AutismKB 2.0

Annotation Detail for MFNG


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Basic Information Top
Gene Symbol:MFNG ( - )
Gene Full Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Band: 22q13.1
Quick LinksEntrez ID:4242; OMIM: 602577; Uniprot ID:MFNG_HUMAN; ENSEMBL ID: ENSG00000100060; HGNC ID: 7038
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04330Notch signaling pathway
No data
No data
Pathway IDPathway Name
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MFNG mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MFNG mRNAaffects expression 17562736
D003474 Curcumin Curcumin results in increased expression of MFNG mRNAincreases expression 17198877
D016572 Cyclosporine Cyclosporine results in decreased expression of MFNG mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of MFNG mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of MFNG mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MFNG mRNAaffects binding|increases activity|increases expression 19710929
D018038 Sodium Selenite Sodium Selenite results in increased expression of MFNG mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D019973 Alcohol-Related Disorders Curcumin 5.4617887948
MESH:D000544 Alzheimer Disease Curcumin 2.6615590663
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7816807698
MESH:D050197 Atherosclerosis Curcumin 3.4518704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 4.8019761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D002545 Brain Ischemia Curcumin 4.6716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1617596214
MESH:D001943 Breast Neoplasms Curcumin 2.3518462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms Dietary Fats 2.3520435547
MESH:D002277 Carcinoma Curcumin 4.0318593918
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.913581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0418414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8218462866
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.107505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1012371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.429022650 19486331
MESH:D002779 Cholestasis Cyclosporine 14.4219486331
MESH:D002779 Cholestasis pirinixic acid 14.4219176532
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D003092 Colitis Curcumin 4.4818200517 16804969 16782535
MESH:D003103 Coloboma Curcumin 4.7918809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5316340194 19359593
MESH:D016510 Corneal Neovascularization Curcumin 5.2018497527
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.102524372 11906362 11298694 14531868 8970840 18759878 12868966 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7518403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.2218204486
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.5716192314 8291058 18692083 9653073 1440618 9022650 18289764 6482804 7440962 18648102 9328219 11289319 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5712392966 19923254 11529661 10915739 16393943 16081117 14725611 19739265 19370779 16109766 10663392 19085960 11743745 16177239 16485898 12594235 10774834 12705907 14550746 19416960 17562736 11834606 18713872 15968718 15619225 16227642 11739529 12958197 19420014 18071297 12153990 17522070 16781746 11461765 12540782 14986274 11421492 2444490 17906064 11287661 19164858
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.5715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004381 Duodenal Ulcer Curcumin 4.3317351913
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Curcumin 20.9019297423
MESH:D005234 Fatty Liver Cyclosporine 20.9019224547
MESH:D005234 Fatty Liver Dietary Fats 20.9017967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 20.9019236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Curcumin 16.7318705752
MESH:D005355 Fibrosis Cyclosporine 16.7312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 16.7318296743
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0018462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Curcumin 3.6217596214
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8118462866 18829502
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 18467677 19772884 19176532
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.3517701891
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Curcumin 10.0518704882
MESH:D006937 Hypercholesterolemia Dietary Fats 10.0521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007249 Inflammation Curcumin 5.6716956363 18403477 17151092
MESH:D007249 Inflammation Dietary Fats 5.6720412841
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2918200517 18596194
MESH:D007333 Insulin Resistance Dietary Fats 13.2111836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 13.2116306350
MESH:D007333 Insulin Resistance Sodium Selenite 13.2114714311
MESH:D007414 Intestinal Neoplasms Curcumin 4.4510783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.2218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.956582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D007889 Leiomyoma Curcumin 4.8318555241
MESH:D007938 Leukemia Curcumin 3.3418462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4516106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.0416106398
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.5818705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5815474484
MESH:D008107 Liver Diseases Acetaminophen 4.2716610002 12969438 12587719 19014921 11587558 19460945 16611625 19784758
MESH:D008107 Liver Diseases Curcumin 4.2716956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8920007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.676587162 3712494 598648 1399818
MESH:D008175 Lung Neoplasms Curcumin 2.2816243823 19359593 18462866
MESH:D008223 Lymphoma Curcumin 3.7518462866
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0016173963
MESH:D008545 Melanoma Curcumin 2.4418462866 17885582
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008569 Memory Disorders Curcumin 4.4317263510
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009101 Multiple Myeloma Curcumin 3.6819372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.2617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.6518495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.9112497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009423 Nervous System Neoplasms Curcumin 6.0118462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity Curcumin 7.7319297423
MESH:D009765 Obesity Dietary Fats 7.7321332399 20518802 17217161 18457598 20132043 19632207 11836018 18674790 16723640
MESH:D009765 Obesity pirinixic acid 7.7320558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010024 Osteoporosis Curcumin 3.6118719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8819020741 18462866
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0019196508 17440100 19401701
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Curcumin 3.4318769126 12497104 15129424 18156803 18226269 10851300 11398177
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.4318760546
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.7619168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2818379247 10666014
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012509 Sarcoma Curcumin 4.3418462866
MESH:D018805 Sepsis Curcumin 4.2818389075
MESH:D013276 Stomach Ulcer Curcumin 3.7319188055 16631530
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.061399818 6582329 6587162 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.508074119
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.5018593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.6018462866
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:04330 Notch signaling pathway
KEGG:00514 Other types of O-glycan biosynthesis
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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