AutismKB 2.0

Annotation Detail for MCC


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Basic Information Top
Gene Symbol:MCC ( DKFZp762O1615,FLJ38893,FLJ46755,MCC1 )
Gene Full Name: mutated in colorectal cancers
Band: 5q22.2
Quick LinksEntrez ID:4163; OMIM: 159350; Uniprot ID:CRCM_HUMAN; ENSEMBL ID: ENSG00000171444; HGNC ID: 6935
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of MCC mRNAincreases expression 19933214
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCC mRNAaffects cotreatment|decreases expression 12634122
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MCC mRNAaffects expression 17484886
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCC mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCC mRNAaffects cotreatment|decreases expression 12634122
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCC mRNAaffects cotreatment|decreases expression 12634122
D015741 Metribolone Metribolone results in increased expression of MCC mRNAincreases expression 17010196
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCC mRNAaffects cotreatment|decreases expression 12634122
C017947 sodium arsenite sodium arsenite results in increased expression of MCC mRNAincreases expression 17879257
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MCC mRNAincreases expression 19465110
19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 14514962 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D011125 Adenomatous Polyposis Coli marker/mechanism 8071957
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2217306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001321 Autistic Disorder marker/mechanism 8071957
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0410355542 15673190 16097048 15721981 16192424 16011737 3786805 15700767 16050911 16227642 18705752 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1518788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1516507464 17306315 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1219524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 12621046 15668235 15340226 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities lead acetate 2.9819769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.9810048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.8916177239 6884620 19085960 3786805 7440962 7179309 10915739 19336974 4309450 15998439 2869522 10092053 21278145 3732212 17522070 11566570 9327722 16227642 15968718 15027814 7120509 6623471
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 18230668 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.3712795759 16239168 12631006 17595544 15959796 19224547 61145 16045604
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005317 Fetal Growth Retardation lead acetate 5.6219769572
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.4720067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9616452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.3312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616354765 8697196 18606429 16959395 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007248 Infertility, Male sodium arsenite 3.1215346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Cadmium Chloride 6.7916962696
MESH:D007674 Kidney Diseases sodium arsenite 6.7920008137
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9116943688 21278145 16221502 11408273 17334410 16239168 17174718 11903743 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3417640975 17805973 17900296 15818738 18420326 15931870 18166357 18339082 18317297 14620537 18187930 17708605 12667390 17557913 17565644 18210741 18395095 18412020 12609069 15362042 15893842 14748882 17525996 18277467 17766677 12546737 18429990 18251166 17976157 16638106 18418968 17761835 17631135 15996030 16011737 12741479 16192424 17714472 14716833 18006644 18263696 14512876 12632512 12389079 15959796 12898905 18156304 15925388 18705752 15123356 11481614 12649538 15057751 16248980 15650968 17922224 16027843 17698563 14724832 18472094 12445418 16136751 16015684 15338365 15052691 12632514 16116963 15370692 12958196 18472332 13678700 15730626 17944888 17481882 20821823 17869086 16033810 18376398 15876570 12666154 18481824 18054572 16097048 18395914 12445421 15673190 17721639 17823541 12586293 14716496 18279442 10355542 18205269
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215720792 16964402 17285989 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8814706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.8119294768
MESH:D008113 Liver Neoplasms sodium arsenite 7.8115276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8116984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1612151625
MESH:D008171 Lung Diseases sodium arsenite 3.3019095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3516712894 15276417 17306315 19931552 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3511884234 19555203
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008607 Mental Retardation marker/mechanism 8071957
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009369 Neoplasms sodium arsenite 2.5811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9220056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2712854658
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4917306315 15276417
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2716039940
MESH:D012004 Rectal Neoplasms marker/mechanism 8071957
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012878 Skin Neoplasms sodium arsenite 5.8819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8816192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9512854658
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5716712894 17306315 16452187 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9611813266
MESH:D014652 Vascular Diseases sodium arsenite 4.7117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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