AutismKB 2.0

Annotation Detail for MFGE8


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Basic Information Top
Gene Symbol:MFGE8 ( BA46,EDIL1,HsT19888,MFG-E8,OAcGD3S,SED1,SPAG10,hP47 )
Gene Full Name: milk fat globule-EGF factor 8 protein
Band: 15q26.1
Quick LinksEntrez ID:4240; OMIM: 602281; Uniprot ID:MFGM_HUMAN; ENSEMBL ID: ENSG00000140545; HGNC ID: 7036
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
200109Integrins in angiogenesis
Related Diseases/Disorders Top
Desease IDDesease Name
1878Ischemia
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MFGE8 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MFGE8 mRNAaffects expression 17562736
C061133 Am 80 Am 80 results in increased expression of MFGE8 mRNAincreases expression 17229644
D001374 Azacitidine Azacitidine affects the expression of MFGE8 mRNAaffects expression 18033690
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of MFGE8 mRNAaffects cotreatment|decreases expression 17905399
C006780 bisphenol A bisphenol A results in decreased expression of MFGE8 mRNAdecreases expression 19371625
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MFGE8 mRNAaffects expression 17484886
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of MFGE8 mRNAincreases expression 17654400
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of MFGE8 mRNAdecreases expression 15331540
D004041 Dietary Fats Dietary Fats results in increased expression of MFGE8 mRNAincreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of MFGE8 mRNAdecreases expression 19371625
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of MFGE8 mRNAdecreases expression 15171707
D004317 Doxorubicin Doxorubicin results in increased expression of MFGE8 mRNAincreases expression 16404146
D000431 Ethanol Ethanol results in decreased expression of MFGE8 mRNAdecreases expression 17920746
D015025 Zearalenone Zearalenone results in decreased expression of MFGE8 mRNAdecreases expression 19371625
D019833 Genistein Genistein results in decreased expression of MFGE8 mRNAdecreases expression 19371625
D008727 Methotrexate MFGE8 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of MFGE8 mRNAaffects cotreatment|decreases expression 17905399
C016340 o,p'-DDT o,p'-DDT results in decreased expression of MFGE8 mRNAdecreases expression 19371625
C041786 palm oil palm oil results in increased expression of MFGE8 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MFGE8 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of MFGE8 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of MFGE8 mRNAincreases expression 18301758
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of MFGE8 mRNAaffects cotreatment|increases expression 19244175
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of MFGE8 mRNAaffects cotreatment|decreases expression 17905399
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of MFGE8 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of MFGE8 mRNAincreases expression 19244175
Pharmacogenomics Knowledge Base Top
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018