AutismKB 2.0

Annotation Detail for MMP15


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MMP15 ( MT2-MMP,MTMMP2,SMCP-2 )
Gene Full Name: matrix metallopeptidase 15 (membrane-inserted)
Band: 16q21
Quick LinksEntrez ID:4324; OMIM: 602261; Uniprot ID:MMP15_HUMAN; ENSEMBL ID: ENSG00000102996; HGNC ID: 7161
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MMP15 mRNAaffects expression 17562736
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of MMP15 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of MMP15 mRNAaffects cotreatment|increases expression 18585445
D002945 Cisplatin Cisplatin results in increased expression of MMP15 mRNAincreases expression 12066199
D004041 Dietary Fats Dietary Fats results in increased expression of MMP15 mRNAincreases expression 18042831
D004958 Estradiol Estradiol results in decreased expression of MMP15 mRNAdecreases expression 15072547
C070081 fulvestrant fulvestrant results in increased expression of MMP15 mRNAincreases expression 15072547
D019833 Genistein Genistein results in decreased expression of MMP15 mRNAdecreases expression 15754008
C031927 hydroquinone hydroquinone affects the expression of MMP15 mRNAaffects expression 15452088
C475919 hydroxytamoxifen hydroxytamoxifen results in decreased expression of MMP15 mRNAdecreases expression 15072547
C041786 palm oil palm oil results in increased expression of MMP15 mRNAincreases expression 18042831
D012643 Selenium Selenium results in decreased expression of MMP15 mRNAdecreases expression 17390030
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of MMP15 mRNAincreases expression 17982090
D014415 Tunicamycin Tunicamycin results in decreased expression of MMP15 mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.0115814532 12690470 17670903
MESH:D000230 Adenocarcinoma Cisplatin 7.2711798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 7.2711473722
MESH:D000230 Adenocarcinoma Genistein 7.2711473722
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.3111874814
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.9615238619
MESH:D001284 Atrophy fulvestrant 4.9111514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.9814601052
MESH:D001943 Breast Neoplasms Cisplatin 2.3819526202 18382427
MESH:D001943 Breast Neoplasms Dietary Fats 2.3820435547
MESH:D001943 Breast Neoplasms Estradiol 2.3819861407 17289903 18497071 12948864 17018787 17261762 16675129 14630087
MESH:D001943 Breast Neoplasms fulvestrant 2.3818984771
MESH:D001943 Breast Neoplasms Genistein 2.3817200150 16541309 16873071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.663084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.6617982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6616924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6616924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0516685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.836189445 17066447 18337622
MESH:D002318 Cardiovascular Diseases Genistein 3.3416332659
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8118566989
MESH:D003092 Colitis Selenium 10.0517936198
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 10.0518200517 16804969 17936198 18023891 16867261 16782535 17991707 16474422 11698051
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4617276891
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5016647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8416177239 11743745 19739265 2444490 17522070 14550746 11287661 19370779 12958197 12392966 11834606 16393943 16081117 19164858 16227642 11739529 16109766 11529661 15619225 16485898 11461765 17562736 19416960 19923254 11421492 12540782 14725611 12705907 16781746 19420014 19085960 12153990 15968718 18713872 14986274 18071297 17906064 12594235 10915739 10663392 10774834
MESH:D056486 Drug-Induced Liver Injury Selenium 3.8415131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Cisplatin 3.8912231392 15033597 12649298 19839026
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004714 Endometrial Hyperplasia Genistein 4.6716402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.6211473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 7.6211473722
MESH:D004938 Esophageal Neoplasms Cisplatin 2.7915464296 17638652 15173087 16785472 16481741
MESH:D005234 Fatty Liver Dietary Fats 3.2919551842 17967931 18296743 19004024
MESH:D005355 Fibrosis Dietary Fats 9.3818296743
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 9.3817994277
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005909 Glioblastoma Genistein 3.2916598420
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.7515102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.3419898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4615464296
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D006689 Hodgkin Disease Cisplatin 3.6416170182 16200630
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D007248 Infertility, Male Atrazine 7.4912948887
MESH:D007248 Infertility, Male fulvestrant 7.4911514358
MESH:D007249 Inflammation Dietary Fats 2.4620412841
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.5918200517
MESH:D007251 Influenza, Human Selenium 4.2916624496
MESH:D007333 Insulin Resistance Dietary Fats 7.4811836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.4816627594 16393666
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.6817994277
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2415464296
MESH:D007674 Kidney Diseases Acetaminophen 10.2715629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 10.2719839026 12649298 15190930 18289764 12231392
MESH:D007674 Kidney Diseases Estradiol 10.2715618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms Estradiol 3.0215610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.8911231351
MESH:D007938 Leukemia Genistein 3.0517468513 18980019
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9018296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.5717823541
MESH:D008107 Liver Diseases Acetaminophen 1.6419460945 11587558 12969438 19784758 19014921 12587719 16611625 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008175 Lung Neoplasms Cisplatin 2.3317225452 11798837 6189445
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.2011807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.2014578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.2015318939
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008545 Melanoma Cisplatin 2.4812883367 17761969 15577323 16809738 18332650 16248763 18176117 16432458 11135225 18505091 12374674 17023156 12393984
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Atrazine 10.441916698
MESH:D008654 Mesothelioma Cisplatin 10.4417638057
MESH:D008654 Mesothelioma Selenium 10.4415107826
MESH:D009203 Myocardial Infarction Genistein 2.8817141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.6517141266
MESH:D009369 Neoplasms Cisplatin 2.9616773208
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.5915464296
MESH:D009421 Nervous System Malformations Estradiol 9.9816427766 11399458
MESH:D009421 Nervous System Malformations Genistein 9.9816427766
MESH:D009447 Neuroblastoma Cisplatin 3.478761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.788761367
MESH:D009765 Obesity Dietary Fats 2.3019632207 11836018 16723640 20132043 18457598 17217161 18674790 21332399 20518802
MESH:D010024 Osteoporosis Genistein 3.2819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1416169203
MESH:D010051 Ovarian Neoplasms Cisplatin 8.0617225452 19769630 15464296 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 8.0619401270
MESH:D010051 Ovarian Neoplasms Genistein 8.0619005980
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0119003803
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.2617698068
MESH:D010300 Parkinson Disease Atrazine 3.2917218051
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.3715464296
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.4417638057
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2816740699
MESH:D011471 Prostatic Neoplasms Genistein 3.2815256057 15378649 16925846
MESH:D051437 Renal Insufficiency Cisplatin 4.4815464296
MESH:D012135 Respiratory Sounds Atrazine 4.5911874814
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.4914601052
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4415464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.3317522103 15958060 18396642
MESH:D013736 Testicular Neoplasms Cisplatin 4.6915464296 17225452
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 2.9715464296 12973940 17225452
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.2616803524
MESH:D014625 Vaginal Neoplasms Cisplatin 4.6815577323
MESH:D014839 Vomiting Cisplatin 4.8111897121
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00786 antagonist Marimastat Antineoplastic Agents;Enzyme Inhibitors
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved