AutismKB 2.0

Annotation Detail for MOCS1


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Basic Information Top
Gene Symbol:MOCS1 ( KIAA0381,MIG11,MOCOD )
Gene Full Name: molybdenum cofactor synthesis 1
Band: 6p21.2
Quick LinksEntrez ID:4337; OMIM: 603707; Uniprot ID:MOCS1_HUMAN; ENSEMBL ID: ENSG00000124615; HGNC ID: 7190
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
H00192Xanthinuria
Inherited disorders of nucleotide metabolism
Genetic disorders
No data
No data
No data
Desease Name
Molybdenum cofactor deficiency, type A
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MOCS1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of MOCS1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MOCS1 mRNAaffects expression 17562736
C006780 bisphenol A bisphenol A results in increased expression of MOCS1 mRNAincreases expression 20678512
D016572 Cyclosporine Cyclosporine results in decreased expression of MOCS1 mRNAdecreases expression 20106945
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of MOCS1 mRNAincreases expression 15458575
D010269 Paraquat Paraquat results in increased expression of MOCS1 mRNAincreases expression 15458575
D010634 Phenobarbital Phenobarbital affects the expression of MOCS1 mRNAaffects expression 19136022
D010634 Phenobarbital Phenobarbital results in increased expression of MOCS1 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid affects the expression of MOCS1 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in increased expression of MOCS1 mRNAincreases expression 18445702
D014415 Tunicamycin Tunicamycin results in increased expression of MOCS1 mRNAincreases expression 15458575
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.507525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.506195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.9317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9316434500
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.0011874814
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001862 Bone Resorption bisphenol A 4.0311985600
MESH:D001943 Breast Neoplasms bisphenol A 2.4517123778
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.663084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.6617173139 1701930 20007298 20935162 6705139
MESH:D002278 Carcinoma in Situ bisphenol A 5.2317123778
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.6316936243
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.7414694615
MESH:D002386 Cataract Acetaminophen 7.7410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3115095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.5321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5312958197 12705907 12392966 10915739 10663392 16081117 14986274 19416960 12540782 11287661 11739529 19739265 18713872 14725611 16485898 11461765 10774834 16109766 17562736 16781746 19164858 11421492 2444490 17522070 12153990 17906064 16227642 15968718 11529661 18071297 19370779 19085960 19420014 16177239 12594235 11743745 19923254 11834606 16393943 14550746 15619225
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.143922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D005234 Fatty Liver Cyclosporine 8.1419224547
MESH:D005234 Fatty Liver pirinixic acid 8.1419236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005911 Gliosis Paraquat 5.4311124998
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly Phenobarbital 9.2116109766
MESH:D006529 Hepatomegaly pirinixic acid 9.2119772884 16221962 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007248 Infertility, Male Paraquat 3.364850670
MESH:D007333 Insulin Resistance bisphenol A 7.6716393666
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.1018776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.4416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7612371664
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9821047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 4.0612969438 19460945 16610002 19014921 16611625 12587719 19784758 11587558
MESH:D008107 Liver Diseases Phenobarbital 4.0619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.6619812893 8742319 21047994 15975961 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 4.6615890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.801399818 18308698 17172636 2563599 6150874
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:C535811 Molybdenum cofactor deficiency marker/mechanism
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009410 Nerve Degeneration Paraquat 3.8516893418
MESH:D009421 Nervous System Malformations bisphenol A 4.1716427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6712819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.6714694615
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010049 Ovarian Diseases bisphenol A 5.2311985600
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5416965848
MESH:D010212 Papilloma Hydrogen Peroxide 4.3012065085
MESH:D010300 Parkinson Disease Paraquat 2.8716510128 11124998 16140633 11445065 11181820 15451049 15824117 12911755
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.6516190885
MESH:D011014 Pneumonia Paraquat 4.6912504350
MESH:D011230 Precancerous Conditions Cyclosporine 9.4812371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.482563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1910548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3820887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3816740699
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011629 Puberty, Precocious bisphenol A 5.0210548101
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9717997886 16324872
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.0911700416
MESH:D012135 Respiratory Sounds Paraquat 4.2711874814
MESH:D012162 Retinal Degeneration Paraquat 3.9916458197
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3018551238
MESH:D012640 Seizures Phenobarbital 6.303137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 3.1412065085
MESH:D019966 Substance-Related Disorders bisphenol A 4.2216045194 16684133
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.181399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014591 Uterine Diseases bisphenol A 5.2714652134
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:00790 Folate biosynthesis
KEGG:01100 Metabolic pathways
REACT:11193 Metabolism of vitamins and cofactors
KEGG:04122 Sulfur relay system
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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