AutismKB 2.0

Annotation Detail for MLL


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Basic Information Top
Gene Symbol:MLL ( ALL-1,CXXC7,FLJ11783,HRX,HTRX1,KMT2A,MLL/GAS7,MLL1A,TET1-MLL,TRX1 )
Gene Full Name: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
Band: 11q23
Quick LinksEntrez ID:4297; OMIM: 159555; Uniprot ID:MLL1_HUMAN; ENSEMBL ID: ENSG00000118058; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00002Acute lymphoblastic leukemia (ALL) (Precursor T lymphoblastic leukemia)
H00001Acute lymphoblastic leukemia (ALL) (Precursor B lymphoblastic leukemia)
Desease IDDesease Name
1767Immunologic deficiency syndrome
1797Vitamin D deficiency
1832Congenital abnormality
1959Granulomatous disease
2051Leukemia
2069Schizophrenia
2237Neoplasm metastasis
2239Lymphoma
2247Osteomyelitis
No data
No data
Desease Name
Leukemia, myeloid/lymphoid or mixed-lineage
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MLL mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MLL mRNAaffects expression 21346803
C412373 AG 1879 AG 1879 inhibits the reaction [deoxynivalenol results in increased expression of MLL mRNA]decreases reaction|increases expression 19438726
D003024 Clozapine Clozapine results in increased expression of MLL mRNAincreases expression 17942719
C007262 deoxynivalenol AG 1879 inhibits the reaction [deoxynivalenol results in increased expression of MLL mRNA]decreases reaction|increases expression 19438726
C007262 deoxynivalenol deoxynivalenol promotes the reaction [SP1 protein binds to MLL promoter]affects binding|increases reaction 19438726
C007262 deoxynivalenol deoxynivalenol results in increased expression of MLL mRNAincreases expression 19438726
C007262 deoxynivalenol SP1 protein promotes the reaction [deoxynivalenol results in increased expression of MLL mRNA]increases expression|increases reaction 19438726
D002945 Cisplatin MLL protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004317 Doxorubicin MLL mRNA results in decreased susceptibility to Doxorubicindecreases response to substance 16322897
D019833 Genistein Genistein results in increased mutagenesis of MLL geneincreases mutagenesis 17468513
C006552 kaempferol kaempferol results in increased mutagenesis of MLL geneincreases mutagenesis 17468513
D026023 Permethrin Permethrin results in increased mutagenesis of MLL geneincreases mutagenesis 12937054
D011794 Quercetin Quercetin results in decreased expression of MLL mRNAdecreases expression 15309432
D011794 Quercetin Quercetin results in increased mutagenesis of MLL geneincreases mutagenesis 17468513
C004648 testosterone enanthate testosterone enanthate affects the expression of MLL mRNAaffects expression 17440010
C025643 vinclozolin vinclozolin affects the expression of MLL mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.0415814532 12690470 17670903
MESH:D000230 Adenocarcinoma Cisplatin 7.3717638652 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 7.3717418594
MESH:D000230 Adenocarcinoma Genistein 7.3711473722
MESH:D000380 Agranulocytosis Clozapine 5.1612649775 16160616 14617031
MESH:D000419 Albuminuria Doxorubicin 4.6421441931
MESH:D000743 Anemia, Hemolytic Quercetin 4.3217084956
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0915336622
MESH:D001327 Autoimmune Diseases Quercetin 4.5119761891
MESH:D019046 Bone Marrow Neoplasms Cisplatin 12.5114601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 12.5114601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.8817150277
MESH:D001943 Breast Neoplasms Cisplatin 2.4119526202 18382427
MESH:D001943 Breast Neoplasms Doxorubicin 2.4115136595 17983394 18695136 17426702 15939500 15567936 16264153 15668708 18382427 16935488 18628466 16595493 16096432 16115903 18234424 15634643 15994142 17369602 16322301 11325840 19526202 16826403 15993339 15692762
MESH:D001943 Breast Neoplasms Genistein 2.4116873071 16541309 17200150
MESH:D001943 Breast Neoplasms kaempferol 2.4116756079
MESH:D001943 Breast Neoplasms Quercetin 2.4118628248
MESH:D002105 Cadmium Poisoning Quercetin 5.6816962696
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9416051944
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.5716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.5716705839
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 11.5717982673
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 11.5718059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.5716924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 11.5719519916 12508355
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0616685392 12023789
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0617234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.1916201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.0517066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.056189445
MESH:D006332 Cardiomegaly Quercetin 3.3619794523
MESH:D009202 Cardiomyopathies Doxorubicin 3.5817924179 17382496 16242529 16651473 17928571 15505089 16455267 16364871 17007740 17329180 16278810 16269455 16612575 17519947 16952015 17131338 17974986 17308081 15811867 16109756 15792986 18627295 17351982 15476868 16731534
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9717334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 8.0416332659
MESH:D002318 Cardiovascular Diseases kaempferol 8.0416756079
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.826135515
MESH:D003072 Cognition Disorders Clozapine 5.0717123785
MESH:D003110 Colonic Neoplasms Genistein 3.9717182828
MESH:D003110 Colonic Neoplasms Quercetin 3.9715741050 11134977 19056647 17148506 17191121 19440933 16640504
MESH:D015179 Colorectal Neoplasms Cisplatin 3.6015273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.6018259882 18802399
MESH:D015179 Colorectal Neoplasms Quercetin 3.6018852136 18095365
MESH:D019465 Craniofacial Abnormalities Permethrin 3.1819861644
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D003877 Dermatitis, Contact Permethrin 5.0814617103
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8019496084
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.8716402076
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.8716647724
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.6915331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.4217416283
MESH:D004362 Drug Toxicity Cisplatin 8.7119839026 12231392 12649298 15033597
MESH:D004362 Drug Toxicity Doxorubicin 8.7118602426
MESH:D050171 Dyslipidemias Clozapine 4.2416402076
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.8517359293
MESH:D016889 Endometrial Neoplasms Genistein 7.8511473722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2918037988
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8016481741 15173087 17638652 15464296 16785472
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7019069698
MESH:D005355 Fibrosis Quercetin 4.0019474275
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D005909 Glioblastoma Doxorubicin 12.2917150277
MESH:D005909 Glioblastoma Genistein 12.2916598420
MESH:D005909 Glioblastoma Quercetin 12.2919804834
MESH:D005910 Glioma Quercetin 3.0817643826
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 5.0715173396 16524712
MESH:D006258 Head and Neck Neoplasms Cisplatin 8.2215102660 15464296
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.2215692506
MESH:D034381 Hearing Loss Cisplatin 4.3719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4915464296
MESH:D006331 Heart Diseases Doxorubicin 3.5416330681 16244372 17888722 18006777 16244371 16879835 18674790 17875725 16707910 16495754 12587719 14766674 16144979
MESH:D006333 Heart Failure Doxorubicin 3.3917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9815692506
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D006689 Hodgkin Disease Cisplatin 7.8816170182 16200630
MESH:D006689 Hodgkin Disease Doxorubicin 7.8815147373 17606976 18501091
MESH:D006943 Hyperglycemia kaempferol 10.1618262572
MESH:D006943 Hyperglycemia Quercetin 10.1611834736 18262572
MESH:D006948 Hyperkinesis Clozapine 5.0316046005
MESH:D006973 Hypertension Quercetin 2.8818356687
MESH:D007248 Infertility, Male vinclozolin 3.0916467254
MESH:D007251 Influenza, Human Quercetin 4.6416624496
MESH:D007299 Insect Bites and Stings Permethrin 5.9615189238 12749493 12971516
MESH:D007627 Keloid Quercetin 5.0617086741
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2715464296
MESH:D007674 Kidney Diseases Cisplatin 10.5512649298 18289764 12231392 15190930 19839026
MESH:D007674 Kidney Diseases Doxorubicin 10.5516775033 15369732 15699352
MESH:D007674 Kidney Diseases Quercetin 10.5516962696
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2316707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5916705839
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.9311231351
MESH:D007938 Leukemia marker/mechanism 12937054
MESH:D007938 Leukemia Genistein 15.4318980019 17468513
MESH:D007938 Leukemia kaempferol 15.4317468513
MESH:D007938 Leukemia Permethrin 15.4312937054
MESH:D007938 Leukemia Quercetin 15.4317468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2916085563
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008064 Lipidoses Clozapine 4.0217567588
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.7116595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.7117823541
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.7112741479
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.817678174
MESH:D008113 Liver Neoplasms Quercetin 4.8118980244
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.262876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.2616842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.2619519916
MESH:D008175 Lung Neoplasms Cisplatin 3.6811798837 6189445 17225452
MESH:D008175 Lung Neoplasms Doxorubicin 3.686189445 17418594
MESH:D008175 Lung Neoplasms Quercetin 3.6816280456
MESH:D008223 Lymphoma Doxorubicin 3.5216098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6715621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.4315458769
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.4312929590 14578162
MESH:D008545 Melanoma Cisplatin 3.6712393984 12374674 16432458 11135225 17023156 18176117 16248763 18332650 17761969 12883367 18505091 15577323 16809738
MESH:D008545 Melanoma Doxorubicin 3.6716827129
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8915990972
MESH:D001523 Mental Disorders Clozapine 4.0616856516
MESH:D008654 Mesothelioma Cisplatin 6.5517638057
MESH:D008654 Mesothelioma Doxorubicin 6.5517638057
MESH:D024821 Metabolic Syndrome X Clozapine 4.4819142101
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5815792986
MESH:D052016 Mucositis Doxorubicin 4.9117415656
OMIM:159555 MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA GENE marker/mechanism
MESH:D009203 Myocardial Infarction Doxorubicin 9.7819429709 15857846
MESH:D009203 Myocardial Infarction Genistein 9.7817141266
MESH:D009203 Myocardial Infarction Quercetin 9.7819595682
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.9117141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.9119207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.7418551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9818259882
MESH:D009369 Neoplasms Cisplatin 5.5416773208
MESH:D009369 Neoplasms Quercetin 5.5415185748
MESH:D009395 Nephritis, Interstitial Cisplatin 4.6315464296
MESH:D009401 Nephrosis Doxorubicin 4.8716899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.0716889571 15640375
MESH:D009421 Nervous System Malformations Genistein 4.1316427766
MESH:D009447 Neuroblastoma Cisplatin 7.278761367
MESH:D009447 Neuroblastoma Doxorubicin 7.2715555623
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.818761367
MESH:D020078 Neurogenic Inflammation Quercetin 4.4517929310
MESH:D009765 Obesity Clozapine 3.0318515891 19142110
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D010024 Osteoporosis Genistein 7.8419401787
MESH:D010024 Osteoporosis kaempferol 7.8416756079
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.4316169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.4319495926
MESH:D012516 Osteosarcoma Doxorubicin 4.1815930896
MESH:D010051 Ovarian Neoplasms Cisplatin 8.1817225452 19769630 6897625 15464296
MESH:D010051 Ovarian Neoplasms Genistein 8.1819005980
MESH:D010051 Ovarian Neoplasms Quercetin 8.1819005980
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.6919003803
MESH:D010190 Pancreatic Neoplasms Quercetin 5.6916965848
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4015464296
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2917983394
MESH:D010997 Pleural Neoplasms Cisplatin 14.3917638057
MESH:D010997 Pleural Neoplasms Doxorubicin 14.3917638057
MESH:D011230 Precancerous Conditions Quercetin 4.0519056647
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0118042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6818437689 16888761 16729912 15749863 15897917 16868541
MESH:D011471 Prostatic Neoplasms Genistein 2.6815256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Quercetin 2.6814715546 17292933
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011618 Psychotic Disorders Clozapine 4.2415331141
MESH:D051437 Renal Insufficiency Cisplatin 10.7315464296
MESH:D051437 Renal Insufficiency Doxorubicin 10.7317922066
MESH:D012509 Sarcoma Doxorubicin 4.0618313854 16767912 15675481 15625365 17710206 17203757
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.7714601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 10.7714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9117846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.6816862918
MESH:D012559 Schizophrenia Clozapine 2.7420521320 17726453 20168265 20521326 18806925 11763009 17667964 18855531 11151749 20452607 19369910 20580759 17123785 20107430 16141801
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0518551238
MESH:D012878 Skin Neoplasms Doxorubicin 2.9915692506
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4815464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6715625365 17203757 16767912
MESH:D013274 Stomach Neoplasms Cisplatin 2.3315958060 18396642 17522103
MESH:D013736 Testicular Neoplasms Cisplatin 4.7215464296 17225452
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.4316010429 17909728
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 16.1516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 16.1516049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 16.1512973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 16.1517653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 16.1516720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.2816803524
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7115577323
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3317334414 16364871 17678736 17638931
MESH:D014839 Vomiting Cisplatin 4.8511897121
MESH:D015430 Weight Gain Clozapine 4.5416141801 20564506 20107430 20521320 17502770 16402076
MESH:D015431 Weight Loss Clozapine 5.1917933447
Pathway ID Pathway Name
KEGG:00310 Lysine degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA241
    • No data
    Releated disease ID Related disease Name
    PA444760Leukemia, Myeloid, Acute
    PA446357Neoplasms, Second Primary
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445013Myelodysplastic Syndromes
    PA445015Primary Myelofibrosis
    PA444759Leukemia, Monocytic, Acute
    Releated drug ID Related drug Name
    PA449552etoposide
    PA450379mercaptopurine
    PA450428methotrexate
    PA130620649granulocyte colony-stimulating factor
    PA451611teniposide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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