AutismKB 2.0

Annotation Detail for MMP8


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Basic Information Top
Gene Symbol:MMP8 ( CLG1,HNC,MMP-8,PMNL-CL )
Gene Full Name: matrix metallopeptidase 8 (neutrophil collagenase)
Band: 11q22.2
Quick LinksEntrez ID:4317; OMIM: 120355; Uniprot ID:MMP8_HUMAN; ENSEMBL ID: ENSG00000118113; HGNC ID: 7175
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1843Metastasis to lymph nodes
2243Bronchiolitis obliterans
1730Disseminated cancer
1904Diabetes mellitus
1918Atherosclerosis
1944Breast cancer
1968Bacterial vaginosis
2041Myelofibrosis
2073Bronchiectasis
2077Sinusitis
2256Aortic aneurysm
Desease Name
CANCER
bladder cancer
overall effect
REPRODUCTION
premature rupture of membranes
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C025205 1,10-phenanthroline 1,10-phenanthroline results in decreased activity of MMP8 proteindecreases activity 15057751
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of MMP8 mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen affects the expression of MMP8 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of MMP8 mRNAincreases expression 18544908
D000537 Aluminum Oxide Aluminum Oxide results in decreased expression of MMP8 mRNAdecreases expression 19464052
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MMP8 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of MMP8 mRNAaffects expression 19654921
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MMP8 mRNAincreases expression 16508911
15056808
D004318 Doxycycline Doxycycline analog results in decreased activity of MMP8 proteindecreases activity 17267227
D004492 Edetic Acid Edetic Acid results in decreased activity of MMP8 proteindecreases activity 15057751
C529593 EMD 527040 EMD 527040 results in increased expression of MMP8 mRNAincreases expression 18221819
D005419 Flavonoids Flavonoids results in decreased expression of MMP8 mRNAdecreases expression 18035473
D007213 Indomethacin Indomethacin results in increased activity of MMP8 proteinincreases activity 17000239
C484027 oligofectamine oligofectamine results in increased expression of MMP8 mRNAincreases expression 14668052
D010100 Oxygen [Paraquat co-treated with Oxygen] results in decreased expression of MMP8 mRNAaffects cotreatment|decreases expression 12882763
D010126 Ozone Ozone results in increased expression of MMP8 mRNAincreases expression 17460151
D010269 Paraquat Paraquat results in increased expression of MMP8 mRNAincreases expression 17215068
D010269 Paraquat [Paraquat co-treated with Oxygen] results in decreased expression of MMP8 mRNAaffects cotreatment|decreases expression 12882763
D010634 Phenobarbital Phenobarbital results in increased expression of MMP8 mRNAincreases expression 12832660
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MMP8 mRNAaffects binding|decreases expression|increases activity 19710929
C113282 prinomastat prinomastat results in decreased activity of MMP8 proteindecreases activity 17267227
D013752 Tetracycline Tetracycline analog results in decreased activity of MMP8 proteindecreases activity 17267227
C117153 tetracycline CMT-8 tetracycline CMT-8 results in decreased expression of MMP8 proteindecreases expression 11172683
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MMP8 mRNAaffects cotreatment|affects expression 16979875
D013853 Thioacetamide POMC protein alternative form promotes the reaction [Thioacetamide results in increased expression of MMP8 mRNA]increases expression|increases reaction 16511523
D013853 Thioacetamide Thioacetamide results in increased expression of MMP8 mRNAincreases expression 16511523
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MMP8 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.276195326
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000169 Acrodermatitis Zinc 5.2316889938 17190629 17202136
MESH:D055371 Acute Lung Injury Oxygen 8.6916759491
MESH:D055371 Acute Lung Injury pirinixic acid 8.6918653653
MESH:D000230 Adenocarcinoma Indomethacin 2.7416537180
MESH:D000236 Adenoma Indomethacin 3.3511497255
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.5417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.5416434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0417306315
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5911874814
MESH:D016301 Alveolar Bone Loss Indomethacin 5.2017225004
MESH:D000544 Alzheimer Disease Indomethacin 6.5317627676 15579461
MESH:D000544 Alzheimer Disease Ozone 6.5315513908
MESH:D000544 Alzheimer Disease Zinc 6.5316410023 17119284 16580781 16325427
MESH:D000755 Anemia, Sickle Cell Zinc 4.7316916123
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D000860 Anoxia Oxygen 4.8820872349
MESH:D001014 Aortic Aneurysm Indomethacin 4.6810231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.7010388637
MESH:D020261 Arsenic Poisoning Arsenic 2.8216835338 18414634 12569548 16251483
MESH:D018771 Arthralgia Indomethacin 5.002160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.7311248219
MESH:D001172 Arthritis, Rheumatoid Ozone 4.7315570426
MESH:D001249 Asthma Ozone 5.0017854713 16373670
MESH:D001249 Asthma Zinc 5.0017085522
MESH:D050197 Atherosclerosis Arsenic 6.7519371607 12928151
MESH:D050197 Atherosclerosis Oxygen 6.7516391483
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001477 Bartter Syndrome Indomethacin 4.8110684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.6619483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 8.6619483382
MESH:D001929 Brain Edema Indomethacin 4.8511481608
MESH:D001930 Brain Injuries Zinc 4.5217109824
MESH:D002545 Brain Ischemia Indomethacin 4.2512524144
MESH:D001943 Breast Neoplasms Indomethacin 2.7817401462
MESH:D001943 Breast Neoplasms Oxygen 2.7817263869
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5418417511 16777450 18315731 17626835 15516495 19059883 14754758
MESH:D002056 Burns Indomethacin 4.5310459503
MESH:D002100 Cachexia Indomethacin 11.8215141370 15625704 11239499 16537180
MESH:D002100 Cachexia Ozone 11.8216183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6115721981 16192424 16227642 16050911 15673190 16124888 18705752 3786805 15700767 10355542 16011737 16097048
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5015504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.033084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 11.0317306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.0318788625
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 11.0316391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.0317173139 6705139 20007298 1701930 20935162
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 11.0317997003
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.5511053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.1811352223 14736730 18791128
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.2917341418
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.4815504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.4815482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 10.4818922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 10.4816543248
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.9318640142
MESH:D002318 Cardiovascular Diseases Arsenic 7.2415738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases Zinc 7.2416936243
MESH:D002340 Carotid Artery Diseases Arsenic 4.1616973168 18022660
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.084080065
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.1418291259
MESH:D002764 Cholecystitis Indomethacin 5.0011181007
MESH:D002779 Cholestasis pirinixic acid 2.7019176532
MESH:D003110 Colonic Neoplasms Indomethacin 2.5611260862 15936596 15963497 15786552 15637740 15625704
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3517054584 11197048 12606626 18059344
MESH:D018352 Coronavirus Infections Indomethacin 5.5417302372
MESH:D019465 Craniofacial Abnormalities Zinc 2.4219302082
MESH:D003715 Dengue Doxycycline 5.8917502914
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003920 Diabetes Mellitus Zinc 4.0616479319
MESH:D003967 Diarrhea Indomethacin 3.637237001 7907874
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.6216393943 19739265 16781746 19416960 12392966 18071297 19420014 16227642 11529661 11834606 12705907 2444490 16485898 15968718 18713872 16177239 10663392 12958197 17562736 19085960 19370779 10915739 10774834 17906064 14725611 11287661 11743745 16081117 14550746 11461765 15619225 14986274 12540782 16109766 11739529 12594235 12153990 11421492 19164858 17522070 19923254
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.6215998439 21278145 15968718 2869522 16177239 10915739 3786805 6884620 10092053 7179309 3732212 16227642 15027814 4309450 19085960 17522070 11566570 7440962 6623471 9327722 19336974 7120509
MESH:D056486 Drug-Induced Liver Injury Tetracycline 8.6217522070
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.6212963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.9818446180 16133044 16326151 18043480 17190690 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 3.9711535926 11991626 17329845 17202747 17045617 10671773 17151854 11595431 17351913 11595415 16699067
MESH:D004417 Dyspnea Oxygen 4.6620016425
MESH:D004421 Dystonia Phenobarbital 3.841851702
MESH:D004487 Edema Indomethacin 10.7216100529 10653021 7907874 19703484 8273558 8985016 7990266
MESH:D004487 Edema pirinixic acid 10.7212083418
MESH:D004487 Edema Tetradecanoylphorbol Acetate 10.729599246 7812673 8113982 15177302 8273558 11698051 16716910
MESH:D004715 Endometriosis Indomethacin 3.9915652904
MESH:D019446 Endotoxemia Indomethacin 4.3318509659
MESH:D004751 Enteritis Indomethacin 4.5710567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.8117980183
MESH:D004802 Eosinophilia Indomethacin 3.8811298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.943659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.7011558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.8020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.406401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.087750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.853659116
MESH:D004938 Esophageal Neoplasms Indomethacin 4.7811005569
MESH:D004938 Esophageal Neoplasms Zinc 4.7816543248
MESH:D005218 Fat Necrosis Thioacetamide 5.5516456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.3112795759 61145 12631006 16239168 16045604 17595544 19224547 15959796
MESH:D005234 Fatty Liver pirinixic acid 12.3120131406 19236843
MESH:D005234 Fatty Liver Tetracycline 12.3119224547 16917069
MESH:D005334 Fever Indomethacin 3.9711852909 10431976 17627676
MESH:D005354 Fibrosarcoma Indomethacin 4.7210962813
MESH:D005355 Fibrosis Carbon Tetrachloride 8.4418705752
MESH:D005355 Fibrosis Indomethacin 8.4417994277
MESH:D005499 Folliculitis Indomethacin 5.0011298111
MESH:D005534 Foot Diseases Arsenic 5.396392382
MESH:D005739 Gas Poisoning Oxygen 5.0520016425
MESH:D005756 Gastritis Acetaminophen 18.0716983495
MESH:D005756 Gastritis Indomethacin 18.0715046732
MESH:D005756 Gastritis Zinc 18.0717241300
MESH:D005909 Glioblastoma Indomethacin 3.4512870263
MESH:D005910 Glioma Indomethacin 3.1616487511 18371953
MESH:D005911 Gliosis Paraquat 4.9911124998
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1511849393
MESH:D006073 Gout Indomethacin 5.1811248219
MESH:D006130 Growth Disorders Zinc 3.8517217573
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.6315482327
MESH:D006333 Heart Failure pirinixic acid 6.8020558911
MESH:D006333 Heart Failure Zinc 6.8017162251
MESH:D006335 Heart Injuries Zinc 5.6017074742
MESH:D016481 Helicobacter Infections Zinc 4.3717241300
MESH:D006501 Hepatic Encephalopathy Indomethacin 10.4215633222
MESH:D006501 Hepatic Encephalopathy Thioacetamide 10.4218665440 15929193 17276928
MESH:D006505 Hepatitis Carbon Tetrachloride 8.9319110552 19900420
MESH:D006505 Hepatitis Thioacetamide 8.9316456712
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.5215135802
MESH:D006527 Hepatolenticular Degeneration Zinc 4.5217276780
MESH:D006529 Hepatomegaly Phenobarbital 7.9116109766
MESH:D006529 Hepatomegaly pirinixic acid 7.9118467677 16221962 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 7.3816870215
MESH:D006930 Hyperalgesia Indomethacin 7.3812727271
MESH:D034321 Hyperamylasemia Indomethacin 5.5417883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006940 Hyperemia Indomethacin 4.8312524144
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3017050553
MESH:D006949 Hyperlipidemias Indomethacin 4.0017546600
MESH:D006973 Hypertension Arsenic 2.819931084 16076760 11953799
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D006987 Hypesthesia Arsenic 5.3916093927
MESH:D007077 Ileal Diseases Indomethacin 4.8518306037 10574470
MESH:D007079 Ileitis Indomethacin 5.1816133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.2016133044
MESH:D007248 Infertility, Male Paraquat 3.144850670
MESH:D007249 Inflammation Flavonoids 8.0417296493
MESH:D007249 Inflammation Indomethacin 8.047812673 12568917 3291741
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 8.047562506 7812673 11698051 8273558 15177302
MESH:D007333 Insulin Resistance pirinixic acid 2.5216306350
MESH:D007410 Intestinal Diseases Indomethacin 4.1617994277 11686837 15610444 11713966 10210152 15831440 11855677 17329856 18236018
MESH:D019586 Intracranial Hypertension Indomethacin 5.2015241188
MESH:D007511 Ischemia Zinc 4.4616584753
MESH:D007579 Jejunal Diseases Indomethacin 4.8510574470 16133968 18306037
MESH:D007642 Keratosis Arsenic 4.8216930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 9.6312587719 15629191
MESH:D007674 Kidney Diseases Indomethacin 9.6317190690
MESH:D007674 Kidney Diseases Zinc 9.6316960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.2616518626
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.7611703811 12228301 10320625
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.8016572323 15631656 10785260
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6118360721
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4417339181
MESH:D007964 Leukocytosis Indomethacin 5.2016537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.5417980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.5411479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.8417157831 16943688 16239168 11408273 17174718 11903743 21278145 17334410 16221502
MESH:D008103 Liver Cirrhosis EMD 527040 10.8418221819
MESH:D008103 Liver Cirrhosis Phenobarbital 10.8421047994
MESH:D008106 Liver Cirrhosis, Experimental therapeutic 15057751
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.8312667390 14716496 16011737 17714472 16097048 12546737 18418968 18210741 15876570 12666154 18277467 17823541 18166357 14512876 18156304 15370692 15362042 12632514 15996030 15338365 14716833 17708605 18187930 15818738 18429990 17761835 15123356 16248980 17565644 17698563 15893842 15673190 17944888 18472094 15052691 12389079 15057751 16136751 17640975 17805973 16033810 12898905 17525996 15730626 14748882 18054572 12586293 13678700 12609069 18006644 18420326 15931870 10355542 17869086 16116963 15925388 17631135 17557913 16192424 17922224 17976157 12445418 12741479 18205269 18481824 17481882 15650968 18395914 11481614 18251166 18279442 18376398 18472332 16638106 18263696 12649538 17721639 18412020 18317297 14620537 16027843 16015684 18339082 18395095 17900296 12958196 18705752 15959796 14724832 20821823 17766677 12632512 12445421
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.8318194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8315474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.8318032466 12175628 15316131 17629604 11172339 18263696 11682029 12891558 15078482 17127702 15288472 18395095 15158331 15095483 16097051 12531686 15716488 14739098 18458672 15362042 17292413 15334695 16343077 18416461 18031379 12085344 16489207 16098781 16248980 16511523 18380797 18615449 10677585 18295389 17355460 11481614 16126171 17050028 15288473 12557150 18606216 15465738 15474484 12679928 15075984
MESH:D008107 Liver Diseases Acetaminophen 12.0516610002 19014921 19460945 12969438 12587719 16611625 11587558 19784758
MESH:D008107 Liver Diseases Arsenic 12.0511134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 12.0517285989 16246199 15720792 15830285 16964402
MESH:D008107 Liver Diseases Phenobarbital 12.0519363144
MESH:D008107 Liver Diseases Thioacetamide 12.0515158337 18374380 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.3816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.3816899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 15.3812479984 15313186 17276928 15633222
MESH:D008113 Liver Neoplasms Arsenic 10.1816368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.1819294768
MESH:D008113 Liver Neoplasms Phenobarbital 10.1819073162 19812893 15975961 21047994 19482888 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 10.1820007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.6315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.632563599 18308698 6150874 17172636 1399818
MESH:D008171 Lung Diseases Ozone 3.2619066396 8266340
MESH:D055370 Lung Injury Oxygen 8.8618339021
MESH:D055370 Lung Injury Ozone 8.8620417186
MESH:D008175 Lung Neoplasms Arsenic 4.7917306315 17976673 19168569
MESH:D008175 Lung Neoplasms Indomethacin 4.7911497255 11053908 16537180
MESH:D008175 Lung Neoplasms Ozone 4.797614698 8597069
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 4.7911807781
MESH:D008223 Lymphoma Doxycycline 4.9520133848
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 6.158985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 6.1512773700
MESH:D008545 Melanoma therapeutic 19330028
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008679 Metaplasia Ozone 4.9310496685
MESH:D008881 Migraine Disorders Indomethacin 3.5511903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.8612636206
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Arsenic 3.8515371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3017484760
MESH:D009362 Neoplasm Metastasis Indomethacin 3.1016537180 11239499 11053908
MESH:D009369 Neoplasms pirinixic acid 1.8717405874
MESH:D009374 Neoplasms, Experimental Indomethacin 3.9710663608 15625704
MESH:D009395 Nephritis, Interstitial Tetracycline 4.619884423
MESH:D009410 Nerve Degeneration Paraquat 3.5816893418
MESH:D009436 Neural Tube Defects Arsenic 3.3416620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9418514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.9412349958
MESH:D020078 Neurogenic Inflammation Arsenic 4.2117056641
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.006374098
MESH:D010003 Osteoarthritis Doxycycline 8.0517267227
MESH:D010003 Osteoarthritis Indomethacin 8.057009135
MESH:D010018 Osteomalacia Phenobarbital 4.1917016548
MESH:D010051 Ovarian Neoplasms Arsenic 2.6917306315
MESH:D010146 Pain Acetaminophen 6.3316870215
MESH:D010146 Pain Indomethacin 6.3317440234 13679232 3291741 17627676
MESH:D010149 Pain, Postoperative Indomethacin 4.5118702446 12538197
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3216965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.3215976015
MESH:D010195 Pancreatitis Indomethacin 3.7617883296 15028970
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.1212065085 18404319 18922899 8330346
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.5416537180
MESH:D010300 Parkinson Disease Paraquat 2.7511181820 15451049 12911755 16510128 11124998 11445065 16140633 15824117
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.2616190885
MESH:D020734 Parkinsonian Disorders Indomethacin 3.9712349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.5411903285
MESH:D010391 Pemphigoid, Bullous Doxycycline 13.1611026799
MESH:D010391 Pemphigoid, Bullous Tetracycline 13.1611026799
MESH:D010437 Peptic Ulcer Indomethacin 4.9811148446
MESH:D010518 Periodontitis Indomethacin 4.7417225004
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.826392382 15371236 16905509
MESH:D010538 Peritonitis Ozone 3.9616369182
MESH:D011014 Pneumonia Ozone 10.4918007984 18929643 18381685
MESH:D011014 Pneumonia Paraquat 10.4912504350
MESH:D011230 Precancerous Conditions Phenobarbital 3.482563599
MESH:D011225 Pre-Eclampsia Zinc 4.0417114810
MESH:D047928 Premature Birth Indomethacin 4.9617000239
MESH:D017096 Prion Diseases Tetracycline 5.2410903871
MESH:D011471 Prostatic Neoplasms Arsenic 3.6716140617
MESH:D011471 Prostatic Neoplasms Zinc 3.6716700911 12429649 16606632 16517595
MESH:D011507 Proteinuria Arsenic 8.9521343184
MESH:D011507 Proteinuria Indomethacin 8.9511849393
MESH:D019310 Pseudolymphoma Phenobarbital 4.3212752131
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8516324872 17997886
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 8.9117627322 18339021
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 8.9111700416
MESH:D012135 Respiratory Sounds Paraquat 3.8911874814
MESH:D012162 Retinal Degeneration Paraquat 8.7716458197
MESH:D012162 Retinal Degeneration Zinc 8.7716584753
MESH:D012640 Seizures Phenobarbital 2.583137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.656407741
MESH:D012871 Skin Diseases Arsenic 2.7019834688 17938729 17050553 17453740 16702368 6392382 16759981 18709164 16353154 17548696 15952646
MESH:D012878 Skin Neoplasms Arsenic 5.9017029826 17050553 17976673 19538983 16251483 15504454
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 5.908330346 8985016 18404319 11807781 12065085
MESH:D013272 Stomach Diseases Indomethacin 4.2510192188 17207306 16113693 15472012 10486359 15038085 17638125 17160473 16280098 16184426 18545984 10215738 18209964
MESH:D013274 Stomach Neoplasms Indomethacin 2.3515609394
MESH:D013276 Stomach Ulcer Indomethacin 3.4318543354 11145282 11595431 18087811 15104355 17657623 10423059 14567935 11906479 11595415 17977527 12467913 18209962 16150113 10878458 16169175 18431645 18181030 16755016 16934674 17627676 12500499 1323529 18237397 17895592 11523592 10750652 18299717 16631530 11729361 17135157 18726076 17918041 18193104 16397915 17654042 12077510 12787963 15138204 16252198 15255614 12498302
MESH:D013398 Sudden Infant Death Oxygen 5.3712563064
MESH:D013964 Thyroid Neoplasms Indomethacin 6.9714736730 18791128 11352223
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.971399818
MESH:D014062 Tongue Neoplasms Zinc 4.2516543248
MESH:D014456 Ulcer Indomethacin 4.7217380554 10574470
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.7519429237 17976673 18640142 11144890 17306315 19322015 15987713
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D014652 Vascular Diseases Arsenic 4.5617056641
MESH:D014839 Vomiting Indomethacin 4.5711897121
MESH:D014947 Wounds and Injuries marker/mechanism 11172683
MESH:D014947 Wounds and Injuries tetracycline CMT-8 5.6611983005 11172683
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00786 antagonist Marimastat Antineoplastic Agents;Enzyme Inhibitors
DB02326 - 1-Hydroxyamine-2-Isobutylmalonic Acid
DB02953 - 2-Thiomethyl-3-Phenylpropanoic Acid
DB03207 - 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid
DB03622 - 2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperidin-1-Yl]-5-Phenyl-1h-Pyrimidine-4,6-Dione
DB03636 - Glycinamid
DB03880 - Batimastat Antineoplastic Agents;Protease Inhibitors
DB06971 - N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREA
DB07397 - (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide
DB07713 - (1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID
DB07772 - (1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID
DB07900 - 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE
DB07904 - 2-HYDROXYCARBAMOYL-4-METHYL-PENTANOIC ACID
DB08028 - BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE
DB08403 - METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID
DB08476 - 3-AMINO-AZACYCLOTRIDECAN-2-ONE
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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