AutismKB 2.0

Annotation Detail for ASL


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Basic Information Top
Gene Symbol:ASL ( ASAL )
Gene Full Name: argininosuccinate lyase
Band: 7q11.21
Quick LinksEntrez ID:435; OMIM: 608310; Uniprot ID:ARLY_HUMAN; ENSEMBL ID: ENSG00000126522; HGNC ID: 746
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-4983citrulline-nitric oxide cycle
ARGININE-SYN4-PWYarginine biosynthesis IV
PWY-4984urea cycle
PWY-5004superpathway of citrulline metabolism
Pathway IDPathway Name
hsa00250Alanine, aspartate and glutamate metabolism
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P02728Arginine biosynthesis
Pathway IDPathway Name
500783Urea cycle
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Argininosuccinic aciduria
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ASL mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen results in decreased expression of ASL mRNAdecreases expression 15120968
D000082 Acetaminophen Acetaminophen results in increased expression of ASL mRNAincreases expression 11779202
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ASL proteinaffects expression 20106945
C018824 ammonium acetate ammonium acetate results in increased activity of ASL proteinincreases activity 16009439
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ASL mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of ASL mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ASL mRNAincreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ASL mRNAincreases expression 17522070
D002725 Chloroform Chloroform results in increased expression of ASL mRNAincreases expression 17522070
D016572 Cyclosporine Cyclosporine results in decreased expression of ASL mRNAdecreases expression 20106945
C056933 fumonisin B1 fumonisin B1 results in decreased expression of ASL mRNAdecreases expression 16221962
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of ASL mRNAincreases expression 11779202
D008713 Methimazole Methimazole results in decreased expression of ASL mRNAdecreases expression 17403546
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of ASL mRNAincreases expression 17522070
C494474 perchlorate perchlorate results in decreased expression of ASL mRNAdecreases expression 17403546
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ASL mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ASL mRNAdecreases expression 16221962
C006253 pirinixic acid pirinixic acid results in increased expression of ASL mRNAincreases expression 18445702
C006253 pirinixic acid pirinixic acid results in decreased expression of ASL mRNAdecreases expression 17164430
D011441 Propylthiouracil Propylthiouracil results in decreased expression of ASL mRNAdecreases expression 17403546
D011794 Quercetin Quercetin results in increased expression of ASL mRNAincreases expression 16455785
C079198 S 1 (combination) ASL protein results in increased susceptibility to S 1 (combination)increases response to substance 16734730
D012643 Selenium Selenium results in increased expression of ASL mRNAincreases expression 19244175
C009250 sevoflurane sevoflurane affects the expression of ASL mRNAaffects expression 15967596
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ASL mRNAaffects binding|decreases expression 16214954
D013752 Tetracycline Tetracycline results in increased expression of ASL mRNAincreases expression 17522070
D013806 Theophylline Theophylline results in decreased expression of ASL mRNAdecreases expression 17522070
D014212 Tretinoin Tretinoin results in increased expression of ASL mRNAincreases expression 16012519
17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.4518653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.4518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2419825857 11798837
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2616835633
MESH:D000505 Alopecia Tretinoin 3.4615955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0717084956
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D056807 Argininosuccinic Aciduria marker/mechanism
MESH:D001169 Arthritis, Experimental Tretinoin 2.9616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Theophylline 5.2112113382 9701106
MESH:D001249 Asthma Tretinoin 5.2116456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7815336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Quercetin 4.2219761891
MESH:D001471 Barrett Esophagus Tretinoin 4.2216935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 26.9716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 26.9719483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 26.9719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 26.9712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 26.9716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001943 Breast Neoplasms Quercetin 1.8918628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8916873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4016813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1511589617
MESH:D002105 Cadmium Poisoning Quercetin 5.3516962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5916011737 16050911 16097048 3786805 16124888 16192424 10355542 15700767 15721981 16227642 18705752 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9716168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.603084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.6012907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.6014691202 15073043 16217749 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.6018788625
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.6012508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.601917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 4.0018347146 18212800
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6819014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9512490120
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 5.0415984520
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0416096774 16051514
MESH:D006332 Cardiomegaly Quercetin 6.4519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4518670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 6.8610977129
MESH:D002386 Cataract Tretinoin 6.8617460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.1220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.1212371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4016129372
MESH:D002637 Chest Pain Theophylline 5.6815238202
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0016835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 6.0112912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 12.7318164287 12927374 16629650 7624871 15500046 18590720 15913567 19486331
MESH:D002779 Cholestasis Cyclosporine 12.7319486331
MESH:D002779 Cholestasis pirinixic acid 12.7319176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.6610220858 19407337
MESH:D002822 Choriocarcinoma Tretinoin 4.9716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.508697196 15668235 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.509407595
MESH:D003092 Colitis Selenium 8.8717936198
MESH:D003092 Colitis Tretinoin 8.8717035595
MESH:D003110 Colonic Neoplasms Quercetin 2.3915741050 19056647 16640504 17191121 11134977 19440933 17148506
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5720501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.5718095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6410048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.649125849 9142499 14991402 9224671 9664655 9211117 8800419 16925845 17551590 10589399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9215213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5819496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 24.8417522070 20133375 18289764 7624871
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 24.8421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 24.8419420014 10663392 11421492 10915739 12958197 18713872 16081117 18071297 17906064 12705907 17522070 11461765 19164858 14725611 16227642 16781746 12594235 19416960 14986274 17562736 15619225 14550746 15968718 10774834 16109766 12540782 19739265 12153990 2444490 11529661 11287661 16393943 16177239 11743745 19085960 12392966 11834606 11739529 19923254 16485898 19370779
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 24.846884620 7120509 4309450 19336974 15027814 3786805 7179309 15998439 10915739 3732212 17522070 6623471 21278145 16227642 10092053 19085960 2869522 7440962 15968718 11566570 16177239 9327722
MESH:D056486 Drug-Induced Liver Injury Chloroform 24.846884620 17522070 3104120 7120509 7440962 3732212 2862719 6623471
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 24.8416221962
MESH:D056486 Drug-Induced Liver Injury Selenium 24.8415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 24.8420420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 24.8417522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004487 Edema pirinixic acid 5.9712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3018230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.3018230668
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8610568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2015821434 15328337 17637181
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.2912903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.379664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 22.8215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.8212631006 15959796 61145 17595544 12795759 19224547 16045604 16239168
MESH:D005234 Fatty Liver Cyclosporine 22.8219224547
MESH:D005234 Fatty Liver pirinixic acid 22.8219236843 20131406
MESH:D005234 Fatty Liver Tetracycline 22.8216917069 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005334 Fever Lipopolysaccharides 3.8511852909 9205823
MESH:D005355 Fibrosis Carbon Tetrachloride 25.7218705752
MESH:D005355 Fibrosis Cyclosporine 25.7212639820 12168785
MESH:D005355 Fibrosis Quercetin 25.7219474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.7220067830
MESH:D005355 Fibrosis Tretinoin 25.7217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 11.1716904648
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 11.1719093184
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005909 Glioblastoma Quercetin 6.8519804834
MESH:D005909 Glioblastoma Tretinoin 6.8517312396
MESH:D005910 Glioma Quercetin 2.9817643826
MESH:D006042 Goiter perchlorate 5.1318801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 7.8718607998 15984520
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.8716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9716084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.2014991402 9664655
MESH:D006333 Heart Failure pirinixic acid 6.5620558911
MESH:D006333 Heart Failure Selenium 6.5617162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 9.0518590720
MESH:D006505 Hepatitis Carbon Tetrachloride 9.0519110552 19900420
MESH:D006529 Hepatomegaly fumonisin B1 13.3916221962
MESH:D006529 Hepatomegaly pirinixic acid 13.3918467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.3915340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.858697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.1316870215
MESH:D006930 Hyperalgesia Tretinoin 7.1316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3816778211
MESH:D006943 Hyperglycemia pirinixic acid 8.6920558911
MESH:D006943 Hyperglycemia Quercetin 8.6911834736 18262572
MESH:D006973 Hypertension Cyclosporine 8.1510903974
MESH:D006973 Hypertension Quercetin 8.1518356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D006980 Hyperthyroidism Methimazole 5.4314678291
MESH:D007037 Hypothyroidism Methimazole 11.3218031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.3218031379 8137927
MESH:D007248 Infertility, Male Theophylline 4.2916988215
MESH:D007249 Inflammation Lipopolysaccharides 4.7512878042 17237260 17963957 17255318 9205823
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7512200463 12878042
MESH:D007251 Influenza, Human Quercetin 10.4216624496
MESH:D007251 Influenza, Human Selenium 10.4216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5817994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4517255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3617551590 15992940
MESH:D007627 Keloid Quercetin 4.7717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Acetaminophen 9.4112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.418314463 10903974 18776723
MESH:D007674 Kidney Diseases Quercetin 9.4116962696
MESH:D007676 Kidney Failure, Chronic Selenium 3.7116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 6.7616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 6.7612371664
MESH:D007859 Learning Disorders sevoflurane 4.5819212262
MESH:D007938 Leukemia arsenic trioxide 9.9715070760
MESH:D007938 Leukemia Quercetin 9.9717468513
MESH:D007938 Leukemia Tretinoin 9.9717143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.9019077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.9016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7620471514 16968895 17050201 19850784 16467208
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7617596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.2217107899 17869043 9834237 12679006 17712046 15748426 12018890 16331271 17217047 16966277 19035177 19225113 16112521 16330433 16823087 11161223 19642359 15336539 11468182 15213294 12712474 15622746 19075265 17649720 16891316
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.2217339181 16823087 17368321 17301526 9834237 16788101 16766008 16891316 19035177 19075265 17712046 16935935 19642359 17294898 16331271 17361223 15748426 17649720 17107899 19225113 17217047 17506722 16140955 12679006 19029980
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1716882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.5115821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.179224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7011903743 17157831 16943688 16221502 21278145 17174718 17334410 16239168 11408273
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.4218006644 18339082 14620537 17708605 17557913 17640975 18395914 15123356 12898905 18205269 18054572 17761835 16015684 17525996 12445418 12445421 18412020 10355542 18376398 15362042 18251166 18418968 12546737 16027843 17714472 15338365 14716496 18187930 15818738 17721639 17823541 12632514 12666154 18429990 15370692 17766677 14512876 18210741 12389079 16248980 17698563 15730626 15925388 15876570 16192424 13678700 16011737 18279442 12958196 18156304 14748882 17805973 17631135 15673190 18277467 12667390 12586293 15996030 14724832 17922224 14716833 18472094 15057751 12741479 17976157 18317297 16638106 18263696 12632512 17900296 20821823 18166357 15959796 11481614 16136751 16116963 18705752 18395095 15893842 15931870 17869086 12649538 17481882 18472332 15052691 18481824 17944888 17565644 16033810 16097048 18420326 12609069 15650968
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.4212878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 8.4212741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.4216248980 18397230
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 6.3217184895
MESH:D008107 Liver Diseases Acetaminophen 6.3216611625 12587719 12969438 19014921 19784758 16610002 19460945 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3217285989 15830285 16964402 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8514706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 17.0415890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 17.0414682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.0419294768
MESH:D008113 Liver Neoplasms pirinixic acid 17.0415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 17.0418980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.0416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.408603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.4020377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.4012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Quercetin 17.4019519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.4012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2115213294
MESH:D055370 Lung Injury Lipopolysaccharides 3.8221114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.6714755239
MESH:D008175 Lung Neoplasms arsenic trioxide 4.6711798837 19825857
MESH:D008175 Lung Neoplasms Quercetin 4.6716280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6711884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.6415318939
MESH:D008527 Medulloblastoma Tretinoin 2.7117453147
MESH:D008545 Melanoma Tretinoin 1.9216752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008569 Memory Disorders sevoflurane 4.5719212262
MESH:D008591 Meningomyelocele Tretinoin 4.2416940565
MESH:D008654 Mesothelioma Selenium 2.7215107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9714977855 11468182 19417148 19549372 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.0316882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0317596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.4619151258
MESH:D009203 Myocardial Infarction Quercetin 5.4619595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.9619207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6718551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7816624393
MESH:D009369 Neoplasms pirinixic acid 7.7317405874
MESH:D009369 Neoplasms Quercetin 7.7315185748
MESH:D009369 Neoplasms Tretinoin 7.7316946489 16594593
MESH:D009395 Nephritis, Interstitial Tetracycline 4.599884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9014600291
MESH:D009421 Nervous System Malformations Tretinoin 8.909125849
MESH:D009436 Neural Tube Defects arsenic trioxide 6.8910525206
MESH:D009436 Neural Tube Defects Tretinoin 6.899142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7218514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.1817929310
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2616049721 12819281
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0419495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.5919769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Quercetin 7.5919005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.5916936753
MESH:D010146 Pain Acetaminophen 6.0816870215
MESH:D010146 Pain Tretinoin 6.0816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.2715580305
MESH:D010190 Pancreatic Neoplasms Quercetin 8.2716965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.2715976015
MESH:D010235 Paraganglioma arsenic trioxide 3.9819927285
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 13.1420133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 13.1412520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.2411026799
MESH:D010954 Plasmacytoma Selenium 4.7015087411
MESH:D011014 Pneumonia Lipopolysaccharides 4.3612224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.5612371664
MESH:D011230 Precancerous Conditions Quercetin 8.5619056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0011896295 11118676 11399792 11222880
MESH:D017096 Prion Diseases Tetracycline 5.2210903871
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.4719131511
MESH:D011471 Prostatic Neoplasms Quercetin 3.4717292933 14715546
MESH:D011507 Proteinuria Tretinoin 3.4316636307
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011625 Pterygium Tretinoin 4.6016723453
MESH:D029424 Pulmonary Disease, Chronic Obstructive Theophylline 4.9918983928
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6110835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9216283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7816646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.3516862918
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4118551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2616192470
MESH:D012878 Skin Neoplasms Tretinoin 5.2616467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4817007042
MESH:D013274 Stomach Neoplasms S 1 (combination) 3.4818553229 16557585 18506536
MESH:D013274 Stomach Neoplasms Tretinoin 3.4817261132
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 9.4920133375
MESH:D013921 Thrombocytopenia Lipopolysaccharides 9.4915821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.2419014326
MESH:D013964 Thyroid Neoplasms Propylthiouracil 11.2415710170
MESH:D013964 Thyroid Neoplasms Tretinoin 11.2416026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.6216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7715213294
MESH:D014376 Tuberculosis Tretinoin 3.1116040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.9416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.9412973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.9416720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1210091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.4216752155
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D014820 Vitiligo Tretinoin 3.8716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D009396 Wilms Tumor Tretinoin 3.8116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
KEGG:00250 Alanine, aspartate and glutamate metabolism
KEGG:00330 Arginine and proline metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25046
    • No data
    Releated disease ID Related disease Name
    PA446794Williams Syndrome
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA451831urea
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00125 - L-Arginine Dietary supplement;Micronutrient;Conditionally Essential Amino Acids
    DB02267 - Argininosuccinate
    DB03814 - 2-(N-Morpholino)-Ethanesulfonic Acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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