AutismKB 2.0

Annotation Detail for MAP3K5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAP3K5 ( ASK1,MAPKKK5,MEKK5 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 5
Band: 6q23.3
Quick LinksEntrez ID:4217; OMIM: 602448; Uniprot ID:M3K5_HUMAN; ENSEMBL ID: ENSG00000197442; HGNC ID: 6857
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04141Protein processing in endoplasmic reticulum
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04722Neurotrophin signaling pathway
No data
Pathway IDPathway Name
200133HIV-1 Nef: Negative effector of Fas and TNF-alpha
200014p38 MAPK signaling pathway
200086TNF receptor signaling pathway
200169Class I PI3K signaling events mediated by Akt
Pathway IDPathway Name
P00018EGF receptor signaling pathway
P00006Apoptosis signaling pathway
P00021FGF signaling pathway
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1709Parkinson disease
2051Leukemia
2106Pancreas cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in increased activity of MAP3K5 proteinincreases activity 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ACTG1 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of AK5 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARIH1 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARL4A mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARL5B mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARRDC5 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ASTN2 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of BCL2L14 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of BTC mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CASKIN1 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CCDC81 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CCL7 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CD3E mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CDS2 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CHI3L3 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CHI3L4 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CHKA mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CLASP1 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of COL3A1 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of COPG mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CXCL5 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DLX4 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DNAHC5 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DNAJB4 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DNAJB9 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DPP6 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of EEA1 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of FOSL2 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of FOS mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GAB2 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GNAL mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GZMM mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of HIST2H2BB mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of IFIT3 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of JUN mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of KDM3A mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of LCN13 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MAFF mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MCL1 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MX2 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MYH3 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NAIP6 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NEDD9 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NPAL2 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NSMCE2 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OLFR1273-PS mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OLFR1339 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OLFR905 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PCDH11X mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PCDH7 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PDCL2 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PDE4B mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PRRX1 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PVR mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of RNF207 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of RTP1 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SCT mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SLC25A2 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SLFN3 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SPZ1 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of STAT3 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SYF2 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TMEM54 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TRP63 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TSC22D2 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TWSG1 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of USP31 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of USP6NL mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of WDFY3 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ZDHHC6 mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ZFAND2A mRNA]affects reaction|increases expression 18700144
D000082 Acetaminophen MAP3K5 protein promotes the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK8 protein]increases activity|increases phosphorylation|increases reaction 18700144
D000082 Acetaminophen MAP3K5 protein promotes the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK9 protein]increases activity|increases phosphorylation|increases reaction 18700144
D000082 Acetaminophen MAP3K5 protein results in increased susceptibility to Acetaminophenincreases response to substance 18700144
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]affects binding|decreases activity|decreases reaction 16449798
D000171 Acrolein Acrolein results in increased expression of MAP3K5 proteinincreases expression 17196791
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MAP3K5 proteinaffects expression 20106945
C412373 AG 1879 AG 1879 inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP3K5 protein]decreases reaction|increases phosphorylation 20181660
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of MAP3K5 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MAP3K5 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAP3K5 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of MAP3K5 mRNAincreases expression 15336504
D002166 Camptothecin Camptothecin results in decreased expression of MAP3K5 mRNAdecreases expression 17374387
C459604 candoxin candoxin results in decreased expression of MAP3K5 mRNAdecreases expression 16309724
D003630 Daunorubicin Daunorubicin results in decreased expression of MAP3K5 mRNAdecreases expression 17374387
C007262 deoxynivalenol AG 1879 inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP3K5 protein]decreases reaction|increases phosphorylation 20181660
C007262 deoxynivalenol deoxynivalenol results in increased phosphorylation of MAP3K5 proteinincreases phosphorylation 20181660
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased activity of MAP3K5 protein]decreases reaction|increases activity 12370186
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in decreased activity of MAP3K5 proteindecreases activity 12370186
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MAP3K5 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of MAP3K5 mRNAincreases expression 19619570
D000431 Ethanol ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of MAP3K5 protein]decreases reaction|increases phosphorylation 19332462
D000431 Ethanol Ethanol results in increased phosphorylation of MAP3K5 proteinincreases phosphorylation 19332462
D005047 Etoposide Etoposide results in decreased expression of MAP3K5 mRNAdecreases expression 17374387
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased activity of MAP3K5 proteinincreases activity 15629441
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of MAP3K5 proteinincreases expression 16157298
C051890 irinotecan irinotecan metabolite results in decreased expression of MAP3K5 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of MAP3K5 mRNAdecreases expression 15956246
C072105 KN 93 KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein]decreases reaction|increases activity 15629441
D009599 Nitroprusside GHRL protein inhibits the reaction [Nitroprusside results in increased phosphorylation of and results in increased activity of MAP3K5 protein]decreases reaction|increases activity|increases phosphorylation 17543279
D009599 Nitroprusside Nitroprusside results in increased phosphorylation of and results in increased activity of MAP3K5 proteinincreases activity|increases phosphorylation 17543279
D009599 Nitroprusside Quercetin inhibits the reaction [GHRL protein inhibits the reaction [Nitroprusside results in increased expression of MAP3K5 protein]]decreases reaction|increases expression 17543279
D010634 Phenobarbital Phenobarbital results in increased expression of MAP3K5 mRNAincreases expression 19270015
D010656 Phenylephrine CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]increases activity|increases reaction 15629441
D010656 Phenylephrine KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein]decreases reaction|increases activity 15629441
D010656 Phenylephrine Phenylephrine results in increased activity of MAP3K5 proteinincreases activity 15629441
C005435 phenylmethylpyrazolone phenylmethylpyrazolone results in decreased activity of MAP3K5 proteindecreases activity 15824197
C006253 pirinixic acid pirinixic acid results in increased expression of MAP3K5 mRNAincreases expression 18445702
D011794 Quercetin Quercetin inhibits the reaction [GHRL protein inhibits the reaction [Nitroprusside results in increased expression of MAP3K5 protein]]decreases reaction|increases expression 17543279
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of MAP3K5 mRNAaffects cotreatment|decreases expression 19059307
D017382 Reactive Oxygen Species Reactive Oxygen Species affects the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]affects binding|affects reaction|decreases activity 16449798
D012402 Rotenone Acetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]affects binding|decreases activity|decreases reaction 16449798
D012402 Rotenone Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]affects binding|decreases activity|decreases reaction 16449798
D012643 Selenium Selenium results in decreased expression of MAP3K5 mRNAdecreases expression 19244175
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAP3K5 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MAP3K5 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MAP3K5 mRNAdecreases expression 19619570
D013853 Thioacetamide Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased activity of MAP3K5 protein]decreases reaction|increases activity 12370186
D013853 Thioacetamide Thioacetamide results in increased activity of MAP3K5 proteinincreases activity 12370186
D014810 Vitamin E Vitamin E results in decreased expression of MAP3K5 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2014745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.2917676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.296195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.2915322242 14514962 11752688
MESH:D000138 Acidosis Ethanol 4.1611192467
MESH:D055371 Acute Lung Injury Acrolein 8.2520525806 21297076
MESH:D055371 Acute Lung Injury pirinixic acid 8.2518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.9720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 3.9711473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.466695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.3117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.3116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.3116835633
MESH:D000419 Albuminuria Raloxifene 4.2717308373 17451421
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9715451039 15451040
MESH:D000544 Alzheimer Disease Acrolein 4.3917570602 15207723 14715435
MESH:D000544 Alzheimer Disease Raloxifene 4.3915800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6511748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.9417084956
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D000853 Anophthalmos Ethanol 4.4915513904
MESH:D001008 Anxiety Disorders Ethanol 3.7411141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7419183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8217460149
MESH:D001161 Arteriosclerosis Acrolein 4.6715014928
MESH:D001172 Arthritis, Rheumatoid phenylmethylpyrazolone 3.7116390820
MESH:D001260 Ataxia Telangiectasia Quercetin 4.6415336622
MESH:D050197 Atherosclerosis Acrolein 3.7816126721 17363696 16037261
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001327 Autoimmune Diseases Quercetin 4.0819761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.5912125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 13.5919483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5515746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.8214601052
MESH:D001919 Bradycardia Phenylephrine 4.2015306635
MESH:D001930 Brain Injuries Nitroprusside 10.3914637104
MESH:D001930 Brain Injuries Raloxifene 10.3916580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.5320146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 3.5317289903 19861407 12948864 18497071 17018787 16675129 17261762 14630087
MESH:D001943 Breast Neoplasms Etoposide 3.5316322251
MESH:D001943 Breast Neoplasms Quercetin 3.5318628248
MESH:D001943 Breast Neoplasms Raloxifene 3.5317261762 17952589 15775269 17893378 17595753 16912660 17440819 15758505 17049068 15572757 16837676 17242785
MESH:D001943 Breast Neoplasms Tamoxifen 3.5321138602 18855134 16273361 17893378 20005174 19221464 19084267 18629630 19410462 18815881 21152245 15565566 20390343 11161223 16873071 19011961 16818667 16202921 17261762 20135344 18984771 19142967 17242785 19189210 19066611 20544844 19288272 15668708 19059307 19155303 18425577 19115204 17440819 19189212 19487384 18351453 20065188 19244106 17049068 19103187 19200415 18997820 18821012 19289846 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5320435547
MESH:D002056 Burns Ethanol 4.3216374292
MESH:D002105 Cadmium Poisoning Quercetin 5.2016962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1216111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.833084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 15.8321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.8316924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 15.8318788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 15.836705139 17173139 1701930 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular Quercetin 15.8319519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 15.8316924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 15.8317997003
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6217234771
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 4.5717015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5720419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.5217572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.5217572228
MESH:D006332 Cardiomegaly Ethanol 14.7819332462
MESH:D006332 Cardiomegaly Phenylephrine 14.7815728586 17287366 11754973 16170337 17124262 11179087
MESH:D006332 Cardiomegaly Quercetin 14.7819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 14.7816120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.8016936243
MESH:D002318 Cardiovascular Diseases Raloxifene 6.8015775269
MESH:D002386 Cataract Acetaminophen 2.3810977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.9620889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 9.9618226522
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.9618566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.924080065
MESH:D002543 Cerebral Hemorrhage phenylmethylpyrazolone 5.4919095969
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6016835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.6018291259
MESH:D002779 Cholestasis pirinixic acid 2.5819176532
MESH:D002971 Cleft Lip Ethanol 3.4115513904
MESH:D002972 Cleft Palate Ethanol 5.4615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4612621046 15340226 16354765 15668235 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.2915800139
MESH:D003092 Colitis Selenium 3.4517936198
MESH:D003110 Colonic Neoplasms irinotecan 3.8017287894 17725105
MESH:D003110 Colonic Neoplasms Quercetin 3.8017148506 17191121 15741050 16640504 19056647 19440933 11134977
MESH:D015179 Colorectal Neoplasms Acrolein 3.4817597105
MESH:D015179 Colorectal Neoplasms irinotecan 3.4816391804 18509181 18259882 17454858 17159606 16303861 15273666
MESH:D015179 Colorectal Neoplasms Quercetin 3.4818095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7814669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 5.1315451039 10194807 15513904 11198716 19302082 11873399 15451040
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 5.1315736158
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.1319769572
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.0819747007
MESH:D003556 Cystitis Acrolein 5.0512161096
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0319031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8817474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.4619496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5817107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.3819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.3817308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.3819279558
MESH:D056486 Drug-Induced Liver Injury marker/mechanism 18700144
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.8317522070 10774834 15968718 11287661 17906064 12153990 11421492 10915739 11834606 19739265 19416960 10663392 16177239 12392966 14986274 19923254 16393943 2444490 12705907 19420014 14725611 11739529 16109766 11743745 19085960 18713872 16081117 12540782 11461765 11529661 16781746 14550746 12958197 15619225 16227642 17562736 18071297 19164858 12594235 16485898 19370779
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 13.8311287661
MESH:D056486 Drug-Induced Liver Injury Ethanol 13.8311566570
MESH:D056486 Drug-Induced Liver Injury Selenium 13.8315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.8320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 13.8312963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004362 Drug Toxicity phenylmethylpyrazolone 7.7112231392 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7111462148
MESH:D004421 Dystonia Phenobarbital 3.691851702
MESH:C538011 Eales disease Vitamin E 4.369068938
MESH:D004487 Edema pirinixic acid 9.6912083418
MESH:D004487 Edema Raloxifene 9.6915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.6912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5615322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.1715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.1719031437
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 6.2120641076
MESH:D016889 Endometrial Neoplasms Estradiol 6.6519148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.6517893378 20544844 19155303 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.739294722 10568697
MESH:D019446 Endotoxemia phenylmethylpyrazolone 5.1312954792
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.783659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.5311558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.266401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.927750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.683659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.7116530937
MESH:D004938 Esophageal Neoplasms Ethanol 6.7116704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7611564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3716456712
MESH:D005234 Fatty Liver Ethanol 21.4718620774 16409862 19236843
MESH:D005234 Fatty Liver phenylmethylpyrazolone 21.4712795759
MESH:D005234 Fatty Liver pirinixic acid 21.4719236843 20131406
MESH:D005234 Fatty Liver Raloxifene 21.4717473493
MESH:D005234 Fatty Liver Tamoxifen 21.4719224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3217920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0316709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9615513904 15451040 10194807 16946407
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8419069698
MESH:D005355 Fibrosis Quercetin 7.6619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.6620067830
MESH:D005756 Gastritis Acetaminophen 9.9716983495
MESH:D005756 Gastritis Ethanol 9.9715046732
MESH:D005909 Glioblastoma Quercetin 3.1719804834
MESH:D005910 Glioma Quercetin 2.9217643826
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.7515173396 16524712
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 4.8820641076
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.0420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.0410048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 10.0416080930
MESH:D006331 Heart Diseases Raloxifene 3.3011110106
MESH:D006333 Heart Failure pirinixic acid 6.2520558911
MESH:D006333 Heart Failure Selenium 6.2517162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2718665440 15929193 17276928
MESH:D006505 Hepatitis Thioacetamide 3.8916456712
MESH:D006529 Hepatomegaly Phenobarbital 12.4616109766
MESH:D006529 Hepatomegaly pirinixic acid 12.4619176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.4615340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5816490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.6915709030
MESH:D006561 Herpes Simplex Etoposide 4.2210809021
MESH:D006689 Hodgkin Disease Etoposide 3.5915147373 17606976 18180244 16135485 16200630
MESH:D019584 Hot Flashes Estradiol 8.9017088409
MESH:D019584 Hot Flashes Vitamin E 8.9014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7018606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.9316870215
MESH:D006930 Hyperalgesia Ethanol 6.9318783367
MESH:D006943 Hyperglycemia pirinixic acid 8.2720558911
MESH:D006943 Hyperglycemia Quercetin 8.2711834736 18262572
MESH:D006973 Hypertension Phenylephrine 11.308949925 12717712
MESH:D006973 Hypertension Quercetin 11.3018356687
MESH:D006973 Hypertension Raloxifene 11.3015787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.3018850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.2518502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular phenylmethylpyrazolone 5.1115824197
MESH:D007249 Inflammation Tamoxifen 4.3019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.3012200463 12878042
MESH:D007251 Influenza, Human Quercetin 16.6116624496
MESH:D007251 Influenza, Human Selenium 16.6116624496
MESH:D007251 Influenza, Human Vitamin E 16.6116624496
MESH:D007333 Insulin Resistance Estradiol 6.4616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.4616306350
MESH:D002532 Intracranial Aneurysm phenylmethylpyrazolone 9.6319381132
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 9.6319381132
MESH:D007511 Ischemia phenylmethylpyrazolone 5.2116301206
MESH:D007569 Jaw Abnormalities Ethanol 9.1115513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1116580747
MESH:D007627 Keloid Quercetin 4.6217086741
MESH:D007674 Kidney Diseases Acetaminophen 21.3115629191 12587719
MESH:D007674 Kidney Diseases Acrolein 21.3112488133
MESH:D007674 Kidney Diseases Estradiol 21.3115618244
MESH:D007674 Kidney Diseases phenylmethylpyrazolone 21.3118085390
MESH:D007674 Kidney Diseases Quercetin 21.3116962696
MESH:D007674 Kidney Diseases Vitamin E 21.3112488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.0216518626
MESH:D007676 Kidney Failure, Chronic Selenium 9.0216518626
MESH:D007680 Kidney Neoplasms Estradiol 6.4815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.4818625569
MESH:D007859 Learning Disorders Ethanol 3.8815451040
MESH:D007889 Leiomyoma Raloxifene 4.1816973256
MESH:D007938 Leukemia Quercetin 2.9917468513
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5717676605
MESH:D008064 Lipidoses Tamoxifen 2.9115342952 17567588
MESH:D008103 Liver Cirrhosis Ethanol 6.2115289165
MESH:D008103 Liver Cirrhosis Phenobarbital 6.2121047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7618295389
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 14.7511682029
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.7514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 14.7518166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.7515474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 14.7512741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.7518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.7512878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 14.7516097051 18295389 18032466 16248980 12679928 16126171 15362042 17292413 15334695 17629604 16098781 15716488 17050028 15288472 18615449 11682029 16489207 15158331 11172339 16343077 15316131 17355460 18416461 18380797 11481614 15078482 12085344 18458672 15288473 18031379 17127702 12175628 15465738 15095483 12531686 15474484 12891558 18395095 16511523 12557150 18606216 14739098 18263696 15075984 10677585
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 14.7516169303
MESH:D008107 Liver Diseases Acetaminophen 6.0019460945 16611625 19014921 11587558 19784758 12587719 12969438 16610002
MESH:D008107 Liver Diseases Phenobarbital 6.0019363144
MESH:D008107 Liver Diseases Thioacetamide 6.0018374380 16337175 15158337
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3217207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 8.6616871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 8.6617276928 15633222 12479984 15313186
MESH:D008113 Liver Neoplasms Aflatoxin B1 19.8115890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.8120195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 19.8119812893 21047994 8742319 15975961 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 19.8120007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 19.8118980244
MESH:D008113 Liver Neoplasms Tamoxifen 19.8116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.8116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.388603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 12.382563599 1399818 6150874 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Quercetin 12.3819519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.3812151625
MESH:D008171 Lung Diseases Acetylcysteine 11.2812815614
MESH:D008171 Lung Diseases Acrolein 11.2811504702
MESH:D008171 Lung Diseases Vitamin E 11.2816863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.6917365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 7.9314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.9318816296 6695378 18569708 20064080 20464547 17053015 18520028 20869020 20135361
MESH:D008175 Lung Neoplasms Quercetin 7.9316280456
MESH:D008175 Lung Neoplasms Tamoxifen 7.9318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.9311884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 7.9311062179
MESH:D008223 Lymphoma Etoposide 3.6812556972 12854902
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.6916891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 8.6915318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.6911731420 19196722 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.4919453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.4919453300
MESH:D008545 Melanoma Reactive Oxygen Species 3.5317992120
MESH:D008545 Melanoma Tamoxifen 3.5312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 9.8819513568
MESH:D008546 Melanoma, Experimental Acrolein 9.8810803710
MESH:D008569 Memory Disorders Ethanol 3.8715451040 18411066
MESH:D008654 Mesothelioma Asbestos, Crocidolite 5.8716966607 16166281 18303189
MESH:D008654 Mesothelioma Selenium 5.8715107826
MESH:D008659 Metabolic Diseases phenylmethylpyrazolone 5.1716301206
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2115863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9316381670
MESH:D052016 Mucositis irinotecan 4.6717159606
MESH:D009101 Multiple Myeloma Raloxifene 3.2016497877
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.2419151258
MESH:D009203 Myocardial Infarction Quercetin 5.2419595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.6916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.6916411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 12.6919207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1317484760
MESH:D009232 Myxoma Raloxifene 5.2116343187
MESH:D009362 Neoplasm Metastasis Acetylcysteine 8.8614720322
MESH:D009362 Neoplasm Metastasis irinotecan 8.8618259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.8619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms Acrolein 10.4817329238
MESH:D009369 Neoplasms Benzo(a)pyrene 10.4811141357
MESH:D009369 Neoplasms pirinixic acid 10.4817405874
MESH:D009369 Neoplasms Quercetin 10.4815185748
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6519200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3917289903
MESH:D009393 Nephritis Acrolein 5.9412653641
MESH:D009410 Nerve Degeneration Rotenone 3.6215790535 18619942 17356569
MESH:D009421 Nervous System Malformations Estradiol 8.3916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.3914600291
MESH:D009436 Neural Tube Defects Acetylcysteine 3.8019446573
MESH:D009447 Neuroblastoma irinotecan 3.308761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7018514411
MESH:D019636 Neurodegenerative Diseases Acrolein 7.7011342003
MESH:D017599 Neuroectodermal Tumors irinotecan 4.398761367
MESH:D020078 Neurogenic Inflammation Quercetin 4.0517929310
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D010018 Osteomalacia Phenobarbital 4.0217016548
MESH:D010024 Osteoporosis Raloxifene 3.1917882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.1519495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.1515579764 15758505 17823083 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 4.5719401270
MESH:D010051 Ovarian Neoplasms Quercetin 4.5719005980
MESH:D010146 Pain Acetaminophen 2.1316870215
MESH:D010190 Pancreatic Neoplasms Ethanol 14.9812384795
MESH:D010190 Pancreatic Neoplasms Etoposide 14.9819003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 14.9816965848
MESH:D010190 Pancreatic Neoplasms Quercetin 14.9816965848
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 14.9815580305
MESH:D010195 Pancreatitis phenylmethylpyrazolone 4.5820035747
MESH:D010212 Papilloma Hydrogen Peroxide 3.7612065085
MESH:D010300 Parkinson Disease Acrolein 5.4217690948
MESH:D010300 Parkinson Disease Rotenone 5.4215451049 19232380 11445065 18191903 11535288 18619942 19114014 16412576 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 3.7815795934 15574749 15927086 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D010787 Photosensitivity Disorders Acrolein 5.3911550810
MESH:D010954 Plasmacytoma Selenium 4.5415087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5610923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2418163543
MESH:D011230 Precancerous Conditions Phenobarbital 8.302563599
MESH:D011230 Precancerous Conditions Quercetin 8.3019056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Daunorubicin 4.5921297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8511222880 11399792 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0417292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0416740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.0417172428
MESH:D011471 Prostatic Neoplasms Quercetin 2.0417292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0416220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0415067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0415084515
MESH:D019310 Pseudolymphoma Phenobarbital 4.1512752131
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9017975199 17365031 15814490 17322281
MESH:D011693 Purpura Raloxifene 5.2115770314
MESH:D051437 Renal Insufficiency Acrolein 4.6712732208
MESH:D015427 Reperfusion Injury phenylmethylpyrazolone 6.4115629865 14654979 15948865 16041266 16753835 15086910
MESH:D015427 Reperfusion Injury pirinixic acid 6.4119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.2112210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012512 Sarcoma, Ewing's Etoposide 4.3814601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.2016862918
MESH:D012640 Seizures Ethanol 5.409754883
MESH:D012640 Seizures Phenobarbital 5.403137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.486407741
MESH:D012852 Sinusitis Phenylephrine 4.367327846
MESH:D012871 Skin Diseases Vitamin E 2.3518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.2119755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.2112065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.218532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.2116192470
MESH:D013088 Spermatocele Tamoxifen 3.9516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7019457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.2720155912 2093021
MESH:D013274 Stomach Neoplasms Ethanol 3.2718456281
MESH:D013274 Stomach Neoplasms irinotecan 3.2715723263
MESH:D013276 Stomach Ulcer Acetylcysteine 6.7417918041
MESH:D013276 Stomach Ulcer Ethanol 6.7411906479 17189318 9211565 9562338 17918041 16755016
MESH:D020521 Stroke Acrolein 13.0016269634
MESH:D020521 Stroke Raloxifene 13.0016837676
MESH:D020521 Stroke Vitamin E 13.0016517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.969754883
MESH:D013610 Tachycardia Nitroprusside 5.2915306635
MESH:D024801 Tauopathies Camptothecin 11.0916930453
MESH:D024801 Tauopathies Daunorubicin 11.0916930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5612697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.801399818
MESH:D013978 Tibial Fractures Estradiol 12.5619048282
MESH:D013978 Tibial Fractures Raloxifene 12.5619048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.8017053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 10.8016720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 10.8017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.8017572228 16712894 8653321
MESH:D014581 Urticaria Acetaminophen 2.6710982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8616837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2116343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
Pathway ID Pathway Name
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:04010 MAPK signaling pathway
KEGG:04722 Neurotrophin signaling pathway
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30601
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA451365sirolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved