AutismKB 2.0

Annotation Detail for MECP2


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Basic Information Top
Gene Symbol:MECP2 ( AUTSX3,DKFZp686A24160,MRX16,MRX79,MRXS13,MRXSL,PPMX,RS,RTS,RTT )
Gene Full Name: methyl CpG binding protein 2 (Rett syndrome)
Band: Xq28
Quick LinksEntrez ID:4204; OMIM: 300005; Uniprot ID:MECP2_HUMAN; ENSEMBL ID: ENSG00000169057; HGNC ID: 6990
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1789Movement disorder
1799Epilepsy
1831Prostate cancer
1848Embryoma
1953Nervous system disease
2047Rett syndrome
2124Autistic disorder
2126Encephalopathies
2146Lupus erythematosus
2221Behavior disease
Desease Name
mental disorder
DEVELOPMENTAL
No data
Desease Name
Angelman syndrome
Rett syndrome, preserved speech variant
Autism, susceptibility to, X-linked-3
Rett syndrome
Mental retardation, X-linked, Lubs type
Encephalopathy, neonatal severe
Mental retardation, X-linked, syndromic 13
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MECP2 mRNAincreases expression 18648102
C075773 4-phenylbutyric acid [4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 proteinaffects acetylation|affects expression 18497984
D000082 Acetaminophen Acetaminophen affects the expression of MECP2 mRNAaffects expression 17562736
D006710 Homocysteine decitabine inhibits the reaction [Homocysteine results in decreased expression of MECP2 mRNA]decreases expression|decreases reaction 18310117
D006710 Homocysteine decitabine inhibits the reaction [Homocysteine results in decreased expression of MECP2 protein]decreases expression|decreases reaction 18310117
D006710 Homocysteine Folic Acid inhibits the reaction [Homocysteine results in decreased expression of MECP2 mRNA]decreases expression|decreases reaction 18310117
D006710 Homocysteine Folic Acid inhibits the reaction [Homocysteine results in decreased expression of MECP2 protein]decreases expression|decreases reaction 18310117
D006710 Homocysteine Homocysteine inhibits the reaction [MECP2 protein binds to CCNA1 promoter]affects binding|decreases reaction 17698632
D006710 Homocysteine trichostatin A inhibits the reaction [Homocysteine results in decreased expression of MECP2 mRNA]decreases expression|decreases reaction 18310117
D006710 Homocysteine trichostatin A inhibits the reaction [Homocysteine results in decreased expression of MECP2 protein]decreases expression|decreases reaction 18310117
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MECP2 mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine inhibits the reaction [MECP2 protein binds to CCNA1 promoter]affects binding|decreases reaction 17698632
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MECP2 mRNAaffects cotreatment|decreases expression 18164116
D001761 Bleomycin MECP2 protein affects the susceptibility to Bleomycinaffects response to substance 21435439
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MECP2 mRNAdecreases expression 15336504
D002087 Butyrates Butyrates inhibits the reaction [MECP2 protein binds to CCNA1 promoter]affects binding|decreases reaction 17698632
D002087 Butyrates Butyrates results in decreased expression of MECP2 mRNAdecreases expression 16042588
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MECP2 mRNAaffects expression 17484886
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of MECP2 mRNAaffects cotreatment|decreases expression 18636392
C014347 decitabine [decitabine co-treated with trichostatin A] results in decreased expression of MECP2 mRNAaffects cotreatment|decreases expression 17891453
C014347 decitabine decitabine inhibits the reaction [Homocysteine results in decreased expression of MECP2 mRNA]decreases expression|decreases reaction 18310117
C014347 decitabine decitabine inhibits the reaction [Homocysteine results in decreased expression of MECP2 protein]decreases expression|decreases reaction 18310117
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MECP2 mRNAaffects cotreatment|decreases expression 18164116
D005419 Flavonoids Flavonoids results in decreased expression of MECP2 mRNAdecreases expression 18035473
D005492 Folic Acid Folic Acid inhibits the reaction [Homocysteine results in decreased expression of MECP2 mRNA]decreases expression|decreases reaction 18310117
D005492 Folic Acid Folic Acid inhibits the reaction [Homocysteine results in decreased expression of MECP2 protein]decreases expression|decreases reaction 18310117
D019833 Genistein Genistein results in increased expression of MECP2 mRNAincreases expression 15256057
D005839 Gentamicins Gentamicins results in increased expression of MECP2 protein mutant formincreases expression 19190538
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of MECP2 mRNAaffects cotreatment|decreases expression 18636392
C017947 sodium arsenite sodium arsenite results in increased expression of MECP2 mRNAincreases expression 19822182
C012589 trichostatin A [decitabine co-treated with trichostatin A] results in decreased expression of MECP2 mRNAaffects cotreatment|decreases expression 17891453
C012589 trichostatin A trichostatin A inhibits the reaction [Homocysteine results in decreased expression of MECP2 mRNA]decreases expression|decreases reaction 18310117
C012589 trichostatin A trichostatin A inhibits the reaction [Homocysteine results in decreased expression of MECP2 protein]decreases expression|decreases reaction 18310117
C012589 trichostatin A trichostatin A inhibits the reaction [MECP2 protein binds to CCNA1 promoter]affects binding|decreases reaction 17698632
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D058186 Acute Kidney Injury Folic Acid 8.9416595132 16316344 17003819
MESH:D058186 Acute Kidney Injury Gentamicins 8.9411274264
MESH:D055371 Acute Lung Injury Bleomycin 9.4517118201
MESH:D055371 Acute Lung Injury Chlorine 9.4520601635
MESH:D000230 Adenocarcinoma Genistein 2.4511473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 15.523712494
MESH:D000236 Adenoma beta-Naphthoflavone 15.5219389873
MESH:D000236 Adenoma Diethylnitrosamine 15.526695378 10737359
MESH:D000236 Adenoma Folic Acid 15.5216963246
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.7919061943 16434500 17620307 17162532 19052882 18056438
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8017306315 16712894
MESH:D000544 Alzheimer Disease Folic Acid 4.4817116317
MESH:D000544 Alzheimer Disease Ozone 4.4815513908
MESH:D017204 Angelman Syndrome marker/mechanism
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D000860 Anoxia Bleomycin 5.3015782499
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5315570426
MESH:D001249 Asthma Ozone 2.6017854713 16373670
OMIM:300496 AUTISM, SUSCEPTIBILITY TO, X-LINKED 3 marker/mechanism
MESH:D001321 Autistic Disorder marker/mechanism 15211631 18621663
MESH:D001321 Autistic Disorder Acetaminophen 2.3418445737
MESH:D001321 Autistic Disorder Folic Acid 2.3421388746
MESH:D001321 Autistic Disorder Homocysteine 2.3416297937 20468076
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.911440618 11289319
MESH:D001943 Breast Neoplasms decitabine 2.0219208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0217474063
MESH:D001943 Breast Neoplasms Folic Acid 2.0216777985
MESH:D001943 Breast Neoplasms Genistein 2.0217200150 16541309 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5917626835 18417511 19059883 18315731 15516495 14754758 16777450
MESH:D002100 Cachexia Ozone 4.6316183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6715673190 18705752 16227642 16011737 15700767 16192424 15721981 16124888 16050911 3786805 16097048 10355542
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.163581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.163084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.1618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.1620084675 19919837 20007298 16328049 16698587 17055752 19383236 19208518 19107877 16935385 19822196 20727157 16540662 19701751 19171122 3084413 19539802 16681979 17428255 18506893 21159647 16502159 20935162 20432363 18494052 10672840 17162532 16878318 16830150 19418558 18785209 18210153 20524982 18056438 18978308 16288022 16807293 10737359 20512989 17173139 17138121 18788625 17978847 19052882 11831363 16569478 20101231 17761372 19519916 18691550 16779866 20214788 19394651 20514400 19335982 18971187 3581430 18393292 18665156
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.1616924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.1617306315 15276417 16507464
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 7.576189445
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.5719215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.5718572023
MESH:D002318 Cardiovascular Diseases Folic Acid 7.4316755160
MESH:D002318 Cardiovascular Diseases Genistein 7.4316332659
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.777505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.7717174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.7719524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5919052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.069022650 19486331
MESH:D002971 Cleft Lip Folic Acid 3.9221254359
MESH:D002972 Cleft Palate Folic Acid 3.5221254359 8946559
MESH:D003110 Colonic Neoplasms Butyrates 5.8815936596
MESH:D003110 Colonic Neoplasms decitabine 5.8817616700
MESH:D003110 Colonic Neoplasms Genistein 5.8817182828
MESH:D015179 Colorectal Neoplasms Azacitidine 3.6319934284
MESH:D015179 Colorectal Neoplasms decitabine 3.6318981723
MESH:D015179 Colorectal Neoplasms Folic Acid 3.6316985020 17087956 17116713 16963246 17245555
MESH:D003324 Coronary Artery Disease Homocysteine 3.7216379339
MESH:D019465 Craniofacial Abnormalities marker/mechanism 19559301
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7011906362 8156756 2524372 14531868 8970840 18759878 11298694 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.393621924 2952479
MESH:D002658 Developmental Disabilities marker/mechanism 19559301
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.1420387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 7.1416886840
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.1416647724
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.7016192314 6679447 7440962 9653073 18692083 8291058 18289764 1440618 9328219 9022650 11289319 18648102 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.7011739529 16177239 19923254 12594235 16781746 19085960 10774834 15968718 16393943 12705907 2444490 17522070 10663392 11421492 11743745 11834606 19420014 14986274 12540782 16227642 15619225 17906064 12153990 19164858 19370779 12958197 14550746 16109766 19416960 11287661 12392966 10915739 18713872 16081117 11529661 18071297 17562736 19739265 14725611 16485898 11461765
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.709327722 15968718 19085960 19336974 17522070 7120509 7179309 15998439 21278145 3732212 16177239 3786805 4309450 10092053 2869522 6884620 7440962 6623471 16227642 11566570 15027814 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.7019107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Gentamicins 4.3611033412 15033597
MESH:D004417 Dyspnea Chlorine 4.5220016425
MESH:D004487 Edema Bleomycin 4.1517118201
OMIM:300673 ENCEPHALOPATHY, NEONATAL SEVERE, DUE TO MECP2 MUTATIONS marker/mechanism
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.6819294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.6819294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.4816402032
MESH:D016889 Endometrial Neoplasms Folic Acid 7.6517301261
MESH:D016889 Endometrial Neoplasms Genistein 7.6511473722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.083581430
MESH:D017889 Exfoliation Syndrome Folic Acid 13.0316504073
MESH:D017889 Exfoliation Syndrome Homocysteine 13.0316504073
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.4916239168 12631006 16045604 12795759 19224547 61145 15959796 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 7.4921071580 20387270
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Carbon Tetrachloride 3.3518705752
MESH:D005739 Gas Poisoning Chlorine 4.9020016425
MESH:D005756 Gastritis Acetaminophen 10.9216983495
MESH:D005756 Gastritis Folic Acid 10.9217171786
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5716452187
MESH:D005901 Glaucoma Folic Acid 11.5016504073
MESH:D005901 Glaucoma Homocysteine 11.5016504073
MESH:D005909 Glioblastoma Genistein 7.2716598420
MESH:D005909 Glioblastoma trichostatin A 7.2718801729
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006258 Head and Neck Neoplasms decitabine 3.4119215824
MESH:D034381 Hearing Loss Gentamicins 4.7917868369 19130971 15968427 18024279
MESH:D006330 Heart Defects, Congenital Folic Acid 7.2916524890 17286298
MESH:D006330 Heart Defects, Congenital Homocysteine 7.2919638421
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.876705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.8719900420 19110552
MESH:D006679 HIV Seropositivity Folic Acid 5.3817209195
MESH:D006689 Hodgkin Disease Bleomycin 7.5217606976 15147373 18501091
MESH:D006689 Hodgkin Disease sodium arsenite 7.5212676792
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4216899240
MESH:D053565 Hypercalciuria Gentamicins 5.6017652376
MESH:D020138 Hyperhomocysteinemia Folic Acid 9.5216395265 16755160 16433478 16397167 16865747
MESH:D020138 Hyperhomocysteinemia Homocysteine 9.5217369066 18234410 17292331
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9815338365
MESH:D007248 Infertility, Male decitabine 6.6617581917
MESH:D007248 Infertility, Male sodium arsenite 6.6612646999 15346721
MESH:D007249 Inflammation Bleomycin 8.2317118201
MESH:D007249 Inflammation Diethylnitrosamine 8.2318785209
MESH:D007249 Inflammation Flavonoids 8.2317296493
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.919022650 8074119
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.6218842672
MESH:D007674 Kidney Diseases Acetaminophen 9.8415629191 12587719
MESH:D007674 Kidney Diseases Gentamicins 9.8418289764 19349640 17934191
MESH:D007674 Kidney Diseases sodium arsenite 9.8420008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.886582329
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 5.2811231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.3710219319
MESH:D007938 Leukemia Azacitidine 10.3419148494
MESH:D007938 Leukemia decitabine 10.3418980019 19235587
MESH:D007938 Leukemia Genistein 10.3417468513 18980019
MESH:D007951 Leukemia, Myeloid Azacitidine 9.5619077051
MESH:D007951 Leukemia, Myeloid decitabine 9.5619117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 6.2618720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.2619387464 18460780 18206229 19010910 18704418 17679729
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.2618206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3618055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.0919299654
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4116239168 11903743 17157831 11408273 21278145 16943688 16221502 17334410 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4118665156 19638242 18522880 18407596 20032147
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.139327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5512958196 18395914 15650968 17557913 17721639 15673190 15893842 12445418 18429990 17922224 18279442 17823541 18263696 14512876 15959796 18251166 14724832 12546737 11481614 15931870 16097048 15876570 17869086 18376398 18472332 12632514 18420326 17805973 20821823 15925388 17976157 12667390 16011737 12389079 12741479 16015684 18277467 12898905 12586293 18156304 16136751 16248980 15123356 15818738 15362042 18472094 14748882 14716496 18339082 13678700 18205269 17714472 18481824 18006644 18166357 18210741 18395095 15338365 12609069 12666154 17481882 18054572 15052691 15730626 17900296 18412020 14716833 17698563 10355542 14620537 18705752 12445421 15057751 17525996 16116963 15370692 18317297 18418968 16027843 17708605 17944888 17640975 16033810 16638106 17565644 17761835 15996030 12649538 18187930 17631135 12632512 17766677 16192424
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.5517823541
MESH:D008107 Liver Diseases Acetaminophen 9.1812969438 16610002 19784758 19014921 12587719 19460945 11587558 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.1817285989 16246199 15830285 15720792 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 9.1817034775
MESH:D008107 Liver Diseases Folic Acid 9.1816877991
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.0816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.0816899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 10.4021295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.4019294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.4019073162 19254457 19690152 21278145 20583210 19638242 21167192 18648771 9163691 2422723 12771043 19551842 19833225 18644402 19255062 20101389 20434301 20118626 19996281 19426721 19850985 18978307 21047994 19294768 19256749 19812893 15885732 18754104 12112319 19499222 19427195 20452335 10737359 18977376 20492335 15175105 20137499 20501860 16942905 21071580 20405173 19090486 19642983 2862719
MESH:D008113 Liver Neoplasms sodium arsenite 10.4015276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.593712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.5918164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.5912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.5917942915 19004024 18253720 19009564 18093689 18775883 19519916 18544905 17854601 2563599 21159647 16267830 3124819 17174075 19126423 18079962 16842330 19539802 18164116 9362446 18282651 18308698
MESH:C537723 Lubs X-linked mental retardation syndrome marker/mechanism
MESH:D008171 Lung Diseases Ozone 7.2719066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 7.2719095001
MESH:D055370 Lung Injury Ozone 3.7420417186
MESH:D008175 Lung Neoplasms Azacitidine 6.5021224363
MESH:D008175 Lung Neoplasms Bleomycin 6.506189445
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.5021163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Ozone 6.508597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 6.5016712894 15276417 17306315 17077188 19931552
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3117718048
MESH:D008223 Lymphoma decitabine 3.3419470736
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.8714578162 12929590
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.5816832597
MESH:D008545 Melanoma Bleomycin 7.2515577320
MESH:D008545 Melanoma decitabine 7.2517785578 16505122
MESH:D008545 Melanoma sodium arsenite 7.2519082730 16487513
MESH:D008545 Melanoma trichostatin A 7.2516505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008591 Meningomyelocele Homocysteine 5.4316602021
OMIM:300055 MENTAL RETARDATION, X-LINKED, SYNDROMIC 13 marker/mechanism
MESH:D008679 Metaplasia Ozone 5.0010496685
MESH:D009006 Monosomy Azacitidine 5.9819299654
MESH:D009101 Multiple Myeloma Azacitidine 11.8918443271 19549372
MESH:D009101 Multiple Myeloma decitabine 11.8918172295
MESH:D009101 Multiple Myeloma trichostatin A 11.8918172295
MESH:D009123 Muscle Hypotonia marker/mechanism 19559301
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.1718694830
MESH:D009190 Myelodysplastic Syndromes Azacitidine 7.6119805378 17611569 18720364 17596541
MESH:D009190 Myelodysplastic Syndromes decitabine 7.6116882708 18608210 19010910 19157545
MESH:D009203 Myocardial Infarction Genistein 6.1017141266
MESH:D009203 Myocardial Infarction Homocysteine 6.1017412321
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.5817141266
MESH:D009207 Myoclonus marker/mechanism 19559301
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.563581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.563581430 9029167
MESH:D009369 Neoplasms 4-phenylbutyric acid 8.2019116145
MESH:D009369 Neoplasms decitabine 8.2019116145 19470736 17925555
MESH:D009369 Neoplasms sodium arsenite 8.2011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5620056578
MESH:D009421 Nervous System Malformations Genistein 3.9216427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.836679447
MESH:D009436 Neural Tube Defects Folic Acid 11.8317438019
MESH:D009436 Neural Tube Defects sodium arsenite 11.8312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0120387270
MESH:D009503 Neutropenia Folic Acid 4.4016322990
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.324026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010024 Osteoporosis Genistein 3.1819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9816169203
MESH:D010051 Ovarian Neoplasms decitabine 11.0819331143 19259094
MESH:D010051 Ovarian Neoplasms Genistein 11.0819005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.0817306315 15276417
MESH:D010051 Ovarian Neoplasms trichostatin A 11.0819331143
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.5319294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.5316540662
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.5319294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010300 Parkinson Disease Homocysteine 3.5316275827
MESH:D010538 Peritonitis Ozone 4.0216369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D011014 Pneumonia Bleomycin 11.0518024389 17071938 16317386
MESH:D011014 Pneumonia Ozone 11.0518007984 18929643 18381685
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.462563599
MESH:D055728 Primary Myelofibrosis decitabine 12.0617616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.0617616702
MESH:D011471 Prostatic Neoplasms Azacitidine 2.1918324645
MESH:D011471 Prostatic Neoplasms Genistein 2.1915378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1916039940
MESH:D011471 Prostatic Neoplasms trichostatin A 2.1918798265 19789329
MESH:D011507 Proteinuria Gentamicins 4.6215033597
MESH:D011654 Pulmonary Edema Bleomycin 5.2115808516
MESH:D011658 Pulmonary Fibrosis marker/mechanism 21435439
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.8317434272 17241526 15322207 14609568 18162602 15541506 21435439 16314464 17177178 16115399 12624602 12574379 11554783 18008008
MESH:D051437 Renal Insufficiency Folic Acid 10.4415728788
MESH:D051437 Renal Insufficiency Gentamicins 10.4415728788 17132701
MESH:D012120 Respiration Disorders Chlorine 5.1118579056
MESH:D012131 Respiratory Insufficiency marker/mechanism 19559301
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012173 Retinitis Gentamicins 6.1718644591
MESH:D015518 Rett Syndrome marker/mechanism 19559301 21316312 19190538 17433737 19000991
MESH:D012208 Rhabdomyosarcoma decitabine 4.3019155313
MESH:D012559 Schizophrenia Folic Acid 4.2116641680
MESH:D012559 Schizophrenia Homocysteine 4.2116641680
MESH:D012871 Skin Diseases Folic Acid 3.2218709164
MESH:D012878 Skin Neoplasms sodium arsenite 5.6618572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.668532709
MESH:D013118 Spinal Cord Diseases Folic Acid 5.3816361298
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7112854658
MESH:D013274 Stomach Neoplasms decitabine 3.4619037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4618456281
MESH:D013274 Stomach Neoplasms Folic Acid 3.4617171786
MESH:D020521 Stroke Folic Acid 4.2416517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 16.463712494 1399818 6582329 6587162 7505956
MESH:D013964 Thyroid Neoplasms Butyrates 16.4617967635
MESH:D013964 Thyroid Neoplasms decitabine 16.4617967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.467505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.128074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.1217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.1216712894 11723127 17306315 16452187
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6711813266
MESH:D014604 Uveal Neoplasms decitabine 4.8117785578
MESH:D014652 Vascular Diseases sodium arsenite 4.3217056641
MESH:D015837 Vestibular Diseases Gentamicins 5.4118776599
MESH:D015431 Weight Loss Bleomycin 5.5312624602
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30729
    • Releated gene ID Related gene Name
    PA30734MEF2C
    PA31943OPRK1
    PA36153SST
    PA28549GAMT
    PA26864CREB1
    Releated disease ID Related disease Name
    PA446191Rett Syndrome
    Releated drug ID Related drug Name
    PA451581tamoxifen
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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