AutismKB 2.0

Annotation Detail for NR3C2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NR3C2 ( FLJ41052,MCR,MGC133092,MLR,MR,NR3C2VIT )
Gene Full Name: nuclear receptor subfamily 3, group C, member 2
Band: 4q31
Quick LinksEntrez ID:4306; OMIM: 600983; Uniprot ID:MCR_HUMAN; ENSEMBL ID: ENSG00000151623; HGNC ID: 7979
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04960Aldosterone-regulated sodium reabsorption
Pathway IDPathway Name
Gene Expression
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00243Hyperkalemic distal renal tubular acidosis (RTA type 4)
Urinary system diseases
Kidney diseases
Desease IDDesease Name
1716Hypoglycemia
1766Renal Cell cancer
1944Breast cancer
2091Hypertension
2075Heart failure
2107Proteinuria
2230Alopecia
2239Lymphoma
Desease Name
Biochemical measures
PHARMACOGENOMIC
potassium response to spironolactone
Desease Name
Biochemical measures
Desease Name
Pseudohypoaldosteronism type I, autosomal dominant
Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NR3C2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of NR3C2 mRNAdecreases expression 20406850
C101850 3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide 3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide binds to and results in decreased activity of NR3C2 proteinaffects binding|decreases activity 16750840
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NR3C2 proteinaffects expression 20106945
D000450 Aldosterone Aldosterone affects the localization of NR3C2 proteinaffects localization 17596522
D000450 Aldosterone Aldosterone binds to and results in increased activity of NR3C2 proteinaffects binding|increases activity 17105867
D000450 Aldosterone Aldosterone results in increased activity of NR3C2 proteinincreases activity 15780662
D000450 Aldosterone Dihydrotestosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]decreases reaction|increases activity 17105867
D000450 Aldosterone Metribolone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]decreases reaction|increases activity 17105867
D000450 Aldosterone Testosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]decreases reaction|increases activity 17105867
D000450 Aldosterone Aldosterone promotes the reaction [NR3C2 protein binds to CREBBP protein]affects binding|increases reaction 19966502
D000450 Aldosterone Aldosterone results in increased activity of NR3C2 proteinincreases activity 15974890
D000450 Aldosterone Aldosterone results in increased expression of and results in increased localization of NR3C2 proteinincreases expression|increases localization 19966502
D000450 Aldosterone NR3C2 protein promotes the reaction [Aldosterone results in increased expression of GAS6 protein]increases expression|increases reaction 19564549
D000450 Aldosterone Aldosterone binds to and results in increased activity of NR3C2 proteinaffects binding|increases activity 15761029
D000450 Aldosterone [Aldosterone binds to NR3C2 protein] which binds to NCOA1 protein alternative formaffects binding 15761029
D000450 Aldosterone [Aldosterone binds to NR3C2 protein] which binds to NCOA5 proteinaffects binding 15761029
D000450 Aldosterone [Aldosterone binds to NR3C2 protein] which binds to NCOA6 protein alternative formaffects binding 15761029
D000450 Aldosterone [Aldosterone binds to NR3C2 protein] which binds to NRIP1 protein alternative formaffects binding 15761029
D000450 Aldosterone [Aldosterone binds to NR3C2 protein] which binds to NSD1 proteinaffects binding 15761029
D000450 Aldosterone [Aldosterone binds to NR3C2 protein] which binds to PPARGC1A protein alternative formaffects binding 15761029
D000450 Aldosterone [Aldosterone binds to NR3C2 protein] which binds to TRIM24 proteinaffects binding 15761029
D013196 Dihydrotestosterone Dihydrotestosterone binds to NR3C2 proteinaffects binding 17105867
D013196 Dihydrotestosterone Dihydrotestosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]decreases reaction|increases activity 17105867
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NR3C2 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NR3C2 mRNAdecreases expression 20106945
D001761 Bleomycin Bleomycin results in decreased expression of NR3C2 mRNAdecreases expression 15808516
D002220 Carbamazepine Carbamazepine results in increased expression of NR3C2 mRNAincreases expression 17112801
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of NR3C2 mRNAincreases expression 16644059
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of NR3C2 mRNAaffects cotreatment|decreases expression 18636392
D003345 Corticosterone Corticosterone binds to NR3C2 proteinaffects binding 16061183
D003348 Cortisone Cortisone results in increased activity of NR3C2 proteinincreases activity 15780662
D016572 Cyclosporine Cyclosporine results in decreased expression of NR3C2 mRNAdecreases expression 20106945
D003350 Cortodoxone Cortodoxone results in increased activity of NR3C2 proteinincreases activity 15780662
D003907 Dexamethasone Dexamethasone results in increased expression of NR3C2 mRNAincreases expression 19022236
C035144 drospirenone drospirenone binds to NR3C2 proteinaffects binding 1493716
14667981
C414690 eplerenone eplerenone binds to and results in decreased activity of NR3C2 proteinaffects binding|decreases activity 15974890
C414690 eplerenone eplerenone binds to and results in decreased activity of NR3C2 proteinaffects binding|decreases activity 15761029
D000431 Ethanol Ethanol results in decreased expression of NR3C2 mRNAdecreases expression 16925589
D000431 Ethanol Ethanol results in increased expression of NR3C2 mRNAincreases expression 17920746
D005419 Flavonoids Flavonoids results in increased expression of NR3C2 mRNAincreases expression 18035473
D005473 Fluoxetine Fluoxetine results in decreased expression of NR3C2 mRNAdecreases expression 11406320
D006854 Hydrocortisone Hydrocortisone results in increased activity of NR3C2 proteinincreases activity 15780662
D006854 Hydrocortisone Hydrocortisone binds to and affects the activity of NR3C2 proteinaffects activity|affects binding 15761029
D007657 Ketone Bodies Ketone Bodies results in increased expression of NR3C2 mRNAincreases expression 15469884
D008713 Methimazole Methimazole results in decreased expression of NR3C2 mRNAdecreases expression 17403546
D015741 Metribolone Metribolone binds to and results in decreased activity of NR3C2 proteinaffects binding|decreases activity 17105867
D015741 Metribolone Metribolone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]decreases reaction|increases activity 17105867
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of NR3C2 mRNAaffects cotreatment|decreases expression 18636392
C494474 perchlorate perchlorate results in decreased expression of NR3C2 mRNAdecreases expression 17403546
D010656 Phenylephrine Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]affects binding|increases reaction 19966502
D010656 Phenylephrine Phenylephrine results in increased expression of and results in increased localization of NR3C2 proteinincreases expression|increases localization 19966502
D010656 Phenylephrine Phenylephrine results in increased expression of NR3C2 mRNAincreases expression 16533503
D010656 Phenylephrine Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]decreases reaction|increases localization 19966502
D011374 Progesterone Progesterone binds to NR3C2 proteinaffects binding 14667981
D011374 Progesterone Progesterone binds to and results in decreased activity of NR3C2 proteinaffects binding|decreases activity 15761029
14667981
D011441 Propylthiouracil Propylthiouracil results in decreased expression of NR3C2 mRNAdecreases expression 17403546
D012964 Sodium NR3C2 protein affects the abundance of Sodiumaffects abundance 16061183
15802372
C017947 sodium arsenite sodium arsenite affects the activity of NR3C2 proteinaffects activity 17173375
D013148 Spironolactone Spironolactone results in increased activity of NR3C2 proteinincreases activity 15780662
D013148 Spironolactone Spironolactone binds to and results in decreased activity of NR3C2 proteinaffects binding|decreases activity 15961248
D013148 Spironolactone Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]decreases reaction|increases localization 19966502
D014284 Triiodothyronine Triiodothyronine affects the expression of NR3C2 mRNAaffects expression 17403546
D013974 Thyroxine Thyroxine affects the expression of NR3C2 mRNAaffects expression 17403546
D013739 Testosterone Testosterone binds to NR3C2 proteinaffects binding 17105867
D013739 Testosterone Testosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]decreases reaction|increases activity 17105867
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of NR3C2 mRNAincreases expression 16533503
C047426 venlafaxine venlafaxine results in decreased expression of NR3C2 mRNAdecreases expression 11406320
C025643 vinclozolin vinclozolin binds to and results in decreased activity of NR3C2 proteinaffects binding|decreases activity 16750840
D014867 Water NR3C2 protein affects the abundance of Wateraffects abundance 15802372
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 7.678986270
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.6718926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 9.0418287403
MESH:D000138 Acidosis Ethanol 9.0411192467
MESH:D055371 Acute Lung Injury Bleomycin 8.4817118201
MESH:D055371 Acute Lung Injury Chlorine 8.4820601635
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.8720127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.406695378
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4617306315 16712894
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8815451039 15451040
MESH:D000544 Alzheimer Disease Ozone 2.3415513908
MESH:D000853 Anophthalmos Ethanol 4.4015513904
MESH:D000860 Anoxia Bleomycin 4.9815782499
MESH:D000987 Antisocial Personality Disorder Testosterone 5.417506515
MESH:D001008 Anxiety Disorders Ethanol 13.0711141031
MESH:D001008 Anxiety Disorders Fluoxetine 13.0718083778
MESH:D001008 Anxiety Disorders vinclozolin 13.0719015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6519183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.7417460149
MESH:D001169 Arthritis, Experimental Dexamethasone 3.2717659584
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4515570426
MESH:D001249 Asthma Ozone 2.5017854713 16373670
MESH:D001321 Autistic Disorder Fluoxetine 3.4119232924 18775368
MESH:D001714 Bipolar Disorder Carbamazepine 3.9120046352 17594078
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 3.8819483382
MESH:D001919 Bradycardia Phenylephrine 4.1115306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9017868700
MESH:D001930 Brain Injuries Progesterone 3.8415665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0617474063 20146248
MESH:D001943 Breast Neoplasms Progesterone 2.0615562024 17614352 16175315
MESH:D001943 Breast Neoplasms Testosterone 2.0617261762
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3416777450 17626835 14754758 15516495 19059883 18315731 18417511
MESH:D002056 Burns Ethanol 4.2316374292
MESH:D002100 Cachexia Ozone 4.3116183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3616227642 3786805 18705752 10355542 15700767 16097048 15673190 16124888 15721981 16050911 16192424 16011737
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 10.2916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 10.2916705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.2912907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.2918788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 10.2915763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.2917306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.6920419170
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 9.696189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.6918572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 9.6918922899
MESH:D006332 Cardiomegaly Ethanol 10.2819332462
MESH:D006332 Cardiomegaly Phenylephrine 10.2815728586 17124262 16170337 11179087 11754973 17287366
MESH:D006332 Cardiomegaly Thyroxine 10.2818093424
MESH:D002318 Cardiovascular Diseases Aldosterone 7.5111230374
MESH:D002318 Cardiovascular Diseases Spironolactone 7.5111230374
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 9.436135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 9.4312371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.4320056578 19524636
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.5120678186
MESH:D002779 Cholestasis Cyclosporine 2.6019486331
MESH:D002971 Cleft Lip Ethanol 3.3515513904
MESH:D002972 Cleft Palate Ethanol 6.0615513904
MESH:D002972 Cleft Palate Hydrocortisone 6.0615826874
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4215824018
MESH:D019465 Craniofacial Abnormalities Carbamazepine 5.129014606
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.1217728286
MESH:D019465 Craniofacial Abnormalities Ethanol 5.1210194807 15513904 11873399 19302082 15451040 11198716 15451039
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 5.1217728286
MESH:D003456 Cryptorchidism vinclozolin 3.9314966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.4918551238
MESH:D003866 Depressive Disorder Fluoxetine 7.7815014590
MESH:D003866 Depressive Disorder venlafaxine 7.7820305041
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0112438553
MESH:D003929 Diabetic Neuropathies Progesterone 4.0717187935
MESH:D003967 Diarrhea Dexamethasone 7.277237001
MESH:D003967 Diarrhea Hydrocortisone 7.277237001
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.0211748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.1420216337 16538175 16538176 15057820
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 10.4818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 10.4818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 10.4817465707
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 10.487179309 15968718 4309450 19336974 9327722 3732212 21278145 16177239 7440962 11566570 17522070 19085960 6884620 3786805 16227642 10092053 2869522 15998439 10915739 6623471 7120509 15027814
MESH:D056486 Drug-Induced Liver Injury Ethanol 10.4811566570
MESH:D004362 Drug Toxicity Carbamazepine 4.1420216337
MESH:D004417 Dyspnea Chlorine 4.1920016425
MESH:D004485 Eczema Dexamethasone 4.0512438553
MESH:D004487 Edema Bleomycin 13.5217118201
MESH:D004487 Edema Dexamethasone 13.5219703484
MESH:D004487 Edema Fluoxetine 13.5212798668
MESH:D004487 Edema Tetradecanoylphorbol Acetate 13.528273558 16716910 8113982 11698051 9599246 15177302 7812673
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 8.2517654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.2517692515
MESH:D004715 Endometriosis Progesterone 3.3916134523
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.8520485159 19915237 18855540 16538176 16415921
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 4.7917275665
MESH:D004828 Epilepsies, Partial Carbamazepine 4.5416628512 15008574 17116037
MESH:D004827 Epilepsy Carbamazepine 3.7620417680 19620853 18234410 19700373 17178248 821787 7988514 19439326 17465707 9014606
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 4.937750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 4.6915276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 5.2919549232
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1816530937
MESH:D004938 Esophageal Neoplasms Ethanol 4.1816704527
MESH:D005076 Exanthema Carbamazepine 5.0420485159
MESH:D005234 Fatty Liver Carbon Tetrachloride 10.9612795759 16045604 12631006 15959796 16239168 61145 19224547 17595544
MESH:D005234 Fatty Liver Cyclosporine 10.9619224547
MESH:D005234 Fatty Liver Ethanol 10.9618620774 19236843 16409862
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2217920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8715513904 10194807 15451040 16946407
MESH:D005355 Fibrosis Carbon Tetrachloride 7.2818705752
MESH:D005355 Fibrosis Cyclosporine 7.2812639820 12168785
MESH:D005391 Firesetting Behavior Testosterone 5.417506515
MESH:D005739 Gas Poisoning Chlorine 4.5720016425
MESH:D005756 Gastritis Ethanol 4.2615046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5016973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8616417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.798708960
MESH:D005909 Glioblastoma Testosterone 3.7717162496
MESH:D015432 Glomerulonephritis, Membranoproliferative Spironolactone 5.6016928621
MESH:D006042 Goiter perchlorate 4.9118801409
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.4220471113
MESH:D006333 Heart Failure marker/mechanism 15722665
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9915720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1919110552 19900420
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.917520565
MESH:D006628 Hirsutism Testosterone 5.2117019078
MESH:D006689 Hodgkin Disease Bleomycin 6.6515147373 18501091 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 6.6512676792
MESH:D019584 Hot Flashes Fluoxetine 9.7414716179
MESH:D019584 Hot Flashes venlafaxine 9.7414716179
MESH:D006930 Hyperalgesia Ethanol 3.3818783367
MESH:D017588 Hyperandrogenism Testosterone 4.8717019078
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1016899240
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.3610459572
MESH:D006965 Hyperplasia Carbamazepine 4.7918773962
MESH:D006973 Hypertension Cyclosporine 7.7010903974
MESH:D006973 Hypertension Dexamethasone 7.7017042910
MESH:D006973 Hypertension Phenylephrine 7.7012717712 8949925
OMIM:605115 HYPERTENSION, EARLY-ONSET, AUTOSOMAL DOMINANT, WITH SEVERE EXACERBATION IN PREGNANCY marker/mechanism
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6715338365
MESH:D006980 Hyperthyroidism Methimazole 5.2114678291
MESH:D006984 Hypertrophy Phenylephrine 4.1712791704 18502941
MESH:D007006 Hypogonadism Testosterone 4.2812002444
MESH:D020514 Hypokalemic Periodic Paralysis Spironolactone 5.7319822448
MESH:D007018 Hypopituitarism Testosterone 5.7617426086
MESH:D007037 Hypothyroidism Methimazole 10.5518031379
MESH:D007037 Hypothyroidism Propylthiouracil 10.5518031379 8137927
MESH:D007174 Impulse Control Disorders Testosterone 5.417506515
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9815869954
MESH:D007248 Infertility, Male sodium arsenite 5.8815346721 12646999
MESH:D007248 Infertility, Male vinclozolin 5.8816467254
MESH:D007249 Inflammation Bleomycin 16.9217118201
MESH:D007249 Inflammation Dexamethasone 16.9211099482 8960868
MESH:D007249 Inflammation Flavonoids 16.9217296493
MESH:D007249 Inflammation Fluoxetine 16.9212798668
MESH:D007249 Inflammation Progesterone 16.9215869954
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 16.928273558 15177302 7812673 7562506 11698051
MESH:D007569 Jaw Abnormalities Ethanol 4.0215513904
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0015604871
MESH:D007674 Kidney Diseases Cyclosporine 5.178314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 5.1720008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 10.3516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.3516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 10.3512371664
MESH:D007859 Learning Disorders Ethanol 3.7915451040
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3016417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5017676605
MESH:D008064 Lipidoses Fluoxetine 4.3417567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.9917174718 16943688 16239168 11408273 17157831 11903743 16221502 21278145 17334410
MESH:D008103 Liver Cirrhosis Ethanol 5.9915289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6618295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.3212632514 18263696 18205269 16192424 15925388 18156304 17761835 17565644 16638106 15123356 15818738 16015684 17708605 12586293 18279442 16027843 18006644 17976157 14620537 18705752 17922224 17900296 13678700 18429990 12667390 12609069 18395914 18317297 16248980 14724832 18210741 16033810 14716496 15052691 12546737 17631135 17869086 12741479 12666154 16116963 17823541 11481614 14512876 18395095 15370692 18187930 18412020 15650968 18376398 15362042 17557913 12632512 15673190 15959796 18251166 16097048 15931870 15893842 17481882 18418968 12445418 17640975 18472094 12445421 17714472 15996030 12898905 16011737 17721639 18420326 17805973 20821823 18054572 15876570 17525996 17944888 15338365 18166357 16136751 15057751 12389079 17766677 15730626 14716833 12649538 18481824 17698563 18339082 10355542 14748882 18277467 12958196 18472332
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.3216718785
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.3218166357
MESH:D008107 Liver Diseases Carbon Tetrachloride 1.9717285989 16246199 15720792 15830285 16964402
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2317207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9614706259 16899240
MESH:D017114 Liver Failure, Acute venlafaxine 8.9619857765
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 12.337678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 12.3315890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 12.3321137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 12.3319294768
MESH:D008113 Liver Neoplasms sodium arsenite 12.3315276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 8.272876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 8.278603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.2712014681 15583823
MESH:D008171 Lung Diseases Ozone 6.548266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 6.5419095001
MESH:D055370 Lung Injury Ozone 3.4320417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 9.7014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 9.7020064080 18816296 20135361 17053015 6695378 20464547 20869020 18569708 18520028
MESH:D008175 Lung Neoplasms Bleomycin 9.706189445
MESH:D008175 Lung Neoplasms Dexamethasone 9.7015824018 11195469
MESH:D008175 Lung Neoplasms Ozone 9.707614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 9.7015276417 16712894 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 9.7011807781
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.4416628512
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 8.5812807724
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.5811408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 8.588985016
MESH:D008545 Melanoma Bleomycin 3.5415577320
MESH:D008545 Melanoma sodium arsenite 3.5416487513 19082730
MESH:D008569 Memory Disorders Ethanol 3.7818411066 15451040
MESH:D001523 Mental Disorders Fluoxetine 7.5116856516
MESH:D001523 Mental Disorders venlafaxine 7.5116856516
MESH:D008607 Mental Retardation Carbamazepine 3.579014606
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3516801185
MESH:D008679 Metaplasia Ozone 4.6710496685
MESH:D008881 Migraine Disorders venlafaxine 4.4618803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8616381670
MESH:D009101 Multiple Myeloma Dexamethasone 3.2015744524 15867202 16118317
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.299809623
MESH:D009207 Myoclonus Fluoxetine 5.458041377
MESH:D009224 Myotonia Congenita Carbamazepine 5.0420399394
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.9118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.917678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.2911141357
MESH:D009369 Neoplasms sodium arsenite 4.2911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2520056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9219348381 18481113
MESH:D009421 Nervous System Malformations Carbamazepine 4.5016990009
MESH:D009436 Neural Tube Defects sodium arsenite 2.8612854658
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 10.3820418887
MESH:D009771 Obsessive-Compulsive Disorder venlafaxine 10.3817503984
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.6516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.6516049721
MESH:D010018 Osteomalacia Carbamazepine 5.0417016548
MESH:D010051 Ovarian Neoplasms Progesterone 4.4516525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.4517306315 15276417
MESH:D010146 Pain Carbamazepine 6.5815215642
MESH:D010146 Pain Fluoxetine 6.5812798668
MESH:D010190 Pancreatic Neoplasms Ethanol 5.1312384795
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.1315976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.8812065085 8330346 18404319 18922899
MESH:D010267 Parapsoriasis Carbamazepine 5.2816538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.4917145499 17679678
MESH:D010538 Peritonitis Ozone 3.7116369182
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.588041377
MESH:D011014 Pneumonia Bleomycin 9.9816317386 18024389 17071938
MESH:D011014 Pneumonia Ozone 9.9818007984 18929643 18381685
MESH:D011230 Precancerous Conditions Cyclosporine 2.8612371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3021297632
MESH:D011248 Pregnancy Complications Carbamazepine 4.739014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 8.689014606
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.6818042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.5018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 4.6720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3717292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3716039940
MESH:D011472 Prostatitis vinclozolin 4.5018629315
MESH:D011546 Pseudohypoaldosteronism marker/mechanism
MESH:D019310 Pseudolymphoma Carbamazepine 5.169591791 12752131
MESH:D011565 Psoriasis Cyclosporine 2.0716882103
MESH:D011654 Pulmonary Edema Bleomycin 4.8815808516
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.6916314464 15322207 17241526 18162602 12624602 17434272 12574379 17177178 16115399 21435439 11554783 15541506 14609568 18008008
MESH:D012120 Respiration Disorders Chlorine 4.7718579056
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.6218379247 11700416
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6918045962
MESH:D012640 Seizures 2,4-dinitrotoluene 11.7118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.7118551238
MESH:D012640 Seizures Carbamazepine 11.719046859 19414003 9844417 16180713 16938433 15946322 16876388
MESH:D012640 Seizures Ethanol 11.719754883
MESH:D020230 Serotonin Syndrome Fluoxetine 5.468704074
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.7616631401
MESH:D012852 Sinusitis Phenylephrine 4.277327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.3110029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 8.3118572023 19524636
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 8.318330346 8985016 18404319 12065085 11807781
MESH:D012893 Sleep Disorders Carbamazepine 4.6919414003
MESH:D013119 Spinal Cord Injuries Progesterone 3.8516503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4612854658
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 4.7916415921 19694795 19915237 15057820 18855540 16538176 20485159
MESH:D013272 Stomach Diseases Dexamethasone 3.8915472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.412093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 2.4118456281
MESH:D013276 Stomach Ulcer Dexamethasone 6.2915138204
MESH:D013276 Stomach Ulcer Ethanol 6.299211565 16755016 17189318 11906479 9562338 17918041
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.889754883
MESH:D013959 Thyroid Diseases Thyroxine 5.2019910387
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.3615710170
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.3916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 10.3916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.3917053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.3917306315 11723127 16712894 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.5510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.5510091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.3911813266
MESH:D014605 Uveitis Cyclosporine 10.301336536
MESH:D014605 Uveitis Dexamethasone 10.301336536
MESH:D014652 Vascular Diseases sodium arsenite 3.9917056641
MESH:D015431 Weight Loss Bleomycin 5.2112624602
MESH:D014985 Xerophthalmia Cyclosporine 4.0017120751
Pathway ID Pathway Name
KEGG:04960 Aldosterone-regulated sodium reabsorption
REACT:71 Gene Expression
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA242
    • No data
    Releated disease ID Related disease Name
    PA444332Gynecomastia
    PA444526Hyperkalemia
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA451483spironolactone
    PA164749044eplerenone
    PA165290928drospirenone/ethinyl estradiol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00393 antagonist Nimodipine Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers
    DB00396 antagonist Synovex S Contraceptives;Progestins
    DB00421 antagonist Novo-Spirozine-50 Tab Diuretics;Aldosterone Antagonists
    DB00588 antagonist Fluticasone Propionate Anti-inflammatory Agents;Adrenergic Agents;Dermatologic Agents;Bronchodilator Agents;Anti-Allergic Agents
    DB00687 agonist Fludrocortisone Anti-inflammatory Agents;Adrenergic Agents
    DB00700 antagonist Eplerenone Antihypertensive Agents;Aldosterone Antagonists
    DB01023 antagonist Lexxel Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Dihydropyridines
    DB01134 agonist Desoxycorticosterone Pivalate Diuretics;Anti-Addison Agents
    DB01395 antagonist Yaz Progestins;Aldosterone Antagonists
    DB03122 - B-Octylglucoside Detergents
    DB04630 - Aldosterone
    DB04652 - (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE Anti-inflammatory Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved