AutismKB 2.0

Annotation Detail for ALDH6A1


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Basic Information Top
Gene Symbol:ALDH6A1 ( MGC40271,MMSADHA,MMSDH )
Gene Full Name: aldehyde dehydrogenase 6 family, member A1
Band: 14q24.3
Quick LinksEntrez ID:4329; OMIM: 603178; Uniprot ID:MMSA_HUMAN; ENSEMBL ID: ENSG00000119711; HGNC ID: 7179
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
VALDEG-PWYvaline degradation I
BETA-ALA-DEGRADATION-I-PWYbeta-alanine degradation I
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P02771Pyrimidine Metabolism
Pathway IDPathway Name
500780Branched-chain amino acid catabolism
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Methylmalonate semialdehyde dehydrogenase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ALDH6A1 mRNAdecreases expression 17547211
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ALDH6A1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ALDH6A1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ALDH6A1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ALDH6A1 proteinaffects expression 20106945
D000499 Allylamine Allylamine affects the expression of ALDH6A1 mRNAaffects expression 15910882
D000638 Amiodarone Amiodarone results in increased expression of ALDH6A1 mRNAincreases expression 17991464
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ALDH6A1 mRNAaffects expression 16483693
D000965 Antimony Antimony results in decreased expression of ALDH6A1 mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of ALDH6A1 mRNAdecreases expression 17547211
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ALDH6A1 mRNAdecreases expression 17547211
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ALDH6A1 mRNAdecreases expression 15336504
D002104 Cadmium Cadmium results in decreased expression of ALDH6A1 mRNAdecreases expression 17547211
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of ALDH6A1 mRNAdecreases expression 17547211
D016572 Cyclosporine Cyclosporine results in decreased expression of ALDH6A1 mRNAdecreases expression 20106945
C014347 decitabine decitabine results in decreased expression of ALDH6A1 mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of ALDH6A1 mRNA]affects reaction|decreases expression 19363521
C056507 gemcitabine gemcitabine results in increased expression of ALDH6A1 mRNAincreases expression 17039268
D008628 Mercury Mercury results in decreased expression of ALDH6A1 mRNAdecreases expression 17547211
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ALDH6A1 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ALDH6A1 mRNAdecreases expression 17101203
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ALDH6A1 mRNAdecreases expression 18178546
C025643 vinclozolin vinclozolin affects the expression of ALDH6A1 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of ALDH6A1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7215322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2611798837 19825857
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.4616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.4616835633
MESH:D000592 Amino Acid Metabolism, Inborn Errors marker/mechanism
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000799 Angioedema Acetaminophen 3.7110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.5319015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6918057881 18218290 20041841
MESH:D050197 Atherosclerosis Cadmium 3.5615687053
MESH:D001281 Atrial Fibrillation Amiodarone 3.8018651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 4.7416634805
MESH:D001778 Blood Coagulation Disorders Amiodarone 20.9719483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.9716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.9719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.9712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001943 Breast Neoplasms decitabine 2.0319208741 18320071
MESH:D001943 Breast Neoplasms gemcitabine 2.0317039268 18382427
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D001991 Bronchitis Antimony 6.008768112
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2011589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.6416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.6416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.643084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.6421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.6416217749 14691202 15553829 15073043 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0012490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5619215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3016120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 9.5219225199 15710769
MESH:D002311 Cardiomyopathy, Dilated Antimony 9.5210334427
MESH:D002311 Cardiomyopathy, Dilated Mercury 9.5210334427
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9518974383
MESH:D002386 Cataract Acetaminophen 2.5110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.746135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 10.7417332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.7412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002779 Cholestasis Cyclosporine 7.4319486331
MESH:D002779 Cholestasis pirinixic acid 7.4319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0516354765 15340226 8697196 12621046 15668235
MESH:D003110 Colonic Neoplasms decitabine 2.3117616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5520501625
MESH:D015179 Colorectal Neoplasms decitabine 2.5518981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9517141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.6919769572
MESH:D003456 Cryptorchidism vinclozolin 4.2114966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.4618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.4618551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9715213294
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.6716823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D004283 Dog Diseases Antimony 5.5212019027
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.5918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.5919739265 11461765 14725611 18071297 12153990 17906064 16781746 10915739 11529661 16227642 12540782 11834606 14550746 19416960 10663392 14986274 15619225 16109766 18713872 12705907 19085960 11287661 19923254 12958197 19164858 11421492 17562736 17522070 16177239 12594235 16393943 2444490 16485898 16081117 15968718 10774834 19420014 12392966 11743745 19370779 11739529
MESH:D056486 Drug-Induced Liver Injury Amiodarone 11.5918218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.5920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:C538011 Eales disease Vitamin E 4.579068938
MESH:D004487 Edema pirinixic acid 6.1412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7715322242 16714409 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9919294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9110568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2812903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver Amiodarone 17.7814986274
MESH:D005234 Fatty Liver arsenic trioxide 17.7815073043
MESH:D005234 Fatty Liver Cyclosporine 17.7819224547
MESH:D005234 Fatty Liver pirinixic acid 17.7820131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005355 Fibrosis Cyclosporine 8.0512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.0520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1316904648
MESH:D005756 Gastritis Acetaminophen 3.5516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.4019215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3410048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.3416080930
MESH:D006333 Heart Failure pirinixic acid 2.4620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006529 Hepatomegaly Amiodarone 13.6615265979
MESH:D006529 Hepatomegaly pirinixic acid 13.6618467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.6615340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616863852 16490937
MESH:D019584 Hot Flashes Vitamin E 3.8414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.928697196 18606429 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.6016870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.758137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D006973 Hypertension Cyclosporine 4.7810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7818670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 4.3817991464 18020914
MESH:D007248 Infertility, Male decitabine 6.6317581917
MESH:D007248 Infertility, Male vinclozolin 6.6316467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7912878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.0916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007674 Kidney Diseases Acetaminophen 22.9112587719 15629191
MESH:D007674 Kidney Diseases Cadmium 22.9116962696 16226777 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 22.9116962696
MESH:D007674 Kidney Diseases Cyclosporine 22.918314463 10903974 18776723
MESH:D007674 Kidney Diseases Mercury 22.9117934191
MESH:D007674 Kidney Diseases Vitamin E 22.9112488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.7412371664
MESH:D007896 Leishmaniasis Antimony 4.7021063981 15220340 12019027 10953559 21182181
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.5619141829 8889330 11475954
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.369643325 11370249 10651420 7854095 10881086
MESH:D007898 Leishmaniasis, Visceral Antimony 8.408142506 11105143 7875148 7854095 1899875 7554475 20495762
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 8.4012707265
MESH:D007938 Leukemia arsenic trioxide 6.2415070760
MESH:D007938 Leukemia decitabine 6.2418980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.1819077051
MESH:D007951 Leukemia, Myeloid decitabine 9.1818454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9116968895 20471514 17050201 16467208 19850784
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9117679729 18704418 19010910 18206229 18460780 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3318055864
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 7.859834237
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.8516966277 17217047 16891316 16331271 19225113 16330433 17869043 9834237 15622746 15336539 11161223 12679006 15213294 12712474 19075265 17712046 19642359 12018890 19035177 15748426 17649720 17107899 16112521 16823087 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2216882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6016417039
MESH:D008064 Lipidoses Amiodarone 3.4215342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.3216169303
MESH:D008107 Liver Diseases Acetaminophen 1.6012587719 16610002 11587558 16611625 19460945 19784758 12969438 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1217185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.707678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.709163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 13.7014682389
MESH:D008113 Liver Neoplasms pirinixic acid 13.7020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.7016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.442876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.448603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.4420377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.4412151625
MESH:D008133 Long QT Syndrome Amiodarone 7.8617391786 11989578 15350150
MESH:D008133 Long QT Syndrome arsenic trioxide 7.8615213294
MESH:D008171 Lung Diseases Amiodarone 7.2212587719
MESH:D008171 Lung Diseases Vitamin E 7.2216863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3518516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.7214755239
MESH:D008175 Lung Neoplasms arsenic trioxide 4.7211798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7211884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.7211062179
MESH:D008223 Lymphoma decitabine 3.3319470736
MESH:D008545 Melanoma decitabine 2.2317785578 16505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D009101 Multiple Myeloma arsenic trioxide 7.0715949261 19417148 19549372 14977855 11468182
MESH:D009101 Multiple Myeloma decitabine 7.0718172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009181 Mycoses Amiodarone 4.7712754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2516105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.2519157545 19010910 16882708 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8416411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.9118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.917678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8316624393
MESH:D009369 Neoplasms decitabine 4.8117925555 19116145 19470736
MESH:D009369 Neoplasms pirinixic acid 4.8117405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1718481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0310525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7618514411
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.5016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.5016049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.8512452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms decitabine 4.8519259094 19331143
MESH:D010146 Pain Acetaminophen 2.2916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.5315580305
MESH:D010190 Pancreatic Neoplasms decitabine 8.5319294695
MESH:D010190 Pancreatic Neoplasms gemcitabine 8.5316929163 11504793 18383843 18992248 17440100
MESH:D010235 Paraganglioma arsenic trioxide 4.0419927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010409 Penile Diseases Antimony 5.599643325
MESH:D010493 Pericarditis Antimony 5.9820465667
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.2515687053
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0511896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.0518042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.6017616702
MESH:D011469 Prostatic Diseases vinclozolin 4.8018220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7319131511
MESH:D011471 Prostatic Neoplasms Cadmium 2.7317075824
MESH:D011471 Prostatic Neoplasms Vitamin E 2.7315084515
MESH:D011472 Prostatitis vinclozolin 4.8018629315
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8011597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.2819155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8316646077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.5718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.5718551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9518724381
MESH:D012871 Skin Diseases Vitamin E 2.4118709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.398532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3916192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5417007042
MESH:D013274 Stomach Neoplasms decitabine 2.5419037991
MESH:D013276 Stomach Ulcer Amiodarone 3.2018087811
MESH:D020521 Stroke Vitamin E 3.4116517955
MESH:D013610 Tachycardia Amiodarone 4.1611238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0619225199
MESH:D013959 Thyroid Diseases Amiodarone 11.6219731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.6212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.9919014326
MESH:D013964 Thyroid Neoplasms decitabine 6.9917967635
MESH:D013971 Thyrotoxicosis Amiodarone 4.7319584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 9.8211989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 9.8215213294
MESH:D014352 Trypanosomiasis Antimony 5.8015220340
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.5216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.5216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.5212845720 11780464 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.5219087683 17616700
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.5510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.5510091137
MESH:D014581 Urticaria Acetaminophen 2.8510982225
MESH:D014604 Uveal Neoplasms decitabine 4.7817785578
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
Pathway ID Pathway Name
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00640 Propanoate metabolism
KEGG:00280 Valine, leucine and isoleucine degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24703
    • No data
    No data
    Releated drug ID Related drug Name
    PA451843l-valine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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