AutismKB 2.0

Annotation Detail for LHX8


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Basic Information Top
Gene Symbol:LHX8 ( Lhx7 )
Gene Full Name: LIM homeobox 8
Band: 1p31.1
Quick LinksEntrez ID:431707; OMIM: 604425; Uniprot ID:LHX8_HUMAN; ENSEMBL ID: ENSG00000162624; HGNC ID: 28838
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2121Ovarian failure
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LHX8 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LHX8 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in increased expression of LHX8 mRNAincreases expression 20106945
D009151 Mustard Gas Mustard Gas results in increased expression of LHX8 mRNAincreases expression 15674843
C105686 SU 5402 SU 5402 results in decreased expression of LHX8 mRNAdecreases expression 15355794
D014212 Tretinoin Tretinoin results in increased expression of LHX8 mRNAincreases expression 16000160
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Mustard Gas 5.2410378619
MESH:D001249 Asthma Tretinoin 5.2416456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001768 Blister Mustard Gas 5.6219167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9316206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2416166294 16873071 16443354
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.6215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.5017687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.2021507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.201917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3616096774 16051514
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 8800419 17551590 9125849 16925845 9664655 9224671 9142499 9211117 14991402
MESH:D004487 Edema Mustard Gas 3.6311428631 9260866 11402378 11428647
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D004890 Erythema Mustard Gas 5.629357497
MESH:D005124 Eye Abnormalities Tretinoin 3.8116938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005355 Fibrosis Cyclosporine 10.1212168785 12639820
MESH:D005355 Fibrosis Tretinoin 10.1217994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.049664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007249 Inflammation Mustard Gas 2.9216001271 11428631 11428620 9357497 8975870 11402378 9260866 11428647 17524151
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2317551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3416766008 17712046 17217047 19642359 17301526 16788101 19225113 9834237 16331271 17107899 15748426 17361223 16140955 17649720 16935935 16891316 17506722 19075265 12679006 19035177 19029980 17294898 17368321 17339181 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.442125692 15890375 9163691 18177683
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.928603461
MESH:D008171 Lung Diseases Mustard Gas 3.6518702808 18161513
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.7114755239
MESH:D008175 Lung Neoplasms Mustard Gas 2.713148597 8781369
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009369 Neoplasms Tretinoin 2.5416594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D009503 Neutropenia Mustard Gas 4.327688884 16761898
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Tretinoin 3.1616870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5515976015
MESH:D011041 Poisoning Mustard Gas 4.1515727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011537 Pruritus Mustard Gas 4.5518058305
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0217620002 17894541 10334151 17266442 17720292
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516283617 16116481
MESH:D012871 Skin Diseases Mustard Gas 2.7816961503 12880345 15451306
MESH:D012878 Skin Neoplasms Tretinoin 2.7316467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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