AutismKB 2.0

Annotation Detail for MEP1A


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Basic Information Top
Gene Symbol:MEP1A ( PPHA )
Gene Full Name: meprin A, alpha (PABA peptide hydrolase)
Band: 6p12.3
Quick LinksEntrez ID:4224; OMIM: 600388; Uniprot ID:MEP1A_HUMAN; ENSEMBL ID: ENSG00000112818; HGNC ID: 7015
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04974Protein digestion and absorption
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1909Migraine
2053Colon cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MEP1A mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MEP1A mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of MEP1A mRNAincreases expression 20458559
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in decreased expression of MEP1A mRNAaffects cotreatment|decreases expression 17639512
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of MEP1A mRNAdecreases expression 20360939
D016226 Phosphorus, Dietary Phosphorus, Dietary results in decreased expression of MEP1A mRNAdecreases expression 17596124
C006253 pirinixic acid pirinixic acid results in decreased expression of MEP1A mRNAdecreases expression 17426115
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in decreased expression of MEP1A mRNAaffects cotreatment|decreases expression 17639512
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3311798837 19825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.103712494
MESH:D000236 Adenoma Diethylnitrosamine 7.106695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.2418056438 17620307 17162532 19061943 16434500 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2416434500
MESH:D000743 Anemia, Hemolytic Quercetin 4.4817084956
MESH:D001260 Ataxia Telangiectasia Quercetin 5.3115336622
MESH:D001327 Autoimmune Diseases Quercetin 4.7119761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.8216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.8219483382
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.0816443354
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0817474063
MESH:D001943 Breast Neoplasms Quercetin 2.0818628248
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002105 Cadmium Poisoning Quercetin 5.9216962696
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.877296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8714691202 11135700 16217749 15073043 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8720727157 20514400 18506893 18665156 17055752 20935162 18393292 18971187 17138121 16681979 16502159 18691550 17761372 18494052 16328049 16779866 16288022 16698587 19171122 19519916 19919837 20432363 17978847 19418558 20214788 16878318 19539802 16807293 16935385 20084675 3084413 3581430 17173139 19335982 19208518 16830150 20007298 19394651 16569478 18056438 19701751 16540662 18210153 18788625 19052882 19107877 10672840 17428255 18785209 19822196 10737359 11831363 19383236 17162532 20512989 20101231 21159647 20524982 18978308
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.8712508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.2617234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D006332 Cardiomegaly Quercetin 3.4419794523
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.237505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.237505956 17174075 2727394 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.4319486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.4319176532
MESH:D003110 Colonic Neoplasms Quercetin 2.4515741050 11134977 19056647 19440933 17191121 17148506 16640504
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6620501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.6618095365 18852136
MESH:D003139 Common Cold Ascorbic Acid 5.8517323712
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.108970840 11906362 18759878 2524372 11298694 14531868 8156756 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.9319496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.9116506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.9120387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.0818692083 7440962 18289764 16192314 9328219 1440618 6482804 9022650 18648102 9653073 8291058 6679447 11289319
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.0819107877
MESH:C538011 Eales disease Ascorbic Acid 5.859068938
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.643581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6412903497
MESH:D005234 Fatty Liver arsenic trioxide 14.5715073043
MESH:D005234 Fatty Liver Diethylnitrosamine 14.5721071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 14.5719236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Quercetin 4.2019474275
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005909 Glioblastoma Quercetin 3.5419804834
MESH:D005910 Glioma Quercetin 3.1317643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 3.8716080930
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 19772884 18467677 19176532
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.5416490937 16863852
MESH:D006943 Hyperglycemia pirinixic acid 10.0120558911
MESH:D006943 Hyperglycemia Quercetin 10.0111834736 18262572
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Quercetin 2.9318356687
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007251 Influenza, Human Quercetin 4.8816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007627 Keloid Quercetin 5.2617086741
MESH:D007674 Kidney Diseases Quercetin 3.2216962696
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.176582329
MESH:D007938 Leukemia arsenic trioxide 6.8415070760
MESH:D007938 Leukemia Quercetin 6.8417468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1719850784 16968895 17050201 20471514 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.369834237 16331271 19642359 11161223 12712474 15336539 16112521 17217047 12679006 16330433 16823087 17107899 16891316 15622746 17649720 12018890 17869043 15748426 17712046 19225113 19035177 16966277 19075265 15213294 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9418407596 20032147 19638242 18522880 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.5412741479
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms arsenic trioxide 11.3814682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.3816942905 10737359 12771043 20118626 20452335 15885732 21278145 19255062 19812893 20405173 20101389 19642983 12112319 9163691 19254457 21047994 19427195 19551842 19499222 2422723 19638242 21071580 15175105 2862719 19426721 20492335 18644402 19996281 18977376 20583210 19690152 19073162 20137499 19256749 18648771 19833225 18754104 19090486 19294768 19850985 18978307 20434301 21167192 20501860
MESH:D008113 Liver Neoplasms pirinixic acid 11.3820007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 11.3818980244
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 20.23598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 20.2320377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 20.2318544905
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 20.2318079962 18282651 18164116 18308698 18544905 17174075 18775883 17854601 18253720 9362446 19126423 19009564 21159647 19004024 19519916 18093689 17942915 16267830 3124819 19539802 16842330 2563599
MESH:D008114 Liver Neoplasms, Experimental Quercetin 20.2319519916
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008171 Lung Diseases Ascorbic Acid 4.1016863852
MESH:D008175 Lung Neoplasms arsenic trioxide 5.1211798837 19825857
MESH:D008175 Lung Neoplasms Ascorbic Acid 5.1216401635
MESH:D008175 Lung Neoplasms Diethylnitrosamine 5.126695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Quercetin 5.1216280456
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2719417148 19549372 15949261 14977855 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 6.0119151258
MESH:D009203 Myocardial Infarction Quercetin 6.0119595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.0616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.0619207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.983581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.983581430 9029167
MESH:D009369 Neoplasms pirinixic acid 5.4017405874
MESH:D009369 Neoplasms Quercetin 5.4015185748
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.756679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.7510525206
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5420387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.6217929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity Ascorbic Acid 4.9117217161
MESH:D009765 Obesity pirinixic acid 4.9120558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4819495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2312452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Quercetin 5.2319005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 9.1015580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 9.1016540662
MESH:D010190 Pancreatic Neoplasms Quercetin 9.1016965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.952563599
MESH:D011230 Precancerous Conditions Quercetin 9.9519056647
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3519131511
MESH:D011471 Prostatic Neoplasms Quercetin 3.3517292933 14715546
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.7114606601
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3616849425
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.9216862918
MESH:D012871 Skin Diseases Ascorbic Acid 3.2618709164
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4917007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4918456281
MESH:D013276 Stomach Ulcer Ascorbic Acid 4.1318726076
MESH:D020521 Stroke Ascorbic Acid 4.4816517955 16403987
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 13.043712494 6582329 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 13.0419014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 13.047505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.858074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.8512845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.8516720314
Pathway ID Pathway Name
KEGG:04974 Protein digestion and absorption
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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