AutismKB 2.0

Annotation Detail for MCAM


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Basic Information Top
Gene Symbol:MCAM ( CD146,MUC18 )
Gene Full Name: melanoma cell adhesion molecule
Band: 11q23.3
Quick LinksEntrez ID:4162; OMIM: 155735; Uniprot ID:MUC18_HUMAN; ENSEMBL ID: ENSG00000076706; HGNC ID: 6934
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1831Prostate cancer
1848Embryoma
1859Ovarian cancer
1902Kidney failure
1904Diabetes mellitus
1918Atherosclerosis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of MCAM mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of MCAM mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of MCAM mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MCAM mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MCAM mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MCAM mRNAincreases expression 17273784
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MCAM proteinincreases expression 17273784
D004041 Dietary Fats Dietary Fats results in increased expression of MCAM mRNAincreases expression 18042831
D004958 Estradiol Estradiol results in increased expression of MCAM mRNAincreases expression 20068009
D005419 Flavonoids Flavonoids results in increased expression of MCAM mRNAincreases expression 18035473
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of MCAM mRNAincreases expression 12773770
12634122
C041786 palm oil palm oil results in increased expression of MCAM mRNAincreases expression 18042831
D010758 Phosphorus Phosphorus results in increased expression of MCAM mRNAincreases expression 17715259
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MCAM mRNAaffects binding|decreases expression|increases activity 19710929
D018038 Sodium Selenite Sodium Selenite results in decreased expression of MCAM mRNAdecreases expression 18175754
D014810 Vitamin E Vitamin E results in increased expression of MCAM mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Estradiol 2.1011473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5316434500
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8318057881 20041841 18218290
MESH:D001161 Arteriosclerosis Dietary Fats 3.9315238619
MESH:D001281 Atrial Fibrillation Amiodarone 3.9218651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.1819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1819483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.1520435547
MESH:D001943 Breast Neoplasms Estradiol 2.1519861407 12948864 18497071 17289903 16675129 17018787 17261762 14630087
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.0815721981 3786805 16192424 16124888 15700767 16050911 15673190 16011737 16227642 16097048 18705752 10355542
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.0816050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.543084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.5418788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5416924424
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9015710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1318974383
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1818566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 7.182727394
MESH:D002779 Cholestasis pirinixic acid 2.8519176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8016285004
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0716393943 12705907 14986274 16081117 11834606 10915739 14550746 19739265 19923254 11287661 10663392 16781746 18713872 19416960 2444490 18071297 12958197 14725611 12153990 16109766 15619225 17522070 12540782 11421492 19420014 15968718 17562736 17906064 19164858 11461765 11739529 16177239 11529661 19085960 16485898 12594235 11743745 19370779 16227642 10774834 12392966
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.0715265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.0721278145 19336974 16227642 10915739 9327722 15027814 7440962 7120509 15968718 10092053 2869522 3732212 19085960 15998439 4309450 6623471 16177239 11566570 17522070 7179309 6884620 3786805
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.0715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:C538011 Eales disease Vitamin E 4.779068938
MESH:D004487 Edema pirinixic acid 2.5112083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.0018566989 11473722 19148513
MESH:D005234 Fatty Liver Amiodarone 19.0414986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.0461145 12631006 16239168 15959796 17595544 12795759 19224547 16045604
MESH:D005234 Fatty Liver Dietary Fats 19.0418296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver pirinixic acid 19.0419236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 8.9518705752
MESH:D005355 Fibrosis Dietary Fats 8.9518296743
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0016080930
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6319110552 19900420
MESH:D006529 Hepatomegaly Amiodarone 8.7215265979
MESH:D006529 Hepatomegaly pirinixic acid 8.7218467677 16221962 19772884 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7116490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 10.2617088409
MESH:D019584 Hot Flashes Vitamin E 10.2614716179
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5816899240
MESH:D006937 Hypercholesterolemia Amiodarone 9.268137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 9.2621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1315338365
MESH:D007037 Hypothyroidism Amiodarone 4.5617991464 18020914
MESH:D007249 Inflammation Dietary Fats 5.2520412841
MESH:D007249 Inflammation Flavonoids 5.2517296493
MESH:D007251 Influenza, Human Vitamin E 4.2816624496
MESH:D007333 Insulin Resistance Dietary Fats 17.7918457598 11836018
MESH:D007333 Insulin Resistance Estradiol 17.7916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 17.7916306350
MESH:D007333 Insulin Resistance Sodium Selenite 17.7914714311
MESH:D007674 Kidney Diseases Acetaminophen 10.1315629191 12587719
MESH:D007674 Kidney Diseases Estradiol 10.1315618244
MESH:D007674 Kidney Diseases Vitamin E 10.1312488133
MESH:D007680 Kidney Neoplasms Estradiol 3.0015610895
MESH:D008064 Lipidoses Amiodarone 3.5315342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.6811408273 11903743 16943688 17334410 16221502 16239168 17174718 21278145 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6818296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9712958196 17922224 15996030 16248980 18705752 12666154 15057751 15931870 16011737 18210741 16116963 14620537 17805973 14512876 17944888 18395914 18418968 15673190 17631135 18251166 16192424 17708605 12632512 16033810 18317297 16015684 17976157 18395095 18156304 15818738 18279442 17900296 12445421 17557913 15362042 16638106 18187930 17481882 18412020 14716496 17721639 17823541 18429990 12389079 18263696 12546737 16027843 15730626 15123356 14716833 18481824 12649538 18166357 18006644 13678700 17761835 12741479 14748882 12667390 15925388 10355542 18472094 17766677 17869086 15338365 16097048 18339082 12632514 15650968 18277467 15893842 15370692 15959796 17714472 12586293 18054572 18205269 18376398 17525996 12898905 15052691 18420326 17565644 18472332 15876570 16136751 17640975 17698563 11481614 12445418 20821823 12609069 14724832
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9715474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.9716169303
MESH:D008107 Liver Diseases Acetaminophen 3.9219460945 12587719 19784758 16611625 11587558 16610002 19014921 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9215720792 15830285 17285989 16964402 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5016899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.4719294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.4716377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6312014681 15583823
MESH:D008133 Long QT Syndrome Amiodarone 3.6011989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 7.5812587719
MESH:D008171 Lung Diseases Vitamin E 7.5816863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5418516814
MESH:D008175 Lung Neoplasms Vitamin E 1.8911062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5817203775 11807958 11408345 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.9417671175
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009181 Mycoses Amiodarone 4.9617974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3216411023
MESH:D009369 Neoplasms pirinixic acid 1.9617405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009421 Nervous System Malformations Estradiol 3.6911399458 16427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity Dietary Fats 4.4516723640 21332399 20518802 18674790 17217161 11836018 20132043 18457598 19632207
MESH:D009765 Obesity pirinixic acid 4.4520558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5816740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5818760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5815084515
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8612832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1318724381
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.708532709
MESH:D013276 Stomach Ulcer Amiodarone 3.3418087811
MESH:D020521 Stroke Vitamin E 3.5416517955
MESH:D013610 Tachycardia Amiodarone 4.3211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2219225199
MESH:D013959 Thyroid Diseases Amiodarone 4.8219731979
MESH:D013971 Thyrotoxicosis Amiodarone 4.9018020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D016171 Torsades de Pointes Amiodarone 4.2417467628 11989578
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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