AutismKB 2.0

Annotation Detail for MET


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Basic Information Top
Gene Symbol:MET ( AUTS9,HGFR,RCCP2,c-Met )
Gene Full Name: met proto-oncogene (hepatocyte growth factor receptor)
Band: 7q31
Quick LinksEntrez ID:4233; OMIM: 164860; Uniprot ID:MET_HUMAN; ENSEMBL ID: ENSG00000105976; HGNC ID: 7029
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
hsa04360Axon guidance
hsa04144Endocytosis
hsa05144Malaria
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05211Renal cell carcinoma
hsa05100Bacterial invasion of epithelial cells
hsa04520Adherens junction
hsa05218Melanoma
hsa04510Focal adhesion
hsa04060Cytokine-cytokine receptor interaction
hsa05200Pathways in cancer
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
Cancers of the urinary system and male genital organs
H00018Gastric cancer
H00046Cholangiocarcinoma
H00021Renal cell carcinoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MET mRNAdecreases expression 19933214
C478479 ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) affects the activity of MET protein mutant formaffects activity 18632630
C478479 ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]decreases reaction|increases phosphorylation 18632630
C478479 ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) results in decreased phosphorylation of and results in decreased activity of MET proteindecreases activity|decreases phosphorylation 18632630
C478479 ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [MET protein mutant form results in decreased susceptibility to ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)]decreases reaction|decreases response to substance 18632630
C478479 ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) MET protein mutant form results in decreased susceptibility to ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)decreases response to substance 18632630
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of MET mRNAdecreases expression 17640349
C498826 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [MET protein mutant form results in decreased susceptibility to ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)]decreases reaction|decreases response to substance 18632630
D000082 Acetaminophen Acetaminophen affects the expression of MET mRNAaffects expression 17562736
C430898 AGN 194204 AGN 194204 results in decreased expression of MET proteindecreases expression 15318936
C103303 alitretinoin alitretinoin results in increased phosphorylation of MET proteinincreases phosphorylation 16192631
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MET mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of MET mRNAdecreases expression 19769630
20458559
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of MET mRNAincreases expression 12839939
D017638 Asbestos, Crocidolite FOSL1 protein promotes the reaction [Asbestos, Crocidolite results in increased expression of MET mRNA]increases expression|increases reaction 12839939
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of MET mRNAincreases expression 12839939
D017638 Asbestos, Crocidolite FOSL1 protein promotes the reaction [Asbestos, Crocidolite results in increased expression of MET mRNA]increases expression|increases reaction 12839939
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MET mRNAdecreases expression 20889680
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MET mRNAdecreases expression 20889680
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MET proteindecreases expression 20889680
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MET mRNAdecreases expression 19150397
C053541 bicalutamide bicalutamide inhibits the reaction [Testosterone results in increased expression of MET mRNA]decreases reaction|increases expression 17371283
11139396
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of MET mRNAincreases expression 15912405
C006780 bisphenol A bisphenol A results in increased expression of MET mRNAincreases expression 19371625
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MET mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased phosphorylation of and results in decreased activity of MET proteindecreases activity|decreases phosphorylation 17976157
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MET mRNAincreases expression 17484886
D002251 Carbon Tetrachloride MET protein affects the reaction [Carbon Tetrachloride results in increased expression of SPP1 protein]affects reaction|increases expression 15070743
D002251 Carbon Tetrachloride [Carbon Tetrachloride co-treated with TM4SF4 protein] results in decreased expression of MET mRNAaffects cotreatment|decreases expression 17069928
D002251 Carbon Tetrachloride [Carbon Tetrachloride co-treated with TM4SF4 protein] results in decreased expression of MET proteinaffects cotreatment|decreases expression 17069928
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of MET mRNAdecreases expression 12832660
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MET mRNAincreases expression 17009398
C031662 CB 3717 CB 3717 inhibits the reaction [Testosterone results in increased expression of MET mRNA]decreases reaction|increases expression 11139396
C031662 CB 3717 CB 3717 results in increased expression of MET mRNAincreases expression 11139396
17371283
C031662 CB 3717 Testosterone inhibits the reaction [CB 3717 results in increased expression of MET mRNA]decreases reaction|increases expression 11139396
D002509 Cephaloridine Cephaloridine results in increased expression of MET mRNAincreases expression 18172885
D003042 Cocaine Cocaine affects the expression of MET mRNAaffects expression 15681117
C014347 decitabine decitabine results in decreased expression of MET mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of MET mRNA]affects reaction|decreases expression 19363521
D004052 Diethylnitrosamine CTNNB1 protein promotes the reaction [Diethylnitrosamine results in decreased expression of MET protein]decreases expression|increases reaction 20583210
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of MET proteindecreases expression 20583210
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of ATP13A4 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of ATP2A1 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of CTSC mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DBP mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of GADD45B mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of GKN3 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of H2-D1 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of IFITM5 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of ITPKB mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of KRT13 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of LANCL1 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of MS4A1 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of OLFR771 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of PLA2G2C mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC22A4 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TSGA10 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of ZFP3 mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ABCA3 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ABTB2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ACO2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of AFM mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of AGXT mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of AHSA1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of AP2B1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ARG1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ARHGAP19 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ARHGAP5 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ARHGEF19 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ARL5A mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ASB14 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ASNS mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATP11C mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATP8B4 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of B2M mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of B3GAT1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of BCKDHB mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of BST2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of C1QC mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CAPZA2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2AP2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CIB3 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CLOCK mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CML5 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of COL6A1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CPEB2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CTSS mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYB5 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP2D13 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP2D22 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP3A13 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP3A44 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP4F16 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of DCT mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of DGUOK mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of DUSP1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of DYNLT1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of EPOR mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of EVI2B mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of EXOC8 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of FAM20B mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of G6PC mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of GADD45G mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of GBP9 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of GFER mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of GIMAP7 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of GLO1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of GSTM2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of H19 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of H2-BL mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of HIRA mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of HNRPC mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of HSD17B11 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of HSPA1B mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of HSPD1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of HTR2A mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ID3 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of IGF1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of IGFBP1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of KCNAB1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of KCNJ14 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of KLF10 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of KLF12 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of LRP1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of LRRC68 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of MALAT1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of MEGF9 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of MKI67 protein]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of MUG1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of MUG2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NAT8 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NDRG1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NDUFA12 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NDUFA7 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NKX6-2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NLRP3 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NPR2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NRN1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of OAT mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of OLFM1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of OLFR203 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of OLFR677 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of P2RX4 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of P2RX7 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PALMD mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PARD6A mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PEBP1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PIGR mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLA1A mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLA2G16 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLA2G2C mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PNRC1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PPM1K mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RAB6B mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RABGAP1L mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RBBP4 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RBP1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RHOH mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RPL17 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RPL27A mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RPL32 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RPL35 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RPL41 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RPL9 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SBP mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SCD2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SCGB1C1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SCN8A mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SCTR mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SERF2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SH2D6 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SLC16A10 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SLC19A2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SLC25A48 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SLC47A1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SMOX mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SOD1 protein]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ST7 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SYT5 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TCEB2 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TLN1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TMEM98 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TMPRSS3 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TMSB4X mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TRAPPC5 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TRPM1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of UBC mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of UGT2B1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of UTRN mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of VEPH1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of VIM mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of VSIG10 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of VSIG4 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of WWOX mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ZCCHC18 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ZFP300 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ZFP36L1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ZZZ3 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of EGFR protein]decreases reaction|increases activity|increases phosphorylation 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of MAPK1 protein]decreases reaction|increases activity|increases phosphorylation 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of MAPK3 protein]decreases reaction|increases activity|increases phosphorylation 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCA protein]decreases reaction|increases activity|increases phosphorylation 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCB protein]decreases reaction|increases activity|increases phosphorylation 17942915
D004052 Diethylnitrosamine MET protein results in increased susceptibility to Diethylnitrosamineincreases response to substance 17942915
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MET mRNAincreases expression 19371625
D004128 Dimethylnitrosamine Dimethylnitrosamine affects the expression of MET mRNAaffects expression 16596271
D004317 Doxorubicin Doxorubicin results in decreased expression of MET proteindecreases expression 16109756
18083897
D004317 Doxorubicin HGF protein inhibits the reaction [Doxorubicin results in decreased expression of MET protein]decreases expression|decreases reaction 16109756
18083897
C045651 epigallocatechin gallate epigallocatechin gallate inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]decreases reaction|increases phosphorylation 19244381
C010452 estradiol-17 beta-benzoate estradiol-17 beta-benzoate affects the expression of MET mRNAaffects expression 15059950
D004958 Estradiol Estradiol results in increased expression of MET mRNAincreases expression 17640349
C015854 estradiol valerate estradiol valerate results in decreased expression of MET mRNAdecreases expression 15972882
D000431 Ethanol Ethanol results in increased expression of MET mRNAincreases expression 15353170
16946407
D015025 Zearalenone Zearalenone results in increased expression of MET mRNAincreases expression 19371625
D005492 Folic Acid Folic Acid inhibits the reaction [Testosterone results in increased expression of MET mRNA]decreases reaction|increases expression 11139396
D005492 Folic Acid Folic Acid results in increased expression of MET mRNAincreases expression 11139396
D005492 Folic Acid Testosterone inhibits the reaction [Folic Acid results in increased expression of MET mRNA]decreases reaction|increases expression 11139396
D019833 Genistein Genistein results in increased expression of MET mRNAincreases expression 19371625
C006552 kaempferol kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]decreases reaction|increases phosphorylation 19244381
D007854 Lead Lead results in decreased expression of MET proteindecreases expression 17298174
C008261 lead acetate lead acetate results in decreased expression of MET proteindecreases expression 17298174
D008767 Methylmercury Compounds Methylmercury Compounds results in decreased expression of MET proteindecreases expression 17298174
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of MET mRNAincreases expression 12634122
C040015 myricetin myricetin inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]decreases reaction|increases phosphorylation 19244381
C484027 oligofectamine oligofectamine results in increased expression of MET mRNAincreases expression 14668052
C016340 o,p'-DDT o,p'-DDT results in increased expression of MET mRNAincreases expression 19371625
D010269 Paraquat Paraquat results in decreased expression of MET proteindecreases expression 17298174
D010634 Phenobarbital Phenobarbital results in increased expression of MET mRNAincreases expression 19270015
19363144
C006253 pirinixic acid pirinixic acid results in increased expression of MET mRNAincreases expression 18301758
D010972 Platelet Activating Factor Platelet Activating Factor results in decreased expression of MET mRNAdecreases expression 15307983
C443641 poly(propyleneimine) poly(propyleneimine) analog affects the expression of MET mRNAaffects expression 16308212
D011794 Quercetin Quercetin inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]decreases reaction|increases phosphorylation 19244381
C037219 quinoline quinoline analog results in decreased activity of MET proteindecreases activity 17964000
C059514 resveratrol resveratrol results in increased expression of MET mRNAincreases expression 19371625
C009166 retinol acetate retinol acetate results in increased expression of MET mRNAincreases expression 16772331
C009277 sodium arsenate sodium arsenate results in decreased expression of MET mRNAdecreases expression 16882884
C017947 sodium arsenite sodium arsenite affects the expression of MET mRNAaffects expression 16507464
C017947 sodium arsenite sodium arsenite results in increased expression of MET mRNAincreases expression 16876216
11241755
C025462 sulindac sulfide sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of MET protein]decreases reaction|increases expression 14710233
D013739 Testosterone bicalutamide inhibits the reaction [Testosterone results in increased expression of MET mRNA]decreases reaction|increases expression 11139396
17371283
D013739 Testosterone CB 3717 inhibits the reaction [Testosterone results in increased expression of MET mRNA]decreases reaction|increases expression 11139396
D013739 Testosterone Folic Acid inhibits the reaction [Testosterone results in increased expression of MET mRNA]decreases reaction|increases expression 11139396
D013739 Testosterone Testosterone inhibits the reaction [CB 3717 results in increased expression of MET mRNA]decreases reaction|increases expression 11139396
D013739 Testosterone Testosterone inhibits the reaction [Folic Acid results in increased expression of MET mRNA]decreases reaction|increases expression 11139396
D013739 Testosterone Testosterone results in increased expression of MET mRNAincreases expression 11139396
17371283
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MET mRNAincreases expression 20067830
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MET mRNAdecreases expression 19933214
D014212 Tretinoin Tretinoin results in increased expression of MET mRNAincreases expression 16051641
C025643 vinclozolin vinclozolin affects the expression of MET mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of MET mRNAdecreases expression 18220299
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30763
  • Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    PA444987Multiple Sclerosis
    PA444818Lung Neoplasms
    PA445742Stomach Neoplasms
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02152 - K-252a Enzyme Inhibitors
    DB06896 - 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
    DB06995 - N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide
    DB06997 - 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide
    DB07369 - N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide
    DB07969 - 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol
    DB08584 - 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline
    DB08700 - 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine
    DB08791 - 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018