AutismKB 2.0

Annotation Detail for MME


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MME ( CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP )
Gene Full Name: membrane metallo-endopeptidase
Band: 3q25.2
Quick LinksEntrez ID:4311; OMIM: 120520; Uniprot ID:NEP_HUMAN; ENSEMBL ID: ENSG00000196549; HGNC ID: 7154
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04974Protein digestion and absorption
hsa05010Alzheimer's disease
hsa04614Renin-angiotensin system
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1809HIV infection
1894Abortion
1904Diabetes mellitus
1934Cancer
1963Amyloidosis
1978Cholestasis
2032Kidney disease
2142Acne
Desease Name
anxiety
low amplitude P300 waves
cerebral amyloid angiopathy.
Alzheimer's disease
PSYCH
NEUROLOGICAL
No data
Desease Name
Neutral endopeptidase deficiency
Membranous glomerulonephritis, antenatal
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049331 acetorphan acetorphan results in decreased activity of MME proteindecreases activity 1624154
3481337
C049331 acetorphan acetorphan results in decreased activity of MME proteindecreases activity 16085334
C109238 acyline acyline results in decreased expression of MME mRNAdecreases expression 17510436
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MME mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MME mRNAaffects cotreatment|decreases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MME mRNAdecreases expression 20064835
D001623 Betamethasone Betamethasone inhibits the reaction [Mustard Gas results in decreased activity of MME protein]decreases activity|decreases reaction 7501459
C053541 bicalutamide bicalutamide results in increased expression of MME mRNAincreases expression 15790403
C006780 bisphenol A bisphenol A results in decreased expression of MME mRNAdecreases expression 20678512
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of MME mRNAincreases expression 15336504
C062766 candoxatril candoxatril results in decreased activity of MME proteindecreases activity 16085334
C060942 candoxatrilat candoxatrilat results in decreased activity of MME proteindecreases activity 16085334
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MME proteinincreases expression 16449355
C086164 CGS 24592 CGS 24592 results in decreased activity of MME proteindecreases activity 16364833
C511403 CGS 35601 CGS 35601 results in decreased activity of MME proteindecreases activity 16364833
D003474 Curcumin Curcumin results in decreased expression of MME mRNAdecreases expression 17198877
D016572 Cyclosporine Cyclosporine results in decreased expression of MME mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of MME mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MME mRNAaffects cotreatment|decreases expression 18164116
D004317 Doxorubicin Doxorubicin results in decreased expression of MME proteindecreases expression 16997790
D004317 Doxorubicin MME protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004745 Enkephalins MME protein results in increased metabolism of Enkephalinsincreases metabolic processing 17906961
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of MME mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of MME mRNAdecreases expression 16202921
19619570
D005419 Flavonoids Flavonoids results in increased expression of MME mRNAincreases expression 18035473
D005492 Folic Acid Folic Acid affects the expression of MME mRNAaffects expression 17320366
C070081 fulvestrant fulvestrant results in increased expression of MME mRNAincreases expression 16202921
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of MME mRNAaffects cotreatment|increases expression 17183730
D008070 Lipopolysaccharides Lipopolysaccharides affects the activity of MME proteinaffects activity 21114838
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of MME mRNAdecreases expression 21114838
12057914
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of MME proteindecreases expression 21114838
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of MME mRNAincreases expression 12738685
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to MME protein]affects binding|increases reaction 17220478
D016685 Mitomycin MME protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D009151 Mustard Gas Betamethasone inhibits the reaction [Mustard Gas results in decreased activity of MME protein]decreases activity|decreases reaction 7501459
D009151 Mustard Gas Mustard Gas results in decreased activity of MME proteindecreases activity 7501459
D026423 S-Nitroso-N-Acetylpenicillamine S-Nitroso-N-Acetylpenicillamine results in decreased expression of MME mRNAdecreases expression 12102619
C041786 palm oil palm oil results in decreased expression of MME mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MME mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of MME mRNAincreases expression 19482888
19270015
C008890 phosphoramidon phosphoramidon results in decreased activity of MME proteindecreases activity 16085334
12193062
D011374 Progesterone Progesterone results in decreased expression of MME mRNAdecreases expression 18070364
D011374 Progesterone Progesterone affects the expression of MME mRNAaffects expression 17251523
C059514 resveratrol resveratrol results in increased activity of MME proteinincreases activity 16162502
D012643 Selenium Selenium deficiency affects the expression of and affects the localization of MME proteinaffects expression|affects localization 17109141
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of MME mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MME mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MME mRNAincreases expression 16704738
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MME mRNAdecreases expression 17586704
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased expression of MME proteindecreases expression 16997790
D015244 Thiorphan Thiorphan results in decreased activity of MME proteindecreases activity 16405511
D015244 Thiorphan [Thiorphan results in decreased activity of MME protein] which affects the activity of AKT1 proteinaffects activity|decreases activity 16405511
D015244 Thiorphan Thiorphan results in decreased activity of MME proteindecreases activity 3519939
D015244 Thiorphan Thiorphan results in decreased activity of MME proteindecreases activity 3519939
3481337
D015244 Thiorphan Thiorphan results in decreased activity of MME proteindecreases activity 16085334
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of MME mRNAincreases expression 18087596
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of MME mRNAaffects cotreatment|increases expression 17183730
D014747 Vinblastine MME protein affects the susceptibility to Vinblastineaffects response to substance 16217747
C511404 ZD4054 ZD4054 results in decreased expression of MME mRNAdecreases expression 19943105
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.586195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.5815322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 11.588875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5219490988
MESH:D000138 Acidosis Ammonium Chloride 3.1118287403
MESH:D058186 Acute Kidney Injury Folic Acid 7.6816595132 16316344 17003819
MESH:D058186 Acute Kidney Injury resveratrol 7.6816538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.6211850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.3120127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 6.3117418594
MESH:D000230 Adenocarcinoma Estradiol 6.3111473722
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.0715814487
MESH:D000236 Adenoma Benzo(a)pyrene 18.136695378
MESH:D000236 Adenoma beta-Naphthoflavone 18.1319389873
MESH:D000236 Adenoma Diethylnitrosamine 18.136695378 10737359
MESH:D000236 Adenoma Folic Acid 18.1316963246
MESH:D000236 Adenoma resveratrol 18.1315688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.7117620307 16434500 19061943 19052882 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 14.7117620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.7116835633
MESH:D000419 Albuminuria Doxorubicin 4.1121441931
MESH:D019973 Alcohol-Related Disorders Curcumin 4.6217887948
MESH:D000544 Alzheimer Disease Curcumin 6.0815590663
MESH:D000544 Alzheimer Disease Folic Acid 6.0817116317
MESH:D000544 Alzheimer Disease resveratrol 6.0816183991 16162502
MESH:D000550 Amblyopia Valproic Acid 4.7717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5611748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.2117497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6319183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.4515238619
MESH:D001169 Arthritis, Experimental resveratrol 3.2117115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.6516807698
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 4.6519898480
MESH:D001249 Asthma Mustard Gas 2.5610378619
MESH:D050197 Atherosclerosis Curcumin 5.9918704882
MESH:D050197 Atherosclerosis resveratrol 5.9917967414 16873680
MESH:D001284 Atrophy fulvestrant 4.4211514358
MESH:D001321 Autistic Disorder Folic Acid 2.3821388746
MESH:D001321 Autistic Disorder Valproic Acid 2.3818940202 17507914 16609825 20603192 18177632 15238991 17688650 18558336 18316065 19460635 17157402 18396377 18775368 19232924 18985861
MESH:D001327 Autoimmune Diseases Curcumin 4.0519761891
MESH:D001714 Bipolar Disorder Valproic Acid 2.8320046352 17594078
MESH:D001768 Blister Mustard Gas 4.7019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.6412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.0315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.038888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2414601052
MESH:D001862 Bone Resorption bisphenol A 3.4611985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8717868700
MESH:D001930 Brain Injuries Progesterone 3.8215845082 15380490 15665606
MESH:D002545 Brain Ischemia Curcumin 8.8216770732
MESH:D002545 Brain Ischemia resveratrol 8.8217600658
MESH:D001932 Brain Neoplasms Curcumin 7.6617596214
MESH:D001932 Brain Neoplasms Doxorubicin 7.6617150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 10.3120146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 10.3117123778
MESH:D001943 Breast Neoplasms Curcumin 10.3119250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms Dietary Fats 10.3120435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 10.3117474063
MESH:D001943 Breast Neoplasms Doxorubicin 10.3116264153 17426702 18695136 15993339 18382427 15692762 15939500 16826403 16096432 15634643 18628466 16322301 15136595 15668708 15567936 17983394 16595493 18234424 17369602 19526202 16115903 15994142 11325840 16935488
MESH:D001943 Breast Neoplasms Estradiol 10.3117289903 18497071 12948864 17018787 19861407 17261762 14630087 16675129
MESH:D001943 Breast Neoplasms Folic Acid 10.3116777985
MESH:D001943 Breast Neoplasms fulvestrant 10.3118984771
MESH:D001943 Breast Neoplasms Progesterone 10.3115562024 17614352 16175315
MESH:D001943 Breast Neoplasms resveratrol 10.3116393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.3120435547
MESH:D001943 Breast Neoplasms ZD4054 10.3119943105
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5117687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3410355542 15673190 16124888 15700767 16097048 15721981 18705752 16227642 16011737 16050911 3786805 16192424
MESH:D002276 Carcinoid Tumor Doxorubicin 4.3516051944
MESH:D002277 Carcinoma Curcumin 7.0918593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.0916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.2118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.2116779866 17978847 17428255 19052882 18785209 16328049 16681979 18506893 20935162 19701751 20101231 18393292 19394651 17055752 20007298 16502159 19383236 17761372 19335982 19171122 18691550 17138121 20524982 16288022 18971187 19208518 16540662 16935385 18056438 20214788 20514400 10672840 18494052 19919837 10737359 19539802 16830150 3084413 17162532 16569478 21159647 18210153 20432363 17173139 11831363 20727157 20084675 19519916 18978308 18665156 16698587 19107877 19418558 19822196 18788625 16807293 16878318 20512989 3581430
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 10.2118059187 17876044 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.2116924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.2117173139 20935162 20007298 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular resveratrol 10.2116227395 19321006
MESH:D002278 Carcinoma in Situ bisphenol A 4.5317123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.1416675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.3418414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 5.3411212258
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.191485588 16201981
MESH:D002292 Carcinoma, Renal Cell Vinblastine 6.191485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 16.0920419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 16.0918462866
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 16.096189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 16.0916227395
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 16.0918922899
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 16.0911212258
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1118850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.2317928571 16269455 17974986 17351982 16242529 17329180 17924179 15505089 16455267 17519947 17007740 16731534 16278810 16364871 16952015 17308081 16612575 17382496 15792986 18627295 15811867 15476868 16109756 16651473 17131338
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7817334414 16243910
MESH:D002318 Cardiovascular Diseases Folic Acid 6.6916755160
MESH:D002318 Cardiovascular Diseases resveratrol 6.6915458977
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 9.3112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.3117174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.3118566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.814080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.0519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.0516835633
MESH:D002779 Cholestasis Cyclosporine 2.5819486331
MESH:D002971 Cleft Lip Folic Acid 3.7321254359
MESH:D002972 Cleft Palate Folic Acid 5.418946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4115668235 15340226 12621046 8697196 16354765
MESH:D003092 Colitis Curcumin 13.5416804969 16782535 18200517
MESH:D003092 Colitis resveratrol 13.5416474422
MESH:D003092 Colitis Selenium 13.5417936198
MESH:D003103 Coloboma Curcumin 4.1418809619
MESH:D003110 Colonic Neoplasms Curcumin 3.6819359593 16340194
MESH:D003110 Colonic Neoplasms resveratrol 3.6816338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.4618259882 18802399
MESH:D015179 Colorectal Neoplasms Folic Acid 4.4616985020 17245555 17116713 17087956 16963246
MESH:D015179 Colorectal Neoplasms resveratrol 4.4616550006
MESH:D015179 Colorectal Neoplasms Vinblastine 4.4618802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6814669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.4518497527
MESH:D003327 Coronary Disease resveratrol 3.4516507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.3117688650 8888407 16575769
MESH:D056587 Cryopyrin-Associated Periodic Syndromes marker/mechanism 12928894
MESH:D003866 Depressive Disorder acetorphan 5.603519939
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.4016873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.1818403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.1820387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 9.1816886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.1817107852
MESH:D003928 Diabetic Nephropathies Curcumin 12.8918204486
MESH:D003928 Diabetic Nephropathies Estradiol 12.8919279558
MESH:D003928 Diabetic Nephropathies resveratrol 12.8916286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.0517187935
MESH:D003967 Diarrhea acetorphan 8.433481337 3519939 1624154
MESH:D003967 Diarrhea Thiorphan 8.433481337
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.2210915739 7179309 17522070 15027814 9327722 6884620 15968718 11566570 2869522 15998439 16177239 6623471 19085960 10092053 21278145 3732212 4309450 7120509 19336974 3786805 16227642 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.2219107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 13.2217416283
MESH:D056486 Drug-Induced Liver Injury Selenium 13.2215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.2220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 13.221733752 19641884
MESH:D004362 Drug Toxicity Doxorubicin 6.9818602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.9811462148
MESH:D004381 Duodenal Ulcer Curcumin 3.6217351913
MESH:D050171 Dyslipidemias Dietary Fats 3.1218367378
MESH:D004421 Dystonia Phenobarbital 9.041851702
MESH:D004421 Dystonia Valproic Acid 9.041851702
MESH:D004487 Edema Mustard Gas 13.2111428647 11402378 11428631 9260866
MESH:D004487 Edema resveratrol 13.218985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.2112711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 13.2116716910 9599246 8273558 8113982 11698051 7812673 15177302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4416714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.9117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 7.9117872969
MESH:D016889 Endometrial Neoplasms Doxorubicin 10.8417359293
MESH:D016889 Endometrial Neoplasms Estradiol 10.8419148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Folic Acid 10.8417301261
MESH:D004715 Endometriosis Progesterone 7.6216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.629294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6918037988
MESH:D019446 Endotoxemia Lipopolysaccharides 3.9415821434 17637181 15328337
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4017923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.323659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 9.3217275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.443922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 8.443922381 16628512
MESH:D004827 Epilepsy Phenobarbital 5.8420417680
MESH:D004827 Epilepsy Valproic Acid 5.8420417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 7.606401628
MESH:D004832 Epilepsy, Absence Valproic Acid 7.607562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.837750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.837750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 8.973659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.973659116
MESH:D004890 Erythema Mustard Gas 4.709357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6516302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.8916530937
MESH:D017889 Exfoliation Syndrome Folic Acid 5.0416504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.4715959796 16045604 12631006 61145 16239168 19224547 12795759 17595544
MESH:D005234 Fatty Liver Curcumin 25.4719297423
MESH:D005234 Fatty Liver Cyclosporine 25.4719224547
MESH:D005234 Fatty Liver Dietary Fats 25.4717967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 25.4721071580 20387270
MESH:D005234 Fatty Liver Valproic Acid 25.4719224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.4216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.708888407 18558336
MESH:D005334 Fever Lipopolysaccharides 3.6211852909 9205823
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.1319069698
MESH:D005355 Fibrosis Carbon Tetrachloride 23.0418705752
MESH:D005355 Fibrosis Curcumin 23.0418705752
MESH:D005355 Fibrosis Cyclosporine 23.0412168785 12639820
MESH:D005355 Fibrosis Dietary Fats 23.0418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 23.0420067830
MESH:D005756 Gastritis Folic Acid 4.6317171786
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2518462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.768708960
MESH:D005901 Glaucoma Folic Acid 4.6616504073
MESH:D005909 Glioblastoma Curcumin 6.4117596214
MESH:D005909 Glioblastoma Doxorubicin 6.4117150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1310696789
MESH:D006258 Head and Neck Neoplasms Curcumin 6.9818462866 18829502
MESH:D006258 Head and Neck Neoplasms Doxorubicin 6.9815692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.7420471113
MESH:D006330 Heart Defects, Congenital Folic Acid 9.7416524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.7411294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.1717888722 16495754 16244371 16879835 12587719 16244372 16707910 18006777 18674790 17875725 16144979 14766674 16330681
MESH:D006333 Heart Failure Doxorubicin 6.2917481944
MESH:D006333 Heart Failure Selenium 6.2917162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5015692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9715720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.9916366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1719900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 6.9816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.9812621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6017701891
MESH:D006558 Herpes Genitalis Estradiol 4.5715709030
MESH:D006561 Herpes Simplex resveratrol 3.7316876885
MESH:D006679 HIV Seropositivity Folic Acid 5.0417209195
MESH:D006689 Hodgkin Disease Doxorubicin 6.5518501091 17606976 15147373
MESH:D006689 Hodgkin Disease Vinblastine 6.5518501091 18180244
MESH:D019584 Hot Flashes Estradiol 3.2917088409
MESH:D006849 Hydrocephalus Valproic Acid 4.4117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5815340226 16959395 8697196 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0816899240
MESH:D006937 Hypercholesterolemia Curcumin 13.0218704882
MESH:D006937 Hypercholesterolemia Dietary Fats 13.0221332399
MESH:D006937 Hypercholesterolemia resveratrol 13.0217188708
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.1116395265 16755160 16433478 16865747 16397167
MESH:D006949 Hyperlipidemias Dietary Fats 7.9021332399
MESH:D006949 Hyperlipidemias resveratrol 7.9016873680
MESH:D006973 Hypertension CGS 35601 7.7416364833
MESH:D006973 Hypertension Cyclosporine 7.7410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.7418670907 18850075
MESH:D006975 Hypertension, Portal candoxatrilat 10.5616085334
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 10.5615338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.1816612254
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9117488730
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.0115869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.0117600658
MESH:D007248 Infertility, Male fulvestrant 3.4511514358
MESH:D007249 Inflammation Curcumin 36.6118403477 16956363 17151092
MESH:D007249 Inflammation Dietary Fats 36.6120412841
MESH:D007249 Inflammation Diethylnitrosamine 36.6118785209
MESH:D007249 Inflammation Flavonoids 36.6117296493
MESH:D007249 Inflammation Lipopolysaccharides 36.619205823 12878042 17963957 17237260 17255318
MESH:D007249 Inflammation Mustard Gas 36.6111428631 8975870 9260866 16001271 11428620 9357497 11402378 11428647 17524151
MESH:D007249 Inflammation Progesterone 36.6115869954
MESH:D007249 Inflammation resveratrol 36.6116366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 36.6112200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 36.617812673 8273558 11698051 15177302 7562506
MESH:D007249 Inflammation Tobacco Smoke Pollution 36.6118590791
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0118200517 18596194
MESH:D007251 Influenza, Human resveratrol 9.5416624496
MESH:D007251 Influenza, Human Selenium 9.5416624496
MESH:D007333 Insulin Resistance bisphenol A 10.6216393666
MESH:D007333 Insulin Resistance Dietary Fats 10.6211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 10.6216627594 16393666
MESH:D007414 Intestinal Neoplasms Curcumin 3.8310783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2117255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9815604871
MESH:D007674 Kidney Diseases Cyclosporine 8.5110903974 18776723 8314463
MESH:D007674 Kidney Diseases Doxorubicin 8.5115369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 8.5115618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.6316707910
MESH:D007676 Kidney Failure, Chronic Selenium 8.6316518626
MESH:D007680 Kidney Neoplasms Cyclosporine 6.0612371664
MESH:D007680 Kidney Neoplasms Estradiol 6.0615610895
MESH:D007889 Leiomyoma Curcumin 4.1518555241
MESH:D007938 Leukemia Curcumin 3.0118462866
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6916085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8016106398
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0717596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.2716087638
MESH:D015458 Leukemia, T-Cell Curcumin 4.3316106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.2415821434
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.5916943688 11903743 11408273 21278145 17174718 16239168 16221502 17334410 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 13.5918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.5918522880 18665156 20032147 19638242 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 13.5921047994
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 16085334
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 7.8218429990 14748882 18279442 17900296 11481614 15931870 15959796 15673190 13678700 12649538 20821823 15338365 17944888 17698563 18166357 12389079 18263696 15052691 17766677 14620537 12632512 18006644 18481824 16136751 12546737 18472332 18395914 12632514 18205269 15925388 12445421 16248980 18412020 15370692 15996030 14716496 17640975 18277467 18395095 14512876 17557913 17708605 15362042 16638106 18187930 18472094 18420326 18210741 12667390 15730626 10355542 12445418 15057751 16015684 16116963 17823541 17565644 17481882 17721639 17869086 18156304 12666154 16011737 17761835 18418968 17805973 12741479 17922224 16192424 18054572 16033810 17714472 15123356 18376398 17976157 15818738 17525996 18251166 15650968 15876570 12586293 12898905 18317297 14724832 16027843 18339082 12958196 18705752 17631135 14716833 15893842 16097048 12609069
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 7.8217355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 7.8216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.8214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 7.8212878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.8212878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.0616246199 15830285 16964402 15720792 17285989
MESH:D008107 Liver Diseases Curcumin 11.0616956363
MESH:D008107 Liver Diseases Diethylnitrosamine 11.0617034775
MESH:D008107 Liver Diseases Folic Acid 11.0616877991
MESH:D008107 Liver Diseases Phenobarbital 11.0619363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3014706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 22.5821137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 22.5819389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 22.5819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 22.5821071580 21278145 19642983 19690152 19090486 18754104 20501860 18648771 19256749 19427195 19833225 20452335 18978307 20101389 20118626 12771043 21167192 19426721 21047994 16942905 20583210 19254457 19073162 20137499 2422723 12112319 20492335 19638242 15885732 15175105 19255062 18977376 20434301 19499222 19996281 19812893 19551842 18644402 20405173 19294768 2862719 10737359 9163691 19850985
MESH:D008113 Liver Neoplasms Mitomycin 22.5815113037
MESH:D008113 Liver Neoplasms Phenobarbital 22.5819812893 15975961 19482888 19073162 21047994 8742319
MESH:D008113 Liver Neoplasms resveratrol 22.5819321006 19073162 19812893 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 22.5816984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 19.5818164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.5812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.5817174075 18079962 16842330 18253720 18093689 18544905 18308698 18164116 17942915 18775883 19126423 19539802 9362446 17854601 18282651 2563599 19004024 19519916 16267830 21159647 3124819 19009564
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 19.5816842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.5817172636 2563599 1399818 18308698 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.5812151625
MESH:D008171 Lung Diseases Mustard Gas 3.1418161513 18702808
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8017228818
MESH:D055370 Lung Injury marker/mechanism 21114838
MESH:D055370 Lung Injury Lipopolysaccharides 3.5721114838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.7518816296 17053015 18569708 6695378 20464547 20135361 20869020 20064080 18520028
MESH:D008175 Lung Neoplasms Curcumin 11.7518462866 19359593 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 11.756695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 11.7517418594 6189445
MESH:D008175 Lung Neoplasms Mustard Gas 11.758781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.7511884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 11.7511807781
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 11.7511091918 12111688 16288123 3440675
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2017718048
MESH:D008223 Lymphoma Curcumin 6.7018462866
MESH:D008223 Lymphoma Doxorubicin 6.7016098063
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8817088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.6517654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 7.6514749477
MESH:D016399 Lymphoma, T-Cell Curcumin 10.0916173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 10.0915621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.8015688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 19.6915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 19.6911408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 19.6911408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 19.698985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Selenium 19.6915318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 19.698985016
MESH:D020149 Manganese Poisoning Estradiol 4.0219453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.2416832597
MESH:D008545 Melanoma Curcumin 6.5818462866 17885582
MESH:D008545 Melanoma Doxorubicin 6.5816827129
MESH:D008545 Melanoma resveratrol 6.5817992120
MESH:D008545 Melanoma Vinblastine 6.5816432458 18332650 17761969 15577320 15577323 18176117 18505091 12374674 16248763 16809738
MESH:D008569 Memory Disorders Curcumin 3.7317263510
MESH:D008654 Mesothelioma Doxorubicin 5.6317638057
MESH:D008654 Mesothelioma Selenium 5.6315107826
MESH:D008659 Metabolic Diseases resveratrol 3.9717112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3216801185
MESH:D008881 Migraine Disorders Valproic Acid 2.8718803445 18765137
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0915792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.6316381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 7.6315006635
MESH:D052016 Mucositis Doxorubicin 4.3417415656
MESH:D009101 Multiple Myeloma Curcumin 6.4919372569
MESH:D009101 Multiple Myeloma resveratrol 6.4916490592 14749477 17049120 17164350 17935668 16267019
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.9017962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.9017962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.628888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.8917596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.3519429709 15857846
MESH:D009203 Myocardial Infarction resveratrol 5.3516525036 16317513 16456233 17125593 17015251 17188708
MESH:D017202 Myocardial Ischemia resveratrol 7.8117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.8112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9316810080
MESH:D009205 Myocarditis resveratrol 4.3017322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0217484760
MESH:D009361 Neoplasm Invasiveness Curcumin 3.9418495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.229029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.2218259882
MESH:D009369 Neoplasms Benzo(a)pyrene 1.9511141357
MESH:D009374 Neoplasms, Experimental resveratrol 3.568985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.0712497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2817289903
MESH:D009401 Nephrosis Doxorubicin 4.3216899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.0318481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.0315640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 13.8611399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 13.8616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.8614600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.1718462866
MESH:D009436 Neural Tube Defects Folic Acid 6.6317438019
MESH:D009436 Neural Tube Defects Valproic Acid 6.6316359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.0215555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3020387270
MESH:D019636 Neurodegenerative Diseases resveratrol 7.3017652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.9817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6520387270
MESH:D009503 Neutropenia Folic Acid 13.2616322990
MESH:D009503 Neutropenia Mustard Gas 13.267688884 16761898
MESH:D009503 Neutropenia Vinblastine 13.2617378895
MESH:D009765 Obesity Curcumin 4.3419297423
MESH:D009765 Obesity Dietary Fats 4.3421332399 20518802 17217161 18674790 16723640 18457598 20132043 19632207 11836018
MESH:D010018 Osteomalacia Phenobarbital 3.9117016548
MESH:D010024 Osteoporosis Curcumin 3.1918719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.8417513867
MESH:D012516 Osteosarcoma Doxorubicin 3.7515930896
MESH:D010049 Ovarian Diseases bisphenol A 4.5311985600
MESH:D010051 Ovarian Neoplasms Curcumin 7.0018462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 7.0019401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.0017393432 16525653
MESH:D010146 Pain acetorphan 5.303519939
MESH:D010190 Pancreatic Neoplasms Curcumin 14.4019196508 19401701 17440100
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 14.4016540662
MESH:D010190 Pancreatic Neoplasms Mitomycin 14.4015113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 14.4016965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 14.4015976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.8512065085 18404319 18922899 8330346
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7812520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6917983394
MESH:D010954 Plasmacytoma Selenium 4.4215087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6917638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.1012224865 11605937
MESH:D011041 Poisoning Mustard Gas 3.3815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1318163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.0612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.062563599
MESH:D011230 Precancerous Conditions Phenobarbital 13.062563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 19.5210548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 19.5216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.5211222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 19.5220603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.2020887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.2020887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17173048
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0217292933
MESH:D011471 Prostatic Neoplasms bicalutamide 2.0219240160 17914592 15638997 18487222 19011039
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0216740699
MESH:D011471 Prostatic Neoplasms Curcumin 2.0211398177 15129424 18769126 18156803 10851300 12497104 18226269
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0216888761 18437689 15749863 16729912 16868541 15897917
MESH:D011471 Prostatic Neoplasms Estradiol 2.0216740699
MESH:D011471 Prostatic Neoplasms resveratrol 2.0217718901 17804756 16731767 17636462 15767336 17675339
MESH:D011537 Pruritus Betamethasone 9.0818058305
MESH:D011537 Pruritus Mustard Gas 9.0818058305
MESH:D019310 Pseudolymphoma Phenobarbital 10.6512752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.6512752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.0616882103
MESH:D011629 Puberty, Precocious bisphenol A 4.3310548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.1319168576
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7410334151 17266442 17894541 17620002 17720292
MESH:D051437 Renal Insufficiency marker/mechanism 10485324
MESH:D051437 Renal Insufficiency Doxorubicin 9.0417922066
MESH:D051437 Renal Insufficiency Folic Acid 9.0415728788
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1216325855
MESH:D015427 Reperfusion Injury resveratrol 3.0417520802 16314181 17058453 16317513 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.6110666014 18379247
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4310835634
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.1818410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4118990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.7619155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6818045962
MESH:D012509 Sarcoma Curcumin 8.2618462866
MESH:D012509 Sarcoma Doxorubicin 8.2616767912 17203757 15625365 15675481 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.8114601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3417846226
MESH:D012559 Schizophrenia Folic Acid 3.6116641680
MESH:D012559 Schizophrenia Valproic Acid 3.6115737665 19110320
MESH:D012640 Seizures Phenobarbital 4.973137016 4039156 16876388 11442880
MESH:D012640 Seizures Valproic Acid 4.973137016 17978042 14763951 16876388 11044598 15475178 1511512 11738929
MESH:D003294 Seizures, Febrile Phenobarbital 4.376407741
MESH:D018805 Sepsis Curcumin 3.7018389075
MESH:D012871 Skin Diseases Folic Acid 4.8718709164
MESH:D012871 Skin Diseases Mustard Gas 4.8716961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 23.6910029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 23.6915692506
MESH:D012878 Skin Neoplasms resveratrol 23.6915837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 23.698532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 23.6916192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 23.698330346 11807781 18404319 8985016 12065085
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 23.6918590791
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1215625365 17203757 16767912
MESH:D013118 Spinal Cord Diseases Folic Acid 5.0416361298
MESH:D013119 Spinal Cord Injuries Progesterone 3.8316503802 15862959
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.0812833885
MESH:D013272 Stomach Diseases phosphoramidon 5.5416280098
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.1520155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.1518456281
MESH:D013274 Stomach Neoplasms Folic Acid 3.1517171786
MESH:D013276 Stomach Ulcer Curcumin 6.8319188055 16631530
MESH:D013276 Stomach Ulcer phosphoramidon 6.8311145282
MESH:D020521 Stroke Folic Acid 3.9716517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0816321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.5316684133 16045194
MESH:D024801 Tauopathies Betamethasone 6.1916930453
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.7715821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.017505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 10.0116010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.011399818
MESH:D013978 Tibial Fractures Estradiol 4.2219048282
MESH:D014062 Tongue Neoplasms resveratrol 3.8216227395
MESH:D014178 Translocation, Genetic Valproic Acid 4.7717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.073119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.3817053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 10.3818593936
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 10.3817653716
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 10.3812846360
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.208888407
MESH:D014565 Urogenital Neoplasms Curcumin 4.8118462866
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.7117473185
MESH:D014591 Uterine Diseases bisphenol A 4.5414652134
MESH:D014594 Uterine Neoplasms resveratrol 3.7117044934
MESH:D014605 Uveitis Cyclosporine 3.521336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.6015577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1312125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.8717334414 17678736 17638931 16364871
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.8717488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7815886252
MESH:D015430 Weight Gain Dietary Fats 3.3616723640
MESH:D014985 Xerophthalmia Cyclosporine 3.9817120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:04640 Hematopoietic cell lineage
KEGG:04974 Protein digestion and absorption
KEGG:04614 Renin-angiotensin system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30864
    • Releated gene ID Related gene Name
    PA24910APP
    Releated disease ID Related disease Name
    PA443803Cough
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443319Alzheimer Disease
    Releated drug ID Related drug Name
    PA164712308Ace Inhibitors, Plain
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00616 inhibitor Candoxatril Antihypertensive Agents;Protease Inhibitors;Prodrugs
    DB01654 inhibitor Thiorphan Antihypertensive Agents;Protease Inhibitors;Vasodilator Agents;Anti-Arrhythmic Agents
    DB02062 - N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine
    DB02557 inhibitor Phosphoramidon Anti-Bacterial Agents;Protease Inhibitors
    DB02558 - N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine
    DB02597 - [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala
    DB08575 - 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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