AutismKB 2.0

Annotation Detail for MAP3K1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAP3K1 ( MAPKKK1,MEKK,MEKK1 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 1
Band: 5q11.2
Quick LinksEntrez ID:4214; OMIM: 600982; Uniprot ID:M3K1_HUMAN; ENSEMBL ID: ENSG00000095015; HGNC ID: 6848
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04912GnRH signaling pathway
hsa04010MAPK signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04120Ubiquitin mediated proteolysis
No data
Pathway IDPathway Name
200031CD40/CD40L signaling
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200003Fc-epsilon receptor I signaling in mast cells
200005BCR signaling pathway
200129JNK signaling in the CD4+ TCR pathway
200152Regulation of cytoplasmic and nuclear SMAD2/3 signaling
200014p38 MAPK signaling pathway
200086TNF receptor signaling pathway
200067FAS (CD95) signaling pathway
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
200148Caspase cascade in apoptosis
200113ErbB1 downstream signaling
200110IFN-gamma pathway
200042Osteopontin-mediated events
200100Ceramide signaling pathway
200190RAC1 signaling pathway
200057CDC42 signaling events
200056TRAIL signaling pathway
Pathway IDPathway Name
P04393Ras Pathway
Pathway IDPathway Name
500445MyD88 cascade
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
1934Cancer
Desease Name
CANCER
breast cancer
Desease Name
Breast cancer
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of MAP3K1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MAP3K1 mRNAaffects expression 17562736
C000188 alachlor alachlor results in increased expression of MAP3K1 mRNAincreases expression 12419858
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAP3K1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MAP3K1 proteinincreases expression 16041517
D001564 Benzo(a)pyrene Nitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased expression of MAP3K1 protein]decreases reaction|increases expression 16041517
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAP3K1 mRNAdecreases expression 19150397
C095105 bexarotene bexarotene results in increased expression of MAP3K1 mRNAincreases expression 16648578
C006780 bisphenol A bisphenol A affects the expression of MAP3K1 mRNAaffects expression 20170705
D002509 Cephaloridine Cephaloridine results in increased expression of MAP3K1 mRNAincreases expression 18172885
D003024 Clozapine Clozapine results in increased expression of MAP3K1 mRNAincreases expression 15860345
D003474 Curcumin Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]decreases reaction|increases expression 17148446
D003474 Curcumin Curcumin results in decreased expression of MAP3K1 mRNAdecreases expression 15713895
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of MAP3K1 mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine results in decreased expression of MAP3K1 mRNAdecreases expression 20106945
D003606 Dacarbazine MAP3K1 protein modified form results in decreased susceptibility to Dacarbazinedecreases response to substance 15123733
D016190 Carboplatin Carboplatin results in decreased expression of MAP3K1 mRNAdecreases expression 18172885
D002945 Cisplatin Cisplatin results in decreased expression of MAP3K1 mRNAdecreases expression 18172885
D004041 Dietary Fats Dietary Fats results in increased expression of MAP3K1 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MAP3K1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MAP3K1 mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MAP3K1 mRNAdecreases expression 12655037
D005620 Freund's Adjuvant [Urethane co-treated with Freund's Adjuvant] results in increased expression of MAP3K1 mRNAaffects cotreatment|increases expression 12400877
D006220 Haloperidol Haloperidol results in increased expression of MAP3K1 mRNAincreases expression 15860345
D006533 Heptachlor Heptachlor results in decreased expression of MAP3K1 proteindecreases expression 9704902
D006581 Hexachlorobenzene Hexachlorobenzene affects the expression of MAP3K1 mRNAaffects expression 15159207
D009589 Nitrogen Oxides Nitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased expression of MAP3K1 protein]decreases reaction|increases expression 16041517
C041786 palm oil palm oil results in increased expression of MAP3K1 mRNAincreases expression 18042831
C488333 Ro 65-7199 Ro 65-7199 affects the expression of MAP3K1 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 results in increased expression of MAP3K1 mRNAincreases expression 14610520
D012967 Sodium Dodecyl Sulfate Sodium Dodecyl Sulfate results in decreased expression of MAP3K1 mRNAdecreases expression 12815608
C025462 sulindac sulfide sulindac sulfide results in decreased expression of MAP3K1 mRNAdecreases expression 12734198
D013629 Tamoxifen Tamoxifen affects the expression of MAP3K1 mRNAaffects expression 17555576
C021751 tanshinone tanshinone results in decreased expression of MAP3K1 mRNAdecreases expression 15849732
C402769 tipifarnib tipifarnib results in increased expression of MAP3K1 mRNAincreases expression 16403772
C113106 tocopheryloxybutyric acid tocopheryloxybutyric acid inhibits the reaction [Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein]decreases reaction|increases activity|increases phosphorylation 11062179
D014520 Urethane tocopheryloxybutyric acid inhibits the reaction [Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein]decreases reaction|increases activity|increases phosphorylation 11062179
D014520 Urethane [Urethane co-treated with Freund's Adjuvant] results in increased expression of MAP3K1 mRNAaffects cotreatment|increases expression 12400877
D014520 Urethane Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 proteinincreases activity|increases phosphorylation 11062179
D014520 Urethane Vitamin E inhibits the reaction [Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein]decreases reaction|increases activity|increases phosphorylation 11062179
D014810 Vitamin E Vitamin E inhibits the reaction [Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein]decreases reaction|increases activity|increases phosphorylation 11062179
D015032 Zinc Zinc results in decreased expression of MAP3K1 mRNAdecreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of MAP3K1 mRNAdecreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1714745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 3.597525203
MESH:D000138 Acidosis Ammonium Chloride 9.4018287403
MESH:D000138 Acidosis Zinc Sulfate 9.407265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5717505938
MESH:D000169 Acrodermatitis Zinc 5.0317202136 17190629 16889938
MESH:D058186 Acute Kidney Injury Cisplatin 3.6315814532 17670903 12690470
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.3720464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 9.3711798837 17638652
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.3714692618
MESH:D000230 Adenocarcinoma Urethane 9.3718316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.3315814487
MESH:D000236 Adenoma Benzo(a)pyrene 6.336695378
MESH:D000236 Adenoma Urethane 6.3316926031 10530776 10822126 17195641 6695378 11497255 17093202
MESH:D000380 Agranulocytosis Clozapine 4.7012649775 14617031 16160616
MESH:D000382 Agricultural Workers' Diseases alachlor 8.3811874814 14769641
MESH:D000382 Agricultural Workers' Diseases Heptachlor 8.3812661182
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7117887948
MESH:D000544 Alzheimer Disease Curcumin 6.2815590663
MESH:D000544 Alzheimer Disease sulindac sulfide 6.2818759972
MESH:D000544 Alzheimer Disease Zinc 6.2817119284 16580781 16325427 16410023
MESH:D000755 Anemia, Sickle Cell Zinc 4.5516916123
MESH:D000799 Angioedema Acetaminophen 3.4710982225
MESH:D000860 Anoxia Zinc Sulfate 4.657265320
MESH:D001005 Anus Neoplasms Dacarbazine 5.9112170190
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7119183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.7115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.7111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4415885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6516807698
MESH:D001249 Asthma Zinc 2.8417085522
MESH:D050197 Atherosclerosis Curcumin 3.1018704882
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1219368416 18080171
MESH:D001327 Autoimmune Diseases Curcumin 4.1319761891
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.5114601052
MESH:D001862 Bone Resorption bisphenol A 8.8611985600
MESH:D001862 Bone Resorption Freund's Adjuvant 8.8616769263
MESH:D001930 Brain Injuries Zinc 4.3317109824
MESH:D002545 Brain Ischemia Curcumin 3.9616770732
MESH:D001932 Brain Neoplasms Curcumin 3.6217596214
MESH:D001943 Breast Neoplasms marker/mechanism 17529967
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.7920146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 7.7916818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 7.7917123778
MESH:D001943 Breast Neoplasms Cisplatin 7.7919526202 18382427
MESH:D001943 Breast Neoplasms Curcumin 7.7919250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms Dacarbazine 7.7917983394
MESH:D001943 Breast Neoplasms Dietary Fats 7.7920435547
MESH:D001943 Breast Neoplasms Heptachlor 7.798738476
MESH:D001943 Breast Neoplasms Hexachlorobenzene 7.7915061365 12709520
MESH:D001943 Breast Neoplasms Tamoxifen 7.7918815881 20859285 17893378 20390343 20135344 18821012 19189210 21138602 19189212 17242785 20544844 19410462 19142967 19487384 15565566 19200415 16202921 19059307 15668708 20065188 19155303 18425577 16873071 19288272 11161223 19244106 19011961 20005174 19115204 17440819 18351453 16818667 19084267 19066611 19221464 19103187 18855134 18629630 18984771 19289846 18997820 17049068 17261762 21152245 16273361
MESH:D001943 Breast Neoplasms tanshinone 7.7915849732 19885617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.5716050911
MESH:D002276 Carcinoid Tumor Dacarbazine 5.7816051944
MESH:D002277 Carcinoma Curcumin 3.5518593918
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1519066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.233084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.2317982673
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.2316924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.6217123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 15.3916247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 15.3916685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 15.3912023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 15.3918414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 15.3912391285
MESH:D002292 Carcinoma, Renal Cell Dacarbazine 4.3216201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.8820419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 9.8817066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Curcumin 9.8818462866
MESH:D002294 Carcinoma, Squamous Cell Zinc 9.8816543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3017572228
MESH:D002318 Cardiovascular Diseases Zinc 3.4116936243
MESH:D002375 Catalepsy Haloperidol 4.5415215559 1977408
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.6914694615
MESH:D002386 Cataract Acetaminophen 6.6910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 5.7220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.7212371664
MESH:D002779 Cholestasis Cyclosporine 6.8819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.8816919318 17110522 17681005 15861022 16105132 17333356 11677210
MESH:D002972 Cleft Palate Urethane 3.6112810352
MESH:D003072 Cognition Disorders Clozapine 4.6017123785
MESH:D003092 Colitis Curcumin 3.8216804969 16782535 18200517
MESH:D003103 Coloboma Curcumin 4.2218809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4419359593 16340194
MESH:D015179 Colorectal Neoplasms Cisplatin 3.1715273666
MESH:D015179 Colorectal Neoplasms Dacarbazine 3.1715273666
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 3.8515095906
MESH:D016510 Corneal Neovascularization Curcumin 4.5418497527
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7919769572
MESH:D019465 Craniofacial Abnormalities Zinc 2.7919302082
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.5020210726
MESH:D003704 Dementia Haloperidol 4.2511575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0019031437
MESH:D017449 Dermatitis, Allergic Contact alachlor 3.858428444
MESH:D003920 Diabetes Mellitus Zinc 3.9016479319
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.5516402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.5518403477
MESH:D003928 Diabetic Nephropathies Curcumin 8.0418204486
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.0419279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1815331141
MESH:D004342 Drug Hypersensitivity Dacarbazine 4.7316508601
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 5.7321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.7316485898 16227642 11743745 17906064 11529661 16109766 2444490 10915739 14550746 12705907 17562736 14986274 12594235 16177239 10774834 14725611 11739529 19085960 15619225 19739265 12153990 16781746 19164858 16081117 16393943 11287661 12540782 19416960 19420014 18071297 19923254 11461765 12392966 11834606 18713872 12958197 19370779 17522070 10663392 11421492 15968718
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 5.7317654400
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7219426721
MESH:D004362 Drug Toxicity Cisplatin 3.5912649298 12231392 15033597 19839026
MESH:D004381 Duodenal Ulcer Curcumin 3.7017351913
MESH:D050171 Dyslipidemias Clozapine 7.9916402076
MESH:D050171 Dyslipidemias Dietary Fats 7.9918367378
MESH:C538011 Eales disease Vitamin E 4.339068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.7912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.7919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.8116202921 19155303 20544844 17893378
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.5620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.5616530937
MESH:D004938 Esophageal Neoplasms Cisplatin 9.5616481741 15464296 16785472 15173087 17638652
MESH:D004938 Esophageal Neoplasms Zinc 9.5616543248
MESH:D005234 Fatty Liver Curcumin 21.1719297423
MESH:D005234 Fatty Liver Cyclosporine 21.1719224547
MESH:D005234 Fatty Liver Dietary Fats 21.1718296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.1715345470
MESH:D005234 Fatty Liver Tamoxifen 21.1719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1614745880
MESH:D018222 Fibromatosis, Aggressive Dacarbazine 10.7119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.7119069698
MESH:D005355 Fibrosis Curcumin 12.7818705752
MESH:D005355 Fibrosis Cyclosporine 12.7812168785 12639820
MESH:D005355 Fibrosis Dietary Fats 12.7818296743
MESH:D005756 Gastritis Acetaminophen 9.9216983495
MESH:D005756 Gastritis Zinc 9.9217241300
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3318462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.858708960
MESH:D005909 Glioblastoma Curcumin 7.1117596214
MESH:D005909 Glioblastoma Dacarbazine 7.1112592361 12853885
MESH:D005910 Glioma tanshinone 3.8816955220
MESH:D006130 Growth Disorders Zinc 3.7217217573
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.2615464296 15102660
MESH:D006258 Head and Neck Neoplasms Curcumin 7.2618829502 18462866
MESH:D034381 Hearing Loss Cisplatin 3.9919898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1215464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0320471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.0316080930
MESH:D006331 Heart Diseases Urethane 3.9916046796
MESH:D006333 Heart Failure Zinc 3.3817162251
MESH:D006335 Heart Injuries Zinc 5.3917074742
MESH:D016481 Helicobacter Infections Zinc 4.1917241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0515720958
MESH:D006527 Hepatolenticular Degeneration Zinc 10.1217276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 10.1217063115
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6817701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5716863852 16490937
MESH:D006689 Hodgkin Disease Cisplatin 7.1216200630 16170182
MESH:D006689 Hodgkin Disease Dacarbazine 7.1218501091 16170182
MESH:D019584 Hot Flashes Vitamin E 3.6014716179
MESH:D006930 Hyperalgesia Acetaminophen 7.2116870215
MESH:D006930 Hyperalgesia Freund's Adjuvant 7.2116769263
MESH:D006937 Hypercholesterolemia Curcumin 8.1418704882
MESH:D006937 Hypercholesterolemia Dietary Fats 8.1421332399
MESH:D006948 Hyperkinesis Clozapine 4.5416046005
MESH:D006949 Hyperlipidemias Dietary Fats 3.2821332399
MESH:D006973 Hypertension Cyclosporine 1.9610903974
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 4.9219662366
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4516569931 16945680
MESH:D007022 Hypotension Zinc Sulfate 4.147265320
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1212013081
MESH:D007248 Infertility, Male alachlor 6.2516466525 12948887 17049205
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2517937319
MESH:D007249 Inflammation Curcumin 10.4416956363 18403477 17151092
MESH:D007249 Inflammation Dietary Fats 10.4420412841
MESH:D007249 Inflammation Freund's Adjuvant 10.4416793879
MESH:D007249 Inflammation Tamoxifen 10.4419457130
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0618596194 18200517
MESH:D007251 Influenza, Human Vitamin E 3.8416624496
MESH:D007333 Insulin Resistance bisphenol A 6.6816393666
MESH:D007333 Insulin Resistance Dietary Fats 6.6811836018 18457598
MESH:D007414 Intestinal Neoplasms Curcumin 3.9010783313
MESH:D007511 Ischemia Zinc 4.2716584753
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0715604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7715464296
MESH:D007674 Kidney Diseases Acetaminophen 16.7712587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 16.7712649298 19839026 12231392 18289764 15190930
MESH:D007674 Kidney Diseases Cyclosporine 16.7718776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 16.7712488133
MESH:D007674 Kidney Diseases Zinc 16.7716960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.0916518626
MESH:D007680 Kidney Neoplasms Cyclosporine 6.3212371664
MESH:D007680 Kidney Neoplasms Tamoxifen 6.3218625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.4211231351
MESH:D007889 Leiomyoma Curcumin 4.2318555241
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.9715237267
MESH:D007938 Leukemia alachlor 6.3214769641
MESH:D007938 Leukemia Curcumin 6.3218462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8816106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.4116106398
MESH:D008064 Lipidoses Clozapine 7.2117567588
MESH:D008064 Lipidoses Tamoxifen 7.2117567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.6718296743
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.3318705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.3316169303
MESH:D008107 Liver Diseases Acetaminophen 3.7519784758 16610002 19014921 11587558 12587719 16611625 19460945 12969438
MESH:D008107 Liver Diseases Curcumin 3.7516956363
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9216871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 9.6221137059 20195826
MESH:D008113 Liver Neoplasms Heptachlor 9.629544696 2422723
MESH:D008113 Liver Neoplasms Tamoxifen 9.6216684651
MESH:D008113 Liver Neoplasms Urethane 9.6217559639 16391232 17093202
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 3.531423854
MESH:D008171 Lung Diseases Vitamin E 2.9316863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.0617053015 18569708 6695378 18816296 20135361 20464547 18520028 20064080 20869020
MESH:D008175 Lung Neoplasms bexarotene 12.0617849452
MESH:D008175 Lung Neoplasms Cisplatin 12.0611798837 6189445 17225452
MESH:D008175 Lung Neoplasms Curcumin 12.0619359593 18462866 16243823
MESH:D008175 Lung Neoplasms Tamoxifen 12.0618625569
MESH:D008175 Lung Neoplasms tipifarnib 12.0616885199
MESH:D008175 Lung Neoplasms Urethane 12.0611544531 11497255 11323394 16391232 10997738 10779650 12957351 7750092 12765245 11074608 6695378 11552296 11992545 11307925 17255336 11062179 10822126 15136453 11893704 16007126 15902970 14587096 15166089 16337739 11807781 11246140 16204055 10530776 16926031 12117781 12466968 16788158 16289808 17195641 17093202
MESH:D008175 Lung Neoplasms Vitamin E 12.0611062179
MESH:D008223 Lymphoma Curcumin 3.3318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3316173963
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7911161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3919428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 12.4515591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.4511731420 16827153 14580682 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental tipifarnib 12.4516648579
MESH:D008325 Mammary Neoplasms, Experimental Zinc 12.4512773700
MESH:D020149 Manganese Poisoning Tamoxifen 4.1719453300
MESH:D008545 Melanoma Carboplatin 9.0516225601 11712820 12040289 16342250
MESH:D008545 Melanoma Cisplatin 9.0517023156 12883367 17761969 12393984 15577323 18332650 16248763 12374674 16809738 18176117 18505091 11135225 16432458
MESH:D008545 Melanoma Curcumin 9.0518462866 17885582
MESH:D008545 Melanoma Dacarbazine 9.0518445842 16939954 16273263 12417787 12202904 17562445 16966688 11135225 17709802 16928243 15020614 16248763 18332650 11254118 12883367 16760174 15577320 17023156 11746506 16034308 17239242 17623835 16225601 12535206 12640292 11712820 16508601 15577323 12393984 15522559 17508024 12025231 16098027 17973783 12439608 18281670 17576460 15917704 15176220 10623706 18176117 18505091 16809738 17761969 17334785 18089842 12556972 17119449
MESH:D008545 Melanoma Tamoxifen 9.0512393984 19393235
MESH:D018328 Melanoma, Amelanotic Cisplatin 17.5415990972
MESH:D018328 Melanoma, Amelanotic Dacarbazine 17.5415990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 17.5415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2119513568
MESH:D008569 Memory Disorders Curcumin 3.8117263510
MESH:D001523 Mental Disorders Clozapine 7.1516856516
MESH:D001523 Mental Disorders Haloperidol 7.1516856516
MESH:D008654 Mesothelioma Cisplatin 3.0917638057
MESH:D024821 Metabolic Syndrome X Clozapine 4.1119142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9116381670
MESH:D009101 Multiple Myeloma alachlor 7.0114769641
MESH:D009101 Multiple Myeloma Curcumin 7.0119372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.5517962980
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0218495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 10.4611141357
MESH:D009369 Neoplasms Carboplatin 10.4617925555 18854779
MESH:D009369 Neoplasms Cisplatin 10.4616773208
MESH:D009369 Neoplasms Urethane 10.4615625555
MESH:D009374 Neoplasms, Experimental Urethane 4.3215582191
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 16.1519196722
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 16.1512497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 16.1519189210 19196722 19200415
MESH:D009395 Nephritis, Interstitial Cisplatin 4.1215464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9819348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 3.6311399458 16427766
MESH:D009423 Nervous System Neoplasms Curcumin 5.2618462866
MESH:D009447 Neuroblastoma Cisplatin 3.268761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5818514411
MESH:D017599 Neuroectodermal Tumors Carboplatin 10.5712837982
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.578761367
MESH:D009669 Nose Neoplasms alachlor 4.4614563481 16698726 16178123 11127290 15580706
MESH:D009765 Obesity Clozapine 7.0019142110 18515891
MESH:D009765 Obesity Curcumin 7.0019297423
MESH:D009765 Obesity Dietary Fats 7.0017217161 20132043 21332399 16723640 19632207 11836018 20518802 18674790 18457598
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 3.7814694615
MESH:D010024 Osteoporosis Curcumin 3.2418719352
MESH:D010049 Ovarian Diseases bisphenol A 4.6211985600
MESH:D010051 Ovarian Neoplasms Cisplatin 7.436897625 19769630 17225452 15464296
MESH:D010051 Ovarian Neoplasms Curcumin 7.4318462866 19020741
MESH:D010051 Ovarian Neoplasms Urethane 7.4316391232
MESH:D010146 Pain Acetaminophen 2.1116870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.1519003803
MESH:D010190 Pancreatic Neoplasms Curcumin 8.1519196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Dacarbazine 8.1511583197
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3511578682
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9615464296
MESH:D003557 Phyllodes Tumor Dacarbazine 6.1217983394
MESH:D010911 Pituitary Neoplasms Urethane 5.0516391232
MESH:D010997 Pleural Neoplasms Cisplatin 4.9717638057
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 4.869918132
MESH:D011230 Precancerous Conditions Cyclosporine 2.9212371664
MESH:D011225 Pre-Eclampsia Zinc 3.8917114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.5910548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.8820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0416740699
MESH:D011471 Prostatic Neoplasms Curcumin 2.0411398177 18226269 12497104 18769126 18156803 10851300 15129424
MESH:D011471 Prostatic Neoplasms Heptachlor 2.0412661182
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0415067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0415084515
MESH:D011471 Prostatic Neoplasms Zinc 2.0416700911 12429649 16606632 16517595
MESH:D011537 Pruritus Ethinyl Estradiol 2.9516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1016882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.6011575062
MESH:D011618 Psychotic Disorders Clozapine 8.2815331141
MESH:D011618 Psychotic Disorders Haloperidol 8.2811575062
MESH:D011629 Puberty, Precocious bisphenol A 4.4210548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.2119168576
MESH:D051437 Renal Insufficiency Cisplatin 4.0515464296
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.6910666014 18379247
MESH:D012135 Respiratory Sounds alachlor 4.5911874814
MESH:D012162 Retinal Degeneration Zinc 3.8516584753
MESH:D012509 Sarcoma Curcumin 9.0118462866
MESH:D012509 Sarcoma Dacarbazine 9.0117898927 18313854
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.0814601052
MESH:D012559 Schizophrenia Clozapine 3.8917123785 20107430 11151749 17726453 20521326 11763009 18806925 20580759 20521320 17667964 20168265 18855531 16141801 20452607 19369910
MESH:D012559 Schizophrenia Haloperidol 3.891830565 19369910 18513383 20107430
MESH:D018805 Sepsis Curcumin 3.7818389075
MESH:D012871 Skin Diseases Vitamin E 2.3418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.4919755658 10029692
MESH:D012878 Skin Neoplasms Urethane 5.4911807781
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9715464296
MESH:D013088 Spermatocele Ethinyl Estradiol 10.3116709447
MESH:D013088 Spermatocele Tamoxifen 10.3116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6719457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4420155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 2.4415958060 18396642 17522103
MESH:D013276 Stomach Ulcer Curcumin 3.1816631530 19188055
MESH:D020521 Stroke Vitamin E 3.2316517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.6216684133 16045194
MESH:D015173 Supratentorial Neoplasms Carboplatin 5.4412837982
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.3620210726
MESH:D013736 Testicular Neoplasms Cisplatin 4.2915464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8515669648
MESH:D013964 Thyroid Neoplasms alachlor 7.348812207
MESH:D013964 Thyroid Neoplasms Dacarbazine 7.3411815960 15634649
MESH:D014062 Tongue Neoplasms Zinc 4.0816543248
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.7017053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 10.7015464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Curcumin 10.7018593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.7016712894 8653321 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.9018462866
MESH:D014581 Urticaria Acetaminophen 2.6410982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 3.8916803524
MESH:D014591 Uterine Diseases bisphenol A 4.6314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.5314692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 8.5318645019
MESH:D014605 Uveitis Cyclosporine 3.611336536
MESH:D014625 Vaginal Neoplasms Cisplatin 10.3715577323
MESH:D014625 Vaginal Neoplasms Dacarbazine 10.3715577323
MESH:D019043 Vascular Neoplasms Urethane 5.5410620525
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2114671159 15869587
MESH:D014839 Vomiting Cisplatin 4.3411897121
MESH:D015430 Weight Gain Clozapine 8.8017502770 16141801 20107430 20521320 20564506 16402076
MESH:D015430 Weight Gain Dietary Fats 8.8016723640
MESH:D015431 Weight Loss Clozapine 4.7117933447
MESH:D014985 Xerophthalmia Cyclosporine 4.0717120751
Pathway ID Pathway Name
KEGG:04912 GnRH signaling pathway
KEGG:04010 MAPK signaling pathway
KEGG:04722 Neurotrophin signaling pathway
KEGG:04622 RIG-I-like receptor signaling pathway
REACT:6900 Signaling in Immune system
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30592
    • No data
    Releated disease ID Related disease Name
    PA443434Arthritis, Rheumatoid
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA449972imiquimod
    PA10804imatinib
    PA449780glutathione
    PA448948chloroquine
    PA451578tacrolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved