AutismKB 2.0

Annotation Detail for CD99


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Basic Information Top
Gene Symbol:CD99 ( HBA71,MIC2,MIC2X,MIC2Y,MSK5X )
Gene Full Name: CD99 molecule
Band: Xp22.32 and Yp11.3
Quick LinksEntrez ID:4267; OMIM: 313470,450000; Uniprot ID:CD99_HUMAN; ENSEMBL ID: ENSG00000002586; HGNC ID: 7082
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04514Cell adhesion molecules (CAMs)
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CD99 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CD99 mRNAdecreases expression 15336504
D008727 Methotrexate CD99 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C006253 pirinixic acid pirinixic acid results in decreased expression of CD99 mRNAdecreases expression 17426115
D012643 Selenium Selenium results in increased expression of CD99 mRNAincreases expression 19244175
D014635 Valproic Acid Valproic Acid results in increased expression of CD99 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of CD99 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of CD99 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 9.9712039119
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.978875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders Valproic Acid 9.5017497229
MESH:D001008 Anxiety Disorders vinclozolin 9.5019015723
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1417286800
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617507914 17157402 17688650 18396377 15238991 18940202 18775368 19232924 18177632 19460635 18558336 18316065 16609825 20603192 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.1817594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001943 Breast Neoplasms Methotrexate 3.0816978400
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D018211 Chondrosarcoma, Mesenchymal marker/mechanism 12817616
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D019465 Craniofacial Abnormalities Methotrexate 4.0812039119 9562676
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.0817688650 16575769 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 4.0819769572
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003550 Cystic Fibrosis Methotrexate 4.4719747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003882 Dermatomyositis Methotrexate 5.4120191521
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5819923254 10663392 2444490 17522070 16393943 11461765 12153990 12958197 15619225 14550746 19164858 14986274 17562736 11287661 12594235 10915739 19370779 11834606 16485898 17906064 11739529 19739265 11743745 14725611 18713872 11529661 19085960 12540782 16081117 16781746 16177239 18071297 15968718 11421492 10774834 16227642 16109766 12705907 12392966 19416960 19420014
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5815131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.581733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.463659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D005234 Fatty Liver pirinixic acid 8.5420131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 8.5414986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D006086 Graft vs Host Disease Methotrexate 5.4516518429
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1016080930
MESH:D006333 Heart Failure pirinixic acid 7.4120558911
MESH:D006333 Heart Failure Selenium 7.4117162251
MESH:D006529 Hepatomegaly pirinixic acid 3.3018467677 19772884 16221962 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007251 Influenza, Human Selenium 12.2516624496
MESH:D007251 Influenza, Human Vitamin E 12.2516624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007674 Kidney Diseases Acetaminophen 6.3912587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.3912488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007805 Language Development Disorders Methotrexate 5.369562676
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008103 Liver Cirrhosis Methotrexate 3.8214986274
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4416169303
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 12587719 19460945 11587558 19784758 16611625 19014921 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8916377806 15890375 20007298
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 12.7518516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 12.7517228818
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008223 Lymphoma Methotrexate 4.1217352296
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D052016 Mucositis Methotrexate 5.6217488658
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.278888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.8720603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.8718220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.9211422049 12752131
MESH:D011565 Psoriasis Methotrexate 3.5017410198
MESH:D051437 Renal Insufficiency Methotrexate 5.0217352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8914763951 11738929 16876388 3137016 15475178 1511512 17978042 11044598
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.798532709
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D013576 Syndactyly Methotrexate 5.329562676
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014581 Urticaria Acetaminophen 3.2410982225
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:04670 Leukocyte transendothelial migration
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30804
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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