AutismKB 2.0

Annotation Detail for MGST3


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Basic Information Top
Gene Symbol:MGST3 ( GST-III )
Gene Full Name: microsomal glutathione S-transferase 3
Band: 1q24.1
Quick LinksEntrez ID:4259; OMIM: 604564; Uniprot ID:MGST3_HUMAN; ENSEMBL ID: ENSG00000143198; HGNC ID: 7064
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-4061glutathione-mediated detoxification
Pathway IDPathway Name
hsa00480Glutathione metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014024 2,4,5,2',4',5'-hexachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of MGST3 mRNAaffects cotreatment|decreases expression 16984957
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MGST3 mRNAaffects expression 21346803
C023035 3,4,5,3',4'-pentachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of MGST3 mRNAaffects cotreatment|decreases expression 16984957
D000082 Acetaminophen Acetaminophen affects the expression of MGST3 mRNAaffects expression 17562736
C039726 artesunate MGST3 mRNA affects the susceptibility to artesunateaffects response to substance 15796179
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MGST3 mRNAdecreases expression 15336504
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of MGST3 mRNAincreases expression 15336504
14729362
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MGST3 mRNAaffects expression 17484886
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of MGST3 mRNAdecreases expression 18178546
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of MGST3 mRNAdecreases expression 19440498
D019826 Cholic Acid Cholic Acid results in increased expression of MGST3 mRNAincreases expression 17521389
C030123 coumarin coumarin results in decreased expression of MGST3 mRNAdecreases expression 18480146
D003976 Diazinon Diazinon results in decreased expression of MGST3 mRNAdecreases expression 19440498
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MGST3 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of MGST3 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MGST3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MGST3 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MGST3 mRNAincreases expression 17557909
D011345 Fenofibrate Fenofibrate results in increased expression of MGST3 mRNAincreases expression 11798191
D019833 Genistein Genistein results in increased expression of MGST3 mRNAincreases expression 15289156
D017313 Fenretinide Fenretinide results in decreased expression of MGST3 mRNAdecreases expression 16467112
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of MGST3 mRNAincreases expression 14729362
D007529 Isoflavones Isoflavones affects the expression of MGST3 mRNAaffects expression 16365062
D008701 Methapyrilene Methapyrilene results in decreased expression of MGST3 mRNAdecreases expression 16393664
C058346 N-(4-methoxyphenyl)retinamide N-(4-methoxyphenyl)retinamide results in decreased expression of MGST3 mRNAdecreases expression 16467112
D009532 Nickel Nickel affects the expression of MGST3 mRNAaffects expression 19440498
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MGST3 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of MGST3 mRNAincreases expression 11798191
17426115
18301758
16221962
C052785 rebamipide rebamipide results in increased expression of MGST3 mRNAincreases expression 18299717
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MGST3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MGST3 mRNAdecreases expression 18796159
18465118
D014415 Tunicamycin Tunicamycin results in decreased expression of MGST3 mRNAdecreases expression 17127020
D002762 Cholecalciferol Cholecalciferol results in decreased expression of MGST3 mRNAdecreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6111752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D055371 Acute Lung Injury Nickel 8.4916166738
MESH:D055371 Acute Lung Injury pirinixic acid 8.4918653653
MESH:D000230 Adenocarcinoma Estradiol 9.6811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.6814692618
MESH:D000230 Adenocarcinoma Fenretinide 9.6810697514
MESH:D000230 Adenocarcinoma Genistein 9.6811473722
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 16.0216628245
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.0216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.0216835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.3611874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.3616487989
MESH:D000505 Alopecia Isoflavones 4.5217569567
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.7916142846
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001932 Brain Neoplasms Fenretinide 4.1416187019
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.8517129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 2.8512948864 17261762 17289903 16675129 14630087 18497071 17018787 19861407
MESH:D001943 Breast Neoplasms Fenretinide 2.8516601279
MESH:D001943 Breast Neoplasms Genistein 2.8516873071 16541309 17200150
MESH:D001943 Breast Neoplasms Nickel 2.8515986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5416124888 15721981 16011737 16227642 10355542 15700767 18705752 16050911 16097048 16192424 3786805 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.4416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.443084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.4418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.4415948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.4416924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 13.4416270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.4416924424
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 3.1116274795
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2318850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 11.3816332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 11.3816936243
MESH:D002318 Cardiovascular Diseases Isoflavones 11.3817689850
MESH:D002386 Cataract Acetaminophen 2.4410977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6118566989
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.2316154183
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 9.1316628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1515861022 16919318 17110522 16105132 11677210 17681005 17333356
MESH:D002779 Cholestasis pirinixic acid 7.1519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0016354765 12621046 8697196 15668235 15340226
MESH:D003110 Colonic Neoplasms Genistein 2.2517182828
MESH:D015179 Colorectal Neoplasms Fenretinide 3.1217273769
MESH:D015179 Colorectal Neoplasms Isoflavones 3.1217116718
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8514669216 17141729
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 2.8417686920
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8410048152 15322242 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3216002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7718551238
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.7217244072 19470301 17100760
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003877 Dermatitis, Contact Nickel 4.412952479
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 6.8719647726
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.8716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2119279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.2018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.2012392966 18071297 11743745 16781746 12153990 16081117 11739529 14725611 10774834 17906064 2444490 15968718 14550746 19739265 19164858 17522070 12594235 18713872 16485898 11421492 11834606 12958197 19370779 16177239 16227642 12705907 17562736 11287661 19923254 19085960 16393943 16109766 11529661 10915739 12540782 14986274 19420014 11461765 15619225 19416960 10663392
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.2016177239 3786805 9327722 10092053 15968718 7120509 2869522 15027814 17522070 15998439 19085960 3732212 16227642 21278145 7440962 6884620 11566570 7179309 4309450 19336974 6623471 10915739
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 11.2017851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.2020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D050171 Dyslipidemias Fenofibrate 4.2516707586
MESH:D004417 Dyspnea Diazinon 4.5516487989
MESH:D004487 Edema pirinixic acid 5.8212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8211000095 12711302
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 11.5917686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5915322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9512538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.0716402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.0716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.5415700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 16.5419148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Fenofibrate 16.5416569247
MESH:D016889 Endometrial Neoplasms Genistein 16.5411473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8110568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 11.7712631006 16239168 15959796 12795759 61145 19224547 17595544 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.7715345470
MESH:D005234 Fatty Liver pirinixic acid 11.7719236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5116513791 15751030 16611131 16002989 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 7.8018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.8020067830
MESH:D005756 Gastritis Acetaminophen 3.4316983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7016452187
MESH:D005909 Glioblastoma Fenretinide 7.0116187019
MESH:D005909 Glioblastoma Genistein 7.0116598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 6.5820471113 17686920
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 8.8319110552 19900420
MESH:D006505 Hepatitis Diazinon 8.8316487989
MESH:D006529 Hepatomegaly pirinixic acid 7.4619176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.4615340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D015658 HIV Infections Nickel 3.6917263646
MESH:D019584 Hot Flashes Estradiol 9.5917088409
MESH:D019584 Hot Flashes Isoflavones 9.5914716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8016354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.5116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1914722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.4416945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.1215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Diazinon 6.4112948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4117937319
MESH:D007249 Inflammation Nickel 4.8616166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8612878042 12200463
MESH:D007333 Insulin Resistance Estradiol 6.6716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.6716306350
MESH:D007410 Intestinal Diseases rebamipide 4.9411686837
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1216580747
MESH:D007674 Kidney Diseases Acetaminophen 5.4215629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.4215618244
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0516518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.3216705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.3216762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 11.3215610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8217184923
MESH:D007938 Leukemia Genistein 2.9017468513 18980019
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7916707609
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6721278145 16221502 17334410 17174718 11408273 17157831 16943688 11903743 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.3215931870 15673190 18251166 17761835 12666154 17708605 14748882 13678700 17823541 17721639 14512876 16097048 15370692 15893842 16015684 18705752 18277467 15123356 12445418 16116963 16136751 15057751 17714472 15338365 16011737 12958196 12649538 18279442 18420326 16192424 18054572 12741479 15818738 15959796 18395095 17525996 17557913 17900296 18412020 16248980 12389079 17565644 17922224 12632514 17698563 14716833 17869086 20821823 15925388 15996030 18472094 18429990 12898905 15730626 17481882 18156304 18006644 12667390 14620537 18187930 18395914 18418968 16638106 17805973 12609069 15876570 14716496 16033810 18472332 12586293 17976157 16027843 12546737 11481614 18376398 18263696 17631135 15052691 14724832 18166357 12632512 17766677 17944888 18205269 10355542 15362042 18317297 18210741 18481824 15650968 12445421 18339082 17640975
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.3214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 8.3215474484
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.3217823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.3215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.3212878042
MESH:D008107 Liver Diseases Acetaminophen 6.2111587558 12969438 19460945 16611625 19014921 19784758 12587719 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2115720792 16964402 16246199 15830285 17285989
MESH:D008107 Liver Diseases Chlorpyrifos 6.2115991261
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7014706259 16899240
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 20.4518644402 16835634
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.4519294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.4515890375 16712894
MESH:D008113 Liver Neoplasms Fenofibrate 20.4518978307
MESH:D008113 Liver Neoplasms Methapyrilene 20.4515890375
MESH:D008113 Liver Neoplasms pirinixic acid 20.4520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.4516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.0515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 9.0518775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.0512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2311884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3015700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2716002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.2016891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 9.2010697514
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.2012929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.2319453300
MESH:D008545 Melanoma artesunate 4.3616273263
MESH:D008545 Melanoma Fenretinide 4.3616270382
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D009062 Mouth Neoplasms Fenretinide 4.1316274795
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009203 Myocardial Infarction Genistein 5.3317141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.3319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.0916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.0917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.0916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6118551238
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 10.978820588
MESH:D009369 Neoplasms Diethylstilbestrol 10.9715313581
MESH:D009369 Neoplasms Fenretinide 10.9715958647 17353921
MESH:D009369 Neoplasms pirinixic acid 10.9717405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.5211399458
MESH:D009421 Nervous System Malformations Estradiol 21.5216427766 11399458
MESH:D009421 Nervous System Malformations Genistein 21.5216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.5214600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6718514411
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4316303764
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.0015081274
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2212819281 16049721
MESH:D010024 Osteoporosis Genistein 7.0919401787
MESH:D010024 Osteoporosis Isoflavones 7.0916562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8616169203
MESH:D010051 Ovarian Neoplasms Estradiol 7.5519401270
MESH:D010051 Ovarian Neoplasms Fenretinide 7.5516133793
MESH:D010051 Ovarian Neoplasms Genistein 7.5519005980
MESH:D010146 Pain Acetaminophen 2.2016870215
MESH:D010190 Pancreatic Neoplasms Fenretinide 3.2615580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.8512065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4315687265 16977796
MESH:D011041 Poisoning Diazinon 4.1317603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.7517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7511118676 11222880 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6620887781
MESH:D011471 Prostatic Neoplasms Cholecalciferol 1.9017024972
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9017136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms Fenretinide 1.9017024972
MESH:D011471 Prostatic Neoplasms Genistein 1.9015256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Isoflavones 1.9017219775 17571952 17374662 16365062
MESH:D011537 Pruritus Ethinyl Estradiol 3.0716919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.3911874814 16611668 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.6416611668 17119214
MESH:D012162 Retinal Degeneration Fenretinide 4.2216303925
MESH:D012640 Seizures 2,4-dinitrotoluene 2.3718551238
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.846418539
MESH:D012878 Skin Neoplasms Fenretinide 16.7416467112
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 16.7412065085
MESH:D012878 Skin Neoplasms N-(4-methoxyphenyl)retinamide 16.7416467112
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.748532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.7416192470
MESH:D013088 Spermatocele Diethylstilbestrol 10.8816709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8816709447
MESH:D013272 Stomach Diseases rebamipide 5.0316184426
MESH:D013274 Stomach Neoplasms rebamipide 3.2115993841
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.9116049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 7.9116712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 7.9116720286
MESH:D014570 Urologic Diseases Diazinon 5.0316487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0710091137
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.1316175088
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 9.1316154183
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.6915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1916002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D014689 Venous Insufficiency coumarin 5.5312708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00480 Glutathione metabolism
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00143 - BSS Plus Dietary supplement;Micronutrient
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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