AutismKB 2.0

Annotation Detail for MLLT4


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Basic Information Top
Gene Symbol:MLLT4 ( AF6,FLJ34371,RP3-431P23.3 )
Gene Full Name: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Band: 6q27
Quick LinksEntrez ID:4301; OMIM: 159559; Uniprot ID:Q59FP0_HUMAN; ENSEMBL ID: ENSG00000130396,ENSG00000249273; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04530Tight junction
hsa04520Adherens junction
No data
No data
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of MLLT4 mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of MLLT4 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MLLT4 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MLLT4 mRNAincreases expression 16239168
D019833 Genistein Genistein results in decreased expression of MLLT4 mRNAdecreases expression 16705744
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MLLT4 mRNAaffects binding|increases activity|increases expression 19710929
C116926 rofecoxib rofecoxib affects the expression of MLLT4 mRNAaffects expression 17070997
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MLLT4 mRNAincreases expression 19933214
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of MLLT4 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 14514962 15322242
MESH:D000138 Acidosis Zinc Sulfate 5.197265320
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Genistein 2.5211473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D000860 Anoxia Zinc Sulfate 5.307265320
MESH:D001169 Arthritis, Experimental rofecoxib 4.4616690336
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Genistein 2.0616873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0410355542 16227642 18705752 16192424 16097048 15721981 16124888 15673190 16011737 16050911 3786805 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.723084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7218788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7216924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.4416332659
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 15340226 15668235 8697196 16354765
MESH:D003110 Colonic Neoplasms Genistein 4.3517182828
MESH:D003110 Colonic Neoplasms rofecoxib 4.3512902858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4717107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4311834606 19420014 19085960 16485898 14986274 11739529 16781746 10663392 19739265 15619225 12705907 17562736 11421492 19370779 16081117 11743745 16177239 16393943 11461765 2444490 16109766 12958197 19416960 12392966 15968718 12540782 18071297 11529661 17906064 12594235 18713872 19164858 17522070 14550746 10915739 19923254 11287661 10774834 16227642 12153990 14725611
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.436623471 9327722 15998439 15968718 19336974 19085960 6884620 10915739 15027814 16177239 7179309 16227642 3786805 2869522 10092053 17522070 7120509 11566570 3732212 4309450 7440962 21278145
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004714 Endometrial Hyperplasia Genistein 4.8716402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4911473722
MESH:D004715 Endometriosis rofecoxib 9.9815652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.989294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.3715959796 16045604 12795759 61145 12631006 16239168 17595544 19224547
MESH:D005234 Fatty Liver pirinixic acid 8.3720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.4720067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005909 Glioblastoma Genistein 3.3816598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319110552 19900420
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 5.2617063115
MESH:D006529 Hepatomegaly pirinixic acid 9.1419772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1416120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3618606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007022 Hypotension Zinc Sulfate 4.697265320
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007410 Intestinal Diseases rofecoxib 5.2915831440
MESH:D007417 Intestinal Polyps rofecoxib 5.5911245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.4315237267
MESH:D007938 Leukemia Genistein 3.1118980019 17468513
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9116221502 11408273 17174718 17334410 16943688 21278145 16239168 11903743 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.9815730626 17922224 16192424 18054572 15057751 18412020 18205269 17481882 12632512 17698563 20821823 14748882 12958196 18472332 12609069 15052691 15650968 12389079 15362042 18006644 17976157 14620537 12741479 18251166 15123356 15925388 14724832 16097048 12586293 18472094 18166357 14716496 16011737 17823541 17766677 12666154 16116963 17869086 18263696 12898905 18187930 16136751 17805973 17708605 18395095 17900296 15893842 12445418 14716833 17714472 17631135 12649538 12445421 16015684 17565644 17557913 18279442 15931870 18481824 18376398 16248980 12546737 15876570 18395914 17721639 18277467 15338365 15370692 11481614 14512876 16027843 15818738 18210741 16638106 18317297 17761835 18339082 15996030 12667390 16033810 13678700 17640975 17944888 18429990 10355542 18418968 18156304 12632514 18420326 15959796 17525996 18705752 15673190
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.9817823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.9815474484
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 6.9817565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.9812878042
MESH:D008107 Liver Diseases Acetaminophen 4.0519460945 16611625 11587558 16610002 19784758 12587719 12969438 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0517285989 15830285 16964402 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.0614706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7319294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.7316377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0614578162 12929590
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction Genistein 5.9317141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.9319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.9217141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.9216411023
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009421 Nervous System Malformations Genistein 10.4116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010003 Osteoarthritis rofecoxib 4.4916690336
MESH:D010024 Osteoporosis Genistein 3.3719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3116169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6519005980
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010149 Pain, Postoperative rofecoxib 5.7116678543 18165598
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Genistein 3.4316925846 15256057 15378649
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04670 Leukocyte transendothelial migration
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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