AutismKB 2.0

Annotation Detail for MFGE8


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Basic Information Top
Gene Symbol:MFGE8 ( BA46,EDIL1,HsT19888,MFG-E8,OAcGD3S,SED1,SPAG10,hP47 )
Gene Full Name: milk fat globule-EGF factor 8 protein
Band: 15q26.1
Quick LinksEntrez ID:4240; OMIM: 602281; Uniprot ID:MFGM_HUMAN; ENSEMBL ID: ENSG00000140545; HGNC ID: 7036
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200109Integrins in angiogenesis
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1878Ischemia
Desease Name
Lupus Erythematosus, Systemic
IMMUNE
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MFGE8 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MFGE8 mRNAaffects expression 17562736
C061133 Am 80 Am 80 results in increased expression of MFGE8 mRNAincreases expression 17229644
D001374 Azacitidine Azacitidine affects the expression of MFGE8 mRNAaffects expression 18033690
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of MFGE8 mRNAaffects cotreatment|decreases expression 17905399
C006780 bisphenol A bisphenol A results in decreased expression of MFGE8 mRNAdecreases expression 19371625
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MFGE8 mRNAaffects expression 17484886
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of MFGE8 mRNAincreases expression 17654400
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of MFGE8 mRNAdecreases expression 15331540
D004041 Dietary Fats Dietary Fats results in increased expression of MFGE8 mRNAincreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of MFGE8 mRNAdecreases expression 19371625
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of MFGE8 mRNAdecreases expression 15171707
D004317 Doxorubicin Doxorubicin results in increased expression of MFGE8 mRNAincreases expression 16404146
D000431 Ethanol Ethanol results in decreased expression of MFGE8 mRNAdecreases expression 17920746
D015025 Zearalenone Zearalenone results in decreased expression of MFGE8 mRNAdecreases expression 19371625
D019833 Genistein Genistein results in decreased expression of MFGE8 mRNAdecreases expression 19371625
D008727 Methotrexate MFGE8 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of MFGE8 mRNAaffects cotreatment|decreases expression 17905399
C016340 o,p'-DDT o,p'-DDT results in decreased expression of MFGE8 mRNAdecreases expression 19371625
C041786 palm oil palm oil results in increased expression of MFGE8 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MFGE8 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of MFGE8 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of MFGE8 mRNAincreases expression 18301758
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of MFGE8 mRNAaffects cotreatment|increases expression 19244175
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of MFGE8 mRNAaffects cotreatment|decreases expression 17905399
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of MFGE8 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of MFGE8 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 13.4418926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 13.4412039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.446195326
MESH:D000138 Acidosis Ethanol 4.3211192467
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma Doxorubicin 4.4917418594
MESH:D000230 Adenocarcinoma Genistein 4.4911473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.5417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.5416434500
MESH:D000419 Albuminuria Doxorubicin 4.3821441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1515451039 15451040
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3115469931
MESH:D000741 Anemia, Aplastic Benzene 4.2411369114 17661222 14761424
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D000853 Anophthalmos Ethanol 4.6515513904
MESH:D001008 Anxiety Disorders Ethanol 3.8711141031
MESH:D001161 Arteriosclerosis Cyclophosphamide 9.7615014928
MESH:D001161 Arteriosclerosis Dietary Fats 9.7615238619
MESH:D001172 Arthritis, Rheumatoid Am 80 5.2816819260
MESH:D001172 Arthritis, Rheumatoid Methotrexate 5.2817286800
MESH:D050197 Atherosclerosis Am 80 4.2416484594
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.9919483382
MESH:D001855 Bone Marrow Diseases Benzene 5.0616183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5314601052
MESH:D001862 Bone Resorption bisphenol A 3.7111985600
MESH:D001932 Brain Neoplasms Doxorubicin 3.6617150277
MESH:D001943 Breast Neoplasms Benzene 5.6717162533 11921183
MESH:D001943 Breast Neoplasms bisphenol A 5.6717123778
MESH:D001943 Breast Neoplasms Cyclophosphamide 5.6711325840 12006526 17388661 17020986 18234424 15093573 15136595 18323546 16978400
MESH:D001943 Breast Neoplasms Dietary Fats 5.6720435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 5.6717129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 5.6718234424 16322301 16096432 17369602 16264153 16595493 18628466 17983394 18695136 16115903 19526202 15994142 15939500 15634643 16826403 15567936 17426702 16935488 18382427 11325840 15136595 15668708 15993339 15692762
MESH:D001943 Breast Neoplasms Genistein 5.6716873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methotrexate 5.6716978400
MESH:D001943 Breast Neoplasms Trichloroethylene 5.6715986119
MESH:D002056 Burns Ethanol 4.4816374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.3715721981 16050911 16227642 16192424 15673190 16011737 15700767 16097048 16124888 10355542 18705752 3786805
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.3716050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6416051944
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 19.3716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.373084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.3718788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 19.3719701751
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 19.3716924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 19.3716234567 18059187 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Ethanol 19.3715289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.3716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 19.371701930 20007298 17173139 6705139 20935162
MESH:D002278 Carcinoma in Situ bisphenol A 4.8217123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.7216152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 6.6016201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.6016201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.596189445
MESH:D006332 Cardiomegaly Ethanol 3.3419332462
MESH:D009202 Cardiomyopathies Doxorubicin 3.4215476868 16952015 17329180 16278810 16269455 15811867 17308081 16612575 17351982 17924179 16731534 15505089 17131338 17007740 17519947 17974986 16364871 16109756 18627295 17382496 16651473 17928571 16242529 15792986 16455267
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8917334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 3.1916332659
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.656135515
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.084080065
MESH:D002779 Cholestasis pirinixic acid 2.7019176532
MESH:D002971 Cleft Lip Ethanol 3.5015513904
MESH:D002972 Cleft Palate Ethanol 3.1015513904
MESH:D003092 Colitis Selenium 3.6117936198
MESH:D003110 Colonic Neoplasms Genistein 2.2617182828
MESH:D015179 Colorectal Neoplasms Azacitidine 2.8719934284
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.8718259882 18802399
MESH:D019465 Craniofacial Abnormalities Benzene 5.3615643154
MESH:D019465 Craniofacial Abnormalities Ethanol 5.3610194807 15451039 11873399 19302082 15513904 15451040 11198716
MESH:D019465 Craniofacial Abnormalities Methotrexate 5.369562676 12039119
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.3619769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3912952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8518551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.0919747007
MESH:D003556 Cystitis Cyclophosphamide 4.8111948286 18372110 18295254 18710439 16413132 15276878 17979934 10498854 12388444 18433785 16651033 16614059 17010015 15643279 16989017 18093676 18483878 12913760 12161096 10700343
MESH:D003872 Dermatitis Benzene 4.6015902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003882 Dermatomyositis Methotrexate 4.9620191521
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9311751995 15331540 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1718772604
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4516647724
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 21.3621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 21.3619164858 11834606 10774834 16109766 14550746 19739265 18713872 15968718 11739529 14986274 2444490 14725611 12153990 16177239 19416960 12705907 19923254 19085960 12594235 19420014 12540782 16081117 16393943 17522070 17562736 16781746 11529661 16227642 19370779 10915739 11743745 12958197 16485898 18071297 10663392 17906064 12392966 11287661 11421492 15619225 11461765
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 21.367120509 19085960 6884620 10092053 6623471 9327722 15998439 17522070 3786805 16227642 11566570 2869522 19336974 21278145 7179309 15968718 7440962 16177239 3732212 4309450 10915739 15027814
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 21.3617654400
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 21.3617416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 21.3611566570
MESH:D056486 Drug-Induced Liver Injury Selenium 21.3615131321
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 21.367120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Doxorubicin 3.5418602426
MESH:D050171 Dyslipidemias Dietary Fats 3.3318367378
MESH:D004421 Dystonia Phenobarbital 3.841851702
MESH:C538011 Eales disease Vitamin E 4.539068938
MESH:D004487 Edema pirinixic acid 2.3312083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 4.9216819260
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.3216402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.3216402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.9415700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.9417359293
MESH:D016889 Endometrial Neoplasms Genistein 11.9411473722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9818037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.0511006010
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.943659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.703922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.406401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.087750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.853659116
MESH:D004938 Esophageal Neoplasms Ethanol 2.7116704527
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.5117595544 12631006 16239168 61145 16045604 12795759 19224547 15959796
MESH:D005234 Fatty Liver Dietary Fats 17.5117967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Ethanol 17.5119236843 16409862 18620774
MESH:D005234 Fatty Liver pirinixic acid 17.5119236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4917920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5516611131 15751030 16513791 16534752 16002989
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.1310194807 16946407 15513904 15451040
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.2418705752
MESH:D005355 Fibrosis Dietary Fats 8.2418296743
MESH:D005756 Gastritis Acetaminophen 10.5516983495
MESH:D005756 Gastritis Ethanol 10.5515046732
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7716452187
MESH:D005909 Glioblastoma Doxorubicin 6.9717150277
MESH:D005909 Glioblastoma Genistein 6.9716598420
MESH:D018316 Gliosarcoma Cyclophosphamide 5.3411389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 11.6016376943 11014644 15172196
MESH:D006086 Graft vs Host Disease Methotrexate 11.6016518429
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4115692506
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9016080930
MESH:D006331 Heart Diseases Doxorubicin 3.3716879835 16144979 18674790 16707910 16495754 12587719 16244372 17888722 14766674 16330681 18006777 16244371 17875725
MESH:D006333 Heart Failure Doxorubicin 11.2017481944
MESH:D006333 Heart Failure pirinixic acid 11.2020558911
MESH:D006333 Heart Failure Selenium 11.2017162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7415692506
MESH:D006402 Hematologic Diseases Benzene 4.4916183116
MESH:D006467 Hemophilia A Cyclophosphamide 5.1211918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.3614986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4319110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 7.9116109766
MESH:D006529 Hepatomegaly pirinixic acid 7.9119176532 16221962 19772884 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6416490937 16863852
MESH:D006689 Hodgkin Disease Cyclophosphamide 7.2317606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 7.2318501091 17606976 15147373
MESH:D019584 Hot Flashes Vitamin E 3.8014716179
MESH:D006930 Hyperalgesia Acetaminophen 7.3616870215
MESH:D006930 Hyperalgesia Ethanol 7.3618783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4421332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4521332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2714722030 12960047
MESH:D006973 Hypertension Benzene 3.0317940673
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D007021 Hypospadias Diethylstilbestrol 4.4116002989
MESH:D007154 Immune System Diseases Cyclophosphamide 5.1616076520
MESH:D007246 Infertility Diethylstilbestrol 4.1915036965
MESH:D007248 Infertility, Male Cyclophosphamide 3.5116517039 7193160
MESH:D007249 Inflammation Dietary Fats 2.3520412841
MESH:D007251 Influenza, Human Selenium 10.3816624496
MESH:D007251 Influenza, Human Vitamin E 10.3816624496
MESH:D007333 Insulin Resistance bisphenol A 11.6916393666
MESH:D007333 Insulin Resistance Dietary Fats 11.6911836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 11.6916306350
MESH:D007569 Jaw Abnormalities Ethanol 4.2515513904
MESH:D007674 Kidney Diseases Acetaminophen 9.5312587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 9.5315369732 15699352 16775033
MESH:D007674 Kidney Diseases Vitamin E 9.5312488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.4616707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.4616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.0816705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.0814681315 15003126 16762066
MESH:D007805 Language Development Disorders Methotrexate 4.949562676
MESH:D007859 Learning Disorders Diethylstilbestrol 9.2217184923
MESH:D007859 Learning Disorders Ethanol 9.2215451040
MESH:D007938 Leukemia Azacitidine 14.3719148494
MESH:D007938 Leukemia Benzene 14.3714694614 17119257 15935818 18335105
MESH:D007938 Leukemia Cyclophosphamide 14.3710602166
MESH:D007938 Leukemia Genistein 14.3717468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9816085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4318172266 17802794 17296974 18587576 17008537 17658394
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.9610373061
MESH:D007951 Leukemia, Myeloid Azacitidine 9.5019077051
MESH:D007951 Leukemia, Myeloid Benzene 9.5017506065
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.3218720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.3219478238
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.0319299654
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 4.5316531727 16819260
MESH:D007970 Leukopenia Cyclophosphamide 4.7911830472 10052129
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6917676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 19.7616943688 11903743 11408273 17157831 17174718 16221502 21278145 16239168 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 19.7618296743
MESH:D008103 Liver Cirrhosis Ethanol 19.7615289165
MESH:D008103 Liver Cirrhosis Methotrexate 19.7614986274
MESH:D008103 Liver Cirrhosis Phenobarbital 19.7621047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.9218295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.4615818738 17900296 17823541 17976157 14748882 12586293 18376398 12741479 16248980 18481824 18156304 17721639 12898905 15876570 18472332 16011737 18395914 17944888 12546737 17631135 18412020 14716833 15673190 12649538 17714472 13678700 18251166 12632512 12445418 17766677 16027843 18279442 16015684 10355542 15338365 15052691 14716496 18705752 12632514 16136751 18210741 18339082 17708605 18166357 17557913 12667390 18277467 18317297 15730626 12958196 12445421 15362042 18429990 15650968 18054572 17525996 17640975 18395095 17761835 18418968 17805973 18263696 12666154 18420326 14512876 15123356 12389079 14724832 15925388 15931870 17698563 11481614 15370692 16116963 18006644 17869086 14620537 16638106 17481882 16097048 20821823 18472094 12609069 18205269 15057751 18187930 16192424 17922224 15893842 15996030 16033810 15959796 17565644
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.4616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 8.4618166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.4617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.4616169303
MESH:D008107 Liver Diseases Acetaminophen 6.2212969438 12587719 19460945 16611625 19784758 19014921 11587558 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2216964402 17285989 15830285 15720792 16246199
MESH:D008107 Liver Diseases Phenobarbital 6.2219363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4817207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9114706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.557678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.5519294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 13.5516712894 15890375
MESH:D008113 Liver Neoplasms Phenobarbital 13.5519812893 19482888 15975961 21047994 19073162 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 13.5520007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 22.012876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Benzene 22.0112562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.0115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 22.0117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 22.0117172636 18308698 2563599 6150874 1399818
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 22.017955063
MESH:D008171 Lung Diseases Vitamin E 3.0616863852
MESH:D017563 Lung Diseases, Interstitial Benzene 11.0914698565
MESH:D017563 Lung Diseases, Interstitial Methotrexate 11.0918516814
MESH:D008175 Lung Neoplasms Azacitidine 4.7921224363
MESH:D008175 Lung Neoplasms Benzene 4.7912562636
MESH:D008175 Lung Neoplasms Doxorubicin 4.7917418594 6189445
MESH:D008175 Lung Neoplasms Vitamin E 4.7911062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9815166399
MESH:D008223 Lymphoma Benzene 22.1817584886 17119257
MESH:D008223 Lymphoma Cyclophosphamide 22.1812854902
MESH:D008223 Lymphoma Diethylstilbestrol 22.1815700306
MESH:D008223 Lymphoma Doxorubicin 22.1816098063
MESH:D008223 Lymphoma Methotrexate 22.1817352296
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.4416675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 8.5211911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.5217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4015621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3416002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.2712562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 13.4311921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 13.4315458769
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.4314578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 13.4315318939
MESH:D008545 Melanoma Doxorubicin 2.2616827129
MESH:D008546 Melanoma, Experimental Acetaminophen 10.2619513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.2616388313
MESH:D008569 Memory Disorders Ethanol 4.0215451040 18411066
MESH:D008654 Mesothelioma Doxorubicin 6.0617638057
MESH:D008654 Mesothelioma Selenium 6.0615107826
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3415792986
MESH:D009006 Monosomy Azacitidine 5.9119299654
MESH:D052016 Mucositis Doxorubicin 11.9417415656
MESH:D052016 Mucositis Methotrexate 11.9417488658
MESH:D009101 Multiple Myeloma Am 80 11.7817229644
MESH:D009101 Multiple Myeloma Azacitidine 11.7819549372 18443271
MESH:D009101 Multiple Myeloma Benzene 11.7817119195
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 3.9118720364 17596541 19805378 17611569
MESH:D009203 Myocardial Infarction Doxorubicin 9.0715857846 19429709
MESH:D009203 Myocardial Infarction Genistein 9.0717141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.0719151258
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.9517141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3017484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.6918551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8918259882
MESH:D009369 Neoplasms Cyclophosphamide 11.2618854779
MESH:D009369 Neoplasms Diethylstilbestrol 11.2615313581
MESH:D009369 Neoplasms pirinixic acid 11.2617405874
MESH:D009369 Neoplasms Trichloroethylene 11.2611911487
MESH:D009401 Nephrosis Doxorubicin 4.6016636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8516889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 15.5711399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.5711399458
MESH:D009421 Nervous System Malformations Genistein 15.5716427766
MESH:D009436 Neural Tube Defects Benzene 3.5615643154
MESH:D009447 Neuroblastoma Cyclophosphamide 6.9215176712 8761367 16115947
MESH:D009447 Neuroblastoma Doxorubicin 6.9215555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7318514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.728761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.168291058
MESH:D009765 Obesity Dietary Fats 4.2918457598 20132043 17217161 19632207 11836018 20518802 16723640 18674790 21332399
MESH:D009765 Obesity pirinixic acid 4.2920558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6616049721
MESH:D009784 Occupational Diseases Benzene 8.6617178637 16737584 15576619 15935809 17119257 15727169 17479406 15913788 15612468
MESH:D009845 Oligospermia Cyclophosphamide 4.5416517039
MESH:D010018 Osteomalacia Phenobarbital 4.1917016548
MESH:D010024 Osteoporosis Genistein 3.1519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9216169203
MESH:D012516 Osteosarcoma Doxorubicin 3.9815930896
MESH:D010049 Ovarian Diseases bisphenol A 4.8211985600
MESH:D010051 Ovarian Neoplasms Benzene 4.9912562636
MESH:D010051 Ovarian Neoplasms Genistein 4.9919005980
MESH:D010146 Pain Acetaminophen 6.3916870215
MESH:D010146 Pain Cyclophosphamide 6.3912161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 8.4211332152
MESH:D010190 Pancreatic Neoplasms Ethanol 8.4212384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.4216965848
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9817983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5015687265 16977796
MESH:D010954 Plasmacytoma Selenium 4.7215087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9817638057
MESH:D011230 Precancerous Conditions Phenobarbital 3.482563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.7121297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.2710548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.2717184923
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0520887781
MESH:D011471 Prostatic Neoplasms Am 80 2.4316289102
MESH:D011471 Prostatic Neoplasms Azacitidine 2.4318324645
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4316740699
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.4317136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.4315846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.4315749863 15897917 16868541 16729912 18437689 16888761
MESH:D011471 Prostatic Neoplasms Genistein 2.4316925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Vitamin E 2.4315084515
MESH:D019310 Pseudolymphoma Phenobarbital 4.3212752131
MESH:D011565 Psoriasis Am 80 6.3916819260
MESH:D011565 Psoriasis Methotrexate 6.3917410198
MESH:D011629 Puberty, Precocious bisphenol A 4.6110548101
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2216636934
MESH:D051437 Renal Insufficiency Doxorubicin 9.9217922066
MESH:D051437 Renal Insufficiency Methotrexate 9.9217352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D012509 Sarcoma Doxorubicin 3.8417710206 15625365 17203757 16767912 18313854 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6217846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.6616636934
MESH:D012640 Seizures 2,6-dinitrotoluene 9.2218551238
MESH:D012640 Seizures Ethanol 9.229754883
MESH:D012640 Seizures Phenobarbital 9.223137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.656407741
MESH:D012871 Skin Diseases Vitamin E 2.4018709164
MESH:D012878 Skin Neoplasms Doxorubicin 2.8715692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4017203757 16767912 15625365
MESH:D013088 Spermatocele Diethylstilbestrol 4.5416709447 16002989
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.3416517039
MESH:D013274 Stomach Neoplasms Benzene 2.8112562636
MESH:D013274 Stomach Neoplasms Ethanol 2.8118456281
MESH:D013276 Stomach Ulcer Ethanol 3.3817918041 9562338 16755016 17189318 11906479 9211565
MESH:D020521 Stroke Vitamin E 3.3816517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.8116684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.109754883
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.8812837982
MESH:D013576 Syndactyly Methotrexate 4.879562676
MESH:D013953 Thymus Neoplasms Benzene 4.7810850423
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.8916010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.891399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.4416049721
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 11.4414692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.4416712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.4417653716
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1510091137
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8816175088
MESH:D014591 Uterine Diseases bisphenol A 13.2414652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 13.2414652134
MESH:D014594 Uterine Neoplasms Benzene 9.3012562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.3015809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2716002989 16513791
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0517678736 16364871 17334414 17638931
MESH:D015430 Weight Gain Dietary Fats 3.5916723640
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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