AutismKB 2.0

Annotation Detail for ASAH1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ASAH1 ( AC,ACDase,ASAH,FLJ21558,FLJ22079,PHP,PHP32 )
Gene Full Name: N-acylsphingosine amidohydrolase (acid ceramidase) 1
Band: 8p22
Quick LinksEntrez ID:427; OMIM: 613468; Uniprot ID:ASAH1_HUMAN; ENSEMBL ID: ENSG00000104763; HGNC ID: 735
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY3DJ-11470sphingosine and sphingosine-1-phosphate metabolism
Pathway IDPathway Name
hsa00600Sphingolipid metabolism
hsa04142Lysosome
hsa01100Metabolic pathways
No data
Pathway IDPathway Name
200100Ceramide signaling pathway
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Lysosomal storage diseases
H00138Farber lipogranulomatosis
Genetic disorders
Desease IDDesease Name
1831Prostate cancer
1943Adenocarcinoma
2051Leukemia
No data
No data
Desease Name
Farber lipogranulomatosis
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ASAH1 mRNAaffects expression 21346803
D000638 Amiodarone Amiodarone results in increased expression of ASAH1 mRNAincreases expression 17567588
15342952
D000638 Amiodarone Amiodarone results in increased expression of ASAH1 mRNAincreases expression 19224547
D000639 Amitriptyline Amitriptyline results in increased expression of ASAH1 mRNAincreases expression 15342952
17567588
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ASAH1 mRNAaffects expression 16483693
C004984 apocarotenal apocarotenal results in increased expression of ASAH1 mRNAincreases expression 17034753
C006632 arsenic trioxide arsenic trioxide results in increased expression of ASAH1 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ASAH1 mRNAincreases expression 20382639
D019207 beta Carotene beta Carotene results in increased expression of ASAH1 mRNAincreases expression 17034753
C006780 bisphenol A bisphenol A results in decreased expression of ASAH1 mRNAdecreases expression 19371625
C084597 chlorcyclizine chlorcyclizine results in increased expression of ASAH1 mRNAincreases expression 15342952
D017291 Clarithromycin Clarithromycin results in increased expression of ASAH1 mRNAincreases expression 15342952
D003024 Clozapine Clozapine results in increased expression of ASAH1 mRNAincreases expression 15342952
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ASAH1 mRNAincreases expression 19638242
D004206 Disopyramide Disopyramide results in increased expression of ASAH1 mRNAincreases expression 15342952
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of ASAH1 mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ASAH1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ASAH1 mRNAincreases expression 16174780
D005047 Etoposide ASAH1 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D015025 Zearalenone Zearalenone results in decreased expression of ASAH1 mRNAdecreases expression 19371625
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of ASAH1 mRNAaffects cotreatment|increases expression 17347304
D005419 Flavonoids Flavonoids results in decreased expression of ASAH1 mRNAdecreases expression 18035473
D005424 Flecainide Flecainide results in increased expression of ASAH1 mRNAincreases expression 15342952
D005472 Fluorouracil ASAH1 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of ASAH1 mRNA]affects reaction|decreases expression 15016801
D005473 Fluoxetine Fluoxetine results in increased expression of ASAH1 mRNAincreases expression 15342952
17567588
D019833 Genistein Genistein results in decreased expression of ASAH1 mRNAdecreases expression 19371625
D007099 Imipramine Imipramine results in increased expression of ASAH1 mRNAincreases expression 15342952
17567588
D016685 Mitomycin ASAH1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C029938 nickel sulfate nickel sulfate results in decreased expression of ASAH1 mRNAdecreases expression 16780908
D010480 Perhexiline Perhexiline results in increased expression of ASAH1 mRNAincreases expression 15342952
C059514 resveratrol resveratrol results in decreased expression of ASAH1 mRNAdecreases expression 19371625
D020280 Sertraline Sertraline results in increased expression of ASAH1 mRNAincreases expression 15342952
C025462 sulindac sulfide sulindac sulfide results in decreased expression of ASAH1 mRNAdecreases expression 16184548
D013629 Tamoxifen Tamoxifen results in increased expression of ASAH1 mRNAincreases expression 15342952
17567588
D001371 trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of ASAH1 mRNAincreases expression 15342952
D015031 Zimeldine Zimeldine results in increased expression of ASAH1 mRNAincreases expression 15342952
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2014745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.5817676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 9.3418287403
MESH:D000138 Acidosis Ethanol 9.3411192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D058186 Acute Kidney Injury resveratrol 3.5516538975
MESH:D055371 Acute Lung Injury nickel sulfate 4.0012718980 19131640 16100012 11954676
MESH:D000230 Adenocarcinoma arsenic trioxide 9.4011798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.4014692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.4017638652
MESH:D000230 Adenocarcinoma Genistein 9.4011473722
MESH:D000236 Adenoma Diethylnitrosamine 6.216695378 10737359
MESH:D000236 Adenoma resveratrol 6.2115688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.5617620307 17162532 19061943 18056438 19052882 16434500
MESH:D000380 Agranulocytosis Clozapine 4.7214617031 12649775 16160616
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9715451040 15451039
MESH:D000544 Alzheimer Disease resveratrol 4.3416183991 16162502
MESH:D000544 Alzheimer Disease sulindac sulfide 4.3418759972
MESH:D000740 Anemia Fluorouracil 3.4216511603 17963324 15504547
MESH:D000853 Anophthalmos Ethanol 4.4915513904
MESH:D001008 Anxiety Disorders Ethanol 13.6911141031
MESH:D001008 Anxiety Disorders Fluoxetine 13.6918083778
MESH:D001008 Anxiety Disorders Sertraline 13.6918822694
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5120041841 18057881 18218290
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.6615885639
MESH:D001169 Arthritis, Experimental resveratrol 6.6617115116
MESH:D050197 Atherosclerosis resveratrol 3.0717967414 16873680
MESH:D001281 Atrial Fibrillation Amiodarone 3.6518651412 19698954
MESH:D001321 Autistic Disorder Fluoxetine 3.1318775368 19232924
MESH:D001321 Autistic Disorder Sertraline 3.1318775368
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.2719483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.2716206674
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.8214601052
MESH:D001862 Bone Resorption bisphenol A 3.5611985600
MESH:D002545 Brain Ischemia beta Carotene 9.4716157235
MESH:D002545 Brain Ischemia resveratrol 9.4717600658
MESH:D001943 Breast Neoplasms bisphenol A 3.5317123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.5317474063
MESH:D001943 Breast Neoplasms Etoposide 3.5316322251
MESH:D001943 Breast Neoplasms Fluorouracil 3.5315136595 18357371 16595493 16110121 18608205 19217205 16557594
MESH:D001943 Breast Neoplasms Genistein 3.5316541309 16873071 17200150
MESH:D001943 Breast Neoplasms resveratrol 3.5317534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 3.5320135344 19487384 19289846 17440819 19066611 19221464 20065188 21138602 18997820 15668708 18629630 15565566 11161223 19142967 18425577 19115204 16818667 18815881 19155303 16873071 17242785 19189212 18821012 16202921 18855134 19011961 18351453 17893378 19200415 19084267 17261762 20544844 21152245 19189210 16273361 19410462 19103187 17049068 20390343 20005174 18984771 20859285 19244106 19059307 19288272
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0211589617
MESH:D002056 Burns Ethanol 4.3216374292
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3216051944
MESH:D002277 Carcinoma Fluorouracil 3.3017121937
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1719066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 15.8316705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 15.8314691202 15073043 16217749 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 15.8318785209 21159647 16540662 16288022 19919837 17978847 19394651 20935162 16830150 20007298 18971187 19822196 20084675 17428255 19335982 20524982 19383236 17138121 10737359 19171122 17162532 16779866 19107877 17173139 18978308 18506893 17055752 11831363 16681979 16328049 18056438 16502159 19519916 18393292 20101231 17761372 18665156 19539802 3581430 19208518 18788625 16935385 20514400 3084413 10672840 20214788 19418558 19701751 18494052 19052882 16878318 18210153 16807293 16569478 20432363 20727157 18691550 20512989 16698587
MESH:D006528 Carcinoma, Hepatocellular Ethanol 15.8315763234 15289165 18788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.8317971768 16799960 18930000 16332177 17088986 17045692
MESH:D006528 Carcinoma, Hepatocellular Genistein 15.8316924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 15.8316227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 15.8316924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.6517123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2516675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.3312391285
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5319014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8618695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8212490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.5317066447 16757204 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.5316227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3217572228
MESH:D006332 Cardiomegaly Ethanol 3.2519332462
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7719225199 15710769
MESH:D002318 Cardiovascular Diseases Genistein 6.7316332659
MESH:D002318 Cardiovascular Diseases resveratrol 6.7315458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7418974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 9.836135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.8320889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.8317174075 7505956 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4019052882
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6311677210 15861022 17333356 17110522 17681005 16919318 16105132
MESH:D002971 Cleft Lip Ethanol 3.4115513904
MESH:D002972 Cleft Palate Ethanol 3.0315513904
MESH:D003072 Cognition Disorders Clozapine 4.6317123785
MESH:D003092 Colitis resveratrol 3.8016474422
MESH:D003110 Colonic Neoplasms Fluorouracil 5.4816340194 17169374 17725105 17172411 16510598 18772588 15001691 17016597 17287894 17018589
MESH:D003110 Colonic Neoplasms Genistein 5.4817182828
MESH:D003110 Colonic Neoplasms resveratrol 5.4816338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.2920501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.2916303861 15148649 16524972 17594712 18509181 17016601 20501625 17094418 17695437 14970324 18802399 18383874 16331619 17255274 17454858 17401013 16282729 18949393 18448328 15289873 18288408 16391804
MESH:D015179 Colorectal Neoplasms resveratrol 3.2916550006
MESH:D003327 Coronary Disease resveratrol 3.5316507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7510525206
MESH:D019465 Craniofacial Abnormalities Ethanol 2.7511198716 15513904 15451039 15451040 19302082 11873399 10194807
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.6918551238
MESH:D007644 Darier Disease Fluorouracil 4.4516733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0319031437
MESH:D003866 Depressive Disorder Amitriptyline 16.6415014590 18083778
MESH:D003866 Depressive Disorder Fluoxetine 16.6415014590
MESH:D003866 Depressive Disorder Imipramine 16.6420305041
MESH:D003866 Depressive Disorder Sertraline 16.6420305041 15014590 18822694
MESH:D003865 Depressive Disorder, Major Sertraline 5.0816968574
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.3616780908 11298694 16823706
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5016873680
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.7416402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7420387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.7416647724
MESH:D003928 Diabetic Nephropathies resveratrol 8.1016286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.1019279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.2115331141
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.1318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.1315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.1319107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.1311566570
MESH:D050171 Dyslipidemias Clozapine 3.9416402076
MESH:D004487 Edema Amitriptyline 14.2412798668
MESH:D004487 Edema Fluoxetine 14.2412798668
MESH:D004487 Edema Imipramine 14.2412798668
MESH:D004487 Edema resveratrol 14.248985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 13.4917872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.4919031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.2516402032
MESH:D016889 Endometrial Neoplasms Genistein 6.7911473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.7919155303 16202921 20544844 17893378
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5217923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7716302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.6320426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.6312903497
MESH:D004938 Esophageal Neoplasms Ethanol 9.6316704527
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.6316337965 16785472 16481741 15173087 17638652
MESH:D055577 Farber Lipogranulomatosis marker/mechanism
MESH:D005234 Fatty Liver Amiodarone 32.3114986274
MESH:D005234 Fatty Liver arsenic trioxide 32.3115073043
MESH:D005234 Fatty Liver Diethylnitrosamine 32.3121071580 20387270
MESH:D005234 Fatty Liver Ethanol 32.3118620774 19236843 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 32.3115345470
MESH:D005234 Fatty Liver Fish Oils 32.3118620774
MESH:D005234 Fatty Liver Tamoxifen 32.3119224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3217920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0316709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9616946407 15513904 10194807 15451040
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8419069698
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9416904648
MESH:D005756 Gastritis Ethanol 4.3515046732
MESH:D005909 Glioblastoma Genistein 3.0416598420
MESH:D005910 Glioma Fluorouracil 2.7316145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1618337622 15162350 15102660
MESH:D006529 Hepatomegaly Amiodarone 3.4215265979
MESH:D006561 Herpes Simplex Etoposide 8.9710809021
MESH:D006561 Herpes Simplex resveratrol 8.9716876885
MESH:D015658 HIV Infections beta Carotene 3.8716960176
MESH:D006689 Hodgkin Disease Etoposide 3.5918180244 17606976 16200630 16135485 15147373
MESH:D019584 Hot Flashes Fluoxetine 4.9714716179
MESH:D006816 Huntington Disease Sertraline 5.6918403212
MESH:D006930 Hyperalgesia Ethanol 3.4618783367
MESH:D006937 Hypercholesterolemia Amiodarone 8.318137927 9751232
MESH:D006937 Hypercholesterolemia resveratrol 8.3117188708
MESH:D006948 Hyperkinesis Clozapine 4.5716046005
MESH:D006949 Hyperlipidemias Fish Oils 8.6715752949
MESH:D006949 Hyperlipidemias resveratrol 8.6716873680
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.1611484837
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0117488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4816945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.1818020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.3117600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2617937319
MESH:D007249 Inflammation Amitriptyline 21.4812798668
MESH:D007249 Inflammation Diethylnitrosamine 21.4818785209
MESH:D007249 Inflammation Flavonoids 21.4817296493
MESH:D007249 Inflammation Fluoxetine 21.4812798668
MESH:D007249 Inflammation Imipramine 21.4812798668
MESH:D007249 Inflammation resveratrol 21.4816366677
MESH:D007249 Inflammation Tamoxifen 21.4819457130
MESH:D007251 Influenza, Human resveratrol 4.2016624496
MESH:D007333 Insulin Resistance bisphenol A 3.0716393666
MESH:D007569 Jaw Abnormalities Ethanol 4.1015513904
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.8716705839
MESH:D007680 Kidney Neoplasms Fluorouracil 10.8716985049
MESH:D007680 Kidney Neoplasms Tamoxifen 10.8718625569
MESH:D007859 Learning Disorders Ethanol 3.8815451040
MESH:D007938 Leukemia arsenic trioxide 5.8615070760
MESH:D007938 Leukemia Genistein 5.8617468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4912560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0817050201 19850784 16467208 20471514 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.0515336539 16112521 11161223 19642359 17217047 17107899 16330433 11468182 19225113 19035177 16331271 17869043 15748426 15213294 12018890 16823087 16966277 15622746 12712474 12679006 19075265 17649720 9834237 16891316 17712046
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.0516087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0316882451
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5717676605
MESH:D008064 Lipidoses marker/mechanism 15342952 16919414
MESH:D008064 Lipidoses Amiodarone 57.5517567588 15342952
MESH:D008064 Lipidoses Amitriptyline 57.5517567588 15342952
MESH:D008064 Lipidoses chlorcyclizine 57.5515342952
MESH:D008064 Lipidoses Clozapine 57.5517567588
MESH:D008064 Lipidoses Fluoxetine 57.5515342952 17567588
MESH:D008064 Lipidoses Imipramine 57.5515342952 17567588
MESH:D008064 Lipidoses Perhexiline 57.5515342952 17567588
MESH:D008064 Lipidoses Sertraline 57.5517567588
MESH:D008064 Lipidoses Tamoxifen 57.5515342952 17567588
MESH:D008064 Lipidoses trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride 57.5515342952
MESH:D008064 Lipidoses Zimeldine 57.5515342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.1819638242 18665156 20032147 18407596 18522880
MESH:D008103 Liver Cirrhosis Ethanol 6.1815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7618295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.3818166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.3817823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.3818564211
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0217034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3217347304 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 19.817678174
MESH:D008113 Liver Neoplasms arsenic trioxide 19.8114682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 19.8119426721 2862719 20101389 19090486 20452335 21071580 18648771 10737359 19690152 20583210 15175105 20501860 19812893 18978307 19254457 20434301 18644402 21047994 19294768 19850985 18754104 20118626 18977376 20405173 19499222 2422723 19427195 19996281 9163691 21167192 19833225 20492335 12771043 19255062 12112319 19642983 20137499 15885732 19073162 19551842 16942905 21278145 19638242 19256749
MESH:D008113 Liver Neoplasms Fluorouracil 19.8116603448 15113037 18383874 17045692
MESH:D008113 Liver Neoplasms Mitomycin 19.8115113037
MESH:D008113 Liver Neoplasms resveratrol 19.8119321006 19812893 20405173 19073162
MESH:D008113 Liver Neoplasms Tamoxifen 19.8116684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.442876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.4420377131
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 12.4417113696
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.4419126423 18282651 18164116 17942915 18775883 19009564 18253720 18308698 18093689 19004024 18079962 16842330 18544905 3124819 2563599 9362446 16267830 17854601 17174075 19519916 21159647 19539802
MESH:D008133 Long QT Syndrome Amiodarone 7.3417391786 11989578 15350150
MESH:D008133 Long QT Syndrome arsenic trioxide 7.3415213294
MESH:D008171 Lung Diseases Amiodarone 3.1512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1318516814
MESH:D008175 Lung Neoplasms arsenic trioxide 6.1219825857 11798837
MESH:D008175 Lung Neoplasms beta Carotene 6.1216401635
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.1221163286 6695378 20970405 20512841
MESH:D008175 Lung Neoplasms Fluorouracil 6.1215246190
MESH:D008175 Lung Neoplasms Tamoxifen 6.1218625569
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4515086387
MESH:D008223 Lymphoma Etoposide 3.6812854902 12556972
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6014749477
MESH:D016778 Malaria, Falciparum Perhexiline 5.6416882315
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.8715688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.8719428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 8.7912929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 8.798985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.7919196723 11731420 19196722 14580682 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.2019453300
MESH:D008545 Melanoma resveratrol 3.2317992120
MESH:D008545 Melanoma Tamoxifen 3.2319393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8415990972
MESH:D008569 Memory Disorders Ethanol 3.8715451040 18411066
MESH:D001523 Mental Disorders Amitriptyline 20.9516856516
MESH:D001523 Mental Disorders Clozapine 20.9516856516
MESH:D001523 Mental Disorders Fluoxetine 20.9516856516
MESH:D001523 Mental Disorders Imipramine 20.9516856516
MESH:D001523 Mental Disorders Sertraline 20.9516856516
MESH:D008659 Metabolic Diseases resveratrol 4.0717112576
MESH:D024821 Metabolic Syndrome X Clozapine 4.1419142101
MESH:D008881 Migraine Disorders Amitriptyline 4.5518803445
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3718986760 16757204
MESH:D009101 Multiple Myeloma arsenic trioxide 6.6214977855 19417148 19549372 15949261 11468182
MESH:D009101 Multiple Myeloma resveratrol 6.6217049120 16267019 16490592 17164350 14749477 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5317962980
MESH:D009164 Mycobacterium Infections Clarithromycin 6.0310063276 18474467
MESH:D009181 Mycoses Amiodarone 4.5612754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9516105982 16882451
MESH:D009203 Myocardial Infarction Genistein 5.5117141266
MESH:D009203 Myocardial Infarction resveratrol 5.5117125593 17188708 16317513 16525036 17015251 16456233
MESH:D017202 Myocardial Ischemia resveratrol 3.7417125593 17015251
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.4017141266
MESH:D009205 Myocarditis resveratrol 4.4217322642
MESH:D009207 Myoclonus Fluoxetine 5.548041377
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.527678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6416624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.263581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.2619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms beta Carotene 5.0417051425
MESH:D009369 Neoplasms Fluorouracil 5.0418600527 16928823 18239605
MESH:D009374 Neoplasms, Experimental resveratrol 3.678985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6519196722 19189210 19200415
MESH:D009421 Nervous System Malformations bisphenol A 8.8111399458 16427766
MESH:D009421 Nervous System Malformations Genistein 8.8116427766
MESH:D009436 Neural Tube Defects arsenic trioxide 2.9010525206
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6120387270
MESH:D019636 Neurodegenerative Diseases resveratrol 7.6117652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.0917929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7720387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2116436463
MESH:D009765 Obesity Clozapine 2.9319142110 18515891
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.1420418887
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.1416049721
MESH:D010024 Osteoporosis Genistein 3.0419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.1116169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.1117513867
MESH:D010049 Ovarian Diseases bisphenol A 4.6511985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.5912452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Genistein 4.5919005980
MESH:D010146 Pain Amitriptyline 10.3312798668
MESH:D010146 Pain Fluoxetine 10.3312798668
MESH:D010146 Pain Imipramine 10.3312798668
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 18.8415580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 18.8416540662
MESH:D010190 Pancreatic Neoplasms Ethanol 18.8412384795
MESH:D010190 Pancreatic Neoplasms Etoposide 18.8419003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 18.8419003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Mitomycin 18.8415113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010235 Paraganglioma arsenic trioxide 3.8519927285
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.678041377
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.272563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.7410548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.7416679765
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.9020887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0519131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0516740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.0517172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0518626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.0515378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms resveratrol 2.0517718901 17675339 15767336 17636462 16731767 17804756
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0515067354
MESH:D011537 Pruritus Ethinyl Estradiol 2.9815861022 16919318
MESH:D011618 Psychotic Disorders Clozapine 3.9415331141
MESH:D011629 Puberty, Precocious bisphenol A 4.4410548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7211597910 12490602 12832656
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7316160472 18286688 18722050 15538739
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.2416325855
MESH:D015427 Reperfusion Injury resveratrol 3.1017058453 16314181 16317513 17520802 15827377
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.3716646077
MESH:D012512 Sarcoma, Ewing's Etoposide 9.3714601052
MESH:D012559 Schizophrenia Clozapine 2.6920521326 20107430 20452607 20580759 11763009 17726453 20521320 20168265 18806925 17667964 11151749 18855531 17123785 19369910 16141801
MESH:D012640 Seizures 2,6-dinitrotoluene 5.3418551238
MESH:D012640 Seizures Ethanol 5.349754883
MESH:D020230 Serotonin Syndrome Fluoxetine 5.558704074
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7418724381
MESH:D012878 Skin Neoplasms resveratrol 2.878985016 15837718
MESH:D012892 Sleep Deprivation Imipramine 5.8519798453
MESH:D007319 Sleep Initiation and Maintenance Disorders Amitriptyline 5.1115341891
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4116709447
MESH:D013088 Spermatocele Tamoxifen 10.4116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7019457130
MESH:D013272 Stomach Diseases beta Carotene 4.7517638125
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.4417007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4418456281
MESH:D013274 Stomach Neoplasms Ethanol 4.4418456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.4417522103 17172411 15786421 18396642 17498489 19015929 19084572 18567086 16424979 16951190
MESH:D013276 Stomach Ulcer Amiodarone 10.5318087811
MESH:D013276 Stomach Ulcer beta Carotene 10.5312500499
MESH:D013276 Stomach Ulcer Ethanol 10.539211565 17189318 11906479 9562338 17918041 16755016
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1916321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.6516684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.969754883
MESH:D013610 Tachycardia Amiodarone 3.9711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8719225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013959 Thyroid Diseases Amiodarone 4.4119731979
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.3419014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.347505956
MESH:D013971 Thyrotoxicosis Amiodarone 4.5318020914 19584973
MESH:D014062 Tongue Neoplasms Fluorouracil 9.0116280240
MESH:D014062 Tongue Neoplasms resveratrol 9.0116227395
MESH:D016171 Torsades de Pointes Amiodarone 15.5217467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 15.5215213294
MESH:D016171 Torsades de Pointes Flecainide 15.5217467628
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.5016049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.5012845720 11780464 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.5017572228 8653321 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.9810091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.6316803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.6317473185
MESH:D014591 Uterine Diseases bisphenol A 4.6614652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.2814692618
MESH:D014594 Uterine Neoplasms resveratrol 14.2817044934
MESH:D014594 Uterine Neoplasms sulindac sulfide 14.2818645019
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2415869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.9717488730
MESH:D015430 Weight Gain Clozapine 4.1816402076 17502770 20564506 16141801 20521320 20107430
MESH:D015431 Weight Loss Clozapine 4.7417933447
Pathway ID Pathway Name
KEGG:04142 Lysosome
KEGG:01100 Metabolic pathways
KEGG:00600 Sphingolipid metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35025
    • No data
    No data
    Releated drug ID Related drug Name
    PA449780glutathione
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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