Annotation Detail for MEFV
Basic Information Top
| Gene Symbol: | MEFV ( FMF,MEF,MGC126560,MGC126586,TRIM20 ) |
|---|---|
| Gene Full Name: | Mediterranean fever |
| Band: | 16p13.3 |
| Quick Links | Entrez ID:4210; OMIM: 608107; Uniprot ID:MEFV_HUMAN; ENSEMBL ID: ENSG00000103313; HGNC ID: 6998 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04621 | NOD-like receptor signaling pathway |
| No data |
| No data |
| No data |
| No data |
| Desease ID | Desease Name |
|---|---|
| Other immune system disease | |
| Immune system diseases | |
| H00288 | Familial Mediterranean fever |
| Desease ID | Desease Name |
|---|---|
| 1711 | Familial Mediterranean fever |
| 1723 | Brucellosis |
| 1744 | Vasculitis |
| 1869 | Behcet syndrome |
| 1963 | Amyloidosis |
| 1977 | Rheumatism |
| 1998 | Enteritis |
| 2083 | IGA glomerulonephritis |
| 2094 | Ulcerative colitis |
| 2111 | Systemic infection |
| Desease Name |
|---|
| arthritis |
| Mediterranean fever |
| IgD |
| Familial Mediterranean Fever |
| ulcerative colitis |
| Behcet's disease thromboembolism, venous |
| multiple sclerosis |
| amyloidosis |
| IMMUNE |
| Behcet's Disease |
| METABOLIC |
| secondary and FMF amyloidosis. |
| No data |
| Desease Name |
|---|
| Familial Mediterranean fever, AD |
| Familial Mediterranean fever, AR |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of MEFV mRNA | affects expression | 17562736 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of MEFV mRNA | affects expression | 16483693 |
| D014303 | Trinitrotoluene | Trinitrotoluene affects the expression of MEFV mRNA | affects expression | 21346803 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000014 | Abnormalities, Drug-Induced | Trinitrotoluene | 4.93 | 7525203 | |
| MESH:D000138 | Acidosis | Ammonium Chloride | 4.30 | 18287403 | |
| MESH:D000799 | Angioedema | Acetaminophen | 4.71 | 10982225 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.39 | 18445737 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 1.41 | 3084413 | |
| MESH:D002386 | Cataract | Acetaminophen | 8.28 | 10977129 | |
| MESH:D002386 | Cataract | Trinitrotoluene | 8.28 | 15817613 14694615 | |
| MESH:D000013 | Congenital Abnormalities | Trinitrotoluene | 4.82 | 15095906 | |
| MESH:D003490 | Cyanosis | Trinitrotoluene | 5.57 | 18551238 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 4.38 | 10774834 12540782 15968718 14725611 16177239 16393943 18071297 2444490 10915739 12594235 19420014 11529661 16227642 19923254 12705907 11739529 16109766 18713872 19739265 19370779 19085960 10663392 17522070 16485898 11834606 16781746 11287661 14550746 14986274 17562736 12958197 11743745 11421492 19164858 11461765 12153990 17906064 12392966 16081117 19416960 15619225 | |
| MESH:D056486 | Drug-Induced Liver Injury | Trinitrotoluene | 4.38 | 18551238 21346803 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 4.96 | 19426721 | |
| MESH:D010505 | Familial Mediterranean Fever | marker/mechanism | |||
| OMIM:134610 | FAMILIAL MEDITERRANEAN FEVER, AUTOSOMAL DOMINANT | marker/mechanism | |||
| MESH:D005756 | Gastritis | Acetaminophen | 4.54 | 16983495 | |
| MESH:D006529 | Hepatomegaly | Trinitrotoluene | 4.88 | 15817613 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 3.06 | 16870215 | |
| MESH:D007248 | Infertility, Male | Trinitrotoluene | 3.95 | 12150543 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.42 | 15629191 12587719 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.71 | 12587719 12969438 16610002 19460945 11587558 19014921 16611625 19784758 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.68 | 16871587 17185352 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.22 | 19513568 | |
| MESH:D009336 | Necrosis | Trinitrotoluene | 5.51 | 18551238 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.26 | 18514411 | |
| MESH:D009784 | Occupational Diseases | Trinitrotoluene | 4.78 | 14694615 17852074 12819281 | |
| MESH:D010146 | Pain | Acetaminophen | 2.77 | 16870215 | |
| MESH:D012640 | Seizures | Trinitrotoluene | 3.72 | 18551238 | |
| MESH:D013163 | Splenomegaly | Trinitrotoluene | 5.85 | 15817613 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.50 | 10982225 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04621 | NOD-like receptor signaling pathway |
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