilia Indomethacin 3.6911298111
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.6320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.6316530937
MESH:D004938 Esophageal Neoplasms Indomethacin 6.6311005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.9016938888 9664655
MESH:D005234 Fatty Liver Dietary Fats 16.0419004024 18296743 17967931 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 16.0420387270 21071580
MESH:D005234 Fatty Liver rosiglitazone 16.0419196556
MESH:D005234 Fatty Liver Tamoxifen 16.0419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005334 Fever Indomethacin 3.7911852909 10431976 17627676
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8019069698
MESH:D005354 Fibrosarcoma Indomethacin 10.9310962813
MESH:D005354 Fibrosarcoma Methylnitrosourea 10.9311555667
MESH:D005355 Fibrosis Dietary Fats 18.1218296743
MESH:D005355 Fibrosis Indomethacin 18.1217994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.1220067830
MESH:D005355 Fibrosis Tretinoin 18.1217994277
MESH:D005499 Folliculitis Indomethacin 4.7811298111
MESH:D005756 Gastritis Indomethacin 4.3615046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5516973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9116417039
MESH:D005909 Glioblastoma Genistein 14.9516598420
MESH:D005909 Glioblastoma Indomethacin 14.9512870263
MESH:D005909 Glioblastoma Manganese 14.9517043766
MESH:D005909 Glioblastoma Tretinoin 14.9517312396
MESH:D005910 Glioma Indomethacin 5.9716487511 18371953
MESH:D005910 Glioma Methylnitrosourea 5.979825942
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9811849393
MESH:D006042 Goiter perchlorate 4.9518801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006073 Gout Indomethacin 4.9711248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.0615482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.0616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7716084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.8920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.8910048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.899664655 14991402
MESH:D006333 Heart Failure Selenium 2.8417162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.2315633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.3215135802
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5312621046 15340226 16120746
MESH:D006561 Herpes Simplex Etoposide 4.1810809021
MESH:D006689 Hodgkin Disease Etoposide 3.5616135485 18180244 15147373 17606976 16200630
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6618606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Indomethacin 11.5112727271
MESH:D006930 Hyperalgesia rosiglitazone 11.5112083418
MESH:D006930 Hyperalgesia Tretinoin 11.5116870215
MESH:D034321 Hyperamylasemia Indomethacin 5.3317883296
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2621332399
MESH:D006940 Hyperemia Indomethacin 4.6212524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2016778211
MESH:D006948 Hyperkinesis Clozapine 4.5316046005
MESH:D006949 Hyperlipidemias Dietary Fats 8.1821332399
MESH:D006949 Hyperlipidemias Indomethacin 8.1817546600
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.1817604070
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7618850075 18670907
MESH:D006980 Hyperthyroidism Methimazole 5.2514678291
MESH:D007037 Hypothyroidism Methimazole 10.7118031379
MESH:D007037 Hypothyroidism Propylthiouracil 10.7118031379 8137927
MESH:D007077 Ileal Diseases Indomethacin 4.6418306037 10574470
MESH:D007079 Ileitis Indomethacin 4.9710651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.9816133044
MESH:D007248 Infertility, Male Methylnitrosourea 6.297193160
MESH:D007248 Infertility, Male vinclozolin 6.2916467254
MESH:D007249 Inflammation Dietary Fats 21.1020412841
MESH:D007249 Inflammation Diethylnitrosamine 21.1018785209
MESH:D007249 Inflammation Indomethacin 21.103291741 12568917 7812673
MESH:D007249 Inflammation Iodine 21.1016001271
MESH:D007249 Inflammation rosiglitazone 21.1012083418
MESH:D007249 Inflammation Tamoxifen 21.1019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 21.1012200463 12878042
MESH:D007251 Influenza, Human Selenium 3.8116624496
MESH:D007333 Insulin Resistance Dietary Fats 6.8411836018 18457598
MESH:D007333 Insulin Resistance rosiglitazone 6.8416306350
MESH:D007410 Intestinal Diseases Indomethacin 8.6511855677 18236018 10210152 15831440 11686837 17329856 15610444 11713966 17994277
MESH:D007410 Intestinal Diseases Tretinoin 8.6517994277
MESH:D019586 Intracranial Hypertension Indomethacin 4.9815241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8017551590 15992940
MESH:D007579 Jejunal Diseases Indomethacin 4.6416133968 10574470 18306037
MESH:D007674 Kidney Diseases Indomethacin 3.0517190690
MESH:D007676 Kidney Failure, Chronic Selenium 3.5516518626
MESH:D007680 Kidney Neoplasms Tamoxifen 2.7418625569
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.6012228301 10320625 11703811
MESH:D007938 Leukemia Genistein 5.7617468513 18980019
MESH:D007938 Leukemia Tretinoin 5.7617143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.6416572323 10785260 15631656
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3616482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.8018360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8016294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9017294898 17712046 17361223 19225113 16823087 15748426 19075265 17368321 19035177 19642359 17506722 17217047 17649720 17339181 16788101 16140955 9834237 17301526 12679006 19029980 16891316 17107899 16766008 16331271 16935935
MESH:D007964 Leukocytosis Indomethacin 4.9816537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.3317980183
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3516417039
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 7.5515526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.559224671
MESH:D008064 Lipidoses Clozapine 7.1717567588
MESH:D008064 Lipidoses Tamoxifen 7.1717567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.3311479899
MESH:D008103 Liver Cirrhosis Dietary Fats 5.9218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.9220032147 19638242 18522880 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.0217823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 8.0218194892
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 8.0215980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.0218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.0212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.0216248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0117034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.5221137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 19.5221295105 19389873
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 19.5218177683
MESH:D008113 Liver Neoplasms Diethylnitrosamine 19.5218978307 20452335 21047994 12771043 20434301 18648771 19850985 18754104 19642983 18644402 19551842 15175105 19294768 19812893 2862719 19690152 2422723 20492335 21167192 9163691 20583210 19426721 21071580 19254457 19427195 12112319 19090486 19638242 19073162 20137499 15885732 10737359 16942905 21278145 19255062 20101389 19996281 20405173 18977376 19499222 20501860 19256749 20118626 19833225
MESH:D008113 Liver Neoplasms Mitomycin 19.5215113037
MESH:D008113 Liver Neoplasms Tamoxifen 19.5216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.5216984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 8.4718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.4717174075 18544905 21159647 19009564 17854601 16267830 18308698 19539802 2563599 17942915 9362446 18079962 3124819 18775883 16842330 18253720 18282651 18164116 19519916 19004024 19126423 18093689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.4712151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.0916080182
MESH:D008175 Lung Neoplasms alpha-Tocopherol 12.0116401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.0118569708 18520028 18816296 20064080 20869020 17053015 20464547 20135361 6695378
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 12.0118597497 19359593 19925653 15390079 16337739 11246140 11696405
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.0121163286 6695378 20970405 20512841
MESH:D008175 Lung Neoplasms Indomethacin 12.0111053908 11497255 16537180
MESH:D008175 Lung Neoplasms Methylnitrosourea 12.0118062963
MESH:D008175 Lung Neoplasms Tamoxifen 12.0118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.0119555203 11884234
MESH:D008223 Lymphoma Etoposide 7.2112854902 12556972
MESH:D008223 Lymphoma Methylnitrosourea 7.2111418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.4214633661
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3819428831
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 24.721500032
MESH:D008325 Mammary Neoplasms, Experimental Genistein 24.7214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Iodine 24.7215922087
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 24.7214999141 16051031 15688392 14633655 12931682 15313902 16944150 15113128 10838139 10767621 11807958 16619500 16827153 19196723 11751437 17131329 17020996
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 24.7216827153
MESH:D008325 Mammary Neoplasms, Experimental Selenium 24.7215318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 24.7211731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Manganese 11.7316551646 16568477 19453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.7319453300
MESH:D008527 Medulloblastoma Tretinoin 2.6317453147
MESH:D008545 Melanoma Tamoxifen 3.0519393235 12393984
MESH:D008545 Melanoma Tretinoin 3.0516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8015990972
MESH:D008591 Meningomyelocele Tretinoin 4.0516940565
MESH:D001523 Mental Disorders Clozapine 7.1116856516
MESH:D001523 Mental Disorders Haloperidol 7.1116856516
MESH:D008654 Mesothelioma Selenium 2.6315107826
MESH:D024821 Metabolic Syndrome X Clozapine 8.8619142101
MESH:D024821 Metabolic Syndrome X rosiglitazone 8.8617261469
MESH:D008881 Migraine Disorders Indomethacin 3.4011903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.6916381670
MESH:D009062 Mouth Neoplasms Indomethacin 7.6912636206
MESH:D009069 Movement Disorders Manganese 4.6616551646
MESH:D052016 Mucositis irinotecan 4.6317159606
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8617596541
MESH:D009203 Myocardial Infarction alpha-Tocopherol 5.8519595682
MESH:D009203 Myocardial Infarction Genistein 5.8517141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.3717141266
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 12.293581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 12.2916537180 11239499 11053908
MESH:D009362 Neoplasm Metastasis irinotecan 12.2918259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 12.2919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 10.3411141357
MESH:D009369 Neoplasms Methylnitrosourea 10.3415533788
MESH:D009369 Neoplasms Nicotine 10.3416365874
MESH:D009369 Neoplasms Tretinoin 10.3416594593 16946489
MESH:D009374 Neoplasms, Experimental Indomethacin 8.3410663608 15625704
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 8.3412696579
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6119189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Nicotine 4.6116365874
MESH:D009410 Nerve Degeneration Manganese 3.9916551646
MESH:D009421 Nervous System Malformations Genistein 14.2916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.2914600291
MESH:D009421 Nervous System Malformations Tretinoin 14.299125849
MESH:D009436 Neural Tube Defects Tretinoin 2.819142499
MESH:D009442 Neurilemmoma Methylnitrosourea 5.1011555667
MESH:D009447 Neuroblastoma irinotecan 6.708761367
MESH:D009447 Neuroblastoma Topotecan 6.7015176712
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.5520387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.5512349958
MESH:D017599 Neuroectodermal Tumors irinotecan 4.358761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7320387270
MESH:D009765 Obesity Clozapine 4.5218515891 19142110
MESH:D009765 Obesity Dietary Fats 4.5217217161 18674790 21332399 11836018 19632207 18457598 16723640 20518802 20132043
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.786374098
MESH:D010003 Osteoarthritis Indomethacin 3.437009135
MESH:D010024 Osteoporosis Genistein 3.0219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7416169203
MESH:D010051 Ovarian Neoplasms Genistein 4.5119005980
MESH:D010051 Ovarian Neoplasms Tretinoin 4.5116936753
MESH:D010146 Pain Indomethacin 5.9717627676 17440234 13679232 3291741
MESH:D010146 Pain Tretinoin 5.9716870215
MESH:D010149 Pain, Postoperative Indomethacin 4.2918702446 12538197
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 14.7816540662
MESH:D010190 Pancreatic Neoplasms Etoposide 14.7819003803
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 14.7816965848
MESH:D010190 Pancreatic Neoplasms Mitomycin 14.7815113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.7815976015
MESH:D010195 Pancreatitis Indomethacin 3.5815028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.3316537180
MESH:D010300 Parkinson Disease Manganese 3.2311181820
MESH:D020734 Parkinsonian Disorders Indomethacin 8.4312349958
MESH:D020734 Parkinsonian Disorders Manganese 8.4316140633
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.3311903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010437 Peptic Ulcer Indomethacin 4.7711148446
MESH:D010518 Periodontitis Indomethacin 4.5317225004
MESH:D010954 Plasmacytoma Selenium 4.5015087411
MESH:D011014 Pneumonia Butylated Hydroxytoluene 4.7811893704
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.232563599
MESH:D047928 Premature Birth Indomethacin 4.7517000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2211399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.2219015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.5518220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9217292933
MESH:D011471 Prostatic Neoplasms Etoposide 1.9217172428
MESH:D011471 Prostatic Neoplasms Genistein 1.9215256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 1.9212376480 15682402
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9215067354
MESH:D011472 Prostatitis vinclozolin 4.5518629315
MESH:D011507 Proteinuria Indomethacin 8.1711849393
MESH:D011507 Proteinuria Tretinoin 8.1716636307
MESH:D011595 Psychomotor Agitation Haloperidol 4.5811575062
MESH:D011618 Psychotic Disorders Clozapine 8.2515331141
MESH:D011618 Psychotic Disorders Haloperidol 8.2511575062
MESH:D011625 Pterygium Tretinoin 4.4116723453
MESH:D011657 Pulmonary Eosinophilia alpha-Tocopherol 5.6014606601
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.1318172121 18155124
MESH:D012174 Retinitis Pigmentosa alpha-Tocopherol 3.8616849425
MESH:D012175 Retinoblastoma Methylnitrosourea 5.1011555667
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7516116481 16283617
MESH:D012512 Sarcoma, Ewing's Etoposide 4.3414601052
MESH:D012559 Schizophrenia Clozapine 3.8816141801 20107430 20452607 18855531 11151749 17726453 17123785 20580759 20521320 11763009 20168265 20521326 17667964 19369910 18806925
MESH:D012559 Schizophrenia Haloperidol 3.8820107430 19369910 1830565 18513383
MESH:D012640 Seizures Nicotine 3.5517873105
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.2919755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.2916192470
MESH:D012878 Skin Neoplasms Tretinoin 8.2916467112
MESH:D013088 Spermatocele Tamoxifen 3.9016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6619457130
MESH:D013272 Stomach Diseases Indomethacin 4.0417207306 17638125 17160473 18209964 10215738 16113693 10486359 16280098 15472012 18545984 16184426 15038085 10192188
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.7120155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 7.7118456281
MESH:D013274 Stomach Neoplasms Indomethacin 7.7115609394
MESH:D013274 Stomach Neoplasms irinotecan 7.7115723263
MESH:D013274 Stomach Neoplasms Methylnitrosourea 7.7116257854 18593901 15930296
MESH:D013274 Stomach Neoplasms Tretinoin 7.7117261132
MESH:D013276 Stomach Ulcer Indomethacin 3.2616755016 11523592 17977527 18193104 12500499 18726076 17135157 18181030 18543354 16934674 12077510 17918041 15138204 11145282 10878458 12787963 16252198 12467913 1323529 14567935 16631530 18087811 15255614 17657623 11906479 11729361 16150113 18299717 15104355 18209962 17627676 18237397 10423059 16169175 10750652 17654042 18431645 11595431 16397915 12498302 17895592 11595415
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.3520210726
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.8511418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 19.447505956
MESH:D013964 Thyroid Neoplasms Indomethacin 19.4414736730 18791128 11352223
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 19.443078959 7505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 19.4415710170
MESH:D013964 Thyroid Neoplasms Tretinoin 19.4416026305 17045167
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.4516785264 16720336 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 5.0817979512 18041664 15735609 18305452
MESH:D014062 Tongue Neoplasms Tretinoin 3.4616051514
MESH:D014376 Tuberculosis Tretinoin 2.9916040207
MESH:D014456 Ulcer Indomethacin 4.5117380554 10574470
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.4717053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.4716712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.3516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.2216752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D014820 Vitiligo Tretinoin 3.6916761959
MESH:D014839 Vomiting Indomethacin 4.3611897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D015430 Weight Gain Clozapine 8.7620564506 20107430 20521320 17502770 16402076 16141801
MESH:D015430 Weight Gain Dietary Fats 8.7616723640
MESH:D015431 Weight Loss Clozapine 4.7017933447
MESH:D009396 Wilms Tumor Tretinoin 3.6516287080
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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