AutismKB 2.0

Annotation Detail for MAP3K4


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Basic Information Top
Gene Symbol:MAP3K4 ( FLJ42439,KIAA0213,MAPKKK4,MEKK4,MTK1,PRO0412 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 4
Band: 6q26
Quick LinksEntrez ID:4216; OMIM: 602425; Uniprot ID:M3K4_HUMAN; ENSEMBL ID: ENSG00000085511; HGNC ID: 6856
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04912GnRH signaling pathway
hsa04010MAPK signaling pathway
No data
Pathway IDPathway Name
200014p38 MAPK signaling pathway
Pathway IDPathway Name
P00046Oxidative stress response
P00018EGF receptor signaling pathway
P00047PDGF signaling pathway
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00036Interleukin signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MAP3K4 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of MAP3K4 mRNAaffects expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MAP3K4 mRNAaffects expression 17562736
C015001 arsenite arsenite results in increased expression of MAP3K4 mRNAincreases expression 18191166
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAP3K4 mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MAP3K4 mRNAincreases expression 19465110
D014212 Tretinoin Tretinoin results in decreased expression of MAP3K4 mRNAdecreases expression 16604517
D014635 Valproic Acid Valproic Acid results in decreased expression of MAP3K4 mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4615322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.468875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001169 Arthritis, Experimental Tretinoin 3.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4016456186
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618985861 18396377 18558336 17157402 15238991 17507914 18316065 18775368 20603192 18940202 19460635 16609825 19232924 17688650 18177632
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.7312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.7316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.508888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.813581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.813084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.811917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 7.6610977129
MESH:D002386 Cataract Tretinoin 7.6617460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.196135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.197505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.439022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.4319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0516354765 8697196 15340226 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 6.059407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D003110 Colonic Neoplasms arsenite 2.6215037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8815322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8810589399 9211117 17551590 9664655 16925845 8800419 9224671 14991402 9125849 9142499
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.888888407 17688650 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1011298694 8156756 8970840 18759878 2524372 12868966 11906362 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.6718692083 16192314 18289764 11289319 6482804 8291058 6679447 7440962 18648102 9653073 9328219 9022650 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.6712594235 16177239 12392966 19416960 10774834 12958197 15619225 11421492 16393943 12540782 19923254 10915739 17562736 17522070 18713872 14986274 12153990 16109766 2444490 12705907 19370779 18071297 16081117 17906064 16485898 11461765 19420014 14550746 10663392 19739265 19164858 19085960 11739529 14725611 11743745 15968718 16227642 11834606 11287661 16781746 11529661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.6720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.671733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.2318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 13.2318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.463659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.807562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.4311564622
MESH:D005124 Eye Abnormalities Tretinoin 9.4316938888 9664655
MESH:D005234 Fatty Liver arsenite 14.6518296743
MESH:D005234 Fatty Liver pirinixic acid 14.6520131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 14.6519224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis arsenite 16.7218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.7220067830
MESH:D005355 Fibrosis Tretinoin 16.7217994277
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9110048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.9114991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3015340226 12621046 16120746
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 16959395 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 8.2716870215
MESH:D006930 Hyperalgesia Tretinoin 8.2716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.7616580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.7617551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.046582329
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0119850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0116294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3017107899 19075265 17339181 16823087 17301526 16788101 17368321 17506722 16935935 17294898 16766008 9834237 16140955 17361223 15748426 19642359 16331271 17712046 17217047 16891316 19225113 19035177 19029980 17649720 12679006
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008103 Liver Cirrhosis arsenite 3.5418296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5216248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 12587719 19460945 11587558 19014921 16611625 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.797678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.7916377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.602876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.60598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6012151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms arsenite 2.5316809336
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5311884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8117596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.8117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms pirinixic acid 5.2617405874
MESH:D009369 Neoplasms Tretinoin 5.2616594593 16946489
MESH:D009389 Neovascularization, Pathologic arsenite 4.7515738583
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4714600291
MESH:D009421 Nervous System Malformations Tretinoin 10.479125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 13.006679447
MESH:D009436 Neural Tube Defects Tretinoin 13.009142499
MESH:D009436 Neural Tube Defects Valproic Acid 13.0016359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Acetaminophen 7.2616870215
MESH:D010146 Pain Tretinoin 7.2616870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5315976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6111222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.6120603192
MESH:D011507 Proteinuria Tretinoin 3.8616636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.7516283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.7519155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012640 Seizures Valproic Acid 6.471511512 17978042 3137016 15475178 11044598 11738929 14763951 16876388
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8916192470
MESH:D012878 Skin Neoplasms Tretinoin 5.8916467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.756587162 3712494 1399818 6582329 7505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.7517045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.288074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
Pathway ID Pathway Name
KEGG:04912 GnRH signaling pathway
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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