AutismKB 2.0

Annotation Detail for MNT


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Basic Information Top
Gene Symbol:MNT ( MAD6,MXD6,ROX,bHLHd3 )
Gene Full Name: MAX binding protein
Band: 17p13.3
Quick LinksEntrez ID:4335; OMIM: 603039; Uniprot ID:MNT_HUMAN; ENSEMBL ID: ENSG00000070444; HGNC ID: 7188
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of MNT mRNAdecreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MNT mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of MNT mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of MNT mRNAdecreases expression 18503570
C106014 gedunin gedunin results in increased expression of MNT mRNAincreases expression 17010675
D019833 Genistein Genistein results in increased expression of MNT mRNAincreases expression 15256057
D009151 Mustard Gas Mustard Gas results in decreased expression of MNT mRNAdecreases expression 15674843
C017947 sodium arsenite sodium arsenite results in increased expression of MNT mRNAincreases expression 17879257
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MNT mRNAincreases expression 18691609
D014212 Tretinoin Tretinoin affects the expression of MNT mRNAaffects expression 16054129
C050414 tripterine tripterine results in increased expression of MNT mRNAincreases expression 17010675
D014810 Vitamin E Vitamin E results in decreased expression of MNT mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 15322242 14514962
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6219825857 11798837
MESH:D000230 Adenocarcinoma Genistein 4.6211473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0817306315 16712894
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.1416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Mustard Gas 5.0810378619
MESH:D001249 Asthma Tretinoin 5.0816456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001768 Blister Mustard Gas 5.3119167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.0016206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.0012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.0016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Genistein 1.9617200150 16873071 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616166294 16873071 16443354
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1517687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7415553829 14691202 11135700 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.7416924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7416507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.741917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7816051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.3816332659
MESH:D002386 Cataract Tretinoin 3.1517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.6112371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.6119524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D054221 Classical Lissencephalies and Subcortical Band Heterotopias marker/mechanism 15028671
MESH:D002972 Cleft Palate marker/mechanism 15028671
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9012621046 8697196 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.909407595
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities marker/mechanism 15028671
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.4910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.4910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.499125849 16925845 9224671 10589399 9664655 17551590 9211117 9142499 14991402 8800419
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.4919769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4117107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema Mustard Gas 7.219260866 11428631 11402378 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.5316714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 12.5318230668
MESH:D004714 Endometrial Hyperplasia Genistein 4.7416402032
MESH:D016889 Endometrial Neoplasms Genistein 7.7911473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.7916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004890 Erythema Mustard Gas 5.319357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5412903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.119664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 13.7815073043
MESH:D005234 Fatty Liver Cyclosporine 13.7819224547
MESH:D005234 Fatty Liver Dietary Fats 13.7817967931 19551842 19004024 18296743
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 22.3612168785 12639820
MESH:D005355 Fibrosis Dietary Fats 22.3618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.3620067830
MESH:D005355 Fibrosis Tretinoin 22.3617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Genistein 7.4416598420
MESH:D005909 Glioblastoma Tretinoin 7.4417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.4510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.459664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 11.4516080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D006689 Hodgkin Disease sodium arsenite 3.2512676792
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.3016870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007248 Infertility, Male sodium arsenite 3.0612646999 15346721
MESH:D007249 Inflammation Dietary Fats 8.6520412841
MESH:D007249 Inflammation Mustard Gas 8.6511428620 11402378 9260866 11428647 8975870 16001271 17524151 9357497 11428631
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6512200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.3916624496
MESH:D007333 Insulin Resistance Dietary Fats 3.1718457598 11836018
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.3015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 10.448314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 10.4420008137
MESH:D007674 Kidney Diseases Vitamin E 10.4412488133
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D007938 Leukemia arsenic trioxide 10.8015070760
MESH:D007938 Leukemia Genistein 10.8018980019 17468513
MESH:D007938 Leukemia Tretinoin 10.8017143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.8419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.8416932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9419850784 16467208 16968895 17050201 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9417596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.8715336539 16823087 12679006 17649720 15748426 19642359 16330433 15622746 11468182 16891316 16966277 15213294 17217047 9834237 11161223 19075265 12018890 17712046 16331271 17869043 19225113 17107899 16112521 12712474 19035177
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.8717712046 16331271 17361223 17368321 16788101 17217047 19075265 15748426 17339181 9834237 17649720 12679006 16891316 19029980 19642359 16140955 17294898 16935935 16823087 17301526 17107899 17506722 19035177 19225113 16766008
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0617823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0616248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0616169303
MESH:D008113 Liver Neoplasms arsenic trioxide 7.6514682389
MESH:D008113 Liver Neoplasms sodium arsenite 7.6516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.0220377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D008171 Lung Diseases Mustard Gas 12.8018161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 12.8019095001
MESH:D008171 Lung Diseases Vitamin E 12.8016863852
MESH:D008175 Lung Neoplasms arsenic trioxide 6.7211798837 19825857
MESH:D008175 Lung Neoplasms Mustard Gas 6.723148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 6.7217077188 17306315 15276417 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7219555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 6.7211062179
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0112929590 14578162
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma sodium arsenite 3.3919082730 16487513
MESH:D008545 Melanoma Tretinoin 3.3916752155
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1819417148 19549372 11468182 14977855 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.5916105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5917596541
MESH:D009203 Myocardial Infarction Genistein 2.9017141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7417141266
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009369 Neoplasms sodium arsenite 5.2811559025
MESH:D009369 Neoplasms Tretinoin 5.2816946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8020056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Genistein 17.1516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.1514600291
MESH:D009421 Nervous System Malformations Tretinoin 17.159125849
MESH:D009436 Neural Tube Defects arsenic trioxide 12.5610525206
MESH:D009436 Neural Tube Defects sodium arsenite 12.5612854658
MESH:D009436 Neural Tube Defects Tretinoin 12.569142499
MESH:D009503 Neutropenia Mustard Gas 4.097688884 16761898
MESH:D009765 Obesity Dietary Fats 2.3121332399 20132043 17217161 16723640 18674790 18457598 19632207 20518802 11836018
MESH:D010024 Osteoporosis Genistein 3.3219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2016169203
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.5719769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Genistein 11.5719005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.5715276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 11.5716936753
MESH:D010146 Pain Tretinoin 2.9916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4115580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4115976015
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D011041 Poisoning Mustard Gas 3.9115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0819131511
MESH:D011471 Prostatic Neoplasms Genistein 2.0816925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0816039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0815084515
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Mustard Gas 4.2518058305
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9610334151 17894541 17266442 17620002 17720292
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0916646077
MESH:D012871 Skin Diseases Mustard Gas 5.1112880345 15451306 16961503
MESH:D012871 Skin Diseases Vitamin E 5.1118709164
MESH:D012878 Skin Neoplasms sodium arsenite 9.7119524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7116192470
MESH:D012878 Skin Neoplasms Tretinoin 9.7116467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8812854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4817007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.4817261132
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.4919014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.4916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2912845720 12973940 20435036 11780464
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2916712894 11723127 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.7611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.7616129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014652 Vascular Diseases sodium arsenite 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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