AutismKB 2.0

Annotation Detail for MMP16


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Basic Information Top
Gene Symbol:MMP16 ( C8orf57,DKFZp761D112,MMP-X2,MT-MMP2,MT-MMP3,MT3-MMP )
Gene Full Name: matrix metallopeptidase 16 (membrane-inserted)
Band: 8q21.3
Quick LinksEntrez ID:4325; OMIM: 602262; Uniprot ID:MMP16_HUMAN; ENSEMBL ID: ENSG00000156103; HGNC ID: 7162
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
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Desease IDDesease Name
1831Prostate cancer
2022Liver cancer
2237Neoplasm metastasis
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MMP16 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MMP16 mRNAincreases expression 15650781
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MMP16 proteinincreases expression 15650781
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of MMP16 mRNAaffects cotreatment|decreases expression 16054899
D002945 Cisplatin Cisplatin results in increased expression of MMP16 mRNAincreases expression 12066199
D005576 Forskolin Forskolin results in increased expression of MMP16 mRNAincreases expression 16751804
D019833 Genistein Genistein results in decreased expression of MMP16 mRNAdecreases expression 15754008
C071834 glycidamide glycidamide results in decreased expression of MMP16 mRNAdecreases expression 17822822
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of MMP16 mRNAaffects cotreatment|decreases expression 16054899
D018021 Lithium Chloride Lithium Chloride results in increased expression of MMP16 mRNAincreases expression 16609697
D015741 Metribolone Metribolone results in decreased expression of MMP16 mRNAdecreases expression 16751804
D015735 Mifepristone Mifepristone results in increased expression of MMP16 mRNAincreases expression 17584828
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of MMP16 mRNAaffects cotreatment|decreases expression 16054899
D012643 Selenium Selenium results in decreased expression of MMP16 mRNAdecreases expression 17390030
D014212 Tretinoin Tretinoin results in decreased expression of MMP16 mRNAdecreases expression 16609697
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D058186 Acute Kidney Injury Cisplatin 4.0115814532 12690470 17670903
MESH:D000230 Adenocarcinoma Cisplatin 4.7511798837 17638652
MESH:D000230 Adenocarcinoma Genistein 4.7511473722
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000544 Alzheimer Disease rosiglitazone 2.8619621015
MESH:D001169 Arthritis, Experimental Dexamethasone 7.6417659584
MESH:D001169 Arthritis, Experimental Tretinoin 7.6416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6616197459 16206674
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.9814601052
MESH:D001943 Breast Neoplasms Cisplatin 2.0219526202 18382427
MESH:D001943 Breast Neoplasms Genistein 2.0216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tretinoin 2.0216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8515721981 18705752 16227642 10355542 15700767 16011737 15673190 16050911 3786805 16097048 16124888 16192424
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6918788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.6917982673
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.691917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0512023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.9017066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9016051514 16096774
MESH:D002318 Cardiovascular Diseases Genistein 3.3416332659
MESH:D002386 Cataract Tretinoin 3.1217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tretinoin 2.699407595
MESH:D003092 Colitis Selenium 9.7417936198
MESH:D003092 Colitis Tretinoin 9.7417035595
MESH:D003110 Colonic Neoplasms Dexamethasone 3.9815824018
MESH:D003110 Colonic Neoplasms Genistein 3.9817182828
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.8417728286
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.849211117 16925845 14991402 17551590 10589399 9224671 9142499 9664655 9125849 8800419
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.4812438553
MESH:D003920 Diabetes Mellitus rosiglitazone 4.3517446233
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.8416647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.8412642470
MESH:D003967 Diarrhea Dexamethasone 3.767237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0117522070 3786805 4309450 7120509 15998439 6884620 6623471 10092053 19085960 7179309 15968718 15027814 2869522 19336974 16227642 3732212 21278145 11566570 10915739 9327722 7440962 16177239
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0115131321
MESH:D004362 Drug Toxicity Cisplatin 3.8912649298 15033597 19839026 12231392
MESH:D004485 Eczema Dexamethasone 4.5212438553
MESH:D004487 Edema Dexamethasone 7.5219703484
MESH:D004487 Edema rosiglitazone 7.5212083418
MESH:D004489 Edema, Cardiac Tretinoin 4.5618230668
MESH:D004714 Endometrial Hyperplasia Genistein 4.6716402032
MESH:D016889 Endometrial Neoplasms Genistein 7.6711473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6716569247
MESH:D004715 Endometriosis Mifepristone 4.4216134523
MESH:D004938 Esophageal Neoplasms Cisplatin 2.7915464296 16481741 15173087 17638652 16785472
MESH:D005124 Eye Abnormalities Tretinoin 3.629664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2919224547 15959796 16239168 12631006 16045604 12795759 61145 17595544
MESH:D005234 Fatty Liver rosiglitazone 8.2919196556
MESH:D005355 Fibrosis Carbon Tetrachloride 9.0518705752
MESH:D005355 Fibrosis Tretinoin 9.0517994277
MESH:D005909 Glioblastoma Genistein 7.3216598420
MESH:D005909 Glioblastoma Tretinoin 7.3217312396
MESH:D006258 Head and Neck Neoplasms Cisplatin 8.0315102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0316096774
MESH:D034381 Hearing Loss Cisplatin 4.3419898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4615464296
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9214991402 9664655
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619110552 19900420
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.097520565
MESH:D006689 Hodgkin Disease Cisplatin 3.6416170182 16200630
MESH:D006869 Hydronephrosis Lithium Chloride 6.1119797860
MESH:D006930 Hyperalgesia rosiglitazone 8.2212083418
MESH:D006930 Hyperalgesia Tretinoin 8.2216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006973 Hypertension Dexamethasone 2.9517042910
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.5418306037
MESH:D007249 Inflammation Dexamethasone 5.648960868 11099482
MESH:D007249 Inflammation rosiglitazone 5.6412083418
MESH:D007251 Influenza, Human Selenium 4.2916624496
MESH:D007333 Insulin Resistance rosiglitazone 3.8316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9515992940 17551590
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.5418306037
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2415464296
MESH:D007674 Kidney Diseases Cisplatin 3.2719839026 12649298 12231392 15190930 18289764
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.8911231351
MESH:D007938 Leukemia Genistein 6.5017468513 18980019
MESH:D007938 Leukemia Tretinoin 6.5017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7516482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0819850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1917339181 17361223 16140955 16823087 19029980 16788101 15748426 17649720 17368321 19035177 16331271 17107899 12679006 17294898 19225113 19642359 16766008 17712046 17217047 19075265 17506722 9834237 16935935 16891316 17301526
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8321278145 11903743 16943688 17174718 11408273 17157831 16239168 16221502 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.8418395095 15338365 11481614 15818738 15959796 15931870 15876570 12666154 13678700 18006644 16192424 16136751 12609069 17823541 18263696 18054572 12667390 17698563 12586293 17714472 18339082 17922224 18429990 18210741 18481824 14512876 18187930 16638106 16033810 15925388 18156304 18317297 12445421 12389079 14724832 15370692 17640975 16248980 18418968 16116963 10355542 16015684 17708605 12546737 18279442 14716496 20821823 18395914 15650968 18376398 15996030 18166357 17525996 14620537 18205269 12445418 16027843 18251166 12741479 18277467 12958196 17557913 17900296 17565644 17721639 15057751 17976157 18472094 12632512 12649538 15362042 12898905 15123356 18472332 16011737 17869086 18420326 17944888 17631135 17805973 17766677 17481882 16097048 14748882 15893842 18705752 17761835 18412020 15052691 12632514 14716833 15673190 15730626
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.8416718785
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.8417823541
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 6.8417347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.8418397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0916246199 17285989 16964402 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.2419294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6412014681 15583823
MESH:D008175 Lung Neoplasms Cisplatin 2.866189445 11798837 17225452
MESH:D008175 Lung Neoplasms Dexamethasone 2.8615824018 11195469
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.3114578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 10.3116827153
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.3115318939
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Cisplatin 3.5311135225 18176117 17761969 15577323 18332650 18505091 12374674 16248763 12883367 16432458 12393984 17023156 16809738
MESH:D008545 Melanoma Tretinoin 3.5316752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8615990972
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D008654 Mesothelioma Cisplatin 6.4217638057
MESH:D008654 Mesothelioma Selenium 6.4215107826
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4217261469
MESH:D009101 Multiple Myeloma Dexamethasone 3.5415867202 16118317 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.649809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.6417596541
MESH:D009203 Myocardial Infarction Genistein 2.8817141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7017141266
MESH:D009369 Neoplasms Cisplatin 5.3616773208
MESH:D009369 Neoplasms Tretinoin 5.3616594593 16946489
MESH:D009395 Nephritis, Interstitial Cisplatin 4.5915464296
MESH:D009421 Nervous System Malformations Genistein 10.0316427766
MESH:D009421 Nervous System Malformations Tretinoin 10.039125849
MESH:D009436 Neural Tube Defects Tretinoin 3.099142499
MESH:D009447 Neuroblastoma Cisplatin 3.478761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.788761367
MESH:D010024 Osteoporosis Genistein 3.2819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1416169203
MESH:D010051 Ovarian Neoplasms Cisplatin 11.506897625 19769630 17225452 15464296
MESH:D010051 Ovarian Neoplasms Genistein 11.5019005980
MESH:D010051 Ovarian Neoplasms Mifepristone 11.5016525653
MESH:D010051 Ovarian Neoplasms Tretinoin 11.5016936753
MESH:D010146 Pain Tretinoin 2.9516870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.5219003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5215976015
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.3715464296
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.4417638057
MESH:D011141 Polyuria Lithium Chloride 6.0819692487
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5721297632
MESH:D011471 Prostatic Neoplasms Genistein 3.4616925846 15378649 15256057
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D051437 Renal Insufficiency Cisplatin 4.4815464296
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0718379247 11700416
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1616116481 16283617
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.4914601052
MESH:D012878 Skin Neoplasms Tretinoin 2.6316467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4415464296
MESH:D013272 Stomach Diseases Dexamethasone 4.4015472012
MESH:D013274 Stomach Neoplasms Cisplatin 2.6417522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 2.6417261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.5415138204
MESH:D013736 Testicular Neoplasms Cisplatin 4.6917225452 15464296
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 2.9712973940 15464296 17225452
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.7416803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.7416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D014605 Uveitis Dexamethasone 4.911336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.6815577323
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D014839 Vomiting Cisplatin 4.8111897121
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00786 antagonist Marimastat Antineoplastic Agents;Enzyme Inhibitors
DB03880 - Batimastat Antineoplastic Agents;Protease Inhibitors
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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