AutismKB 2.0

Annotation Detail for RAB8A


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Basic Information Top
Gene Symbol:RAB8A ( MEL,RAB8 )
Gene Full Name: RAB8A, member RAS oncogene family
Band: 19p13.11
Quick LinksEntrez ID:4218; OMIM: 165040; Uniprot ID:RAB8A_HUMAN; ENSEMBL ID: ENSG00000167461; HGNC ID: 7007
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04972Pancreatic secretion
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
2248Cytomegalovirus infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RAB8A mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RAB8A mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of RAB8A mRNAdecreases expression 15336504
D020682 Cefixime [RAB8A protein results in increased localization of SLC15A1 protein] which results in increased uptake of Cefiximeincreases localization|increases uptake 19074526
D020682 Cefixime RAB8A protein results in increased uptake of Cefiximeincreases uptake 19074526
D016572 Cyclosporine Cyclosporine results in decreased expression of RAB8A mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RAB8A mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAB8A mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in decreased expression of RAB8A mRNAdecreases expression 16709241
C056507 gemcitabine gemcitabine results in decreased expression of RAB8A mRNAdecreases expression 17039268
D006220 Haloperidol Haloperidol results in decreased expression of RAB8A mRNAdecreases expression 15860345
C027020 methylglucoside RAB8A protein results in increased uptake of methylglucosideincreases uptake 19074526
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [SNCA protein mutant form binds to RAB8A protein]affects binding|increases reaction 15099020
D012402 Rotenone Rotenone promotes the reaction [SNCA protein mutant form binds to RAB8A protein]affects binding|increases reaction 15099020
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAB8A mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of RAB8A mRNAincreases expression 16054129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9314514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3814692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.3817638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000740 Anemia Fluorouracil 8.8516511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.8511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001321 Autistic Disorder Haloperidol 2.7319368416 18080171
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.1216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.0116110121 16595493 18357371 18608205 15136595 16557594 19217205
MESH:D001943 Breast Neoplasms gemcitabine 2.0118382427 17039268
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D001943 Breast Neoplasms Tretinoin 2.0116443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7616051944
MESH:D002277 Carcinoma Fluorouracil 8.3317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.3316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6716705839
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.6717971768 16332177 16799960 17045692 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.671917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7816280240 16757204 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7816096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918670907 18850075 16120746
MESH:D002375 Catalepsy Haloperidol 4.991977408 15215559
MESH:D002386 Cataract Tretinoin 3.1217460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.706135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7012371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 7.9119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9116105132 15861022 16919318 17681005 11677210 17333356 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8315668235 8697196 12621046 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.839407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2416340194 16510598 17172411 17725105 18772588 15001691 17016597 17287894 17018589 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018949393 17454858 17016601 16303861 17094418 15148649 16331619 16524972 15289873 18509181 14970324 16282729 16391804 20501625 17255274 17695437 18448328 18383874 18288408 17401013 17594712 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.469142499 16925845 8800419 9125849 9211117 10589399 9224671 17551590 14991402 9664655
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D007644 Darier Disease Fluorouracil 4.8716733453
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9020210726
MESH:D003704 Dementia Haloperidol 4.6311575062
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.7521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.2715322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.2718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4615173087 17638652 16337965 16785472 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.9716938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 7.7619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.7615345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Cyclosporine 15.1612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.1620067830
MESH:D005355 Fibrosis Tretinoin 15.1617994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Tretinoin 3.0417312396
MESH:D005910 Glioma Fluorouracil 2.8916145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.9115162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.9116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.629664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1415340226 18606429 16959395 8697196 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.2516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1216580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.1215992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 2.378314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.6812371664
MESH:D007680 Kidney Neoplasms Fluorouracil 12.6816985049
MESH:D007938 Leukemia Tretinoin 2.7917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7519285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0819850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1919029980 17339181 17361223 17217047 17294898 9834237 16891316 16788101 16823087 19642359 17301526 19035177 19225113 17712046 16140955 19075265 12679006 16331271 16935935 16766008 17506722 15748426 17649720 17107899 17368321
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3218397230 16248980
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.537678174
MESH:D008113 Liver Neoplasms Fluorouracil 7.5317045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.842876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8412151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.3615246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3619555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8715086387
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D001523 Mental Disorders Haloperidol 4.0916856516
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6716757204 18986760
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.947678174 18551238
MESH:D009369 Neoplasms Fluorouracil 5.2418600527 16928823 18239605
MESH:D009369 Neoplasms Tretinoin 5.2416946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.9217356569 18619942 15790535
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.739125849
MESH:D009436 Neural Tube Defects Tretinoin 3.099142499
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 5.4312349958
MESH:D020258 Neurotoxicity Syndromes 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 8.8216725203
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 8.8216436463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4816049721
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3616936753
MESH:D010146 Pain Tretinoin 2.9516870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.8916500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms gemcitabine 8.8911504793 16929163 17440100 18383843 18992248
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.8915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010300 Parkinson Disease 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6.2516140633 11181820 15451049
MESH:D010300 Parkinson Disease Rotenone 6.2518191903 15451049 16412576 11445065 19232380 11535288 18619942 16140633 19114014
MESH:D020734 Parkinsonian Disorders 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 10.0812349958
MESH:D020734 Parkinsonian Disorders Rotenone 10.0815795934 18197244 15927086 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.4118626508 19082440
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011595 Psychomotor Agitation Haloperidol 5.0311575062
MESH:D011618 Psychotic Disorders Haloperidol 4.2911575062
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0616160472 18722050 18286688 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1616283617 16116481
MESH:D012559 Schizophrenia Haloperidol 2.8120107430 18513383 1830565 19369910
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5718551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.578532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.5716192470
MESH:D012878 Skin Neoplasms Tretinoin 9.5716467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5217522103 19084572 18396642 15786421 16424979 16951190 18567086 17498489 17172411 19015929
MESH:D013274 Stomach Neoplasms Tretinoin 2.5217261132
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.7720210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0617045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 10.0016280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.0016051514
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3116049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.6216803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.6216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
KEGG:04972 Pancreatic secretion
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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