AutismKB 2.0

Annotation Detail for MCM2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MCM2 ( BM28,CCNL1,CDCL1,D3S3194,KIAA0030,MGC10606,MITOTIN,cdc19 )
Gene Full Name: minichromosome maintenance complex component 2
Band: 3q21.3
Quick LinksEntrez ID:4171; OMIM: 116945; Uniprot ID:MCM2_HUMAN; ENSEMBL ID: ENSG00000073111; HGNC ID: 6944
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03030DNA replication
hsa04110Cell cycle
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Cell Cycle Checkpoints
No data
No data
Pathway IDPathway Name
500964Removal of licensing factors from origins
500932Switching of origins to a post-replicative state
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2122Protein-energy malnutrition
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of MCM2 mRNAincreases expression 17547211
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MCM2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of MCM2 mRNAdecreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of MCM2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MCM2 proteinaffects expression 20106945
D000965 Antimony Antimony results in increased expression of MCM2 mRNAincreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in increased expression of MCM2 mRNAincreases expression 17547211
C006632 arsenic trioxide arsenic trioxide results in increased expression of MCM2 mRNAincreases expression 17530438
17547211
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MCM2 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MCM2 mRNAdecreases expression 20382639
C053541 bicalutamide bicalutamide results in decreased expression of MCM2 mRNAdecreases expression 15638997
C006780 bisphenol A bisphenol A results in increased expression of MCM2 mRNAincreases expression 17268063
16474171
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MCM2 mRNAdecreases expression 15336504
D002104 Cadmium Cadmium results in increased expression of MCM2 mRNAincreases expression 17547211
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of MCM2 mRNAincreases expression 17547211
D002857 Chromium Chromium results in increased expression of MCM2 mRNAincreases expression 17547211
C030123 coumarin coumarin results in increased expression of MCM2 mRNAincreases expression 18480146
C029892 cupric chloride cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM2 mRNA]decreases expression|increases reaction 19789329
D003474 Curcumin Curcumin results in decreased expression of MCM2 mRNAdecreases expression 18299980
D016572 Cyclosporine Cyclosporine results in decreased expression of MCM2 mRNAdecreases expression 20106945
D002945 Cisplatin Cisplatin results in increased expression of MCM2 mRNAincreases expression 16061661
D004041 Dietary Fats Dietary Fats results in increased expression of MCM2 mRNAincreases expression 18457598
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of MCM2 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MCM2 mRNA]decreases reaction|increases expression 17854601
D004221 Disulfiram cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM2 mRNA]decreases expression|increases reaction 19789329
D004221 Disulfiram Disulfiram results in decreased expression of MCM2 mRNAdecreases expression 19789329
C067311 docetaxel [zoledronic acid co-treated with docetaxel] results in decreased expression of MCM2 proteinaffects cotreatment|decreases expression 17562444
D004958 Estradiol Estradiol results in increased expression of MCM2 mRNAincreases expression 17268063
16474171
D004958 Estradiol Estradiol affects the expression of MCM2 mRNAaffects expression 15598610
D004958 Estradiol [Progesterone co-treated with Estradiol] affects the localization of MCM2 proteinaffects cotreatment|affects localization 16966611
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of MCM2 proteinaffects cotreatment|decreases expression 16966611
D004967 Estrogens [Malathion co-treated with Estrogens] results in increased expression of MCM2 mRNAaffects cotreatment|increases expression 18204794
D004967 Estrogens [Parathion co-treated with Estrogens] results in increased expression of MCM2 mRNAaffects cotreatment|increases expression 18204794
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MCM2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MCM2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MCM2 mRNAaffects cotreatment|increases expression 17942748
D005031 Ethylenethiourea Ethylenethiourea results in decreased expression of MCM2 mRNAdecreases expression 18801409
D005031 Ethylenethiourea Ethylenethiourea results in increased expression of MCM2 mRNAincreases expression 18801409
D005472 Fluorouracil MCM2 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D019833 Genistein Genistein results in increased expression of MCM2 mRNAincreases expression 16474171
D008294 Malathion [Malathion co-treated with Estrogens] results in increased expression of MCM2 mRNAaffects cotreatment|increases expression 18204794
D008294 Malathion Malathion results in increased expression of MCM2 mRNAincreases expression 18204794
D008628 Mercury Mercury results in increased expression of MCM2 mRNAincreases expression 17547211
D008713 Methimazole Methimazole results in increased expression of MCM2 mRNAincreases expression 17403546
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in decreased expression of MCM2 mRNAdecreases expression 12634122
C008493 methylselenic acid methylselenic acid affects the expression of MCM2 mRNAaffects expression 14617803
D010278 Parathion [Parathion co-treated with Estrogens] results in increased expression of MCM2 mRNAaffects cotreatment|increases expression 18204794
C494474 perchlorate perchlorate results in decreased expression of MCM2 mRNAdecreases expression 17403546
18801409
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MCM2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of MCM2 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of MCM2 mRNAincreases expression 18301758
17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of MCM2 mRNA]increases expression|increases reaction 17950772
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of MCM2 mRNAincreases expression 16474171
D011192 Potassium Dichromate Potassium Dichromate results in increased expression of MCM2 mRNAincreases expression 17547211
D011374 Progesterone [Progesterone co-treated with Estradiol] affects the localization of MCM2 proteinaffects cotreatment|affects localization 16966611
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of MCM2 proteinaffects cotreatment|decreases expression 16966611
D011374 Progesterone Progesterone results in decreased expression of MCM2 mRNAdecreases expression 16966611
D011441 Propylthiouracil Propylthiouracil results in decreased expression of MCM2 mRNAdecreases expression 17403546
C017947 sodium arsenite sodium arsenite results in decreased expression of MCM2 mRNAdecreases expression 12760830
C025462 sulindac sulfide sulindac sulfide results in decreased expression of MCM2 mRNAdecreases expression 16184548
D014284 Triiodothyronine Triiodothyronine results in increased expression of MCM2 mRNAincreases expression 17403546
D013629 Tamoxifen Tamoxifen affects the expression of MCM2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MCM2 mRNAdecreases expression 16714409
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MCM2 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MCM2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MCM2 mRNAdecreases expression 16611356
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MCM2 mRNAincreases expression 15667827
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of MCM2 mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in decreased expression of MCM2 mRNAdecreases expression 18230668
D014212 Tretinoin Tretinoin results in decreased expression of MCM2 mRNAdecreases expression 16249480
C088658 zoledronic acid [zoledronic acid co-treated with docetaxel] results in decreased expression of MCM2 proteinaffects cotreatment|decreases expression 17562444
C088658 zoledronic acid zoledronic acid results in decreased expression of MCM2 proteindecreases expression 17562444
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9914745880
MESH:D000014 Abnormalities, Drug-Induced Disulfiram 11.2317676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.236195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.2315322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3817505938
MESH:D000163 Acquired Immunodeficiency Syndrome Disulfiram 5.029207937
MESH:D058186 Acute Kidney Injury Cisplatin 7.4917670903 15814532 12690470
MESH:D058186 Acute Kidney Injury zoledronic acid 7.4919715164
MESH:D055371 Acute Lung Injury pirinixic acid 2.6218653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 4.9320200999
MESH:D000230 Adenocarcinoma arsenic trioxide 21.7019825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 21.7020127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 21.7017638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 21.7011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 21.7014692618
MESH:D000230 Adenocarcinoma Ethylenethiourea 21.707955072
MESH:D000230 Adenocarcinoma Fluorouracil 21.7017638652
MESH:D000230 Adenocarcinoma Genistein 21.7011473722
MESH:D000236 Adenoma Benzo(a)pyrene 5.506695378
MESH:D000236 Adenoma Diethylnitrosamine 5.506695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.3818056438 19061943 17162532 19052882 17620307 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.3817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.3816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.3816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3417306315 16712894
MESH:D000382 Agricultural Workers' Diseases Malathion 7.8517119214 11874814
MESH:D000382 Agricultural Workers' Diseases Parathion 7.8511874814 17119214
MESH:D000437 Alcoholism Disulfiram 4.5517079463 18968458 10841824
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5217887948
MESH:D000505 Alopecia Tretinoin 3.1815955085
MESH:D000544 Alzheimer Disease Curcumin 4.1215590663
MESH:D000544 Alzheimer Disease sulindac sulfide 4.1218759972
MESH:D000740 Anemia Fluorouracil 7.1016511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.1011748828
MESH:D000799 Angioedema Acetaminophen 3.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5419183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.1415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.1411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.0215885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.0216412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.1916807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1916292516
MESH:D001249 Asthma Tretinoin 2.1616456186
MESH:D050197 Atherosclerosis Cadmium 5.9115687053
MESH:D050197 Atherosclerosis Curcumin 5.9118704882
MESH:D001321 Autistic Disorder Acetaminophen 2.1518445737
MESH:D001321 Autistic Disorder Mercury 2.1517497416
MESH:D001327 Autoimmune Diseases Curcumin 9.2619761891
MESH:D001327 Autoimmune Diseases Mercury 9.2616634805
MESH:D001471 Barrett Esophagus Tretinoin 3.8816935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 23.6316206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 23.6319483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 23.6319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 23.6312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 23.6316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4015746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.3314601052
MESH:D001859 Bone Neoplasms zoledronic acid 4.4519442620 15867366 11697798 17312309 16778634 16121404
MESH:D001862 Bone Resorption bisphenol A 8.1711985600
MESH:D001862 Bone Resorption zoledronic acid 8.178053405 11869084 18404659 15845617 16769263 18496637
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7817868700
MESH:D001930 Brain Injuries Progesterone 3.7215665606 15380490 15845082
MESH:D002545 Brain Ischemia Curcumin 3.7916770732
MESH:D001932 Brain Neoplasms Curcumin 3.4717596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 19.7217474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 19.7217123778
MESH:D001943 Breast Neoplasms Chromium 19.7215986119
MESH:D001943 Breast Neoplasms Cisplatin 19.7218382427 19526202
MESH:D001943 Breast Neoplasms Curcumin 19.7218593918 18462866 19250217 16243823
MESH:D001943 Breast Neoplasms Dietary Fats 19.7220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 19.7217474063
MESH:D001943 Breast Neoplasms Disulfiram 19.7217026967
MESH:D001943 Breast Neoplasms docetaxel 19.7218628466 17369602 19526202 15692762 16264153 16495393 15567936
MESH:D001943 Breast Neoplasms Estradiol 19.7216675129 18497071 17261762 17289903 14630087 12948864 19861407 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 19.7216110121 19217205 18608205 15136595 18357371 16595493 16557594
MESH:D001943 Breast Neoplasms Genistein 19.7216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Malathion 19.7212762645
MESH:D001943 Breast Neoplasms Parathion 19.7212762645
MESH:D001943 Breast Neoplasms Progesterone 19.7217614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tamoxifen 19.7219289846 18821012 19221464 19410462 15565566 19066611 19155303 16273361 18629630 17049068 19142967 19084267 15668708 19011961 18425577 16818667 17893378 17242785 18815881 16873071 18351453 21152245 18855134 17440819 20544844 18984771 11161223 20065188 19189210 20005174 19189212 19244106 19115204 19200415 16202921 19487384 20135344 19288272 20390343 19103187 19059307 21138602 18997820 17261762 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 19.7220435547
MESH:D001943 Breast Neoplasms Tretinoin 19.7216873071 16443354 16166294
MESH:D001943 Breast Neoplasms zoledronic acid 19.7218695136 16096432
MESH:D001991 Bronchitis Antimony 5.578768112
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8211589617
MESH:D002177 Candidiasis Disulfiram 5.3115325261
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9216111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.1116051944
MESH:D002277 Carcinoma Curcumin 16.4118593918
MESH:D002277 Carcinoma Disulfiram 16.4117026967
MESH:D002277 Carcinoma Fluorouracil 16.4117121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 16.4116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9719066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6016168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 35.9516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 35.9516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 35.953084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 35.9521507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 35.9515073043 16217749 15553829 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 35.9517982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 35.9510672840 10737359 20214788 19519916 19208518 19418558 19701751 19822196 19919837 3581430 19171122 18494052 16935385 20512989 17978847 16830150 18788625 18210153 18393292 21159647 19539802 16779866 20514400 11831363 16502159 18971187 16878318 19335982 16569478 16807293 17138121 3084413 17055752 17162532 18506893 20101231 16288022 16698587 17173139 17428255 17761372 19107877 19052882 19383236 16328049 20084675 20727157 20935162 20432363 19394651 18691550 18665156 18056438 20007298 16681979 20524982 16540662 18785209 18978308
MESH:D006528 Carcinoma, Hepatocellular Estradiol 35.9516924424
MESH:D006528 Carcinoma, Hepatocellular Estrogens 35.9515341023
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 35.9518930000 17045692 17971768 16332177 16799960 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 35.9516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 35.9517173139 20935162 1701930 6705139 20007298
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 35.9516507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 35.9516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 35.951917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4417123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 18.2012023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 18.2018414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung Disulfiram 18.2017026967
MESH:D002289 Carcinoma, Non-Small-Cell Lung docetaxel 18.2011894018
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 18.2012391285
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 18.2019233551
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3219014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.9818695887
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 5.9818507039
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6412490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 15.5420419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 15.5417066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell Curcumin 15.5418462866
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 15.5416280240 16757204 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 15.5418572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 15.5416051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0518850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Antimony 5.8110334427
MESH:D002311 Cardiomyopathy, Dilated Mercury 5.8110334427
MESH:D002318 Cardiovascular Diseases Genistein 2.9216332659
MESH:D002386 Cataract Acetaminophen 10.5110977129
MESH:D002386 Cataract Disulfiram 10.5117936468 15003327
MESH:D002386 Cataract Tretinoin 10.5117460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 30.536135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 30.5320889678
MESH:D002471 Cell Transformation, Neoplastic Cadmium 30.5317332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 30.5312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 30.532727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 30.5318566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 30.532727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 30.5319524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.724080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.7819052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.7816835633
MESH:D002779 Cholestasis Cyclosporine 10.9519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.9517681005 11677210 16919318 17333356 16105132 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 10.9519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.9015668235 12621046 8697196 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 4.909407595
MESH:D019970 Cocaine-Related Disorders Disulfiram 5.2019462300
MESH:D003092 Colitis Curcumin 7.8718200517 16782535 16804969
MESH:D003092 Colitis Tretinoin 7.8717035595
MESH:D003103 Coloboma Curcumin 4.0618809619
MESH:D003110 Colonic Neoplasms Curcumin 5.1216340194 19359593
MESH:D003110 Colonic Neoplasms Fluorouracil 5.1215001691 17169374 16510598 16340194 17725105 17016597 17172411 18772588 17287894 17018589
MESH:D003110 Colonic Neoplasms Genistein 5.1217182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.2820501625
MESH:D015179 Colorectal Neoplasms Cisplatin 4.2815273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.2816524972 17016601 16331619 18448328 17401013 17094418 18509181 17594712 16282729 14970324 18383874 18288408 16303861 17255274 20501625 15289873 15148649 18949393 16391804 18802399 17454858 17695437
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 4.2815531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6014669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.3618497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.3210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.3210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.329142499 10589399 9125849 8800419 9211117 17551590 9664655 16925845 9224671 14991402
MESH:D016638 Critical Illness Estrogens 5.4016670151
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.1218551238
MESH:D007644 Darier Disease Fluorouracil 4.2416733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.5915213294
MESH:D003704 Dementia Polychlorinated Biphenyls 4.2116140633
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8319031437
MESH:D017449 Dermatitis, Allergic Contact Mercury 6.0216823706
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 6.0216823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1518249437
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 11.8319647726
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 11.8318403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 11.8320387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 11.8316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 11.8317107852
MESH:D003928 Diabetic Nephropathies Curcumin 12.3618204486
MESH:D003928 Diabetic Nephropathies Estradiol 12.3619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.3619279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9617187935
MESH:D004283 Dog Diseases Antimony 5.1112019027
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.8921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.8918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.8916781746 16109766 14725611 11421492 12392966 17522070 16393943 10915739 16485898 10774834 2444490 19416960 15619225 16227642 12540782 11834606 11529661 18071297 11739529 11461765 19164858 17906064 19420014 16177239 17562736 19085960 19739265 12705907 14550746 14986274 19923254 15968718 12594235 16081117 10663392 12958197 12153990 11287661 19370779 11743745 18713872
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.8919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.8920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5419426721
MESH:D004362 Drug Toxicity Cisplatin 6.8012231392 12649298 19839026 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.8011462148
MESH:D004381 Duodenal Ulcer Curcumin 3.5317351913
MESH:D050171 Dyslipidemias Dietary Fats 3.0518367378
MESH:D004421 Dystonia Phenobarbital 3.501851702
MESH:D004487 Edema pirinixic acid 4.9512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 4.9512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.0915322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.0918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.3312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.3317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 12.3319031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.0416402032
MESH:D016889 Endometrial Neoplasms Estradiol 19.4111473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Ethylenethiourea 19.417955072
MESH:D016889 Endometrial Neoplasms Genistein 19.4111473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 19.4119155303 16202921 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 19.4116569247
MESH:D004715 Endometriosis Progesterone 7.3516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.3510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.573659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.323922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.5920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.086401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.727750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.473659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5616302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.1720426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 15.1712903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 15.1716530937
MESH:D004938 Esophageal Neoplasms Cisplatin 15.1716481741 15173087 17638652 15464296 16785472
MESH:D004938 Esophageal Neoplasms docetaxel 15.1716337965
MESH:D004938 Esophageal Neoplasms Fluorouracil 15.1716785472 17638652 15173087 16481741 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.4511564622
MESH:D005124 Eye Abnormalities Tretinoin 7.4516938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 34.7515073043
MESH:D005234 Fatty Liver Curcumin 34.7519297423
MESH:D005234 Fatty Liver Cyclosporine 34.7519224547
MESH:D005234 Fatty Liver Dietary Fats 34.7517967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 34.7520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.7515345470
MESH:D005234 Fatty Liver pirinixic acid 34.7520131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 34.7519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8816709447
MESH:D005264 Femoral Fractures zoledronic acid 5.2816234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6419069698
MESH:D005355 Fibrosis Curcumin 22.1018705752
MESH:D005355 Fibrosis Cyclosporine 22.1012168785 12639820
MESH:D005355 Fibrosis Dietary Fats 22.1018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.1020067830
MESH:D005355 Fibrosis Tretinoin 22.1017994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7416904648
MESH:D005756 Gastritis Acetaminophen 3.1216983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1618462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.678708960
MESH:D005909 Glioblastoma Curcumin 9.7917596214
MESH:D005909 Glioblastoma Genistein 9.7916598420
MESH:D005909 Glioblastoma Tretinoin 9.7917312396
MESH:D005910 Glioma Fluorouracil 2.6316145905
MESH:D006042 Goiter perchlorate 4.8018801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0410696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 15.3315464296 15102660
MESH:D006258 Head and Neck Neoplasms Curcumin 15.3318829502 18462866
MESH:D006258 Head and Neck Neoplasms Fluorouracil 15.3318337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 15.3316096774
MESH:D034381 Hearing Loss Cisplatin 3.8319898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6016084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 3.9715464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.2720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.2711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.279664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.1920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8411000095
MESH:D006529 Hepatomegaly Phenobarbital 11.3116109766
MESH:D006529 Hepatomegaly pirinixic acid 11.3118467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.3115340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5017701891
MESH:D006558 Herpes Genitalis Estradiol 4.4715709030
MESH:D006689 Hodgkin Disease Cisplatin 6.0316170182 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 6.0312676792
MESH:D019584 Hot Flashes Estradiol 3.2017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.498697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 10.6216870215
MESH:D006930 Hyperalgesia Tretinoin 10.6216870215
MESH:D006930 Hyperalgesia zoledronic acid 10.6216769263
MESH:D006934 Hypercalcemia zoledronic acid 4.5519622757 18089816
MESH:D006937 Hypercholesterolemia Curcumin 7.6118704882
MESH:D006937 Hypercholesterolemia Dietary Fats 7.6121332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0316778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.1121332399
MESH:D006973 Hypertension Cyclosporine 4.1510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.1518850075 18670907
MESH:D006980 Hyperthyroidism Methimazole 5.0914678291
MESH:D006996 Hypocalcemia zoledronic acid 5.6312669777
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2816945680 16569931
MESH:D007037 Hypothyroidism Methimazole 10.1818031379
MESH:D007037 Hypothyroidism Propylthiouracil 10.1818031379 8137927
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.2017937319
MESH:D007248 Infertility, Male Parathion 9.2016029889
MESH:D007248 Infertility, Male sodium arsenite 9.2012646999 15346721
MESH:D007249 Inflammation Curcumin 15.9318403477 17151092 16956363
MESH:D007249 Inflammation Dietary Fats 15.9320412841
MESH:D007249 Inflammation Diethylnitrosamine 15.9318785209
MESH:D007249 Inflammation Progesterone 15.9315869954
MESH:D007249 Inflammation Tamoxifen 15.9319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.9312200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9618200517 18596194
MESH:D007333 Insulin Resistance bisphenol A 14.5716393666
MESH:D007333 Insulin Resistance Dietary Fats 14.5711836018 18457598
MESH:D007333 Insulin Resistance Estradiol 14.5716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 14.5716306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2417994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.7410783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.3015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8815604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.5815464296
MESH:D007674 Kidney Diseases Acetaminophen 37.1815629191 12587719
MESH:D007674 Kidney Diseases Cadmium 37.1816962696 16322080 16226777
MESH:D007674 Kidney Diseases Cadmium Chloride 37.1816962696
MESH:D007674 Kidney Diseases Chromium 37.1817934191
MESH:D007674 Kidney Diseases Cisplatin 37.1812231392 12649298 19839026 15190930 18289764
MESH:D007674 Kidney Diseases Cyclosporine 37.188314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 37.1815618244
MESH:D007674 Kidney Diseases Mercury 37.1817934191
MESH:D007674 Kidney Diseases Potassium Dichromate 37.1819665454
MESH:D007674 Kidney Diseases sodium arsenite 37.1820008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 23.3116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 23.3116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 23.3112371664
MESH:D007680 Kidney Neoplasms Estradiol 23.3115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 23.3116985049
MESH:D007680 Kidney Neoplasms Tamoxifen 23.3118625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.2411231351
MESH:D007889 Leiomyoma Curcumin 4.0718555241
MESH:D007896 Leishmaniasis Antimony 4.3521063981 15220340 12019027 21182181 10953559
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.2211475954 8889330 19141829
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 4.949643325 10881086 11370249 7854095 10651420
MESH:D007898 Leishmaniasis, Visceral Antimony 7.338142506 11105143 7854095 20495762 7875148 1899875 7554475
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 7.3312707265
MESH:D007938 Leukemia arsenic trioxide 12.5115070760
MESH:D007938 Leukemia Curcumin 12.5118462866
MESH:D007938 Leukemia Genistein 12.5117468513 18980019
MESH:D007938 Leukemia Tretinoin 12.5117143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Disulfiram 3.9317026967
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 13.5312560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 13.5316106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 13.5318089816
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.7616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.0214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 7.8419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 7.8416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.4616467208 16968895 17050201 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.4617596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 10.749834237
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 10.7416891316 17649720 16330433 12712474 12018890 11468182 15213294 16823087 17217047 19035177 15336539 19642359 15622746 17107899 16966277 9834237 16331271 16112521 19225113 17712046 17869043 19075265 11161223 15748426 12679006
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 10.7416891316 16766008 17712046 17217047 19035177 19029980 17361223 17506722 17649720 12679006 16823087 16331271 17294898 15748426 16140955 17368321 19642359 17301526 17339181 19225113 16788101 16935935 9834237 19075265 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 9.9816882451
MESH:D015458 Leukemia, T-Cell Curcumin 9.9816106398
MESH:D017880 Limb Deformities, Congenital Disulfiram 7.3117676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.319224671
MESH:D008064 Lipidoses Tamoxifen 2.7615342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 9.1418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.1420032147 19638242 18665156 18407596 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 9.1421047994
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 9.5017355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 9.5014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 9.5017823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 9.5018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 9.5016248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 7.9319784758 11587558 19014921 12587719 12969438 16611625 19460945 16610002
MESH:D008107 Liver Diseases Curcumin 7.9316956363
MESH:D008107 Liver Diseases Diethylnitrosamine 7.9317034775
MESH:D008107 Liver Diseases Phenobarbital 7.9319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 37.007678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 37.009163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 37.0014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 37.0020195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 37.0018648771 19850985 21278145 19255062 19499222 19551842 19638242 21167192 20137499 19996281 19812893 10737359 18754104 2422723 18977376 19090486 2862719 21047994 19426721 15885732 19254457 20583210 15175105 19833225 12112319 19427195 19690152 20405173 20101389 20492335 21071580 18644402 12771043 9163691 19642983 19256749 20452335 20434301 19294768 16942905 20118626 19073162 20501860 18978307
MESH:D008113 Liver Neoplasms Ethylenethiourea 37.0011940454
MESH:D008113 Liver Neoplasms Fluorouracil 37.0018383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 37.0019812893 21047994 15975961 8742319 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 37.0020007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 37.0016712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 37.0016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 37.0016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 22.762876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 22.768603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 22.7620377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.7619126423 19519916 3124819 19009564 2563599 18544905 18775883 16267830 16842330 9362446 18093689 19539802 18308698 18079962 18282651 17174075 18253720 19004024 18164116 17942915 21159647 17854601
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 22.762563599 6150874 18308698 1399818 17172636
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 22.761423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.7612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.9315213294
MESH:D008171 Lung Diseases sodium arsenite 2.7919095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 15.8914755239
MESH:D008175 Lung Neoplasms arsenic trioxide 15.8919825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 15.8920464547 20064080 18816296 20869020 18569708 17053015 6695378 18520028 20135361
MESH:D008175 Lung Neoplasms Cisplatin 15.8917225452 11798837 6189445
MESH:D008175 Lung Neoplasms Curcumin 15.8919359593 18462866 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 15.896695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 15.8915246190
MESH:D008175 Lung Neoplasms sodium arsenite 15.8917306315 15276417 16712894 17077188 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 15.8918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.8911884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2415086387
MESH:D008223 Lymphoma Curcumin 3.1918462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.1616173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.9416891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 14.9412929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 14.9411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.9411731420 19196722 19196723 16827153 14580682
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 14.9417312309
MESH:D020149 Manganese Poisoning Estradiol 10.7919453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.7919453300
MESH:D008527 Medulloblastoma Tretinoin 2.5417453147
MESH:D008545 Melanoma Cisplatin 13.4318176117 12883367 12393984 15577323 16432458 16809738 11135225 17761969 12374674 17023156 18505091 18332650 16248763
MESH:D008545 Melanoma Curcumin 13.4317885582 18462866
MESH:D008545 Melanoma Disulfiram 13.4315367699
MESH:D008545 Melanoma docetaxel 13.4312417787
MESH:D008545 Melanoma sodium arsenite 13.4316487513 19082730
MESH:D008545 Melanoma Tamoxifen 13.4319393235 12393984
MESH:D008545 Melanoma Tretinoin 13.4316752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 9.6915990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 9.6915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0319513568
MESH:D008569 Memory Disorders Curcumin 3.6417263510
MESH:D008591 Meningomyelocele Tretinoin 3.8916940565
MESH:D008654 Mesothelioma Cisplatin 5.8817638057
MESH:D008654 Mesothelioma zoledronic acid 5.8816675582
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2316801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.3417671175
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.1116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.1116757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 9.9619417148 15949261 19549372 14977855 11468182
MESH:D009101 Multiple Myeloma Curcumin 9.9619372569
MESH:D009101 Multiple Myeloma zoledronic acid 9.9616996129 18089719 19621390
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.3717962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.1118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.2716105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.2717596541
MESH:D009203 Myocardial Infarction Genistein 4.8217141266
MESH:D009203 Myocardial Infarction pirinixic acid 4.8219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.7016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 11.7017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 11.7016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.5318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.5318551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 14.4216624393
MESH:D009361 Neoplasm Invasiveness Curcumin 14.4218495463
MESH:D009361 Neoplasm Invasiveness Disulfiram 14.4218047805
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 11.633581430 9029167
MESH:D009362 Neoplasm Metastasis Disulfiram 11.6315367699
MESH:D009362 Neoplasm Metastasis Tamoxifen 11.6319393235
MESH:D009362 Neoplasm Metastasis zoledronic acid 11.6315867366 17312309 19139120
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 19.4711141357
MESH:D009369 Neoplasms Cisplatin 19.4716773208
MESH:D009369 Neoplasms Disulfiram 19.4717079463
MESH:D009369 Neoplasms Fluorouracil 19.4718600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 19.4717405874
MESH:D009369 Neoplasms sodium arsenite 19.4711559025
MESH:D009369 Neoplasms Tretinoin 19.4716594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.1420056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 8.9912497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 8.9919196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Disulfiram 8.6515367699
MESH:D009389 Neovascularization, Pathologic Estradiol 8.6517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 3.9415464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8218481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 25.2411399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 25.2411399458 16427766
MESH:D009421 Nervous System Malformations Genistein 25.2416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.2414600291
MESH:D009421 Nervous System Malformations Tretinoin 25.249125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.0718462866
MESH:D009436 Neural Tube Defects arsenic trioxide 9.9910525206
MESH:D009436 Neural Tube Defects sodium arsenite 9.9912854658
MESH:D009436 Neural Tube Defects Tretinoin 9.999142499
MESH:D009447 Neuroblastoma Cisplatin 3.158761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.6918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.6920387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.158761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5620387270
MESH:D020258 Neurotoxicity Syndromes Disulfiram 11.4111005259
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 11.4116436463
MESH:D020258 Neurotoxicity Syndromes Malathion 11.4115081274
MESH:D009765 Obesity Curcumin 6.4419297423
MESH:D009765 Obesity Dietary Fats 6.4421332399 20518802 17217161 11836018 19632207 16723640 18457598 20132043 18674790
MESH:D009765 Obesity pirinixic acid 6.4420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.3016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.3016049721
MESH:D010014 Osteolysis zoledronic acid 4.8215867366
MESH:D010018 Osteomalacia Phenobarbital 3.8217016548
MESH:D010024 Osteoporosis Curcumin 9.9818719352
MESH:D010024 Osteoporosis Genistein 9.9819401787
MESH:D010024 Osteoporosis zoledronic acid 9.9817882678
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.5816169203
MESH:D012516 Osteosarcoma Disulfiram 4.7418047805
MESH:D010049 Ovarian Diseases bisphenol A 4.4411985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 27.3919769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Cisplatin 27.396897625 17225452 15464296 19769630
MESH:D010051 Ovarian Neoplasms Curcumin 27.3918462866 19020741
MESH:D010051 Ovarian Neoplasms Disulfiram 27.3917026967
MESH:D010051 Ovarian Neoplasms Estradiol 27.3919401270
MESH:D010051 Ovarian Neoplasms Genistein 27.3919005980
MESH:D010051 Ovarian Neoplasms Progesterone 27.3916525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 27.3917306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 27.3916936753
MESH:D010146 Pain Acetaminophen 8.7716870215
MESH:D010146 Pain Tretinoin 8.7716870215
MESH:D010146 Pain zoledronic acid 8.7716475674
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 21.3415580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 21.3419003803
MESH:D010190 Pancreatic Neoplasms Curcumin 21.3419196508 19401701 17440100
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 21.3416540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 21.3419003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 21.3416965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 21.3415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1811578682
MESH:D010235 Paraganglioma arsenic trioxide 3.6619927285
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.1716702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6912520081
MESH:D010409 Penile Diseases Antimony 5.209643325
MESH:D010493 Pericarditis Antimony 5.5620465667
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.7915464296
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.8315687053
MESH:D010997 Pleural Neoplasms Cisplatin 4.7817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0418163543
MESH:D011230 Precancerous Conditions Cyclosporine 12.5912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 12.592563599
MESH:D011230 Precancerous Conditions Phenobarbital 12.592563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 7.7010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.7011118676 11222880 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.9220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.9220887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 8.2219131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 8.2217292933
MESH:D011471 Prostatic Neoplasms bicalutamide 8.2215638997 19011039 18487222 17914592 19240160
MESH:D011471 Prostatic Neoplasms bisphenol A 8.2216740699
MESH:D011471 Prostatic Neoplasms Cadmium 8.2217075824
MESH:D011471 Prostatic Neoplasms Curcumin 8.2218769126 11398177 18156803 18226269 15129424 12497104 10851300
MESH:D011471 Prostatic Neoplasms Disulfiram 8.2219789329
MESH:D011471 Prostatic Neoplasms docetaxel 8.2218824434 16644109 16520278 19103299
MESH:D011471 Prostatic Neoplasms Estradiol 8.2216740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 8.2219082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 8.2215256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms methylselenic acid 8.2216205645
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 8.2215721890
MESH:D011471 Prostatic Neoplasms sodium arsenite 8.2216039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 8.2215067354
MESH:D011471 Prostatic Neoplasms zoledronic acid 8.2212438248 19103299
MESH:D011507 Proteinuria Tretinoin 3.1016636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 3.9412752131
MESH:D011565 Psoriasis Cyclosporine 2.0116882103
MESH:D011625 Pterygium Tretinoin 4.2416723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2410548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.0519168576
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5518722050 15538739 18286688 16160472
MESH:D051437 Renal Insufficiency Cisplatin 3.8815464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.1019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.5318379247 10666014
MESH:D012135 Respiratory Sounds Malathion 8.8611874814 17119214
MESH:D012135 Respiratory Sounds Parathion 8.8611874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3218990726
MESH:D012140 Respiratory Tract Diseases Malathion 9.6517119214
MESH:D012140 Respiratory Tract Diseases Parathion 9.6517119214
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.5916116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6418045962
MESH:D012509 Sarcoma Curcumin 3.6418462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 14.3816646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 14.3814601052
MESH:D012512 Sarcoma, Ewing's zoledronic acid 14.3816121404
MESH:D012640 Seizures 2,4-dinitrotoluene 7.5918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 7.5918551238
MESH:D012640 Seizures Phenobarbital 7.593137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.276407741
MESH:D018805 Sepsis Curcumin 3.6218389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.8710029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 14.8719524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.878532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.8716192470
MESH:D012878 Skin Neoplasms Tretinoin 14.8716467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.7815464296
MESH:D013088 Spermatocele Ethinyl Estradiol 9.7116709447
MESH:D013088 Spermatocele Tamoxifen 9.7116709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.0515862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.0519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3712854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 9.2117007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 9.2120155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 9.2115958060 17522103 18396642
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 9.2118456281
MESH:D013274 Stomach Neoplasms docetaxel 9.2116557585
MESH:D013274 Stomach Neoplasms Fluorouracil 9.2117172411 16424979 19084572 18396642 15786421 17522103 17498489 18567086 16951190 19015929
MESH:D013274 Stomach Neoplasms Tretinoin 9.2117261132
MESH:D013276 Stomach Ulcer Curcumin 3.0319188055 16631530
MESH:D019966 Substance-Related Disorders bisphenol A 3.4416045194 16684133
MESH:D013736 Testicular Neoplasms Cisplatin 4.1215464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 22.5819014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 22.587505956
MESH:D013964 Thyroid Neoplasms Ethylenethiourea 22.5811940454
MESH:D013964 Thyroid Neoplasms Phenobarbital 22.581399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 22.5815710170
MESH:D013964 Thyroid Neoplasms Tretinoin 22.5816026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.1319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.2416280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.2416051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.4215213294
MESH:D014352 Trypanosomiasis Antimony 5.3715220340
MESH:D014376 Tuberculosis Tretinoin 2.8716040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 24.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 24.1816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 24.1812973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 24.1817053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 24.1817225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms Curcumin 24.1818593936
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 24.1817306315 16452187 16712894 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 24.1816712894 8653321 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.7218462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.1710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.1710091137
MESH:D014581 Urticaria Acetaminophen 2.4810982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 18.7316803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 18.7316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 18.7311813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 18.7316129372
MESH:D014591 Uterine Diseases bisphenol A 4.4514652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.9714692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 7.9718645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.0516752155
MESH:D014605 Uveitis Cyclosporine 3.431336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.0815577323
MESH:D014652 Vascular Diseases sodium arsenite 3.8817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0412125929
MESH:D014689 Venous Insufficiency coumarin 5.2212708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0515869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.5416761959
MESH:D014839 Vomiting Cisplatin 4.1611897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6915886252
MESH:D015430 Weight Gain Dietary Fats 3.2716723640
MESH:D009396 Wilms Tumor Tretinoin 3.5016287080
MESH:D014947 Wounds and Injuries Estrogens 4.2911172683
MESH:D014985 Xerophthalmia Cyclosporine 3.8817120751
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
KEGG:03030 DNA replication
REACT:383 DNA Replication
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164742061
    • No data
    Releated disease ID Related disease Name
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA449957ibuprofen
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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