AutismKB 2.0

Annotation Detail for MCM6


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Basic Information Top
Gene Symbol:MCM6 ( MCG40308,Mis5,P105MCM )
Gene Full Name: minichromosome maintenance complex component 6
Band: 2q21.3
Quick LinksEntrez ID:4175; OMIM: 601806; Uniprot ID:MCM6_HUMAN; ENSEMBL ID: ENSG00000076003; HGNC ID: 6949
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03030DNA replication
hsa04110Cell cycle
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Cell Cycle Checkpoints
No data
No data
Pathway IDPathway Name
500964Removal of licensing factors from origins
500932Switching of origins to a post-replicative state
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1887Carcinoma
2067Primary tumor
No data
No data
Desease Name
Lactase persistance/nonpersistance
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of MCM6 mRNAincreases expression 15890375
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MCM6 mRNAincreases expression 18648102
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MCM6 mRNAincreases expression 15890375
D000082 Acetaminophen Acetaminophen affects the expression of MCM6 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of MCM6 mRNAincreases expression 15890375
C000188 alachlor alachlor results in increased expression of MCM6 mRNAincreases expression 12419858
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MCM6 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of MCM6 proteinincreases expression 19364129
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MCM6 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MCM6 mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of MCM6 mRNAincreases expression 16474171
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MCM6 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MCM6 mRNAaffects expression 17484886
D003345 Corticosterone Corticosterone results in decreased expression of MCM6 mRNAdecreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of MCM6 mRNAdecreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MCM6 mRNAincreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of MCM6 mRNAincreases expression 15890375
D004317 Doxorubicin Doxorubicin results in decreased expression of MCM6 mRNAdecreases expression 16243910
D004958 Estradiol Estradiol results in increased expression of MCM6 mRNAincreases expression 16474171
D004958 Estradiol Estradiol inhibits the reaction [Progesterone affects the localization of MCM6 protein]affects localization|decreases reaction 16966611
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MCM6 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MCM6 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MCM6 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MCM6 mRNAaffects expression 17351261
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of MCM6 mRNA]affects reaction|decreases expression 15016801
D019833 Genistein Genistein results in increased expression of MCM6 mRNAincreases expression 16474171
D008701 Methapyrilene Methapyrilene results in increased expression of MCM6 mRNAincreases expression 15890375
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of MCM6 mRNAincreases expression 20713471
C008493 methylselenic acid methylselenic acid affects the expression of MCM6 mRNAaffects expression 14617803
C008493 methylselenic acid methylselenic acid results in decreased expression of MCM6 mRNAdecreases expression 12517777
D010126 Ozone Ozone results in increased expression of MCM6 mRNAincreases expression 16716893
C093973 PD 98059 PD 98059 affects the expression of MCM6 mRNAaffects expression 14516785
C093973 PD 98059 PD 98059 affects the expression of MCM6 proteinaffects expression 14516785
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MCM6 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of MCM6 mRNAincreases expression 19363144
19482888
19270015
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of MCM6 mRNAincreases expression 15890375
C006253 pirinixic acid pirinixic acid results in increased expression of MCM6 mRNAincreases expression 17950772
16985257
18301758
18445702
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of MCM6 mRNA]increases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid results in increased expression of MCM6 mRNAincreases expression 15890375
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of MCM6 mRNAincreases expression 16474171
D011374 Progesterone Estradiol inhibits the reaction [Progesterone affects the localization of MCM6 protein]affects localization|decreases reaction 16966611
D011374 Progesterone Progesterone affects the localization of MCM6 proteinaffects localization 16966611
D011374 Progesterone Progesterone results in decreased expression of MCM6 mRNAdecreases expression 16966611
C059514 resveratrol resveratrol results in decreased expression of MCM6 mRNAdecreases expression 15767336
C488333 Ro 65-7199 Ro 65-7199 affects the expression of MCM6 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 results in increased expression of MCM6 mRNAincreases expression 14610520
D012402 Rotenone Rotenone results in increased expression of MCM6 mRNAincreases expression 19013527
D013629 Tamoxifen Tamoxifen results in increased expression of MCM6 proteinincreases expression 17098229
D013629 Tamoxifen [Tretinoin co-treated with Tamoxifen] results in increased expression of MCM6 proteinaffects cotreatment|increases expression 17098229
D013629 Tamoxifen Tamoxifen affects the expression of MCM6 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MCM6 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MCM6 mRNAdecreases expression 16611356
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MCM6 mRNAincreases expression 19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MCM6 proteindecreases expression 16548065
D014212 Tretinoin [Tretinoin co-treated with Tamoxifen] results in increased expression of MCM6 proteinaffects cotreatment|increases expression 17098229
D014212 Tretinoin Tretinoin results in increased expression of MCM6 proteinincreases expression 17098229
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1314745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.956195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.9515322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5317505938
MESH:D058186 Acute Kidney Injury resveratrol 3.4916538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.7518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 22.7019825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 22.7020127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 22.7016033868
MESH:D000230 Adenocarcinoma Doxorubicin 22.7017418594
MESH:D000230 Adenocarcinoma Estradiol 22.7011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 22.7014692618
MESH:D000230 Adenocarcinoma Fluorouracil 22.7017638652
MESH:D000230 Adenocarcinoma Genistein 22.7011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 23.123712494
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 23.1216176798
MESH:D000236 Adenoma Benzo(a)pyrene 23.126695378
MESH:D000236 Adenoma Dimethylnitrosamine 23.1219555203
MESH:D000236 Adenoma Methylcholanthrene 23.126695378 10545420
MESH:D000236 Adenoma resveratrol 23.1215688382
MESH:D018248 Adenoma, Liver Cell Phenobarbital 14.9317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.9316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.9316835633
MESH:D000382 Agricultural Workers' Diseases alachlor 4.2614769641 11874814
MESH:D000419 Albuminuria Doxorubicin 4.1621441931
MESH:D000505 Alopecia Tretinoin 3.2915955085
MESH:D000544 Alzheimer Disease Ozone 4.0315513908
MESH:D000544 Alzheimer Disease resveratrol 4.0316162502 16183991
MESH:D000686 Amyloidosis Diethylstilbestrol 4.0915469931
MESH:D000740 Anemia Fluorouracil 7.5115504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5111748828
MESH:D000799 Angioedema Acetaminophen 3.4310982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.7915885639
MESH:D001169 Arthritis, Experimental resveratrol 10.7917115116
MESH:D001169 Arthritis, Experimental Tretinoin 10.7916412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.3015570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.3016292516
MESH:D001249 Asthma Ozone 4.4917854713 16373670
MESH:D001249 Asthma Tretinoin 4.4916456186
MESH:D050197 Atherosclerosis Methylcholanthrene 6.1411922910
MESH:D050197 Atherosclerosis resveratrol 6.1417967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001471 Barrett Esophagus Tretinoin 4.0216935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.601440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 18.9716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 18.9719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 18.9712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 18.9716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5015746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2814601052
MESH:D001862 Bone Resorption bisphenol A 3.5011985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9217868700
MESH:D001930 Brain Injuries Progesterone 3.8615665606 15380490 15845082
MESH:D002545 Brain Ischemia resveratrol 3.8817600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.4617150277
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 11.9320146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.9317474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 11.9317123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 11.9315324884 17129689
MESH:D001943 Breast Neoplasms Doxorubicin 11.9315668708 15994142 15634643 15136595 17983394 15692762 18382427 16826403 16595493 18628466 17369602 15939500 17426702 15993339 16115903 16264153 15567936 19526202 18234424 18695136 11325840 16096432 16935488 16322301
MESH:D001943 Breast Neoplasms Estradiol 11.9318497071 16675129 17261762 12948864 14630087 17289903 19861407 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 11.9315136595 16110121 19217205 18357371 18608205 16557594 16595493
MESH:D001943 Breast Neoplasms Genistein 11.9316873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylcholanthrene 11.9317474063
MESH:D001943 Breast Neoplasms Progesterone 11.9317614352 15562024 16175315
MESH:D001943 Breast Neoplasms resveratrol 11.9316393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 11.9318997820 15565566 19103187 19155303 19066611 19189212 17261762 20135344 20005174 19189210 18821012 19115204 18984771 16873071 16273361 16202921 17049068 19084267 19244106 15668708 19059307 11161223 19288272 20544844 17242785 18351453 21138602 19011961 18629630 17893378 20065188 18815881 19487384 19142967 19289846 19221464 19410462 18855134 17440819 20390343 21152245 19200415 18425577 16818667 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.9320435547
MESH:D001943 Breast Neoplasms Tretinoin 11.9316443354 16166294 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3618417511 17626835 15516495 18315731 19059883 14754758 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9511589617
MESH:D002100 Cachexia Ozone 4.3316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3816011737 16227642 3786805 15700767 16192424 16050911 18705752 15721981 10355542 15673190 16124888 16097048
MESH:D002276 Carcinoid Tumor Doxorubicin 10.9716051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.9716051944
MESH:D002277 Carcinoma Dimethylnitrosamine 17.3319555203
MESH:D002277 Carcinoma Fluorouracil 17.3317121937
MESH:D002277 Carcinoma Methylcholanthrene 17.3310545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 17.3316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1119066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7416168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 33.967296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 33.963084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 33.9612907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 33.9615553829 11135700 14691202 15073043 16217749
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 33.9618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 33.9616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 33.9616023760 18059187 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 33.9616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 33.9618930000 16332177 16799960 17045692 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 33.9616924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 33.9617173139 20007298 6705139 1701930 20935162
MESH:D006528 Carcinoma, Hepatocellular resveratrol 33.9616227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 33.9616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 33.961917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.5817123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.1916675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4619014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 9.617296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 9.6116201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.6118695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7612490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 16.3420419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 16.3416033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 16.346189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 16.3416757204 16280240 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell resveratrol 16.3416227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 16.3416096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1416120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.2617007740 15505089 16242529 18627295 15792986 17351982 17928571 16651473 17924179 17308081 16952015 16269455 15811867 16109756 17329180 17519947 16612575 17382496 16455267 15476868 16278810 17131338 17974986 16364871 16731534
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8016243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 6.5716332659
MESH:D002318 Cardiovascular Diseases resveratrol 6.5715458977
MESH:D002386 Cataract Acetaminophen 6.4110977129
MESH:D002386 Cataract Tretinoin 6.4117460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 18.107505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 18.1020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.1012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.1018566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 18.1016192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.854080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.7419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 16.7419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.7417681005 17110522 16919318 17333356 16105132 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 16.7419176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7416461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.1615668235 8697196 12621046 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.169407595
MESH:D003092 Colitis resveratrol 8.3116474422
MESH:D003092 Colitis Tretinoin 8.3117035595
MESH:D003110 Colonic Neoplasms Fluorouracil 5.3717018589 17725105 18772588 16510598 17287894 15001691 17169374 16340194 17016597 17172411
MESH:D003110 Colonic Neoplasms Genistein 5.3717182828
MESH:D003110 Colonic Neoplasms resveratrol 5.3716338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 5.9820501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 5.9818802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 5.9817255274 18288408 16524972 16282729 18383874 16391804 17454858 18949393 15148649 14970324 18802399 18448328 16331619 15289873 18509181 17594712 17094418 17016601 16303861 17695437 20501625 17401013
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 5.9815531428
MESH:D015179 Colorectal Neoplasms resveratrol 5.9816550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7217141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.4916507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.4710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.478800419 10589399 9664655 17551590 9125849 16925845 9142499 9211117 14991402 9224671
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.1712952375 16002989
MESH:D007644 Darier Disease Fluorouracil 4.3816733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7215213294
MESH:D003704 Dementia Polychlorinated Biphenyls 4.3416140633
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9619031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.048970840 2524372 11298694 14531868 18759878 11906362 12868966 8156756
MESH:D017449 Dermatitis, Allergic Contact alachlor 6.048428444
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.123621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.4416873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 3.9516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9517107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.0519279558
MESH:D003928 Diabetic Nephropathies resveratrol 13.0516286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.0519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0917187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 13.488291058 9022650 18692083 6482804 18289764 9328219 9653073 18648102 11289319 7440962 16192314 6679447 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.4815968718 16781746 10663392 14725611 16485898 11834606 19164858 16109766 15619225 19085960 18713872 10915739 11739529 11461765 10774834 18071297 14550746 11287661 11421492 12705907 19420014 12958197 2444490 16081117 12540782 16177239 19370779 16227642 12594235 19416960 17562736 14986274 12153990 19739265 17522070 17906064 12392966 19923254 11529661 16393943 11743745
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.484309450 19336974 9327722 15027814 2869522 7179309 19085960 21278145 16177239 15998439 16227642 3786805 17522070 6623471 15968718 3732212 7440962 10092053 10915739 7120509 11566570 6884620
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 13.488172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 13.4817416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.4820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6819426721
MESH:D004362 Drug Toxicity Doxorubicin 7.1118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.1111462148
MESH:D004421 Dystonia Phenobarbital 3.631851702
MESH:D004487 Edema pirinixic acid 9.3612083418
MESH:D004487 Edema resveratrol 9.368985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.3612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.5616714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.5618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 18.7612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 18.7617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 18.7617872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 18.7619031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.5416402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.5416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 25.6115700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 25.6117359293
MESH:D016889 Endometrial Neoplasms Estradiol 25.6118566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 25.6111473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 25.6117893378 19155303 20544844 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 25.6116569247
MESH:D004715 Endometriosis Progesterone 7.7616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.769294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7418037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4517923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.713659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.463922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.206401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.857750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.613659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 15.903581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.9020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 15.9012903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 15.9016530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 15.9017016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 15.9015173087 16481741 16337965 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.8311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.839664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 26.0015073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 26.0061145 15959796 17595544 16239168 16045604 12631006 19224547 12795759
MESH:D005234 Fatty Liver Cyclosporine 26.0019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 26.0015345470
MESH:D005234 Fatty Liver pirinixic acid 26.0020131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 26.0019224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.3716534752 16611131 16002989 16513791 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.606705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1214745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.0919069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.0919069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.5314633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 17.8718705752
MESH:D005355 Fibrosis Cyclosporine 17.8712168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.8720067830
MESH:D005355 Fibrosis Tretinoin 17.8717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8816904648
MESH:D005756 Gastritis Acetaminophen 3.2616983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.5416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.818708960
MESH:D005909 Glioblastoma Doxorubicin 10.3717150277
MESH:D005909 Glioblastoma Genistein 10.3716598420
MESH:D005909 Glioblastoma Tretinoin 10.3717312396
MESH:D005910 Glioma Fluorouracil 2.7016145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.667505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1810696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 11.3715692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.3715162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 11.3716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7416084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.8020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.8011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.8014991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.2017875725 16144979 18006777 16707910 16244372 12587719 16495754 16879835 14766674 16330681 18674790 17888722 16244371
MESH:D006333 Heart Failure Doxorubicin 6.2017481944
MESH:D006333 Heart Failure pirinixic acid 6.2020558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5415692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 7.946705139
MESH:D006505 Hepatitis Carbon Tetrachloride 7.9419110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 12.0916109766
MESH:D006529 Hepatomegaly pirinixic acid 12.0919176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.0915340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.6215709030
MESH:D006561 Herpes Simplex resveratrol 3.7816876885
MESH:D006689 Hodgkin Disease Doxorubicin 3.0815147373 18501091 17606976
MESH:D019584 Hot Flashes Estradiol 3.3417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.638697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.5716870215
MESH:D006930 Hyperalgesia Tretinoin 6.5716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1216899240
MESH:D006937 Hypercholesterolemia resveratrol 3.6517188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1716778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8320558911
MESH:D006949 Hyperlipidemias resveratrol 3.6616873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.5115034207
MESH:D006965 Hyperplasia Diethylstilbestrol 9.5112960047 14722030
MESH:D006973 Hypertension Cyclosporine 4.3910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.3918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6915338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9517488730
MESH:D007021 Hypospadias Diethylstilbestrol 9.9216002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.9216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.1615869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.1617600658
MESH:D007246 Infertility Diethylstilbestrol 3.9715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0912013081
MESH:D007248 Infertility, Male alachlor 6.1616466525 12948887 17049205
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1617937319
MESH:D007249 Inflammation Progesterone 10.1515869954
MESH:D007249 Inflammation resveratrol 10.1516366677
MESH:D007249 Inflammation Tamoxifen 10.1519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.1512878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.1316624496
MESH:D007333 Insulin Resistance bisphenol A 10.7516393666
MESH:D007333 Insulin Resistance Estradiol 10.7516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 10.7516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.3717994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.609022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.7216580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.7215992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0315604871
MESH:D007674 Kidney Diseases Acetaminophen 12.4412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 12.4418776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 12.4416775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 12.4415618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.7916707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 24.836582329
MESH:D007680 Kidney Neoplasms Cyclosporine 24.8312371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 24.8315003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 24.8315610895
MESH:D007680 Kidney Neoplasms Fluorouracil 24.8316985049
MESH:D007680 Kidney Neoplasms Tamoxifen 24.8318625569
OMIM:223100 LACTOSE INTOLERANCE, ADULT TYPE marker/mechanism
MESH:D007859 Learning Disorders Diethylstilbestrol 3.6717184923
MESH:D007938 Leukemia alachlor 13.2714769641
MESH:D007938 Leukemia arsenic trioxide 13.2715070760
MESH:D007938 Leukemia Genistein 13.2718980019 17468513
MESH:D007938 Leukemia Tretinoin 13.2717143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7416085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 10.3716972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 10.3716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.2719077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.2716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.5917050201 19850784 16968895 20471514 16467208
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.5917596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 11.2212712474 16966277 15622746 16330433 11468182 19642359 17649720 12679006 19035177 11161223 16112521 19225113 15213294 17107899 9834237 15748426 16891316 16331271 17712046 17217047 17869043 12018890 19075265 15336539 16823087
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 11.2216087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 11.2217107899 16935935 16891316 15748426 9834237 16331271 16788101 17368321 17339181 17301526 19075265 17712046 17649720 12679006 16823087 17217047 19035177 19029980 17294898 16766008 17361223 19225113 19642359 17506722 16140955
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9716882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.029224671
MESH:D008064 Lipidoses Tamoxifen 2.8717567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.8617334410 16221502 16943688 17157831 11408273 11903743 17174718 21278145 16239168
MESH:D008103 Liver Cirrhosis Phenobarbital 5.8621047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.4912586293 14716496 18317297 17481882 12609069 12898905 18481824 15338365 17640975 17805973 15362042 17714472 16033810 12649538 16192424 14512876 12667390 16136751 18339082 12389079 18187930 18376398 18166357 17976157 17565644 18251166 18418968 18006644 12445421 15931870 15123356 12632514 16097048 18263696 16027843 18054572 16248980 14620537 17766677 15925388 17900296 12546737 13678700 12445418 14724832 16011737 12632512 18472332 17631135 16015684 17944888 14748882 18395095 17698563 18205269 17823541 18210741 15052691 18395914 15673190 16116963 17708605 18705752 15730626 15057751 17761835 11481614 15959796 18420326 15818738 14716833 18412020 15876570 18277467 20821823 15370692 15996030 17922224 12958196 12666154 17525996 17869086 18429990 17557913 17721639 16638106 12741479 18472094 18279442 15893842 10355542 15650968 18156304
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 14.4918629640 16009107 15504291 17719030 15793283 15723089 15798949 17201889 15744066 17203207 15067225 15383259 15366600 16627068 17666798 16169303 15081153 14726149 18672772 15369754 17640959 14643895 17881167 15577212 16544323 18095165 15842777 15591649 18567088 16603200 15298665 18239293 17465448 15571005 17196135 16570917 18210741 17198567 17348192 14568256 17432682 15161499 15339415 17724770 18364076 18371158 14659978 18237412 16042886 16270385 17534399 12925901 15733078 15099470 18637143 15479170 15492853 15138612 14709902 15763062 12918455 17036385 15086199 15942678 15864749
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 14.4916595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.4914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 14.4917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.4918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 14.4916248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 5.7819460945 16611625 12969438 11587558 12587719 16610002 19014921 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.7815720792 16964402 17285989 16246199 15830285
MESH:D008107 Liver Diseases Phenobarbital 5.7819363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.2317185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.2316899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 14.2317457977
MESH:D008113 Liver Neoplasms 2-nitrofluorene 56.7515890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 56.7515890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 56.7515890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms arsenic trioxide 56.7514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 56.7520195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 56.7519294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 56.7516712894 15890375
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 56.7515890375 3113478
MESH:D008113 Liver Neoplasms Fluorouracil 56.7516603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms Methapyrilene 56.7515890375
MESH:D008113 Liver Neoplasms Phenobarbital 56.7519812893 8742319 19482888 19073162 15975961 21047994
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 56.7515890375 20101389 19690152 18648771
MESH:D008113 Liver Neoplasms pirinixic acid 56.7515890375 20007298 16377806
MESH:D008113 Liver Neoplasms resveratrol 56.7519812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms Tamoxifen 56.7516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 56.7516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 38.09598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 38.098603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 38.0920377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 38.0912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 38.091848544 15603536 6150874
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 38.0917085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 38.09598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 38.092563599 1399818 6150874 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 38.091423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 38.0912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0415213294
MESH:D008171 Lung Diseases Ozone 3.108266340 19066396
MESH:D055370 Lung Injury Ozone 3.4620417186
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 19.1119931552 12438228 15893417 18813816 18508827 16401635 14755239 9255578 16061637 15172992 17139156
MESH:D008175 Lung Neoplasms Aflatoxin B1 19.1114755239
MESH:D008175 Lung Neoplasms arsenic trioxide 19.1111798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 19.1120135361 18569708 18520028 18816296 17053015 20464547 20064080 20869020 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 19.1119555203 11884234 16061637
MESH:D008175 Lung Neoplasms Doxorubicin 19.116189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 19.1115246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 19.1120512841 10545420 1399818 21163286 16271038 20970405 15390079 6695378 11893704 16337739 17909032 9230183 7750092
MESH:D008175 Lung Neoplasms Ozone 19.117614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 19.1118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 19.1111884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3815086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.7415166399
MESH:D008223 Lymphoma Diethylstilbestrol 6.7815700306
MESH:D008223 Lymphoma Doxorubicin 6.7816098063
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9317088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.7817654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 7.7814749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1715621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1016002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.6515688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.6519428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 24.4412807724
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 24.4415458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 24.4411807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 24.4414578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 24.4417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 24.448985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 24.4416827153 14580682 19196723 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.2719453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.2719453300
MESH:D008527 Medulloblastoma Tretinoin 2.6217453147
MESH:D008545 Melanoma Doxorubicin 6.6116827129
MESH:D008545 Melanoma resveratrol 6.6117992120
MESH:D008545 Melanoma Tamoxifen 6.6112393984 19393235
MESH:D008545 Melanoma Tretinoin 6.6116752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1719513568
MESH:D008591 Meningomyelocele Tretinoin 4.0316940565
MESH:D008654 Mesothelioma Doxorubicin 2.8917638057
MESH:D008659 Metabolic Diseases resveratrol 4.0117112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3716801185
MESH:D008679 Metaplasia Ozone 4.6910496685
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1315792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.5016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.5016757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.3817415656
MESH:D009101 Multiple Myeloma alachlor 10.6214769641
MESH:D009101 Multiple Myeloma arsenic trioxide 10.6219549372 19417148 14977855 11468182 15949261
MESH:D009101 Multiple Myeloma resveratrol 10.6216490592 17164350 17049120 17935668 14749477 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.4617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1116239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.5916105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.5917596541
MESH:D009203 Myocardial Infarction Doxorubicin 12.0815857846 19429709
MESH:D009203 Myocardial Infarction Genistein 12.0817141266
MESH:D009203 Myocardial Infarction pirinixic acid 12.0819151258
MESH:D009203 Myocardial Infarction resveratrol 12.0816456233 16317513 16525036 17125593 17188708 17015251
MESH:D017202 Myocardial Ischemia resveratrol 7.9417125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.9412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.3716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.3717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.3716411023
MESH:D009205 Myocarditis resveratrol 4.3517322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0717484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5716624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.493581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.4918259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.4919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 13.4711141357
MESH:D009369 Neoplasms Diethylstilbestrol 13.4715313581
MESH:D009369 Neoplasms Fluorouracil 13.4718239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 13.4717405874
MESH:D009369 Neoplasms Tretinoin 13.4716946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 3.618985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5919189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3317289903
MESH:D009401 Nephrosis Doxorubicin 4.3716899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.1618481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.1616889571 15640375
MESH:D009410 Nerve Degeneration Rotenone 3.5715790535 17356569 18619942
MESH:D009421 Nervous System Malformations bisphenol A 33.2516427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 33.2511399458
MESH:D009421 Nervous System Malformations Estradiol 33.2516427766 11399458
MESH:D009421 Nervous System Malformations Genistein 33.2516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 33.2514600291
MESH:D009421 Nervous System Malformations Tretinoin 33.259125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 10.566679447
MESH:D009436 Neural Tube Defects arsenic trioxide 10.5610525206
MESH:D009436 Neural Tube Defects Tretinoin 10.569142499
MESH:D009447 Neuroblastoma Doxorubicin 3.0515555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.2618514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.2617652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.0217929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1616436463
MESH:D009669 Nose Neoplasms alachlor 4.4216698726 11127290 15580706 14563481 16178123
MESH:D009765 Obesity pirinixic acid 1.7120558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.074026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.603988306
MESH:D010018 Osteomalacia Phenobarbital 3.9617016548
MESH:D010024 Osteoporosis Genistein 3.0019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 8.9116169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.9117513867
MESH:D012516 Osteosarcoma Doxorubicin 3.7915930896
MESH:D010049 Ovarian Diseases bisphenol A 4.5811985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.4619769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 13.4619401270
MESH:D010051 Ovarian Neoplasms Genistein 13.4619005980
MESH:D010051 Ovarian Neoplasms Progesterone 13.4616525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 13.4616936753
MESH:D010146 Pain Acetaminophen 5.5116870215
MESH:D010146 Pain Tretinoin 5.5116870215
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 14.6312384795
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 14.6315580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 14.6315113037 16500647 16929163 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 14.6316965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.6315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.097296757
MESH:D010235 Paraganglioma arsenic trioxide 3.7919927285
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 5.2516702228
MESH:D010300 Parkinson Disease Rotenone 5.2519232380 16412576 19114014 16140633 11535288 18191903 18619942 15451049 11445065
MESH:D020734 Parkinsonian Disorders Rotenone 3.7315574749 15795934 18197244 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8312520081
MESH:D010538 Peritonitis Ozone 3.7416369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.066228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7417983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.7514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.2715687265 16977796
MESH:D010997 Pleural Neoplasms Doxorubicin 4.7417638057
MESH:D011014 Pneumonia Ozone 3.9918381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1718163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.8412371664
MESH:D011230 Precancerous Conditions Phenobarbital 7.842563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 19.9210548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 19.9217184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 19.9216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.9211896295 11399792 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.3420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.3420887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 4.7419131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 4.7417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 4.7416740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 4.7417136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 4.7418437689 15749863 15897917 16888761 16868541 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 4.7416740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 4.7418626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 4.7415256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms methylselenic acid 4.7416205645
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 4.7415721890
MESH:D011471 Prostatic Neoplasms resveratrol 4.7417675339 15767336 17804756 16731767 17636462 17718901
MESH:D011471 Prostatic Neoplasms Tamoxifen 4.7415067354
MESH:D011507 Proteinuria Tretinoin 3.2316636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9115861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.0812752131
MESH:D011565 Psoriasis Cyclosporine 2.0816882103
MESH:D011625 Pterygium Tretinoin 4.3816723453
MESH:D011629 Puberty, Precocious bisphenol A 4.3810548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6718286688 16160472 18722050 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 3.8317922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1716325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.8819058328
MESH:D015427 Reperfusion Injury resveratrol 5.8817520802 16314181 15827377 16317513 17058453
MESH:D012135 Respiratory Sounds alachlor 4.5511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.073692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7316283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7018045962
MESH:D012509 Sarcoma Doxorubicin 3.6415625365 18313854 17203757 16767912 17710206 15675481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.0016646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.0016326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3817846226
MESH:D012640 Seizures Phenobarbital 2.433137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.416407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 19.8510029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 19.8515692506
MESH:D012878 Skin Neoplasms resveratrol 19.858985016 15837718
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 19.858532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 19.8516192470
MESH:D012878 Skin Neoplasms Tretinoin 19.8516467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1717203757 16767912 15625365
MESH:D013088 Spermatocele Diethylstilbestrol 17.7316709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 17.7316709447
MESH:D013088 Spermatocele Tamoxifen 17.7316709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.5216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.5219457130
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.8512587719
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.8717007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.8720155912 2093021
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 5.8716033868
MESH:D013274 Stomach Neoplasms Fluorouracil 5.8716424979 16951190 17522103 19015929 19084572 18396642 15786421 18567086 17498489 17172411
MESH:D013274 Stomach Neoplasms Tretinoin 5.8717261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1316321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.5816684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 24.043712494 6582329 7505956 6587162 1399818
MESH:D013964 Thyroid Neoplasms alachlor 24.048812207
MESH:D013964 Thyroid Neoplasms arsenic trioxide 24.0419014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 24.0416010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 24.041399818
MESH:D013964 Thyroid Neoplasms Tretinoin 24.0416026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.2719048282
MESH:D014062 Tongue Neoplasms Fluorouracil 14.5416280240
MESH:D014062 Tongue Neoplasms resveratrol 14.5416227395
MESH:D014062 Tongue Neoplasms Tretinoin 14.5416051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5615213294
MESH:D014376 Tuberculosis Tretinoin 2.9716040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 17.648074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 17.6411780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 17.6417053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 17.6416452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 17.6417653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 17.6416712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 2.6110982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 19.7616175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 19.7616803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 19.7617473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 19.7616129372
MESH:D014591 Uterine Diseases bisphenol A 12.4314652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.4314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 13.8416690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.8414692618
MESH:D014594 Uterine Neoplasms resveratrol 13.8417044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.2016752155
MESH:D014605 Uveitis Cyclosporine 3.571336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.0416513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1814671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.0217334414 16364871 17678736 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.0217488730
MESH:D014820 Vitiligo Tretinoin 3.6716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8315886252
MESH:D009396 Wilms Tumor Tretinoin 3.6316287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0317120751
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
KEGG:03030 DNA replication
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30696
    • Releated gene ID Related gene Name
    PA26352CDX2
    PA33536POU2F1
    PA28589GATA6
    PA29349HNF4A
    Releated disease ID Related disease Name
    PA444711Lactose Intolerance
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA449957ibuprofen
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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