AutismKB 2.0

Annotation Detail for MOG


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Basic Information Top
Gene Symbol:MOG ( MGC26137,MOGIG2 )
Gene Full Name: myelin oligodendrocyte glycoprotein
Band: 6p22.1
Quick LinksEntrez ID:4340; OMIM: 159465; Uniprot ID:MOG_HUMAN; ENSEMBL ID: ENSG00000204655; HGNC ID: 7197
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1828Encephalitis
1877Multiple sclerosis
2069Schizophrenia
2124Autistic disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MOG mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MOG mRNAaffects expression 16483693
D004390 Chlorpyrifos Chlorpyrifos affects the expression of MOG mRNAaffects expression 17452286
D006220 Haloperidol Haloperidol results in decreased expression of MOG mRNAdecreases expression 17177202
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MOG mRNAaffects binding|increases activity|increases expression 19710929
C089730 rosiglitazone [rosiglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of MOG mRNAaffects binding|increases activity|increases expression 18543250
C025643 vinclozolin vinclozolin affects the expression of MOG mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of MOG mRNAdecreases expression 19244175
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of MOG mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 11.5918287403
MESH:D000138 Acidosis Zinc Sulfate 11.597265320
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.6311874814 16611668 17119214
MESH:D000544 Alzheimer Disease rosiglitazone 2.8919621015
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D000860 Anoxia Zinc Sulfate 5.307265320
MESH:D001008 Anxiety Disorders vinclozolin 3.8019015723
MESH:D001321 Autistic Disorder Acetaminophen 2.1318445737
MESH:D001321 Autistic Disorder Haloperidol 2.1318080171 19368416
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002375 Catalepsy Haloperidol 5.1915215559 1977408
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003456 Cryptorchidism vinclozolin 4.5814966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.0620210726
MESH:D003704 Dementia Haloperidol 4.7811575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.4817446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 2.9812642470
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6310774834 11834606 12540782 19923254 12594235 16227642 11739529 16109766 11529661 10915739 12153990 16081117 16781746 11287661 14550746 14986274 19164858 15619225 16485898 19739265 19420014 11421492 19370779 2444490 10663392 12958197 16393943 17906064 18713872 19085960 14725611 15968718 11461765 16177239 12392966 12705907 19416960 17522070 17562736 18071297 11743745
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema pirinixic acid 7.6912083418
MESH:D004487 Edema rosiglitazone 7.6912083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental marker/mechanism 17654737
MESH:D005234 Fatty Liver pirinixic acid 8.6519236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 8.6519196556
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6216417039
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 5.2617063115
MESH:D006529 Hepatomegaly pirinixic acid 3.2519176532 16221962 18467677 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006930 Hyperalgesia Acetaminophen 8.4416870215
MESH:D006930 Hyperalgesia rosiglitazone 8.4412083418
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D007022 Hypotension Zinc Sulfate 4.697265320
MESH:D007248 Infertility, Male vinclozolin 3.1716467254
MESH:D007249 Inflammation rosiglitazone 3.2212083418
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007333 Insulin Resistance pirinixic acid 7.9316306350
MESH:D007333 Insulin Resistance rosiglitazone 7.9316306350
MESH:D007674 Kidney Diseases Acetaminophen 6.3315629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.3312488133
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.4315237267
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0216417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6915474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.6917347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6916169303
MESH:D008107 Liver Diseases Acetaminophen 4.4112969438 12587719 19784758 16610002 11587558 19014921 19460945 16611625
MESH:D008107 Liver Diseases Chlorpyrifos 4.4115991261
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8820007298 16377806 15890375
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.5116827153
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D001523 Mental Disorders Haloperidol 4.2916856516
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.5517261469
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.3015081274
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1818220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.2218220299
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2715084515
MESH:D011472 Prostatitis vinclozolin 5.2218629315
MESH:D011595 Psychomotor Agitation Haloperidol 5.2111575062
MESH:D011618 Psychotic Disorders Haloperidol 4.3911575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.8917119214 16611668 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.2116611668 17119214
MESH:D012559 Schizophrenia Haloperidol 2.8220107430 19369910 18513383 1830565
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.416418539
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.9420210726
MESH:D014581 Urticaria Acetaminophen 3.2010982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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