AutismKB 2.0

Annotation Detail for MLH1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MLH1 ( COCA2,FCC2,HNPCC,HNPCC2,MGC5172,hMLH1 )
Gene Full Name: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
Band: 3p22.2
Quick LinksEntrez ID:4292; OMIM: 120436; Uniprot ID:MLH1_HUMAN; ENSEMBL ID: ENSG00000076242; HGNC ID: 7127
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03430Mismatch repair
hsa05213Endometrial cancer
hsa05210Colorectal cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
H00020Colorectal cancer
H00026Endometrial cancer
H00027Ovarian cancer
Cancers of the breast and female genital organs
Desease IDDesease Name
1809HIV infection
1832Congenital abnormality
1870Drug abuse
1934Cancer
1979Testicular dysfunction
1998Enteritis
2003Metaplastic polyp
2038Gastritis
2094Ulcerative colitis
Desease Name
ovarian cancer
AGING
colorectal cancer
functional differences
CANCER
stomach cancer
Crohn's disease and ulcerative colitis
endometrial cancer
esophageal cancer
breast cancer
colorectal cancer.
acute myeloid leukemia
inflammatory bowel disease
IMMUNE
lung cancer
longevity
hereditary non-polyposis colon cancer.
No data
Desease Name
Mismatch repair cancer syndrome
Colorectal cancer, hereditary nonpolyposis, type 2
Muir-Torre syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MLH1 mRNAaffects expression 21346803
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of MLH1 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of MLH1 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MLH1 mRNAdecreases expression 12419474
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of MLH1 mRNAdecreases expression 11906922
D016572 Cyclosporine Cyclosporine results in increased expression of MLH1 mRNAincreases expression 20106945
C014347 decitabine decitabine affects the methylation of MLH1 promoteraffects methylation 18069755
C014347 decitabine [decitabine co-treated with trichostatin A] affects the methylation of MLH1 promoteraffects cotreatment|affects methylation 18069755
C014347 decitabine decitabine results in decreased methylation of MLH1 promoterdecreases methylation 19080631
19032668
C014347 decitabine decitabine results in increased expression of MLH1increases expression 19080631
C014347 decitabine decitabine results in increased expression of MLH1 mRNAincreases expression 19417133
19032668
C014347 decitabine decitabine results in increased expression of MLH1 proteinincreases expression 19259094
C014347 decitabine PXD101 promotes the reaction [decitabine results in increased expression of MLH1 protein]increases expression|increases reaction 19259094
D004052 Diethylnitrosamine [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MLH1 mRNAaffects cotreatment|decreases expression 18253720
D004052 Diethylnitrosamine [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MLH1 mRNAaffects cotreatment|increases expression 18775883
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MLH1 mRNAincreases expression 15766595
D004054 Diethylstilbestrol MLH1 gene mutant form affects the susceptibility to Diethylstilbestrolaffects response to substance 15700306
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased methylation of MLH1 promoterdecreases methylation 14633667
C045651 epigallocatechin gallate epigallocatechin gallate results in increased expression of MLH1 mRNAincreases expression 14633667
C045651 epigallocatechin gallate epigallocatechin gallate results in increased expression of MLH1 proteinincreases expression 14633667
D011345 Fenofibrate [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MLH1 mRNAaffects cotreatment|decreases expression 18253720
D011345 Fenofibrate [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MLH1 mRNAaffects cotreatment|increases expression 18775883
D011345 Fenofibrate Fenofibrate results in increased expression of MLH1 mRNAincreases expression 18775883
D005472 Fluorouracil MLH1 mRNA affects the susceptibility to Fluorouracilaffects response to substance 18497967
D005472 Fluorouracil MLH1 protein affects the susceptibility to Fluorouracilaffects response to substance 18949393
D005472 Fluorouracil MLH1 protein results in increased susceptibility to Fluorouracilincreases response to substance 17914563
C419708 gefitinib gefitinib results in decreased expression of MLH1 mRNAdecreases expression 16685379
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of MLH1 mRNAincreases expression 15458575
C051890 irinotecan MLH1 protein affects the susceptibility to irinotecanaffects response to substance 18949393
C015329 lycopene lycopene results in increased expression of MLH1 mRNAincreases expression 16886892
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in decreased expression of MLH1 proteindecreases expression 17671175
D008770 Methylnitrosourea Methylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]affects binding|increases reaction 16204460
D008770 Methylnitrosourea MLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]affects reaction|increases activity 13679151
D008770 Methylnitrosourea MLH1 protein affects the susceptibility to Methylnitrosoureaaffects response to substance 12967659
D008770 Methylnitrosourea MLH1 protein promotes the reaction [MGMT protein results in decreased susceptibility to Methylnitrosourea]decreases response to substance|increases reaction 13679151
D010269 Paraquat Paraquat results in increased expression of MLH1 mRNAincreases expression 15458575
C006253 pirinixic acid pirinixic acid results in increased expression of MLH1 mRNAincreases expression 20127075
C487081 PXD101 PXD101 promotes the reaction [decitabine results in increased expression of MLH1 protein]increases expression|increases reaction 19259094
C037219 quinoline quinoline analog results in increased expression of MLH1 mRNAincreases expression 19417133
C017947 sodium arsenite sodium arsenite results in increased expression of MLH1 mRNAincreases expression 12634122
C047246 temozolomide MLH1 protein affects the susceptibility to temozolomideaffects response to substance 12967659
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MLH1 mRNAincreases expression 19465110
C012589 trichostatin A [decitabine co-treated with trichostatin A] affects the methylation of MLH1 promoteraffects cotreatment|affects methylation 18069755
D014415 Tunicamycin Tunicamycin results in increased expression of MLH1 mRNAincreases expression 15458575
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6214514962 11752688 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D000230 Adenocarcinoma Fluorouracil 4.6217638652
MESH:D000230 Adenocarcinoma Methylnitrosourea 4.6215688392 15113128
MESH:D000236 Adenoma Diethylnitrosamine 2.726695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.9516434500 19061943 19052882 17620307 18056438 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.9516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.9516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6717306315 16712894
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5411874814
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2615469931
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9610965797
MESH:D000740 Anemia Fluorouracil 8.0217963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.0211748828
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.3715014928
MESH:D001249 Asthma epigallocatechin gallate 3.3216516891
MESH:D001254 Astrocytoma temozolomide 6.2515865885
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.8419761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D001943 Breast Neoplasms Cyclophosphamide 3.6212006526 18234424 16978400 17388661 18323546 11325840 15136595 17020986 15093573
MESH:D001943 Breast Neoplasms decitabine 3.6218320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6217474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.6217129689 15324884
MESH:D001943 Breast Neoplasms Fluorouracil 3.6215136595 18608205 19217205 16110121 18357371 16595493 16557594
MESH:D001943 Breast Neoplasms Methylnitrosourea 3.6214633655 11306469 16253758
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6220435547
MESH:C537421 Cafe au lait spots, multiple marker/mechanism
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4416051944
MESH:D002277 Carcinoma Fluorouracil 7.5917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.2616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.263084413
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 16.2619701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.2617978847 20524982 17138121 10672840 18506893 16698587 18393292 18665156 19171122 18971187 18210153 20432363 21159647 11831363 16935385 16540662 16779866 20101231 19701751 17428255 20007298 19107877 19539802 20935162 16328049 18056438 19919837 18494052 16569478 17055752 16878318 16807293 20214788 20512989 16502159 17162532 20727157 10737359 19052882 16681979 3084413 19519916 17173139 19418558 18788625 16830150 19208518 19394651 16288022 18691550 17761372 18785209 20514400 20084675 19822196 19383236 19335982 18978308 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 16.2616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.2616332177 16799960 17045692 18930000 17088986 17971768
MESH:D006528 Carcinoma, Hepatocellular quinoline 16.26598648
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.2615276417 16507464 17306315
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.6616152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 3.8719233551 18347146 17290066 15496427 16230376 20005069
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 6.4616201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.4618695887
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.2119215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.2118986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.2118572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.3616936243
MESH:D002386 Cataract Acetaminophen 7.1110977129
MESH:D002386 Cataract Methylnitrosourea 7.1112484553
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 24.356135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 24.3512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 24.3517174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 24.352727394
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 24.357505956 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 24.3519524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6916835633
MESH:D002779 Cholestasis Cyclosporine 7.2019486331
MESH:D002779 Cholestasis pirinixic acid 7.2019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0112621046 8697196 15668235 15340226 16354765
MESH:D003110 Colonic Neoplasms decitabine 5.6617616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.6615001691 17018589 16510598 17287894 17725105 17016597 17169374 16340194 18772588 17172411
MESH:D003110 Colonic Neoplasms irinotecan 5.6617725105 17287894
OMIM:609310 COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 2 marker/mechanism
MESH:D015179 Colorectal Neoplasms marker/mechanism 18497967 18718023 18949393
MESH:D015179 Colorectal Neoplasms decitabine 4.7018981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.7018802399 17016601 18383874 16391804 16524972 15289873 20501625 17094418 17401013 17594712 17454858 17255274 18509181 18288408 15148649 18949393 17695437 18448328 14970324 16331619 16282729 16303861
MESH:D015179 Colorectal Neoplasms gefitinib 4.7017594712
MESH:D015179 Colorectal Neoplasms irinotecan 4.7018259882 17454858 17159606 15273666 16391804 18509181 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2415322242 10048152 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3412952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7918551238
MESH:D003556 Cystitis Cyclophosphamide 4.7518483878 16614059 18295254 18093676 12161096 18433785 10700343 10498854 16651033 16413132 17010015 18372110 17979934 12388444 18710439 12913760 11948286 15276878 15643279 16989017
MESH:D007644 Darier Disease Fluorouracil 4.5616733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.8810990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1518772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8720387270
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 6.8716988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8717107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.3618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.3612540782 10915739 15619225 17906064 10774834 19085960 11739529 15968718 11743745 11421492 12153990 14725611 11529661 18713872 19164858 19416960 19370779 11461765 14986274 18071297 14550746 17522070 17562736 16781746 16393943 11287661 10663392 19739265 16485898 16177239 2444490 12705907 12392966 16081117 16227642 16109766 19923254 19420014 12958197 11834606 12594235
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.3619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D050171 Dyslipidemias Fenofibrate 4.2616707586
MESH:D004487 Edema pirinixic acid 5.8712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6718230668 15322242 16714409
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.2619294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.2619294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.4616804899 15700306
MESH:D016889 Endometrial Neoplasms Fenofibrate 7.4616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8210568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 3.9911006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.3917638652 16337965 16785472 16481741 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver Cyclosporine 11.8619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 11.8621071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 11.8619236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5216513791 16534752 16611131 16002989 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.0011555667
MESH:D005355 Fibrosis Cyclosporine 7.7412639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.7420067830
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 12.0516452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 12.0516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma temozolomide 7.6315865885
MESH:D005909 Glioblastoma trichostatin A 7.6318801729
MESH:D005910 Glioma Fluorouracil 9.7216145905
MESH:D005910 Glioma Methylnitrosourea 9.729825942
MESH:D005910 Glioma temozolomide 9.7210871815 16327979
MESH:D018316 Gliosarcoma Cyclophosphamide 5.2811389073
MESH:D005911 Gliosis Paraquat 4.9311124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.8115172196 11014644 16376943
MESH:D006258 Head and Neck Neoplasms decitabine 7.4019215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.4015162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4020558911
MESH:D006390 Hemangioendothelioma quinoline 5.67598648
MESH:D006394 Hemangiosarcoma quinoline 4.79598648
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.0611918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.3014986274
MESH:D006529 Hepatomegaly pirinixic acid 7.5216221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5215340226 12621046 16120746
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.9916135485 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 6.9912676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8116959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5216870215
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2114722030 12960047
MESH:D006973 Hypertension Cyclosporine 4.6610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6618670907 18850075
MESH:D006976 Hypertension, Pulmonary gefitinib 4.5318424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 6.0118424623
MESH:D007021 Hypospadias Diethylstilbestrol 4.3516002989
MESH:D007154 Immune System Diseases Cyclophosphamide 5.1016076520
MESH:D007246 Infertility Diethylstilbestrol 4.1415036965
MESH:D007248 Infertility, Male Cyclophosphamide 19.557193160 16517039
MESH:D007248 Infertility, Male decitabine 19.5517581917
MESH:D007248 Infertility, Male Methylnitrosourea 19.557193160
MESH:D007248 Infertility, Male Paraquat 19.554850670
MESH:D007248 Infertility, Male sodium arsenite 19.5512646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 4.5118785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5112878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.4916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Acetaminophen 9.2515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.2518776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 9.2520008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0716518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 21.4116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 21.4112371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 21.4116762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Fluorouracil 21.4116985049
MESH:D007680 Kidney Neoplasms gefitinib 21.4118625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8417184923
MESH:D007938 Leukemia Cyclophosphamide 10.1910602166
MESH:D007938 Leukemia decitabine 10.1919235587 18980019
MESH:D007938 Leukemia temozolomide 10.1917500047
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4017802794 17658394 18587576 18172266 17008537 17296974
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.9210373061
MESH:D007951 Leukemia, Myeloid decitabine 3.8019117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1319387464 19010910 18206229 18460780 18704418 17679729
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.1318206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2318055864
MESH:D007970 Leukopenia Cyclophosphamide 4.7411830472 10052129
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.0415526292
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7018407596 18522880 19638242 18665156 20032147
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 4.7917481882
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 4.7915474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7912878042
MESH:D008107 Liver Diseases Acetaminophen 3.7019784758 11587558 16610002 12969438 19460945 16611625 19014921 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 3.7017034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 24.447678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.4421047994 19294768 20118626 19499222 20583210 19690152 15885732 18754104 19996281 20101389 20501860 16942905 19833225 12771043 19551842 19073162 9163691 19426721 19850985 18644402 19090486 15175105 19256749 21278145 21167192 19638242 2422723 18648771 21071580 19254457 20492335 18977376 10737359 20452335 19642983 19812893 20405173 20137499 20434301 12112319 19255062 19427195 2862719 18978307
MESH:D008113 Liver Neoplasms Diethylstilbestrol 24.4416712894 15890375
MESH:D008113 Liver Neoplasms Fenofibrate 24.4418978307
MESH:D008113 Liver Neoplasms Fluorouracil 24.4416603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 24.4415890375 16377806 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 24.4415276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.4416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.996135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.9918544905 17854601 19009564 16842330 19539802 18282651 19126423 18253720 16267830 18093689 18079962 19519916 18775883 2563599 3124819 17174075 21159647 18164116 18308698 17942915 19004024 9362446
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 12.9918253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.9912151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.2416080182
MESH:D008171 Lung Diseases sodium arsenite 3.0219095001
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.2920970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 6.2915246190
MESH:D008175 Lung Neoplasms Methylnitrosourea 6.2918062963
MESH:D008175 Lung Neoplasms sodium arsenite 6.2916712894 17306315 17077188 19931552 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2919555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5615086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9215166399
MESH:D008223 Lymphoma marker/mechanism 15700306
MESH:D008223 Lymphoma Cyclophosphamide 16.6312854902
MESH:D008223 Lymphoma decitabine 16.6319470736
MESH:D008223 Lymphoma Diethylstilbestrol 16.6315700306
MESH:D008223 Lymphoma Methylnitrosourea 16.6316257854 11418001
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 9.9416675587
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 9.9414633661
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.9811911406
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2816002989
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 6.4218375820
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 6.4219196723 16619500 12931682 10767621 16944150 11807958 16051031 15313902 16827153 11751437 14633655 15113128 14999141 10838139 17131329 17020996 15688392
MESH:D008545 Melanoma decitabine 9.4016505122 17785578
MESH:D008545 Melanoma epigallocatechin gallate 9.4017992120 11746506
MESH:D008545 Melanoma sodium arsenite 9.4019082730 16487513
MESH:D008545 Melanoma temozolomide 9.4018281670 12374674 17576461 16432458 15577323 16260697 16260693 10623706 16248763 12829675 17623835 16225601
MESH:D008545 Melanoma trichostatin A 9.4016505122
MESH:D008546 Melanoma, Experimental Acetaminophen 10.0819513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.0816388313
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.6617671175
OMIM:276300 MISMATCH REPAIR CANCER SYNDROME marker/mechanism
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4618986760 16757204
MESH:D052016 Mucositis irinotecan 4.7817159606
MESH:D055653 Muir-Torre Syndrome marker/mechanism
MESH:D009101 Multiple Myeloma decitabine 7.1218172295
MESH:D009101 Multiple Myeloma trichostatin A 7.1218172295
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.2617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2519010910 16882708 19157545 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.0519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7716411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.637678174 18551238
MESH:D009362 Neoplasm Metastasis marker/mechanism 17717427
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.229029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 9.2218259882
MESH:D009362 Neoplasm Metastasis quinoline 9.22598648
MESH:D009369 Neoplasms Cyclophosphamide 26.4818854779
MESH:D009369 Neoplasms decitabine 26.4819116145 17925555 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 26.4815313581
MESH:D009369 Neoplasms Fluorouracil 26.4818239605 18600527 16928823
MESH:D009369 Neoplasms lycopene 26.4817051425
MESH:D009369 Neoplasms Methylnitrosourea 26.4815533788
MESH:D009369 Neoplasms pirinixic acid 26.4817405874
MESH:D009369 Neoplasms sodium arsenite 26.4811559025
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 8.6512696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.6520056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0919348381 18481113
MESH:D009410 Nerve Degeneration Paraquat 3.5416893418
MESH:D009421 Nervous System Malformations Diethylstilbestrol 8.9211399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9214600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0012854658
MESH:D009442 Neurilemmoma Methylnitrosourea 5.2611555667
MESH:D009447 Neuroblastoma Cyclophosphamide 11.098761367 16115947 15176712
MESH:D009447 Neuroblastoma irinotecan 11.098761367
MESH:D009447 Neuroblastoma temozolomide 11.0915176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.5720387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 10.778761367 12837982
MESH:D017599 Neuroectodermal Tumors irinotecan 10.778761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2916436463
MESH:D009503 Neutropenia Cyclophosphamide 4.118291058
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2316049721
MESH:D009845 Oligospermia Cyclophosphamide 4.4816517039
MESH:D010051 Ovarian Neoplasms marker/mechanism 19032668
MESH:D010051 Ovarian Neoplasms decitabine 7.6219259094 19331143
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.6215276417 17306315
MESH:D010051 Ovarian Neoplasms trichostatin A 7.6219331143
MESH:D010146 Pain Acetaminophen 6.2516870215
MESH:D010146 Pain Cyclophosphamide 6.2512161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 19.4411332152
MESH:D010190 Pancreatic Neoplasms decitabine 19.4419294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 19.4416540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 19.4416500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 19.4416965848
MESH:D010190 Pancreatic Neoplasms trichostatin A 19.4419294695
MESH:D010212 Papilloma Hydrogen Peroxide 3.8612065085
MESH:D010300 Parkinson Disease Paraquat 2.7316140633 11445065 15824117 15451049 16510128 11124998 11181820 12911755
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.2116190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.2711550810
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4515687265 16977796
MESH:D011014 Pneumonia Paraquat 4.2212504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.3112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.312563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6821297632
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.8017184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8011222880 11118676 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 11.6817616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.6817616702
MESH:D011471 Prostatic Neoplasms marker/mechanism 15583422
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.4117136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.4115846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.4119082440 18626508
MESH:D011471 Prostatic Neoplasms gefitinib 2.4117914592 16685379 15651060
MESH:D011471 Prostatic Neoplasms lycopene 2.4115084515 17337101
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.4112376480 15682402
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4116039940
MESH:D011471 Prostatic Neoplasms trichostatin A 2.4118798265 19789329
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 9.0316636934
MESH:D011658 Pulmonary Fibrosis gefitinib 9.0318424623
MESH:D011658 Pulmonary Fibrosis Paraquat 9.0316324872 17997886
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8218286688 18722050 16160472 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.7011700416
MESH:D012135 Respiratory Sounds Paraquat 3.8311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 8.7418155124 18172121
MESH:D012162 Retinal Degeneration Paraquat 8.7416458197
MESH:D012175 Retinoblastoma Methylnitrosourea 5.2611555667
MESH:D012208 Rhabdomyosarcoma decitabine 4.1919155313
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.6116636934
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3918551238
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.7012065085
MESH:D012878 Skin Neoplasms sodium arsenite 12.7019524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.708532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.7016192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.4816709447 16002989
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.2816517039
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6212854658
MESH:D013274 Stomach Neoplasms decitabine 6.1719037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.1718456281
MESH:D013274 Stomach Neoplasms Fluorouracil 6.1718567086 16424979 16951190 18396642 15786421 17522103 17172411 17498489 19084572 19015929
MESH:D013274 Stomach Neoplasms irinotecan 6.1715723263
MESH:D013274 Stomach Neoplasms Methylnitrosourea 6.1715930296 18593901 16257854
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.8312837982
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.0011418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms decitabine 15.8217967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.827505956
MESH:D013964 Thyroid Neoplasms gefitinib 15.8216940797
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 15.823078959 7505956
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7916280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.8716049721
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 14.8714692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 14.8719087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 14.8716712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.8716712894 16452187 17306315 11723127
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0910091137
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.7616175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.7616803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.7611813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.8515809267 16690809
MESH:D014604 Uveal Neoplasms decitabine 4.6817785578
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 10.8416002989 16513791
MESH:D014625 Vaginal Neoplasms temozolomide 10.8415577323
MESH:D014652 Vascular Diseases sodium arsenite 4.2017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:05210 Colorectal cancer
KEGG:05213 Endometrial cancer
REACT:27271 Meiotic Recombination
KEGG:03430 Mismatch repair
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA240
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA444485Hodgkin Disease
    PA444840Lymphoma
    PA443622Carcinoma, Non-Small-Cell Lung
    PA447322therapy-related acute myeloid leukemia (t-ML)
    PA443756Colonic Neoplasms
    PA445503Rectal Neoplasms
    Releated drug ID Related drug Name
    PA449014cisplatin
    PA449383docetaxel
    PA449197dacarbazine
    PA451112procarbazine
    PA128406956fluorouracil
    PA450198leucovorin
    PA450205levamisole
    PA452621antineoplastic agents
    PA164713220Pyrimidine analogues
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved