AutismKB 2.0

Annotation Detail for MEF2D


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Basic Information Top
Gene Symbol:MEF2D ( DKFZp686I1536 )
Gene Full Name: myocyte enhancer factor 2D
Band: 1q22
Quick LinksEntrez ID:4209; OMIM: 600663; Uniprot ID:MEF2D_HUMAN; ENSEMBL ID: ENSG00000116604; HGNC ID: 6997
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Myogenesis
Pathway IDPathway Name
200020Signaling events mediated by HDAC Class III
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of MEF2D mRNAaffects expression 18343893
D000082 Acetaminophen Acetaminophen affects the expression of MEF2D mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MEF2D mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine affects the expression of MEF2D proteinaffects expression 19002953
D001374 Azacitidine Azacitidine results in increased expression of MEF2Dincreases expression 12094073
D004041 Dietary Fats Dietary Fats results in decreased expression of MEF2D mRNAdecreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MEF2D mRNAincreases expression 17005392
C041786 palm oil palm oil results in decreased expression of MEF2D mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MEF2D mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of MEF2D mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of MEF2D mRNAaffects expression 18343893
D014212 Tretinoin Tretinoin results in decreased expression of MEF2D proteindecreases expression 15059897
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6815469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.3019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.3012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.3016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9820435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9815324884 17129689
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.723084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.7215948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.721917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3316051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9812621046 15340226 16354765 15668235 8697196
MESH:D002972 Cleft Palate Tretinoin 5.989407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4920055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4917551590 9142499 10589399 9211117 9125849 16925845 8800419 9224671 9664655 14991402
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7512952375 16002989
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7017522070 12153990 17906064 14725611 18071297 18713872 15968718 11743745 16177239 2444490 12958197 10774834 19420014 11739529 10915739 19164858 11834606 19923254 19085960 14550746 16081117 11461765 11421492 10663392 11287661 15619225 16109766 11529661 12594235 16485898 12705907 12392966 16227642 16781746 14986274 12540782 19739265 17562736 19416960 16393943 19370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.8515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.8518230668
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.9316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.9515700306 16804899
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.2611564622
MESH:D005124 Eye Abnormalities Tretinoin 9.2616938888 9664655
MESH:D005234 Fatty Liver Dietary Fats 8.2818296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver pirinixic acid 8.2819236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7516611131 15751030 16534752 16002989 16513791
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Dietary Fats 16.0818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0820067830
MESH:D005355 Fibrosis Tretinoin 16.0817994277
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.1816452187
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 11.7711294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.7711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 11.7714991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly pirinixic acid 8.9919176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9916120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 16959395 16354765 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6514722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 4.7916002989
MESH:D007246 Infertility Diethylstilbestrol 4.5515036965
MESH:D007249 Inflammation Dietary Fats 5.1920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.6111836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.5116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.5117551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.2912587719 15629191
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.6016762066 15003126 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2817184923
MESH:D007938 Leukemia Azacitidine 6.9219148494
MESH:D007938 Leukemia Tretinoin 6.9217143497
MESH:D007951 Leukemia, Myeloid Azacitidine 10.3719077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.3716932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.2917596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.2919850784 16294345 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.3719299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2619029980 17107899 12679006 16331271 17217047 16766008 19225113 17712046 16140955 19642359 17301526 19035177 16891316 17649720 17506722 16788101 16935935 9834237 17368321 17339181 19075265 16823087 17361223 17294898 15748426
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4916248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6619784758 16611625 12969438 11587558 19460945 19014921 12587719 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.7315890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 7.7316377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008175 Lung Neoplasms Azacitidine 2.6521224363
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6511884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7816002989
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D009006 Monosomy Azacitidine 6.3519299654
MESH:D009101 Multiple Myeloma Azacitidine 4.0818443271 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 8.0119805378 17611569 18720364 17596541
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.0117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009369 Neoplasms Diethylstilbestrol 8.7315313581
MESH:D009369 Neoplasms pirinixic acid 8.7317405874
MESH:D009369 Neoplasms Tretinoin 8.7316946489 16594593
MESH:D009421 Nervous System Malformations Diethylstilbestrol 17.6011399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.6014600291
MESH:D009421 Nervous System Malformations Tretinoin 17.609125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity Dietary Fats 4.5616723640 19632207 21332399 18674790 17217161 11836018 18457598 20518802 20132043
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3916936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.4314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8915687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 10.3717184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.3711896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Azacitidine 3.6718324645
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.6715046698 17136230 15846301
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D012878 Skin Neoplasms Tretinoin 5.8016467112
MESH:D013088 Spermatocele Diethylstilbestrol 4.9816709447 16002989
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8316712894 16452187 17306315
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 10.0516175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.0516129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.4314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.2715809267 16690809
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6516002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
REACT:21303 Myogenesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30735
    • No data
    No data
    Releated drug ID Related drug Name
    PA451578tacrolimus
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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