AutismKB 2.0

Annotation Detail for MEF2C


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Basic Information Top
Gene Symbol:MEF2C ( C5DELq14.3; DEL5q14.3 )
Gene Full Name: myocyte enhancer factor 2C
Band: 5q14.3
Quick LinksEntrez ID:4208; OMIM: 600662; Uniprot ID:MEF2C_HUMAN; ENSEMBL ID: ENSG00000081189; HGNC ID: 6996
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
Pathway IDPathway Name
Myogenesis
Signalling by NGF
Signaling in Immune system
Pathway IDPathway Name
200182Trk receptor signaling mediated by the MAPK pathway
200002Regulation of nuclear SMAD2/3 signaling
200154Signaling mediated by p38-alpha and p38-beta
200019Signaling events mediated by HDAC Class II
200113ErbB1 downstream signaling
200191Regulation of retinoblastoma protein
Pathway IDPathway Name
P00046Oxidative stress response
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1809HIV infection
1904Diabetes mellitus
2022Liver cancer
Desease Name
Bone mineral density (hip)
tonometry
METABOLIC
Desease Name
Height
Bone mineral density (hip)
Tonometry
Desease Name
Mental retardation, stereotypic movements, epilepsy, and/or cerebral malformations
Chromosome 5q14.3 deletion syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MEF2C mRNAdecreases expression 18648102
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]decreases reaction|increases expression 10737771
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of MEF2C mRNAincreases expression 18007998
D000638 Amiodarone Amiodarone results in increased expression of MEF2C mRNAincreases expression 19774075
D001151 Arsenic Arsenic affects the expression of MEF2C mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MEF2C mRNAdecreases expression 20064835
C006780 bisphenol A bisphenol A results in increased expression of MEF2C mRNAincreases expression 18007998
C487049 BXL628 BXL628 results in decreased expression of MEF2C mRNAdecreases expression 16003237
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MEF2C mRNAaffects expression 17484886
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of MEF2C mRNAincreases expression 16934159
D016572 Cyclosporine Cyclosporine results in increased expression of MEF2C mRNAincreases expression 20106945
C014347 decitabine decitabine results in increased expression of MEF2C mRNAincreases expression 19151715
C081021 Go 6976 Go 6976 inhibits the reaction [Phenylephrine results in increased activity of MEF2C protein]decreases reaction|increases activity 19124542
C056599 icariin icariin affects the localization of MEF2C proteinaffects localization 18423597
C056599 icariin icariin results in increased expression of MEF2C mRNAincreases expression 18423597
C056599 icariin SB 203580 inhibits the reaction [icariin affects the localization of MEF2C protein]affects localization|decreases reaction 18423597
C056599 icariin SB 203580 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]decreases reaction|increases expression 18423597
C056599 icariin U 0126 inhibits the reaction [icariin affects the localization of MEF2C protein]affects localization|decreases reaction 18423597
C056599 icariin U 0126 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]decreases reaction|increases expression 18423597
C063302 KN 62 KN 62 inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]decreases reaction|increases expression 10737771
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MEF2C mRNAincreases expression 19285098
C008493 methylselenic acid methylselenic acid results in increased expression of MEF2C mRNAincreases expression 18548127
D009151 Mustard Gas Mustard Gas results in increased expression of MEF2C mRNAincreases expression 15674843
C007350 nitrofen nitrofen results in decreased expression of MEF2C mRNAdecreases expression 18280291
D010656 Phenylephrine Go 6976 inhibits the reaction [Phenylephrine results in increased activity of MEF2C protein]decreases reaction|increases activity 19124542
D010656 Phenylephrine Phenylephrine results in increased activity of MEF2C proteinincreases activity 19124542
D010656 Phenylephrine 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]decreases reaction|increases expression 10737771
D010656 Phenylephrine KN 62 inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]decreases reaction|increases expression 10737771
D010656 Phenylephrine Phenylephrine results in increased expression of MEF2C mRNAincreases expression 10737771
C006253 pirinixic acid pirinixic acid results in decreased expression of MEF2C mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of MEF2C mRNAincreases expression 17951219
C059514 resveratrol resveratrol results in increased expression of MEF2C mRNAincreases expression 12002526
C116926 rofecoxib rofecoxib affects the expression of MEF2C mRNAaffects expression 17070997
C093642 SB 203580 SB 203580 inhibits the reaction [icariin affects the localization of MEF2C protein]affects localization|decreases reaction 18423597
C093642 SB 203580 SB 203580 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]decreases reaction|increases expression 18423597
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MEF2C mRNAdecreases expression 19465110
C113580 U 0126 U 0126 inhibits the reaction [icariin affects the localization of MEF2C protein]affects localization|decreases reaction 18423597
C113580 U 0126 U 0126 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]decreases reaction|increases expression 18423597
D014635 Valproic Acid Valproic Acid results in increased expression of MEF2C mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of MEF2C mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4914514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.498875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7119490988
MESH:D000168 Acrocephalosyndactylia U 0126 5.2317694057
MESH:D058186 Acute Kidney Injury resveratrol 3.6316538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.8918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9320127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.373712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.376695378
MESH:D000236 Adenoma resveratrol 10.3715688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0816835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.9617306315
MESH:D000544 Alzheimer Disease icariin 4.6719782061 19858766
MESH:D000544 Alzheimer Disease resveratrol 4.6716183991 16162502
MESH:D000550 Amblyopia Valproic Acid 4.9817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 5.1115146954
MESH:D001008 Anxiety Disorders Valproic Acid 8.2117497229
MESH:D001008 Anxiety Disorders vinclozolin 8.2119015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8319183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 8.4418218290 18057881 20041841
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 8.4417460149
MESH:D020261 Arsenic Poisoning Arsenic 2.8016251483 12569548 16835338 18414634
MESH:D001169 Arthritis, Experimental resveratrol 7.4817115116
MESH:D001169 Arthritis, Experimental rofecoxib 7.4816690336
MESH:D001249 Asthma Mustard Gas 2.6410378619
MESH:D050197 Atherosclerosis Arsenic 6.4119371607 12928151
MESH:D050197 Atherosclerosis resveratrol 6.4117967414 16873680
MESH:D001281 Atrial Fibrillation Amiodarone 3.7218651412 19698954
MESH:D001321 Autistic Disorder Valproic Acid 2.0317688650 19460635 17157402 20603192 18940202 18558336 18775368 15238991 18396377 18985861 16609825 19232924 18177632 17507914 18316065
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.771440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 2.9520046352 17594078
MESH:D001768 Blister Mustard Gas 4.9119167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 14.0319483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.0319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.0312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001847 Bone Diseases icariin 6.1618295595
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.508888407
MESH:D001862 Bone Resorption bisphenol A 3.6411985600
MESH:D001919 Bradycardia Phenylephrine 4.3015306635
MESH:D002545 Brain Ischemia icariin 9.9219303870
MESH:D002545 Brain Ischemia resveratrol 9.9217600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2620146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.2617123778
MESH:D001943 Breast Neoplasms decitabine 2.2618320071 19208741
MESH:D001943 Breast Neoplasms resveratrol 2.2616393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2620435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7310378619 17687719
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5415673190 18705752 15700767 16011737 16227642 10355542 15721981 16192424 16097048 16124888 3786805 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.273581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.2716507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.2718788625
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.2719321006 16227395
MESH:D002278 Carcinoma in Situ bisphenol A 4.7417123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3516675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.567296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.2217687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.2220419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.2219215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.2216227395
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.8618640142
MESH:D006332 Cardiomegaly Phenylephrine 6.4311754973 15728586 16170337 17124262 17287366 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4318850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8115710769 19225199
MESH:D002318 Cardiovascular Diseases Arsenic 7.0115738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases resveratrol 7.0115458977
MESH:D002340 Carotid Artery Diseases Arsenic 4.1016973168 18022660
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8418974383
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.027505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.0212371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.3419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.3419486331
MESH:D002779 Cholestasis pirinixic acid 12.3419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0016354765 8697196 12621046 15340226 15668235
MESH:D003092 Colitis resveratrol 3.8916474422
MESH:D003110 Colonic Neoplasms decitabine 5.7617616700
MESH:D003110 Colonic Neoplasms resveratrol 5.7616338953
MESH:D003110 Colonic Neoplasms rofecoxib 5.7612902858
MESH:D015179 Colorectal Neoplasms decitabine 2.6618981723
MESH:D015179 Colorectal Neoplasms resveratrol 2.6616550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6016507316
MESH:D019465 Craniofacial Abnormalities nitrofen 3.7811405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.788888407 17688650 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.1114966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5711906362 8156756 8970840 18759878 2524372 12868966 14531868 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.263621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5716873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.7616286809
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.2818289764 9653073 18692083 6679447 9022650 8291058 11289319 1440618 6482804 18648102 16192314 7440962 9328219
MESH:D056486 Drug-Induced Liver Injury Amiodarone 14.2818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.2816227642 15998439 21278145 7179309 17522070 10915739 7440962 15027814 4309450 3732212 2869522 6884620 19336974 3786805 16177239 7120509 9327722 10092053 19085960 6623471 11566570 15968718
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 14.2817851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.2820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 14.281733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D004421 Dystonia Valproic Acid 3.821851702
MESH:D004487 Edema Mustard Gas 14.6411428631 11428647 11402378 9260866
MESH:D004487 Edema pirinixic acid 14.6412083418
MESH:D004487 Edema resveratrol 14.648985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.6412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.7917872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8719294695
MESH:D004715 Endometriosis rofecoxib 8.6215652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.629294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6117923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.913659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.6716628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.387562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.823659116
MESH:D007172 Erectile Dysfunction icariin 5.2016281085 15329286
MESH:D004890 Erythema Mustard Gas 4.919357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.143581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8311564622
MESH:D005234 Fatty Liver Amiodarone 22.3014986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.3016239168 15959796 19224547 12631006 61145 12795759 16045604 17595544
MESH:D005234 Fatty Liver Cyclosporine 22.3019224547
MESH:D005234 Fatty Liver pirinixic acid 22.3019236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 22.3019224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.908888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.776705139
MESH:D005355 Fibrosis Carbon Tetrachloride 13.3118705752
MESH:D005355 Fibrosis Cyclosporine 13.3112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.3120067830
MESH:D005534 Foot Diseases Arsenic 5.316392382
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0516417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.817505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.3219215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.5220471113
MESH:D006330 Heart Defects, Congenital nitrofen 10.5216080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.446705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.4419900420 19110552
MESH:D006529 Hepatomegaly Amiodarone 13.0215265979
MESH:D006529 Hepatomegaly pirinixic acid 13.0219176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.0215340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic nitrofen 3.8510541330 15764645 16863852 12407540 16080930 10359170 11588001 15756563 17270546 7760232 18280291 17245593 9476886 10898224 16473863 15578192 7576705 10693666 12547725 8863223 16720372 12194112 10646786 10370016 10898222 12759764 12746050 11076806 16292651 15136996 15707848 11409163 11685700 12505043 9575882 11584395 10370017 9698600 17618886 15088113 11051153 9859898 18958481 7520565 15185205 12021965 9473106 12904592 11057544 15793718 16490937 11329586 18280292
MESH:D006561 Herpes Simplex resveratrol 3.9416876885
MESH:D006849 Hydrocephalus Valproic Acid 4.6217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.808697196 16959395 15340226 16354765 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006937 Hypercholesterolemia Amiodarone 8.598137927 9751232
MESH:D006937 Hypercholesterolemia resveratrol 8.5917188708
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2417050553
MESH:D006949 Hyperlipidemias resveratrol 3.8016873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7015034207
MESH:D006973 Hypertension Arsenic 11.6116076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 11.6110903974
MESH:D006973 Hypertension Phenylephrine 11.6112717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.6118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D006984 Hypertrophy Phenylephrine 4.3318502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0917488730
MESH:D006987 Hypesthesia Arsenic 5.3116093927
MESH:D007037 Hypothyroidism Amiodarone 4.2718020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4017600658
MESH:D007248 Infertility, Male decitabine 6.3917581917
MESH:D007248 Infertility, Male vinclozolin 6.3916467254
MESH:D007249 Inflammation Mustard Gas 7.6516001271 11428620 17524151 8975870 9357497 11428631 11428647 9260866 11402378
MESH:D007249 Inflammation resveratrol 7.6516366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6512200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.3016624496
MESH:D007333 Insulin Resistance bisphenol A 6.7916393666
MESH:D007333 Insulin Resistance pirinixic acid 6.7916306350
MESH:D007410 Intestinal Diseases rofecoxib 4.7915831440
MESH:D007417 Intestinal Polyps rofecoxib 5.1411245490
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.779022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007642 Keratosis Arsenic 4.7412749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 2.2018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.616582329
MESH:D007680 Kidney Neoplasms Cyclosporine 6.6112371664
MESH:D007859 Learning Disorders icariin 5.0819782061
MESH:D007938 Leukemia decitabine 2.9518980019 19235587
MESH:D007948 Leukemia, Monocytic, Acute U 0126 5.0616972261
MESH:D007951 Leukemia, Myeloid decitabine 3.7818454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.8419387464 18460780 18704418 19010910 17679729 18206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8417596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2118055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.3917339181
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.3916087638
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4816417039
MESH:D008064 Lipidoses Amiodarone 3.3415342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6721278145 17157831 11408273 17174718 16239168 17334410 16221502 11903743 16943688
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7315650968 12445418 17721639 15338365 15893842 18277467 15996030 18472094 12958196 18006644 14724832 17708605 12667390 18472332 18263696 17698563 15876570 18420326 15959796 12609069 10355542 18376398 12632514 18054572 12586293 18210741 12445421 17823541 18205269 12389079 18429990 15370692 11481614 18251166 16011737 14716833 20821823 15818738 15123356 14716496 18317297 12666154 15052691 18395095 17640975 18395914 17766677 15673190 16116963 15730626 12546737 17761835 18156304 17481882 17976157 16015684 17557913 16033810 15362042 16097048 12898905 17900296 18339082 16638106 18187930 14620537 17565644 18412020 17525996 15925388 13678700 14748882 12632512 16136751 16192424 17714472 18418968 12649538 17631135 14512876 18279442 17805973 12741479 17869086 16027843 15931870 18705752 17922224 18481824 16248980 18166357 15057751 17944888
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7315474484
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 4.7317565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7312878042
MESH:D008107 Liver Diseases Arsenic 4.0211134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0217285989 16246199 16964402 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4814706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 16.7516368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.7521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.7519294768
MESH:D008113 Liver Neoplasms pirinixic acid 16.7516377806 15890375 20007298
MESH:D008113 Liver Neoplasms resveratrol 16.7520405173 19812893 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.7516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 8.901399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.9012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.9012151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3911989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 11.6312587719
MESH:D008171 Lung Diseases Mustard Gas 11.6318702808 18161513
MESH:D008171 Lung Diseases nitrofen 11.6316863852 9614859 9859898 17245593
MESH:D017563 Lung Diseases, Interstitial Amiodarone 10.4318516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.4317228818
MESH:D008175 Lung Neoplasms Arsenic 4.6117976673 19168569 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.6120869020 20464547 18520028 18569708 17053015 18816296 20064080 20135361 6695378
MESH:D008175 Lung Neoplasms Mustard Gas 4.613148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6119555203 11884234
MESH:D008223 Lymphoma decitabine 3.2519470736
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0717088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0015688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 2.9611606380 8985016
MESH:D008545 Melanoma decitabine 3.4316505122 17785578
MESH:D008545 Melanoma resveratrol 3.4317992120
MESH:D008569 Memory Disorders icariin 5.0619782061
OMIM:613443 MENTAL RETARDATION, STEREOTYPIC MOVEMENTS, EPILEPSY, AND/OR CEREBRAL MALFORMATIONS marker/mechanism
MESH:D008659 Metabolic Diseases resveratrol 4.1617112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D008881 Migraine Disorders Valproic Acid 3.0218803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0016381670
MESH:D009101 Multiple Myeloma decitabine 6.9418172295
MESH:D009101 Multiple Myeloma resveratrol 6.9417164350 16490592 16267019 17049120 14749477 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6217962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.818888407
MESH:D009181 Mycoses Amiodarone 4.6512754197 17974566
MESH:D009190 Myelodysplastic Syndromes decitabine 7.0416882708 19010910 18608210 19157545
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.0417596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.4019151258
MESH:D009203 Myocardial Infarction resveratrol 5.4017188708 16317513 16525036 16456233 17125593 17015251
MESH:D017202 Myocardial Ischemia Arsenic 14.1915371236
MESH:D017202 Myocardial Ischemia resveratrol 14.1917125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 14.1912213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7616411023
MESH:D009205 Myocarditis resveratrol 4.5117322642
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.373581430
MESH:D009369 Neoplasms Benzo(a)pyrene 7.5211141357
MESH:D009369 Neoplasms decitabine 7.5219470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 7.5217405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.768985016
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 8.8011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.8014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.266679447
MESH:D009436 Neural Tube Defects Arsenic 11.2616620997
MESH:D009436 Neural Tube Defects Valproic Acid 11.268888407 16359493
MESH:D019636 Neurodegenerative Diseases resveratrol 3.6117652729
MESH:D020078 Neurogenic Inflammation Arsenic 9.9417056641
MESH:D020078 Neurogenic Inflammation resveratrol 9.9417929310
MESH:D009503 Neutropenia Mustard Gas 3.7416761898 7688884
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.216482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.773988306
MESH:D010003 Osteoarthritis rofecoxib 4.2316690336
MESH:D010024 Osteoporosis icariin 4.4618236786 19747809
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0317513867
MESH:D010049 Ovarian Diseases bisphenol A 4.7411985600
MESH:D010051 Ovarian Neoplasms Arsenic 7.6517306315
MESH:D010051 Ovarian Neoplasms decitabine 7.6519259094 19331143
MESH:D010051 Ovarian Neoplasms U 0126 7.6516211241
MESH:D010149 Pain, Postoperative rofecoxib 5.1416678543 18165598
MESH:D010190 Pancreatic Neoplasms decitabine 2.6819294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.247296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.7416905509 15371236 6392382
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.226228378
MESH:D011041 Poisoning Mustard Gas 3.5715727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0212371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 27.8210548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 27.8216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 27.8211896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 27.8220603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 27.8218220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.4917616702
MESH:D011469 Prostatic Diseases vinclozolin 4.6918220299
MESH:D011470 Prostatic Hyperplasia BXL628 6.2716957418 15572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.9920887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.9016140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9016740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.9016205645
MESH:D011471 Prostatic Neoplasms resveratrol 1.9017636462 16731767 17675339 17718901 17804756 15767336
MESH:D011472 Prostatitis vinclozolin 4.6918629315
MESH:D011507 Proteinuria Arsenic 3.7821343184
MESH:D011537 Pruritus Mustard Gas 3.8518058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.2911422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5410548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.5312490602 11597910 12832656
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.5310334151 17266442 17894541 17720292 17620002
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3316325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.1719058328
MESH:D015427 Reperfusion Injury resveratrol 6.1715827377 16314181 17520802 16317513 17058453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.193692021
MESH:D012208 Rhabdomyosarcoma decitabine 10.2219155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.2219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0415737665 19110320
MESH:D012640 Seizures Valproic Acid 2.581511512 11738929 3137016 15475178 14763951 16876388 11044598 17978042
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8418724381
MESH:D012852 Sinusitis Phenylephrine 4.467327846
MESH:D012871 Skin Diseases Arsenic 4.9218709164 19834688 16759981 15952646 17938729 16702368 6392382 17548696 16353154 17050553 17453740
MESH:D012871 Skin Diseases Mustard Gas 4.9215451306 12880345 16961503
MESH:D012878 Skin Neoplasms Arsenic 12.6319538983 17976673 15504454 17029826 16251483 17050553
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.6319755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 12.6315837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.6316192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2912833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3920155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 2.3919037991
MESH:D013276 Stomach Ulcer Amiodarone 3.1018087811
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2716321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.7416684133 16045194
MESH:D013610 Tachycardia Amiodarone 4.0511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9519225199
MESH:D013959 Thyroid Diseases Amiodarone 11.2219731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.631399818 6582329 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms decitabine 6.6317967635
MESH:D013971 Thyrotoxicosis Amiodarone 4.6219584973 18020914
MESH:D014062 Tongue Neoplasms resveratrol 4.0016227395
MESH:D016171 Torsades de Pointes Amiodarone 3.9411989578 17467628
MESH:D014178 Translocation, Genetic Valproic Acid 4.9817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.273119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.148074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.1419322015 17306315 11144890 15987713 17976673 18640142 19429237
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.1417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.1419087683 17616700
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.408888407
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.8917473185
MESH:D014591 Uterine Diseases bisphenol A 4.7614652134
MESH:D014594 Uterine Neoplasms resveratrol 3.9017044934
MESH:D014604 Uveal Neoplasms decitabine 4.6617785578
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D014652 Vascular Diseases Arsenic 4.4917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0617488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
REACT:21303 Myogenesis
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30734
    • Releated gene ID Related gene Name
    PA30729MECP2
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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