AutismKB 2.0

Annotation Detail for MDK


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MDK ( FLJ27379,MK,NEGF2 )
Gene Full Name: midkine (neurite growth-promoting factor 2)
Band: 11p11.2
Quick LinksEntrez ID:4192; OMIM: 162096; Uniprot ID:MK_HUMAN; ENSEMBL ID: ENSG00000110492; HGNC ID: 6972
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200115Syndecan-4-mediated signaling events
200107Glypican 2 network
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1780Brain ischemia
1781Rheumatoid arthritis
1901Endometriosis
1904Diabetes mellitus
1934Cancer
1954Stroke
2072Neurofibromatosis
Desease Name
colorectal cancer
CANCER
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C103303 alitretinoin alitretinoin results in increased expression of MDK mRNAincreases expression 14502603
C061133 Am 80 Am 80 results in increased expression of MDK mRNAincreases expression 17229644
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MDK mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MDK mRNAdecreases expression 20106945
C053541 bicalutamide bicalutamide results in increased expression of MDK mRNAincreases expression 15638997
D002330 Carmustine Carmustine results in decreased expression of MDK mRNAdecreases expression 15980968
D002809 Chondroitin Sulfates Chondroitin Sulfates analog binds to MDK proteinaffects binding 12221095
D002809 Chondroitin Sulfates [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK proteinaffects binding 15385557
D002809 Chondroitin Sulfates [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK proteinaffects binding 14699094
D003513 Cycloheximide Cycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of MDK mRNA]decreases expression|increases reaction 11007951
D003871 Dermatan Sulfate [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK proteinaffects binding 15385557
D003871 Dermatan Sulfate [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK proteinaffects binding 14699094
D004317 Doxorubicin MDK mRNA results in decreased susceptibility to Doxorubicindecreases response to substance 16322897
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MDK mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MDK mRNAdecreases expression 16174780
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDK mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MDK mRNAdecreases expression 17557909
16174780
D015025 Zearalenone Zearalenone results in decreased expression of MDK mRNAdecreases expression 19371625
D005665 Furosemide Furosemide results in increased expression of MDK mRNAincreases expression 16526316
C419708 gefitinib gefitinib inhibits the reaction [TGFA protein results in increased expression of MDK mRNA]decreases reaction|increases expression 18424623
D019833 Genistein Genistein results in decreased expression of MDK mRNAdecreases expression 19371625
D006072 Gossypol Gossypol results in decreased expression of MDK mRNAdecreases expression 19825521
D006072 Gossypol zoledronic acid promotes the reaction [Gossypol results in decreased expression of MDK mRNA]decreases expression|increases reaction 19825521
D017313 Fenretinide Fenretinide results in increased expression of MDK mRNAincreases expression 16671099
D016685 Mitomycin MDK protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D010100 Oxygen Oxygen deficiency results in increased expression of MDK mRNAincreases expression 17914565
D010672 Phenytoin Phenytoin results in increased expression of MDK mRNAincreases expression 14741686
D010795 Phthalic Acids Phthalic Acids results in increased expression of MDK mRNAincreases expression 15728792
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of MDK mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of MDK mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of MDK mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of MDK mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Cycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of MDK mRNA]decreases expression|increases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MDK mRNAdecreases expression 11007951
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDK mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MDK mRNAincreases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of MDK mRNAincreases expression 17138961
D014212 Tretinoin Tretinoin results in increased expression of MDK mRNAincreases expression 16604517
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of MDK mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of MDK mRNAincreases expression 19244175
C088658 zoledronic acid zoledronic acid promotes the reaction [Gossypol results in decreased expression of MDK mRNA]decreases expression|increases reaction 19825521
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3014745880
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 7.868986270 9118846 3425630 6195326 9677735 10563481
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.8611752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D058186 Acute Kidney Injury zoledronic acid 4.2419715164
MESH:D055371 Acute Lung Injury Oxygen 4.3116759491
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.2320200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.8720464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 12.8717418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.8714692618
MESH:D000230 Adenocarcinoma Fenretinide 12.8710697514
MESH:D000230 Adenocarcinoma Genistein 12.8711473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.516695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1316835633
MESH:D000419 Albuminuria Doxorubicin 4.3121441931
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000860 Anoxia Oxygen 4.8120872349
MESH:D001008 Anxiety Disorders marker/mechanism 19217924
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7116412693
MESH:D001172 Arthritis, Rheumatoid Am 80 4.9016819260
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.9016292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D050197 Atherosclerosis Am 80 10.5616484594
MESH:D050197 Atherosclerosis Oxygen 10.5616391483
MESH:D050197 Atherosclerosis Phenytoin 10.5615136057
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.2020106747
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4514601052
MESH:D001859 Bone Neoplasms zoledronic acid 4.7316778634 16121404 17312309 11697798 15867366 19442620
MESH:D001862 Bone Resorption zoledronic acid 4.4815845617 18496637 11869084 8053405 18404659 16769263
MESH:D001932 Brain Neoplasms Carmustine 13.6216187019
MESH:D001932 Brain Neoplasms Doxorubicin 13.6217150277
MESH:D001932 Brain Neoplasms Fenretinide 13.6216187019
MESH:D001943 Breast Neoplasms alitretinoin 6.7516344269
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.7520146248 17474063
MESH:D001943 Breast Neoplasms Doxorubicin 6.7515939500 15692762 16826403 16595493 19526202 15567936 16096432 17426702 15993339 18234424 16264153 17983394 15136595 15668708 18695136 16115903 18628466 18382427 17369602 16935488 15634643 11325840 16322301 15994142
MESH:D001943 Breast Neoplasms Fenretinide 6.7516601279
MESH:D001943 Breast Neoplasms Genistein 6.7516873071 17200150 16541309
MESH:D001943 Breast Neoplasms Oxygen 6.7517263869
MESH:D001943 Breast Neoplasms Tamoxifen 6.7521138602 18351453 19059307 18855134 19289846 19011961 20065188 18629630 16273361 15565566 17242785 19142967 18821012 16202921 20859285 16873071 18997820 20135344 20390343 19189210 17049068 19189212 16818667 15668708 18425577 11161223 20005174 17440819 18984771 19115204 19410462 17893378 17261762 20544844 19103187 19221464 19288272 19084267 19066611 18815881 19244106 19155303 19487384 21152245 19200415
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7520435547
MESH:D001943 Breast Neoplasms Tretinoin 6.7516873071 16443354 16166294
MESH:D001943 Breast Neoplasms zoledronic acid 6.7516096432 18695136
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6916050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.5616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.4517876044 16234567 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 8.4516270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.4516924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.4516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.451917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 6.0320005069 17290066 18347146 19233551 15496427 16230376
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 6.0319233551
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.601485588 16201981
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 6.6018507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.2220419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.226189445
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 10.2216274795
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.2216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2316120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.3715811867 17351982 17382496 17308081 16278810 17519947 16952015 16109756 17131338 16731534 15792986 16269455 17329180 15476868 17007740 16364871 16455267 17924179 16242529 15505089 16612575 16651473 17928571 17974986 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8617334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 3.1416332659
MESH:D002386 Cataract Tretinoin 2.9517460283
MESH:D002493 Central Nervous System Diseases Phenytoin 5.064080065
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 12.1516154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 12.1516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7017110522 17681005 15861022 16919318 11677210 16105132 17333356
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.6211748493
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.5115894690
MESH:D002971 Cleft Lip Phenytoin 4.032227380
MESH:D002972 Cleft Palate Phenytoin 9.321687470 6862529 6856622 10789828 2227380 3877104
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.3215340226 15668235 8697196 12621046 16354765
MESH:D002972 Cleft Palate Tretinoin 9.329407595
MESH:D003092 Colitis Selenium 8.6917936198
MESH:D003092 Colitis Tretinoin 8.6917035595
MESH:D003103 Coloboma Phenytoin 4.939212184
MESH:D003110 Colonic Neoplasms Genistein 2.2517182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.6318802399 18259882
MESH:D015179 Colorectal Neoplasms Fenretinide 3.6317273769
MESH:D015179 Colorectal Neoplasms gefitinib 3.6317594712
MESH:D000013 Congenital Abnormalities Phenytoin 8.7010627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.7014669216 17141729
MESH:D019465 Craniofacial Abnormalities Phenytoin 5.2119952982 9212184 8986270
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2115322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.219211117 16925845 8800419 17551590 9224671 10589399 9142499 14991402 9125849 9664655
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.2119769572
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1219031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.5716285004
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.1216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.2719279558
OMIM:607208 DRAVET SYNDROME Phenytoin 5.1511748493
MESH:D003875 Drug Eruptions Phenytoin 5.2615024534
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.3817416283
MESH:D056486 Drug-Induced Liver Injury Selenium 8.3815131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 8.3815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3820420201
MESH:D004362 Drug Toxicity Doxorubicin 7.5118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5111462148
MESH:D004417 Dyspnea Furosemide 9.9716935035
MESH:D004417 Dyspnea Oxygen 9.9720016425
MESH:C538011 Eales disease Vitamin E 4.459068938
MESH:D004487 Edema Furosemide 6.3811834646
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.3812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 20.0916819260
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.0912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 20.0917654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.0919031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.3416402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.5017359293
MESH:D016889 Endometrial Neoplasms Genistein 16.5011473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.5016202921 19155303 20544844 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 16.5016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8110568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9118037988
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.9620235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.981399206 6251365
MESH:D004828 Epilepsies, Partial Phenytoin 4.6711558140 17116037
MESH:D004827 Epilepsy Phenytoin 3.8120417680 11434505 821787
MESH:D017029 Epilepsy, Complex Partial Phenytoin 5.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 4.823659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2416938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 6.9615345470
MESH:D005234 Fatty Liver Tamoxifen 6.9614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0916709447
MESH:D005264 Femoral Fractures zoledronic acid 5.5816234978
MESH:D005313 Fetal Death Phenytoin 9.9310627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.9311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2814745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.6219069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.6219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.8220067830
MESH:D005355 Fibrosis Tretinoin 7.8217994277
MESH:D005739 Gas Poisoning Oxygen 4.9720016425
MESH:D005885 Gingival Hyperplasia Phenytoin 5.429029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.9814659971 16390469
MESH:D005909 Glioblastoma Carmustine 20.5916187019
MESH:D005909 Glioblastoma Doxorubicin 20.5917150277
MESH:D005909 Glioblastoma Fenretinide 20.5916187019
MESH:D005909 Glioblastoma Genistein 20.5916598420
MESH:D005909 Glioblastoma Tretinoin 20.5917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.3015692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.3016096774
MESH:D034381 Hearing Loss Furosemide 4.6217868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.9020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.9011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 14.9014991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 14.9016080930
MESH:D006331 Heart Diseases Doxorubicin 3.3217875725 14766674 16244372 16707910 18006777 16144979 16495754 12587719 18674790 16330681 16879835 17888722 16244371
MESH:D006333 Heart Failure Doxorubicin 11.1417481944
MESH:D006333 Heart Failure Furosemide 11.1416845234 12660669 16011733
MESH:D006333 Heart Failure Selenium 11.1417162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6815692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6515340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6216490937 16863852
MESH:D006689 Hodgkin Disease Doxorubicin 3.2118501091 15147373 17606976
MESH:D019584 Hot Flashes Vitamin E 3.7214716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8016959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Tretinoin 7.5616870215
MESH:D006930 Hyperalgesia zoledronic acid 7.5616769263
MESH:D006934 Hypercalcemia Furosemide 10.5617652376
MESH:D006934 Hypercalcemia zoledronic acid 10.5618089816 19622757
MESH:D053565 Hypercalciuria Furosemide 5.4117652376
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.4610459572
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.6315086907
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8218850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.0416612254
MESH:D006976 Hypertension, Pulmonary gefitinib 4.5218424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 5.9918424623
MESH:D006996 Hypocalcemia zoledronic acid 5.9412669777
MESH:C537153 Hypomagnesemia primary Furosemide 5.4111041285
MESH:D007019 Hypoproteinemia Furosemide 5.6316096441
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716945680 16569931
MESH:D007022 Hypotension Furosemide 4.3911041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.1715811171
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8017937319
MESH:D007248 Infertility, Male Gossypol 6.8011202417 9639145
MESH:D007249 Inflammation Tamoxifen 4.4719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.4712878042 12200463
MESH:D007251 Influenza, Human Selenium 10.1316624496
MESH:D007251 Influenza, Human Vitamin E 10.1316624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.1214714311
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.3916144296
MESH:D007674 Kidney Diseases Doxorubicin 9.5016775033 15369732 15699352
MESH:D007674 Kidney Diseases Furosemide 9.5011041285
MESH:D007674 Kidney Diseases Vitamin E 9.5012488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.2516707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.2516518626
MESH:D007680 Kidney Neoplasms gefitinib 7.3118625569
MESH:D007680 Kidney Neoplasms Tamoxifen 7.3118625569
MESH:D007938 Leukemia Genistein 6.0018980019 17468513
MESH:D007938 Leukemia Tretinoin 6.0017143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9116085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.5518089816
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4819285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0416294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 7.6316819260 16531727
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.6319225113 16823087 16140955 16935935 16766008 16891316 17217047 17361223 15748426 19035177 12679006 17649720 16331271 19075265 17506722 16788101 17368321 17301526 19029980 17107899 9834237 17339181 17712046 19642359 17294898
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7916707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008064 Lipidoses Tamoxifen 2.9817567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.3216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.3217823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.3218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.3212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.3216248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.3216169303
MESH:D008107 Liver Diseases Phenytoin 3.1614986274
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 9.9520195826 21137059
MESH:D008113 Liver Neoplasms Mitomycin 9.9515113037
MESH:D008113 Liver Neoplasms Tamoxifen 9.9516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.9516984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 5.4117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.4112151625
MESH:D008171 Lung Diseases Vitamin E 3.0116863852
MESH:D055370 Lung Injury Oxygen 4.2718339021
MESH:D008175 Lung Neoplasms alitretinoin 8.1416413115
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.1417053015 18816296 20064080 18569708 18520028 6695378 20869020 20464547 20135361
MESH:D008175 Lung Neoplasms Doxorubicin 8.1417418594 6189445
MESH:D008175 Lung Neoplasms Tamoxifen 8.1418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1411884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 8.1411062179
MESH:D008223 Lymphoma Doxorubicin 3.2916098063
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.8314737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3215621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5119428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 26.1215458769
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 26.1210697514
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 26.1218375820
MESH:D008325 Mammary Neoplasms, Experimental Genistein 26.1214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 26.1215318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 26.1214580682 16827153 11731420 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 26.1217312309
MESH:D020149 Manganese Poisoning Tamoxifen 4.3019453300
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Carmustine 9.3312393984
MESH:D008545 Melanoma Doxorubicin 9.3316827129
MESH:D008545 Melanoma Fenretinide 9.3316270382
MESH:D008545 Melanoma Tamoxifen 9.3319393235 12393984
MESH:D008545 Melanoma Tretinoin 9.3316752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9415990972
MESH:D008569 Memory Disorders marker/mechanism 19217924
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008607 Mental Retardation Phenytoin 3.599212184
MESH:D008654 Mesothelioma Doxorubicin 9.7617638057
MESH:D008654 Mesothelioma Selenium 9.7615107826
MESH:D008654 Mesothelioma zoledronic acid 9.7616675582
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2815792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.1616381670
MESH:D009062 Mouth Neoplasms Fenretinide 8.1616274795
MESH:D052016 Mucositis Doxorubicin 4.5417415656
MESH:D009101 Multiple Myeloma Am 80 7.6017229644
MESH:D009101 Multiple Myeloma zoledronic acid 7.6019621390 18089719 16996129
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9417596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.6315857846 19429709
MESH:D009203 Myocardial Infarction Genistein 5.6317141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.4817141266
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.2717484760
MESH:D009224 Myotonia Congenita Phenytoin 5.161896199
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.0918259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.0919393235
MESH:D009362 Neoplasm Metastasis zoledronic acid 9.0917312309 15867366 19139120
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms alitretinoin 10.9416946489
MESH:D009369 Neoplasms Benzo(a)pyrene 10.9411141357
MESH:D009369 Neoplasms Fenretinide 10.9417353921 15958647
MESH:D009369 Neoplasms Tretinoin 10.9416594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7519200415 19189210 19196722
MESH:D009397 Nephrocalcinosis Furosemide 5.6315086907
MESH:D009401 Nephrosis Doxorubicin 4.5316636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.7915640375 16889571
MESH:D009421 Nervous System Malformations Genistein 15.0216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.0214600291
MESH:D009421 Nervous System Malformations Tretinoin 15.029125849
MESH:D009436 Neural Tube Defects Phenytoin 7.159118846
MESH:D009436 Neural Tube Defects Tretinoin 7.159142499
MESH:D009447 Neuroblastoma Doxorubicin 3.1415555623
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4316303764
MESH:D053206 Nocturnal Enuresis Furosemide 5.6317945291
MESH:D010014 Osteolysis zoledronic acid 5.1215867366
MESH:D010018 Osteomalacia Phenytoin 5.1617016548
MESH:D010024 Osteoporosis Genistein 7.0719401787
MESH:D010024 Osteoporosis zoledronic acid 7.0717882678
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8616169203
MESH:D012516 Osteosarcoma Doxorubicin 3.9215930896
MESH:D010051 Ovarian Neoplasms Fenretinide 7.5716133793
MESH:D010051 Ovarian Neoplasms Genistein 7.5719005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.5716936753
MESH:D010146 Pain Phenytoin 10.4115215642
MESH:D010146 Pain Tretinoin 10.4116870215
MESH:D010146 Pain zoledronic acid 10.4116475674
MESH:D010190 Pancreatic Neoplasms Fenretinide 8.3415580305
MESH:D010190 Pancreatic Neoplasms Mitomycin 8.3415113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.3415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9117983394
MESH:D010954 Plasmacytoma Selenium 4.6415087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9117638057
MESH:D017689 Polydactyly Phenytoin 4.849212184
MESH:D011141 Polyuria Furosemide 5.4117945291
MESH:D017499 Porokeratosis alitretinoin 5.7516144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9511896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Am 80 4.1316289102
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 4.1317292933
MESH:D011471 Prostatic Neoplasms bicalutamide 4.1315638997 17914592 19011039 19240160 18487222
MESH:D011471 Prostatic Neoplasms Doxorubicin 4.1315897917 16888761 16868541 15749863 18437689 16729912
MESH:D011471 Prostatic Neoplasms Fenretinide 4.1317024972
MESH:D011471 Prostatic Neoplasms gefitinib 4.1317914592 15651060 16685379
MESH:D011471 Prostatic Neoplasms Genistein 4.1316925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Sodium Selenite 4.1318760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 4.1315067354
MESH:D011471 Prostatic Neoplasms Vitamin E 4.1315084515
MESH:D011471 Prostatic Neoplasms zoledronic acid 4.1319103299 12438248
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D019310 Pseudolymphoma Phenytoin 5.298603615 1419762 12752131
MESH:D011565 Psoriasis Am 80 4.0016819260
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011658 Pulmonary Fibrosis gefitinib 3.9118424623
MESH:D051437 Renal Insufficiency Doxorubicin 3.9817922066
MESH:D015427 Reperfusion Injury Furosemide 3.7916526316
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 8.9512394941 15912074 16096441
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 8.9517627322 18339021
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012162 Retinal Degeneration Fenretinide 4.2216303925
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716283617 16116481
MESH:D012509 Sarcoma Doxorubicin 3.7815625365 18313854 17710206 17203757 16767912 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.8514601052 16326096
MESH:D012512 Sarcoma, Ewing's zoledronic acid 9.8516121404
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5417846226
MESH:D012640 Seizures Phenytoin 3.589844417 15946322 16876388 11044598 3691417 3137016 19919933 10029267
MESH:D012871 Skin Diseases Vitamin E 2.3818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.7010029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 16.7015692506
MESH:D012878 Skin Neoplasms Fenretinide 16.7016467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.7016192470
MESH:D012878 Skin Neoplasms Tretinoin 16.7016467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3217203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7316709447
MESH:D013088 Spermatocele Tamoxifen 10.7316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7919457130
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.9120235791
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3420155912 2093021
MESH:D013274 Stomach Neoplasms Furosemide 3.3417052386
MESH:D013274 Stomach Neoplasms Tretinoin 3.3417261132
MESH:D020521 Stroke Vitamin E 3.3316517955
MESH:D013398 Sudden Infant Death Oxygen 5.3012563064
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.1517909728 16010429
MESH:D013964 Thyroid Neoplasms gefitinib 11.1516940797
MESH:D013964 Thyroid Neoplasms Tretinoin 11.1516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5716051514
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.1717053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.1717653716
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 11.1716720286
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.1716712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 8.9916154183
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3215869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9817638931 17678736 16364871 17334414
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30717
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved