AutismKB 2.0

Annotation Detail for MMP19


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MMP19 ( MMP18,RASI-1 )
Gene Full Name: matrix metallopeptidase 19
Band: 12q13.2
Quick LinksEntrez ID:4327; OMIM: 601807; Uniprot ID:MMP19_HUMAN; ENSEMBL ID: ENSG00000123342; HGNC ID: 7165
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1702Skin tumor
1741Extramammary Paget's disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MMP19 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MMP19 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MMP19 mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in decreased expression of MMP19 mRNAdecreases expression 19654921
D006064 Gonadotropins, Equine [Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of MMP19 mRNAaffects cotreatment|increases expression 15831568
D006063 Chorionic Gonadotropin [Gonadotropins, Equine co-treated with Chorionic Gonadotropin] results in increased expression of MMP19 mRNAaffects cotreatment|increases expression 15831568
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MMP19 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of MMP19 mRNAincreases expression 19482888
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of MMP19 mRNAaffects expression 16962184
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.446195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4411752688 14514962 15322242
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2317620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2316835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5917306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D020261 Arsenic Poisoning Arsenic 2.9216251483 12569548 16835338 18414634
MESH:D050197 Atherosclerosis Arsenic 3.3812928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7117687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.2216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.223581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.223084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 9.2217306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.221701930 17173139 20007298 6705139 20935162
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7418922899 17687452 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3018640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 3.6117938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5216973168 18022660
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.196135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.197505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.329022650 19486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1912621046 15340226 15668235 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.102524372 12868966 14531868 8156756 11298694 18759878 8970840 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.4518289764 18648102 18692083 11289319 1440618 16192314 8291058 6482804 9328219 6679447 9022650 7440962 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4516393943 14725611 16485898 16109766 11743745 19739265 10774834 11461765 11529661 12958197 18713872 2444490 12705907 11834606 12153990 16227642 12594235 19923254 18071297 11287661 10663392 16081117 14550746 17522070 12392966 14986274 11739529 10915739 17562736 16177239 12540782 11421492 15619225 19085960 19420014 15968718 19164858 16781746 19370779 19416960 17906064
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 18230668 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005534 Foot Diseases Arsenic 5.946392382
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly Phenobarbital 9.4816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4816120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6817050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Arsenic 5.4911953799 16076760 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4918850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.9416093927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007642 Keratosis Arsenic 5.3316930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.046582329
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7017339181
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 6.8611587558 16611625 12587719 19014921 16610002 12969438 19784758 19460945
MESH:D008107 Liver Diseases Arsenic 6.8611134558
MESH:D008107 Liver Diseases Phenobarbital 6.8619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.377678174
MESH:D008113 Liver Neoplasms Arsenic 11.3716368122
MESH:D008113 Liver Neoplasms Phenobarbital 11.378742319 19482888 15975961 19073162 21047994 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.292876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.29598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.2917172636 2563599 6150874 18308698 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.2912151625
MESH:D008175 Lung Neoplasms Arsenic 2.4817976673 17306315 19168569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4819555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D017202 Myocardial Ischemia Arsenic 9.6515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.6512213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.207678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.876679447
MESH:D009436 Neural Tube Defects Arsenic 7.8716620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.6417056641
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010051 Ovarian Neoplasms Arsenic 2.8017306315
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.336392382 15371236 16905509
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Arsenic 3.5716140617
MESH:D011507 Proteinuria Arsenic 4.2621343184
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4518551238
MESH:D012640 Seizures Phenobarbital 6.453137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012871 Skin Diseases Arsenic 2.8019834688 15952646 18709164 17938729 16353154 17050553 16702368 16759981 6392382 17453740 17548696
MESH:D012878 Skin Neoplasms Arsenic 6.0417050553 15504454 17029826 19538983 16251483 17976673
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0416192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.761399818 6582329 7505956 6587162 3712494
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.761399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.838074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.8319322015 18640142 11144890 19429237 15987713 17306315 17976673
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014652 Vascular Diseases Arsenic 5.0717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00786 antagonist Marimastat Antineoplastic Agents;Enzyme Inhibitors
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved