Annotation Detail for TRPM1
Basic Information Top
| Gene Symbol: | TRPM1 ( CSNB1C,LTRPC1,MLSN1 ) |
|---|---|
| Gene Full Name: | transient receptor potential cation channel, subfamily M, member 1 |
| Band: | 15q13.3 |
| Quick Links | Entrez ID:4308; OMIM: 603576; Uniprot ID:TRPM1_HUMAN; ENSEMBL ID: ENSG00000134160; HGNC ID: 7146 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| No data |
| No data |
| Desease Name |
|---|
| PHARMACOGENOMIC |
| response to antipsychotic treatment |
| Desease Name |
|---|
| Response to antipsychotic treatment |
| Desease Name |
|---|
| Night blindness, congenital stationary, type IC |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D004052 | Diethylnitrosamine | Diethylnitrosamine results in increased expression of TRPM1 mRNA | increases expression | 17942915 |
| D004052 | Diethylnitrosamine | MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TRPM1 mRNA] | decreases reaction|increases expression | 17942915 |
| D008345 | Manganese | Manganese results in increased expression of TRPM1 mRNA | increases expression | 17175027 |
| C025340 | manganese chloride | manganese chloride results in increased expression of TRPM1 mRNA | increases expression | 17175027 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000236 | Adenoma | Diethylnitrosamine | 3.08 | 10737359 6695378 | |
| MESH:D018248 | Adenoma, Liver Cell | Diethylnitrosamine | 4.64 | 17162532 19052882 16434500 19061943 18056438 17620307 | |
| MESH:D000756 | Anemia, Sideroblastic | Manganese | 12.69 | 16910769 | |
| MESH:D000756 | Anemia, Sideroblastic | manganese chloride | 12.69 | 16910769 | |
| MESH:D001943 | Breast Neoplasms | Diethylnitrosamine | 2.19 | 17474063 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylnitrosamine | 1.88 | 20214788 18210153 16502159 20935162 17055752 19052882 20514400 19171122 18665156 18978308 10737359 20084675 20727157 18494052 16328049 16288022 10672840 20432363 16569478 17138121 18971187 3581430 16935385 19701751 19418558 17978847 19919837 19107877 18788625 16540662 19208518 19383236 16878318 17173139 16807293 19539802 17761372 19335982 19394651 16698587 20101231 17162532 19519916 16830150 18506893 20007298 17428255 20512989 19822196 18785209 11831363 16779866 3084413 16681979 18691550 20524982 18393292 18056438 21159647 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Diethylnitrosamine | 3.15 | 7505956 2727394 21159647 17174075 | |
| MESH:D018281 | Cholangiocarcinoma | Diethylnitrosamine | 4.10 | 19052882 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Diethylnitrosamine | 2.27 | 20387270 | |
| MESH:D056486 | Drug-Induced Liver Injury | Diethylnitrosamine | 2.15 | 19107877 | |
| MESH:D004931 | Esophageal Achalasia | Diethylnitrosamine | 5.98 | 16302075 | |
| MESH:D005234 | Fatty Liver | Diethylnitrosamine | 3.67 | 20387270 21071580 | |
| MESH:D005909 | Glioblastoma | Manganese | 4.18 | 17043766 | |
| MESH:D007249 | Inflammation | Diethylnitrosamine | 2.57 | 18785209 | |
| MESH:D008103 | Liver Cirrhosis | Diethylnitrosamine | 3.03 | 18522880 18665156 20032147 18407596 19638242 | |
| MESH:D008107 | Liver Diseases | Diethylnitrosamine | 2.18 | 17034775 | |
| MESH:D008113 | Liver Neoplasms | Diethylnitrosamine | 2.36 | 18977376 20583210 21071580 21278145 2422723 20452335 19090486 16942905 20101389 20492335 15175105 18644402 19254457 19833225 2862719 12771043 19551842 18978307 19294768 19427195 19642983 9163691 18648771 19426721 19638242 19256749 20405173 20118626 20137499 21047994 19850985 20501860 20434301 19812893 19996281 12112319 18754104 19255062 21167192 19073162 19690152 19499222 15885732 10737359 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Diethylnitrosamine | 2.88 | 19539802 18282651 9362446 18164116 2563599 21159647 19519916 18253720 19009564 19126423 16267830 17174075 17854601 18544905 17942915 18093689 18308698 18079962 3124819 18775883 16842330 19004024 | |
| MESH:D008175 | Lung Neoplasms | Diethylnitrosamine | 1.77 | 6695378 20970405 21163286 20512841 | |
| MESH:D020149 | Manganese Poisoning | Manganese | 6.39 | 16551646 16568477 19453300 | |
| MESH:D009069 | Movement Disorders | Manganese | 5.54 | 16551646 | |
| MESH:D009362 | Neoplasm Metastasis | Diethylnitrosamine | 2.70 | 9029167 3581430 | |
| MESH:D009410 | Nerve Degeneration | Manganese | 4.62 | 16551646 | |
| MESH:D019636 | Neurodegenerative Diseases | Diethylnitrosamine | 3.73 | 20387270 | |
| MESH:D009461 | Neurologic Manifestations | Diethylnitrosamine | 5.98 | 20387270 | |
| OMIM:613216 | NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1C | marker/mechanism | |||
| MESH:D010190 | Pancreatic Neoplasms | Diethylnitrosamine | 2.54 | 16540662 | |
| MESH:D010300 | Parkinson Disease | Manganese | 3.50 | 11181820 | |
| MESH:D020734 | Parkinsonian Disorders | Manganese | 4.92 | 16140633 | |
| MESH:D011230 | Precancerous Conditions | Diethylnitrosamine | 3.97 | 2563599 | |
| MESH:D013274 | Stomach Neoplasms | Diethylnitrosamine | 1.76 | 18456281 | |
| MESH:D013964 | Thyroid Neoplasms | Diethylnitrosamine | 3.32 | 7505956 |
| No data |