AutismKB 2.0

Annotation Detail for MIPEP


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Basic Information Top
Gene Symbol:MIPEP ( HMIP,MIP )
Gene Full Name: mitochondrial intermediate peptidase
Band: 13q12.12
Quick LinksEntrez ID:4285; OMIM: 602241; Uniprot ID:MIPEP_HUMAN; ENSEMBL ID: ENSG00000027001; HGNC ID: 7104
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MIPEP mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of MIPEP mRNAaffects expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MIPEP mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MIPEP mRNAdecreases expression 20382639
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MIPEP mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MIPEP mRNAaffects cotreatment|affects expression 17602206
D017313 Fenretinide Fenretinide affects the expression of MIPEP mRNAaffects expression 16570282
D008701 Methapyrilene Methapyrilene results in decreased expression of MIPEP mRNAdecreases expression 16393664
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of MIPEP mRNAdecreases expression 17616710
C021751 tanshinone tanshinone results in decreased expression of MIPEP mRNAdecreases expression 15849732
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma Fenretinide 3.1410697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.983712494
MESH:D000236 Adenoma Diethylnitrosamine 6.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1419061943 19052882 16434500 18056438 17162532 17620307
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001932 Brain Neoplasms Fenretinide 4.5116187019
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D001943 Breast Neoplasms Fenretinide 2.2116601279
MESH:D001943 Breast Neoplasms tanshinone 2.2119885617 15849732
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.817296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8116540662 17978847 18978308 16878318 18971187 16502159 21159647 17138121 16698587 16328049 16830150 16288022 20214788 18393292 10737359 16935385 19822196 18788625 18665156 16807293 19418558 19171122 20007298 20935162 19335982 18506893 3581430 20084675 16569478 3084413 19383236 19701751 19107877 19208518 20512989 10672840 20101231 17055752 17162532 19539802 18691550 19394651 16681979 18210153 16779866 17173139 11831363 20514400 20727157 19519916 18056438 17761372 20432363 19052882 18494052 18785209 20524982 19919837 17428255
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 6.8117159502 16270382
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 3.2216274795
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.867505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8620889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.8617174075 7505956 21159647 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.7116154183
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2719486331 9022650
MESH:D015179 Colorectal Neoplasms Fenretinide 2.6817273769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0114531868 18759878 11906362 12868966 8156756 11298694 2524372 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.5018289764 7440962 18648102 6482804 9653073 9022650 18692083 16192314 9328219 11289319 1440618 6679447 8291058
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5019107877
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.523581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5220426865
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.5215264214 15547721 15878914 16704527 15547733 15623463 16510608 16805852 15150132
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3520387270 21071580
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005909 Glioblastoma Fenretinide 4.0016187019
MESH:D005910 Glioma tanshinone 4.0816955220
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 5.4019662366
MESH:D007249 Inflammation Diethylnitrosamine 2.4618785209
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.846582329
MESH:D007972 Leukoplakia, Oral Fenretinide 6.3116707609
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9120032147 18407596 18522880 19638242 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms Clofibric Acid 8.0017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0020137499 18977376 18754104 19090486 19690152 21047994 18648771 2422723 12112319 19551842 19256749 19294768 15175105 19850985 21278145 21167192 19812893 16942905 19254457 20583210 20101389 19996281 12771043 2862719 20405173 18978307 18644402 20118626 10737359 19427195 20452335 20434301 19499222 19833225 19426721 19255062 20492335 21071580 19638242 20501860 9163691 19642983 19073162 15885732
MESH:D008113 Liver Neoplasms Methapyrilene 8.0015890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.263712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.2618079962 16842330 16267830 9362446 19539802 3124819 19009564 17854601 18775883 19519916 18544905 2563599 17942915 19126423 18253720 21159647 18164116 18282651 17174075 18308698 19004024 18093689
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 21163286 20512841 6695378
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 3.6710697514
MESH:D008545 Melanoma Fenretinide 2.8516270382
MESH:D009062 Mouth Neoplasms Fenretinide 4.4516274795
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.903581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.903581430 9029167
MESH:D009369 Neoplasms Fenretinide 3.3717353921 15958647
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.9216303764
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4312819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.434026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010051 Ovarian Neoplasms Fenretinide 3.2716133793
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.7616540662
MESH:D010190 Pancreatic Neoplasms Fenretinide 5.7615580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D011471 Prostatic Neoplasms Fenretinide 4.0717024972
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.533692021
MESH:D012162 Retinal Degeneration Fenretinide 9.5316303925
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms Fenretinide 3.5616467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6518456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6517575124 12958204
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.566582329 1399818 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.567505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.778074119
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 8.7716720286
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 4.7216154183
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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